Attila Szabo

• Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila & Djurovic, Srdjan (2020). Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, behavior, and immunity.  ISSN 0889-1591.  87, s 634- 644 . doi: 10.1016/j.bbi.2020.02.008 Fulltekst i vitenarkiv.
• Nardai, Sandor; Laszlo, Marcell; Szabo, Attila; Alan, Alpar; Hanics, Janos; Zahola, Peter; Merkely, Béla; Frecska, Ede & Nagy, Zoltan (2020). N,N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats. Experimental Neurology.  ISSN 0014-4886.  327 . doi: 10.1016/j.expneurol.2020.113245
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas & Ueland, Thor (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry.  ISSN 1664-0640.  11 . doi: 10.3389/fpsyt.2020.00672 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interplay with dyslipidemia is a central driver in the pathogenesis of CVD. We hypothesize that evaluation of atherogenic lipid ratios together with inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis, could give novel information on immune-related mechanisms involved in early CVD risk in patients with psychotic disorders. Methods: As a measure for CVD risk we calculated atherogenic lipid ratios using established sex-specific cut-offs: Total cholesterol/high-density lipoprotein; HDL-c (TC/HDL) and triglyceride/HDL-c (TG/HDL) were evaluated in 571 schizophrenia (SCZ) and 247 bipolar disorder (BD) patients, and in 99 healthy controls (HC). In addition, as a measure of low-grade inflammation, we measured fasting plasma levels of nine stable atherogenic inflammatory markers in patients (SCZ, BD) and in HC. The elevated inflammatory markers and CVD risk in patients, as reflected by TC/HDL and TG/HDL, were further assessed in multivariable analyses adjusting for comorbid cardio-metabolic risk factors. Results: A markedly higher proportion (26%-31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses. Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies. Keywords: CVD risk; bipolar disorder; dyslipidemia; inflammatory biomarkers; schizophrenia.

• Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid; Bjella, Thomas; Aukrust, Pål; Le Hellard, Stephanie; Stavrum, Anne-Kristin; Melle, Ingrid; Andreassen, Ole Andreas & Djurovic, Srdjan (2020). Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder. Frontiers in Psychiatry.  ISSN 1664-0640.  11, s 1- 10 . doi: 10.3389/fpsyt.2020.00642 Fulltekst i vitenarkiv.
• Thompson, Caitlin & Szabo, Attila (2020). Psychedelics as a novel approach to treating autoimmune conditions. Immunology Letters.  ISSN 0165-2478.  228, s 45- 54 . doi: 10.1016/j.imlet.2020.10.001 Fulltekst i vitenarkiv.
• Veréb, Zoltán; Mazlo, Anett; Szabo, Attila; Póliska, Szilárd; Kiss, Attila; Litauszky, Krisztina; Koncz, Gábor; Boda, Zoltan; Rajnavölgyi, Éva & Bácsi, Attila (2020). Vessel Wall-Derived Mesenchymal Stromal Cells Share Similar Differentiation Potential and Immunomodulatory Properties with Bone Marrow-Derived Stromal Cells. Stem Cells International.  ISSN 1687-966X.  2020 . doi: 10.1155/2020/8847038 Fulltekst i vitenarkiv.
• Wedervang-Resell, Kirsten; Ueland, Thor; Aukrust, Pål; Friis, Svein; Holven, Kirsten Bjørklund; Johannessen, Cecilie Haggag; Lekva, Tove; Lonning, Vera Louise Hiorth; Smelror, Runar; Szabo, Attila; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis. Nature NPJ Schizophrenia.  ISSN 2334-265X.  6, s 1- 8 . doi: 10.1038/s41537-020-00112-5 Fulltekst i vitenarkiv.
