Sigrun Hope

• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva; Abrahamsen, Tore G; Nerhus, Mari; Wedervang-Resell, Kirsten; Lonning, Vera Louise Hiorth; Johannessen, Jarle; Steen, Nils Eiel; Agartz, Ingrid; Stenberg, Nina; Hundhausen, Thomas Eckhard; Mørkrid, Lars & Andreassen, Ole Andreas (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal.  ISSN 0892-6638.  34(6), s 8114- 8124 . doi: 10.1096/fj.201900855RRR
• Nordstrøm, Marianne; Retterstøl, Kjetil; Hope, Sigrun & Kolset, Svein Olav (2020). Nutritional challenges in children and adolescents with Down syndrome. The Lancet Child and Adolescent Health.  ISSN 2352-4642.  4(6), s 455- 464 . doi: 10.1016/S2352-4642(19)30400-6
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas & Ueland, Thor (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry.  ISSN 1664-0640.  11 . doi: 10.3389/fpsyt.2020.00672 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interplay with dyslipidemia is a central driver in the pathogenesis of CVD. We hypothesize that evaluation of atherogenic lipid ratios together with inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis, could give novel information on immune-related mechanisms involved in early CVD risk in patients with psychotic disorders. Methods: As a measure for CVD risk we calculated atherogenic lipid ratios using established sex-specific cut-offs: Total cholesterol/high-density lipoprotein; HDL-c (TC/HDL) and triglyceride/HDL-c (TG/HDL) were evaluated in 571 schizophrenia (SCZ) and 247 bipolar disorder (BD) patients, and in 99 healthy controls (HC). In addition, as a measure of low-grade inflammation, we measured fasting plasma levels of nine stable atherogenic inflammatory markers in patients (SCZ, BD) and in HC. The elevated inflammatory markers and CVD risk in patients, as reflected by TC/HDL and TG/HDL, were further assessed in multivariable analyses adjusting for comorbid cardio-metabolic risk factors. Results: A markedly higher proportion (26%-31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses. Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies. Keywords: CVD risk; bipolar disorder; dyslipidemia; inflammatory biomarkers; schizophrenia.

• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob; Zhu, Zhaozhong; Tucker-Drob, Elliot M.; Nivard, Michel G.; Grotzinger, Andrew D.; Posthuma, Danielle; Yu, Dongmei; Stahl, Eli A.; Walters, Raymond K.; Anney, Richard J.L.; Duncan, Laramie E.; Ge, Tian; Belangero, Sintia I.; Cook, Edwin H.; Hoekstra, Pieter J.; Keski-Rahkonen, Anna; Kirov, George; Luykx, Jurjen J.; Rohde, Luis A.; Agerbo, Esben; Arranz, M.J.; Asherson, Philip; Bækvad-Hansen, Marie; Bellgrove, Mark A.; Belliveau Jr, Richard A.; Buitelaar, Jan; Bybjerg-Grauholm, Jonas; Casas, Miquel; Chambert, Kimberly; Cerrato, Felecia; Churchhouse, Claire; Cormand, Bru; Crosbie, Jennifer; Dalsgaard, Søren; Haavik, Jan; Hakonarson, Hakon; Hansen, Christine S.; Mors, Ole; Zayats, Tetyana; Bettella, Francesco; Hope, Sigrun; Hultman, Christina M.; Nærland, Terje; Bøen, Erlend; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Malt, Ulrik Fredrik; Melle, Ingrid; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Espeseth, Thomas; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Jönsson, Erik Gunnar; Andreassen, Ole Andreas; Agartz, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne & Joa, Inge (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell.  ISSN 0092-8674.  179(7), s 1469- 1482 . doi: 10.1016/j.cell.2019.11.020 Fulltekst i vitenarkiv.
• Grove, Jakob; Ripke, Stephan; Als, Thomas D.; Mattheisen, Manuel; Walters, Raymond K.; Won, Hyejung; Pallesen, Jonatan; Agerbo, Esben; Andreassen, Ole Andreas; Anney, Richard; Awashti, Swapnil; Belliveau, Rich; Bettella, Francesco; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Christensen, Jane H.; Churchhouse, Claire; Dellenvall, Karin; Demontis, Ditte; De Rubeis, Silvia; Devlin, Bernie; Djurovic, Srdjan; Dumont, Ashley L.; Goldstein, Jacqueline I.; Hansen, Christine S.; Hauberg, Mads Engel; Hollegaard, Mads V.; Hope, Sigrun; Howrigan, Daniel P.; Huang, Hailiang; Hultman, Christina M.; Klei, Lambertus; Maller, Julian; Martin, Joanna; Martin, Alicia R.; Moran, Jennifer L.; Nyegaard, Mette; Nærland, Terje; Palmer, Duncan S.; Palotie, Aarno; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; dPoterba, Timothy; Poulsen, Jesper Buchhave; St. Pourcain, Beate; Qvist, Per; Rehnström, Karola; Reichenberg, Abraham; Reichert, Jennifer; Robinson, Elise B.; Roeder, Kathryn; Roussos, Panos; Saemundsen, Evald; Sandin, Sven; Satterstrom, F. Kyle; Smith, George Davey; Stefánsson, Hreinn; Steinberg, Stacy; Stevens, Christine R.; Sullivan, Patrick F.; Turley, Patrick; Walters, G. Bragi; Xu, Xinyi; Stefansson, Kari; Geschwind, Daniel H.; Nordentoft, Merete; Hougaard, David M.; Werge, Thomas; Mors, Ole; Mortensen, Preben Bo; Neale, Benjamin M.; Daly, Mark J. & Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics.  ISSN 1061-4036.  51, s 431- 444 . doi: 10.1038/s41588-019-0344-8 Vis sammendrag

  Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping Genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared With other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD

• Hassel, Bjørnar; Rogne, Ane Gretesdatter & Hope, Sigrun (2019). Intellectual disability associated with pyridoxine-responsive epilepsies: The need to protect cognitive development. Frontiers in Psychiatry.  ISSN 1664-0640.  10:116, s 1- 8 . doi: 10.3389/fpsyt.2019.00116 Fulltekst i vitenarkiv.
• Holmøy, Anne Katrin; Johannessen, Cecilie Haggag; Hope, Sigrun; Van Walsem, Marleen Regina; Aanonsen, Nils Olav & Hassel, Bjørnar (2019). Uncovering health and social care needs among myotonic dystrophy patients: Utility of the Needs and Provisions Complexity Scale. Acta Neurologica Scandinavica.  ISSN 0001-6314.  139(6), s 526- 532 . doi: 10.1111/ane.13086
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Gardsjord, Erlend Strand; Aas, Monica; Iversen, Trude; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Thor & Andreassen, Ole Andreas (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine.  ISSN 0033-2917.  49(10), s 1749- 1757 . doi: 10.1017/S0033291718004142 Vis sammendrag

  Background. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role

• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail & Andreassen, Ole Andreas (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine.  ISSN 0033-2917.  17(2) . doi: 10.1017/S0033291719000400 Fulltekst i vitenarkiv.
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid & Andreassen, Ole Andreas (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2018.08.007 Fulltekst i vitenarkiv.
• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna; Gran, Jon Michael; Aas, Monica; Michelsen, Annika; Reichborn-Kjennerud, Ted; Nesvåg, Ragnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Torill & Andreassen, Ole Andreas (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139, s 37- 45 . doi: 10.1111/acps.12971
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports.  ISSN 2045-2322.  8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w Fulltekst i vitenarkiv.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational Psychiatry.  ISSN 2158-3188.  8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1 Fulltekst i vitenarkiv.
• Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene; Gardsjord, Erlend Strand; Jørgensen, Kjetil Nordbø; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  82, s 263- 271 . doi: 10.1016/j.pnpbp.2017.11.004
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Fulltekst i vitenarkiv.
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 881- 890 . doi: 10.1093/schbul/sbw183 Fulltekst i vitenarkiv.
• Høyland, Anne Lise; Øgrim, Kjell Geir; Lydersen, Stian; Hope, Sigrun; Engstrøm, Morten; Torske, Tonje; Nærland, Terje & Andreassen, Ole Andreas (2017). Event-related potentials in a cued Go-NoGo task associated with executive functions in adolescents with autism spectrum disorder; A case-control study. Frontiers in Neuroscience.  ISSN 1662-4548.  11:393, s 1- 13 . doi: 10.3389/fnins.2017.00393 Fulltekst i vitenarkiv.
