Siv Hege Lyngstad

• Lyngstad, Siv Hege; Bettella, Francesco; Aminoff, Sofie Ragnhild; Athanasiu, Lavinia; Andreassen, Ole Andreas; Færden, Ann & Melle, Ingrid (2020). Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  141(5), s 452- 464 . doi: 10.1111/acps.13167 Fulltekst i vitenarkiv.
• Lyngstad, Siv Hege; Gardsjord, Erlend Strand; Engen, Magnus Johan; Haatveit, Beathe; Ihler, Henrik Myhre; Wedervang-Resell, Kirsten; Simonsen, Carmen Elisabeth; Melle, Ingrid & Færden, Ann (2020). Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334. . doi: 10.1007/s00406-020-01112-3 Fulltekst i vitenarkiv.
• Engen, Magnus Johan; Simonsen, Carmen Elisabeth; Melle, Ingrid; Færden, Ann; Lyngstad, Siv Hege; Haatveit, Beathe; Vaskinn, Anja & Ueland, Torill (2019). Cognitive functioning in patients with first-episode psychosis stratified by level of negative symptoms: A 1-year follow-up study. Psychiatry Research.  ISSN 0165-1781.  281, s 1- 7 . doi: 10.1016/j.psychres.2019.112554
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag; Reponen, Elina Johanna; Lyngstad, Siv Hege; Lekva, Tove; Aukrust, Pål; Ueland, Thor; Andreassen, Ole Andreas; Agartz, Ingrid & Myhre, Anne Margrethe (2019). Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms. Psychoneuroendocrinology.  ISSN 0306-4530.  112:104513, s 1- 7 . doi: 10.1016/j.psyneuen.2019.104513 Fulltekst i vitenarkiv.
• Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg; Dieset, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid; Marder, Stephen R. & Melle, Ingrid (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research.  ISSN 0165-1781.  267, s 140- 147 . doi: 10.1016/j.psychres.2018.05.065 Fulltekst i vitenarkiv.
• Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid & Steen, Vidar Martin (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research.  ISSN 0920-9964.  197, s 253- 260 . doi: 10.1016/j.schres.2017.10.042 Fulltekst i vitenarkiv. Vis sammendrag

  Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.

• Lyngstad, Siv Hege; Gardsjord, Erlend Strand; Simonsen, Carmen Elisabeth; Engen, Magnus Johan; Romm, Kristin Lie; Melle, Ingrid & Færden, Ann (2018). Consequences of persistent depression and apathy in first-episode psychosis ? A one-year follow-up study. Comprehensive Psychiatry.  ISSN 0010-440X.  86, s 60- 66 . doi: 10.1016/j.comppsych.2018.07.015

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