• Brown, Peter; RELISH, Consortium; Szabo, Attila & Zhou, Yaoqi (2019). Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database: The Journal of Biological Databases and Curation.  ISSN 1758-0463.  2019 . doi: 10.1093/database/baz085
• Frecska, Ede; Kovács, Attila Istvan & Szabo, Attila (2019). The Protective Role of Dimethyltryptamine against Ischemia-Reperfusion Injury, In Michael J Winkelman & Ben Sessa (ed.),  Advances in Psychedelic Medicine: State-of-the-Art Therapeutic Applications.  Praeger.  ISBN 978-1-4408-6410-0.  Chapter 11.  s 214 - 231
• Szabo, Attila (2019). Effects of Psychedelics on Inflammation and Immunity, In Michael J Winkelman & Ben Sessa (ed.),  Advances in Psychedelic Medicine: State-of-the-Art Therapeutic Applications.  Praeger.  ISBN 978-1-4408-6410-0.  Chapter 10.  s 193 - 213
• Uthaug, Malin V.; Lancelotta, Rafael; Szabo, Attila; Davis, Alan K.; Riba, Jordi & Ramaekers, Johannes Geradus (2019). Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment. Psychopharmacology.  ISSN 0033-3158.  s 1- 13 . doi: 10.1007/s00213-019-05414-w
• Agod, Zsofia; Pazmandi, Kitti; Bencze, Dora; Vereb, Gyorgy; Biro, Tamas; Szabo, Attila; Rajnavölgyi, Éva; Bácsi, Attila; Engel, Pablo & Lanyi, Arpad (2018). Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8. Frontiers in Immunology.  ISSN 1664-3224.  9 . doi: 10.3389/fimmu.2018.00062
• Fekete, Tünde; Bencze, Dora; Csoma, Eszter; Szabo, Attila; Biro, Tamas; Bácsi, Attila & Pazmandi, Kitti (2018). Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells. Frontiers in Immunology.  ISSN 1664-3224.  9 . doi: 10.3389/fimmu.2018.02314
• Fekete, Tunde; Suto, Mate Istvan; Bencze, Dora; Mazlo, Anett; Szabo, Attila; Biro, Tamas; Bácsi, Attila & Pazmandi, Kitti (2018). Human plasmacytoid and monocyte-derived dendritic cells display distinct metabolic profile upon RIG-I activation. Frontiers in Immunology.  ISSN 1664-3224.  9 . doi: 10.3389/fimmu.2018.03070
• Szabo, Attila; Gogolák, Péter; Koncz, Gábor; Földvári, Zsofia; Pazmandi, Kitti; Miltner, Noemi; Póliska, Szilárd; Bácsi, Attila; Djurovic, Srdjan & Rajnavölgyi, Éva (2018). Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Scientific Reports.  ISSN 2045-2322.  8:1765, s 1- 12 . doi: 10.1038/s41598-018-20173-y Fulltekst i vitenarkiv.
• Agod, Zsofia; Fekete, Tunde; Budai, Marietta M; Varga, Aliz; Szabo, Attila; Moon, Hyelim; Boldogh, Istvan; Biro, Tamas; Lanyi, Arpad; Bácsi, Attila & Pazmandi, Kitti (2017). Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells. Redox Biology.  ISSN 2213-2317.  13, s 633- 645 . doi: 10.1016/j.redox.2017.07.016
• Horvath, Lájos; Szummer, Csaba & Szabo, Attila (2017). Weak phantasy and visionary phantasy: the phenomenological significance of altered states of consciousness. Phenomenology and the Cognitive Sciences.  ISSN 1568-7759.  17(1), s 117- 129 . doi: 10.1007/s11097-016-9497-4
• Szummer, Csaba; Horvath, Lajos; Szabo, Attila; Frecska, Ede & Orzoi, Kristof (2017). The hyperassociative mind: The psychedelic experience and Merleau-Ponty’s “wild being”. Journal of Psychedelic Studies.  ISSN 2559-9283.  2, s 55- 64 . doi: 10.1556/2054.01.2017.006
• Frecska, Ede; Kovács, Attila Istvan; Szabo, Attila; Ferencz, Csaba & Móré, Csaba E. (2016). Basics of the medical use of ayahuasca: Physiology of dimethyltryptamine [Az ayahuasca orvosi alkalmazasanak alapjai: A dimetiltriptamin szomatofiziologiaja]. Lege Artis Medicinae.  ISSN 0866-4811.  26(9-10), s 413- 420
• Szabo, Attila; Fekete, Tunde; Koncz, Gábor; Kumar, Brahma V; Pazmandi, Kitti; Földvári, Zsofia; Hegedus, Balazs; Garay, Tamas; Bácsi, Attila; Rajnavölgyi, Éva & Lanyi, Arpad (2016). RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1. Cellular Signalling.  ISSN 0898-6568.  28(5), s 335- 347 . doi: 10.1016/j.cellsig.2016.01.012
• Szabo, Attila & Frecska, Ede (2016). Dimethyltryptamine (DMT): a biochemical Swiss Army knife in neuroinflammation and neuroprotection?. Neural Regeneration Research.  ISSN 1673-5374.  11(3), s 396- 397 . doi: 10.4103/1673-5374.179041
• Szabo, Attila; Kovács, Attila L.; Riba, Jordi; Djurovic, Srdjan; Rajnavölgyi, Éva & Frecska, Ede (2016). The endogenous hallucinogen and trace amine N,N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells. Frontiers in Neuroscience.  ISSN 1662-4548.  10:423 . doi: 10.3389/fnins.2016.00423 Fulltekst i vitenarkiv.