• Johannessen, Tor Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Høyland, Anne Lise; Strohmaier, Jana; Heiberg, Arvid; Rietschel, Marcella; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Parents’ Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder—Data from a Norwegian Sample. International Journal of Molecular Sciences.  ISSN 1422-0067.  18(5), s 1- 14 . doi: 10.3390/ijms18051078 Fulltekst i vitenarkiv.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Haram, Marit; Falk, Ragnhild Sørum; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  136(4), s 400- 408 . doi: 10.1111/acps.12783
• Quintana, Daniel; Westlye, Lars Tjelta; Hope, Sigrun; Nærland, Terje; Elvsåshagen, Torbjørn; Dørum, Erlend Solberg; Rustan, Øyvind; Valstad, Mathias; Rezvaya, Liudmila; Lishaugen, Hanna; Stensønes, Elise; Yaqub, Sheraz; Smerud, Knut Terje; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2017). Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial. Translational Psychiatry.  ISSN 2158-3188.  e1136(7), s 1- 9 . doi: 10.1038/tp.2017.103 Fulltekst i vitenarkiv.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2016). Inflammatory evidence for the psychosis continuum model. Psychoneuroendocrinology.  ISSN 0306-4530.  67, s 189- 197 . doi: 10.1016/j.psyneuen.2016.02.011
• Nerhus, Mari; Berg, Akiah Ottesen; Kvitland, Levi Røstad; Dieset, Ingrid; Hope, Sigrun; Dahl, Sandra Rinne; Weibell, Melissa Anne E.a; Romm, Kristin Lie; Færden, Ann; Andreassen, Ole Andreas & Melle, Ingrid (2016). Low vitamin D is associated with negative and depressive symptoms in psychotic disorders. Schizophrenia Research.  ISSN 0920-9964.  178(1-3), s 44- 49 . doi: 10.1016/j.schres.2016.08.024 Fulltekst i vitenarkiv. Vis sammendrag

  BACKGROUND: There are indications that low S-25(OH)D is associated with increased disease severity in psychotic disorder. Our first aim was to investigate the relations between low S-25(OH)D and positive, negative and depressive symptoms. Our second aim was to explore if associations between S-25(OH)D and symptoms were influenced by levels of inflammatory markers. METHODS: Participants (N=358) with a medical history of one or more psychotic episodes were recruited. Current symptomatology was assessed by The Structured Interview for the Positive and Negative Syndrome Scaleanalyzed by a five-factor model. The Calgary Depression Scale for Schizophrenia was used to assess depression and suicidal ideation. Blood samples were analyzed for S-25(OH)D, CRP, sTNF-R1, IL-Ra and OPG. We performed bivariate correlations and multiple regression models to evaluate the effect of S-25(OH)D on the outcomes. RESULTS: Low S-25(OH)D was significantly associated with negative symptoms (adjusted R2=0.113, F(6,357)=8.58, p<0.001) and with depression (adjusted R2=0.045, F(4,357)=5.233, p<0.001) when adjusting for possible confounding factors (i.e. gender, education, diagnose, hospitalization status, ethnicity, season and thyroid status). CRP was correlated with both S-25(OH)D (rho=-0.13, p=0.02) and negative symptoms (rho=0.14, p=0.01), but did not act as a mediator. The correlations between S-25(OH)D and the inflammatory markers sTNF-R1, IL-Ra and OPG were not significant. CONCLUSION: There is a strong association between low S-25(OH)D and higher negative and depressive symptoms in psychotic disorders. Randomized controlled trials should be performed to investigate the effect of vitamin D supplementation as adjuvant treatment strategy in patients with prominent negative or depressive symptoms.

• Dieset, Ingrid; Haukvik, Unn Kristin H.; Melle, Ingrid; Røssberg, Jan Ivar; Ueland, Thor; Hope, Sigrun; Dale, Anders M.; Djurovic, Srdjan; Aukrust, Pål; Agartz, Ingrid & Andreassen, Ole Andreas (2015). Association between altered brain morphology and elevated peripheral endothelial markers — Implications for psychotic disorders. Schizophrenia Research.  ISSN 0920-9964.  161(2-3), s 222- 228 . doi: 10.1016/j.schres.2014.11.006
• Hope, Sigrun; Hoseth, Eva Zsuzsanna; Dieset, Ingrid; Mørch, Ragni Helene; Aas, Monica; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Toril; Agartz, Ingrid; Ueland, Thor; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2015). Inflammatory markers are associated with general cognitive abilities in schizophrenia and bipolar disorder patients and healthy controls. Schizophrenia Research.  ISSN 0920-9964.  165(2-3), s 188- 194 . doi: 10.1016/j.schres.2015.04.004
• Hope, Sigrun; Johannessen, Christen Horn; Aanonsen, Nils Olav & Strømme, Petter (2015). The investigation of inborn errors of metabolism as an underlying cause of idiopathic intellectual disability in adults in Norway. European Journal of Neurology.  ISSN 1351-5101.  23(51), s 36- 44 . doi: 10.1111/ene.12884
• Hoseth, Eva Zsuzsanna; Westlye, Lars Tjelta; Hope, Sigrun; Dieset, Ingrid; Aukrust, Pål; Melle, Ingrid; Haukvik, Unn Kristin H.; Agartz, Ingrid; Ueland, Toril; Ueland, Thor & Andreassen, Ole Andreas (2015). Association between cytokine levels, verbal memory and hippocampus volume in psychotic disorders and healthy controls. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  133(1), s 53- 62 . doi: 10.1111/acps.12467 Fulltekst i vitenarkiv.
• Hope, Sigrun; Ueland, Thor; Steen, Nils Eiel; Dieset, Ingrid; Lorentzen, Steinar; Berg, Akiah Ottesen; Agartz, Ingrid; Aukrust, Pål & Andreassen, Ole Andreas (2013). Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophrenia Research.  ISSN 0920-9964.  145(1-3), s 36- 42 . doi: 10.1016/j.schres.2012.12.023
• Dieset, Ingrid; Djurovic, Srdjan; Tesli, Martin Steen; Hope, Sigrun; Mattingsdal, Morten; Michelsen, Annika; Joa, Inge; Larsen, Tor Ketil; Agartz, Ingrid; Melle, Ingrid; Røssberg, Jan Ivar; Aukrust, Pål; Andreassen, Ole Andreas & Ueland, Thor (2012). Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder. American Journal of Psychiatry.  ISSN 0002-953X.  169(12), s 1292- 1300 . doi: 10.1176/appi.ajp.2012.11091431 Vis sammendrag

  OBJECTIVE: Immunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, and genome-wide association studies (GWAS) point to the major histocompatibility complex, a region that contains many immune-related genes. One of the strongest candidate risk genes for schizophrenia and bipolar disorder is the NOTCH4 gene within the major histocompatibility complex. The authors investigated the NOTCH4 gene expression in individuals with bipolar disorder and schizophrenia relative to healthy comparison subjects and identified putative expression quantitative trait loci in and around the NOTCH4 gene. METHOD: The authors measured and compared NOTCH4 mRNA in whole blood in 690 individuals (479 patients and 211 healthy comparison subjects) and adjusted for a range of confounders. The authors also genotyped 20 single-nucleotide polymorphisms (SNPs) and investigated possible associations between expression quantitative trait loci and NOTCH4 expression. RESULTS: The authors found a strong association between NOTCH4 expression and bipolar disorder after adjusting for a range of confounders and multiple testing. In addition, seven SNPs within the NOTCH4 gene region were associated with enhanced NOTCH4 mRNA levels. Three of these expression quantitative trait loci were independent (not in linkage disequilibrium). CONCLUSIONS: The results indicate that the association between NOTCH4 DNA markers and bipolar disorder is related to altered function at the mRNA level, supporting the notion that NOTCH4 pathways are involved in the pathophysiology of bipolar disorder.