• Bacskai, Ildiko; Mazlo, Anett; Kis-Toth, Katalin; Szabo, Attila; Panyi, Gyorgy; Sarkadi, Balazs; Apati, Agota & Rajnavölgyi, Éva (2015). Mesenchymal stromal cell-like cells set the balance of stimulatory and inhibitory signals in monocyte-derived dendritic cells. Stem Cells and Development.  ISSN 1547-3287.  24(15), s 1805- 1816 . doi: 10.1089/scd.2014.0509
• Szabo, Attila (2015). Psychedelics and immunomodulation: novel approaches and therapeutic opportunities. Frontiers in Immunology.  ISSN 1664-3224.  6 . doi: 10.3389/fimmu.2015.00358
• Szabo, Attila (2015). Psychoneuroimmunology and the embodied mind. Lege Artis Medicinae.  ISSN 0866-4811.  25(10), s 445- 453
• Szabo, Attila; Kazai, Anita; Frecska, Ede & Brys, Zoltan (2015). Psychedelics and quasi-psychedelics in the light of contemporary research: Medical cannabis, MDMA, salvinorin A, ibogaine and ayahuasca. Neuropsychopharmacologia Hungarica.  ISSN 1419-8711.  17(3), s 120- 128
• Fekete, Tunde; Pazmandi, Kitti; Szabo, Attila; Bácsi, Attila; Koncz, Gábor & Rajnavölgyi, Éva (2014). The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin. Journal of Leukocyte Biology.  ISSN 0741-5400.  96(4), s 579- 589 . doi: 10.1189/jlb.2A0114-048RR
• Pazmandi, Kitti; Agod, Zsofia; Kumar, Brahma V; Szabo, Attila; Fekete, Tunde; Sogor, Viktoria; Veres, Agota; Boldogh, Istvan; Rajnavölgyi, Éva; Lanyi, Arpad & Bácsi, Attila (2014). Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells. Free Radical Biology & Medicine.  ISSN 0891-5849.  77, s 281- 290 . doi: 10.1016/j.freeradbiomed.2014.09.028
• Szabo, Attila; Horvath, Lajos & Szummer, Csaba (2014). Phenomenology and altered states of consciousness: A new framework for analysis?. Psychologia Hungarica Caroliensis.  ISSN 2064-2504.  2(2), s 7- 29 . doi: 10.12663/PSYHUNG.2.2014.2.1
• Szabo, Attila; Kovacs, Attila; Frecska, Ede & Rajnavölgyi, Éva (2014). Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells. PLOS ONE.  ISSN 1932-6203.  9(8) . doi: 10.1371/journal.pone.0106533
• Szabo, Attila; Magyarics, Zoltan; Pazmandi, Kitti; Gopcsa, Laszlo; Rajnavölgyi, Éva & Bácsi, Attila (2014). TLR ligands upregulate RIG‐I expression in human plasmacytoid dendritic cells in a type I IFN‐independent manner. Immunology and Cell Biology.  ISSN 0818-9641.  92(8), s 671- 678 . doi: 10.1038/icb.2014.38
• Szabo, Attila & Rajnavölgyi, Éva (2014). Finding a fairy in the forest: ELF4, a novel and critical element of type I interferon responses. Cellular & Molecular Immunology.  ISSN 1672-7681.  11(3), s 218- 220 . doi: 10.1038/cmi.2014.1
• Brys, Zoltan; Pluhar, Andras; Kis, Tibor J; Buda, Bela & Szabo, Attila (2013). Network analysis of neurotransmitter related human kinase genes. Possible role of SRC, RAF1, PTK2B?. Neuropsychopharmacologia Hungarica.  ISSN 1419-8711.  15(3), s 165- 171
• Frecska, Ede; Szabo, Attila; Winkelman, Michael J; Luna, Luis Eduardo & McKenna, Dennis J (2013). A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity. Journal of Neural Transmission.  ISSN 0300-9564.  120(9), s 1295- 1303 . doi: 10.1007/s00702-013-1024-y
• Szabo, Attila; Gogolák, Péter; Pazmandi, Kitti; Kis-Toth, Katalin; Riedl, Karin; Wizel, Benjamin; Lingnau, Karen; Bácsi, Attila; Rethi, Bence & Rajnavölgyi, Éva (2013). The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs. PLOS ONE.  ISSN 1932-6203.  8(2) . doi: 10.1371/journal.pone.0055264
• Szabo, Attila & Rajnavölgyi, Éva (2013). Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses. American Journal of Clinical and Experimental Immunology.  ISSN 2164-7712.  2(3), s 195- 207
• Szabo, Attila & Rajnavölgyi, Éva (2013). The brain-immune-gut triangle: innate immunity in psychiatric and neurological disorders. Current Immunology Reviews.  ISSN 1875-631X.  9(4), s 241- 248 . doi: 10.2174/1573395509666131203225659
• Fekete, Tunde; Szabo, Attila; Beltrame, Luca; Vivar, Nancy; Pivarcsi, Andor; Lanyi, Arpad; Cavalieri, Duccio; Rajnavölgyi, Éva & Rethi, Bence (2012). Constraints for monocyte‐derived dendritic cell functions under inflammatory conditions. European Journal of Immunology.  ISSN 0014-2980.  42(2), s 458- 469 . doi: 10.1002/eji.201141924
• Szabo, Attila; Bene, Krisztian; Gogolák, Péter; Rethi, Bence; Lanyi, Arpad; Jankovich, Istvan; Dezsö, Balazs & Rajnavölgyi, Éva (2012). RLR‐mediated production of interferon‐β by a human dendritic cell subset and its role in virus‐specific immunity. Journal of Leukocyte Biology.  ISSN 0741-5400.  92(1), s 159- 169 . doi: 10.1189/jlb.0711360
• Szabo, Attila; Osman, Rolah M; Bacskai, Ildiko; Kumar, Brahma V; Agod, Zsofia; Lanyi, Arpad; Gogolák, Péter & Rajnavölgyi, Éva (2012). Temporally designed treatment of melanoma cells by ATRA and polyI:C results in enhanced chemokine and IFNβ secretion controlled differently by TLR3 and MDA5. Melanoma research.  ISSN 0960-8931.  22(5), s 351- 361 . doi: 10.1097/CMR.0b013e328357076c
• Benko, Szilvia; Magyarics, Zoltan; Szabo, Attila & Rajnavölgyi, Éva (2008). Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors. Biological chemistry.  ISSN 1431-6730.  389(5), s 469- 485 . doi: 10.1515/BC.2008.054

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• Frecska, Ede & Szabo, Attila (2017). The Endogenous Hallucinogen N, N-Dimethyltryptamine Displays Protective Effects Against Hypoxia in Cultured Human Cortical Neurons and Glial-Like Cells and Protects Against Renal Ischemia-Reperfusion Injury. Neuropsychopharmacology.  ISSN 0893-133X.  43, s S111- S112 . doi: 10.1038/npp.2017.264
• Impellizzeri, Agata Antonina Rita; Szabo, Attila; Fjerdingstad, Hege Brincker; Sullivan, Gareth; Glover, Joel; Andreassen, Ole Andreas & Djurovic, Srdjan (2017). Using Stem Cells to Understand the Underlying Mechanisms of Polygenic Risk of Severe Mental Disorders.
• Fekete, Tunde; Pazmandi, Kitti; Szabo, Attila; Bácsi, Attila; Koncz, Gábor & Rajnavölgyi, Éva (2014). The mammalian target of rapamycin controls polyi:C-induced antiviral and inflammatory cytokine responses in human conventional dendritic cells. The FEBS Journal.  ISSN 1742-464X.  281
• Frecska, Ede; Szabo, Attila; Kovacs, Attila & Rajnavölgyi, Éva (2014). The Endogenous Hallucinogen N, N-Dimethyltryptamine and 5-Methoxy-N, N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the sigma-1 Receptor of Human Dendritic Cells. Neuropsychopharmacology.  ISSN 0893-133X.  s S620- S621 . doi: 10.1038/npp.2014.279
• Szabo, Attila; Kovacs, Attila; Frecska, Ede & Rajnavölgyi, Éva (2014). Activation of the Sigma-1 receptor by specific ligands inhibits human inflammatory dendritic cell functions and effector T-lymphocyte responses. Alzheimer's & Dementia.  ISSN 1552-5260.  10(4) . doi: 10.1016/j.jalz.2014.07.017
• Rajnavölgyi, Éva; Szabo, Attila; Bene, Krisztian; Lanyi, Arpad; Rethi, Bence; Dezsö, Balazs & Gogolak, Peter (2012). Human CD1a+ dendritic cells mediate potent anti-viral immune responses via Rig-i and Mda5 signalling. Immunology.  ISSN 0019-2805.  137
• Szabo, Attila; Fekete, Tunde; Beltrame, Luca; Cavalieri, Duccio; Rajnavölgyi, Éva & Rethi, Bence (2010). Dendritic cell inactivation by long-term TLR triggering. International Immunology.  ISSN 0953-8178.  22, s ii10- ii24 . doi: 10.1093/intimm/dxq111

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