• Dieset, Ingrid; Hope, Sigrun; Ueland, Thor; Bjella, Thomas; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Røssberg, Jan Ivar & Andreassen, Ole Andreas (2012). Cardiovascular risk factors during second generation antipsychotic treatment are associated with increased C-reactive protein. Schizophrenia Research.  ISSN 0920-9964.  140(1-3), s 169- 174 . doi: 10.1016/j.schres.2012.06.040
• Hope, Sigrun; Dieset, Ingrid; Agartz, Ingrid; Steen, Nils Eiel; Ueland, Thor; Melle, Ingrid; Aukrust, Pål & Andreassen, Ole Andreas (2011). Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. Journal of Psychiatric Research.  ISSN 0022-3956.  45(12), s 1608- 1616 . doi: 10.1016/j.jpsychires.2011.08.003
• Steen, Nils Eiel; Lorentzen, Steinar; Barrett, Elisabeth Ann; Lagerberg, Trine Vik; Hope, Sigrun; Larsson, Sara; Berg, Akiah Ottesen; Agartz, Ingrid; Melle, Ingrid; Berg, Jens Petter & Andreassen, Ole Andreas (2011). Sex-specific cortisol levels in bipolar disorder and schizophrenia during mental challenge - Relationship to clinical characteristics and medication. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  35(4), s 1100- 1107 . doi: 10.1016/j.pnpbp.2011.03.008
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Hope, Sigrun; Barrett, Elisabeth Ann; Larsson, Sara; Mork, Erlend; Almås, Bjørg; Løvås, Kristian; Agartz, Ingrid; Melle, Ingrid; Berg, Jens Petter & Andreassen, Ole Andreas (2011). Increased systemic cortisol metabolism in patients with schizophrenia and bipolar disorder: a mechanism for increased stress vulnerability?. Journal of Clinical Psychiatry.  ISSN 0160-6689.  72(11), s 1515- 1521 . doi: 10.4088/JCP.10m06068yel
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Agartz, Ingrid; Lorentzen, Steinar; Djurovic, Srdjan; Steen, Nils Eiel; Ueland, Thor & Andreassen, Ole Andreas (2010). Osteoprotegerin levels in patients with severe mental disorders. Journal of Psychiatry & Neuroscience.  ISSN 1180-4882.  35(5), s 304- 310 . doi: 10.1503/jpn.090088
• Steen, Nils Eiel; Tesli, Martin Steen; Kähler, Anna Katarina; Methlie, Paal; Hope, Sigrun; Barrett, Elisabeth Ann; Larsson, Sara; Mork, Erlend; Løvås, Kristian; Røssberg, Jan Ivar; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Lorentzen, Steinar; Berg, Jens Petter & Andreassen, Ole Andreas (2010). SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  34(8), s 1500- 1506 . doi: 10.1016/j.pnpbp.2010.08.013
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Steen, Nils Eiel; Birkenæs, Astrid Brate; Lorentzen, Steinar; Agartz, Ingrid; Ueland, T & Andreassen, Ole Andreas (2009). Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor. Bipolar Disorders.  ISSN 1398-5647.  11(7), s 726- 734

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• Hope, Sigrun; Nordstrøm, Marianne; Retterstøl, Kjetil; Iversen, Per Ole & Kolset, Svein Olav (2018). Retten til et helsefremmende kosthold for personer med utviklingshemning. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(2), s 122- 123 . doi: 10.4045/tidsskr.17.0985
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva Albertsen & Abrahamsen, T.G. (2018). High Serum Vitamin B12 in Children, Adolescents and Adults with Neurodevelopmental Disorders..
• Kolset, Svein Olav; Nordstrøm, Marianne; Hope, Sigrun; Retterstøl, Kjetil & Iversen, Per Ole (2018). Securing rights and nutritional Health for persons with intellectual disabilities - a pressing challenge. Food & Nutrition Research.  ISSN 1654-6628.  62 . doi: 10.29219/fnr.v62.1268 Fulltekst i vitenarkiv.
• Hope, Sigrun; Melle, Ingrid; Ueland, Thor; Lorentzen, Steinar; Steen, Nils Eiel; Berg, Akiah Ottesen; Dieset, Ingrid; Agartz, Ingrid; Aukrust, Pål & Andreassen, Ole Andreas (2011). INTERLEUKIN 1 RECEPTOR ANTAGONIST AND TUMOR NECROSIS FACTOR RECEPTOR 1 ARE ASSOCIATED WITH GENERAL SEVERITY AND PSYCHOTIC SYMPTOMS IN SCHIZOPHRENIA AND BIPOLAR DISORDER. Schizophrenia Bulletin.  ISSN 0586-7614.  37, s 115- 116
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Steen, Nils Eiel; Birkenæs, Astrid Brate; Lorentzen, Steinar; Agartz, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2009). SIMILAR INFLAMMATORY PROFILE IN BIPOLAR DISORDER AND SCHIZOPHRENIA: SELECTIVE INCREASE IN SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR I AND VON WILLEBRAND FACTOR. Schizophrenia Bulletin.  ISSN 0586-7614.  35, s 235- 235

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