Siv Hege Lyngstad

• Åsbø, Gina; Ueland, Torill; Haatveit, Beathe ; Bjella, Thomas; Flaaten, Camilla Bärthel & Wold, Kristin Fjelnseth [Vis alle 13 forfattere av denne artikkelen] (2022). The Time is Ripe for a Consensus Definition of Clinical Recovery in First-episode Psychosis: Suggestions Based on a 10-Year Follow-up Study. Schizophrenia Bulletin. ISSN 0586-7614. 48(4), s. 839–849. doi: 10.1093/schbul/sbac035.
• Flaaten, Camilla Bärthel; Melle, Ingrid; Bjella, Thomas; Engen, Magnus Johan; Åsbø, Gina & Wold, Kristin Fjelnseth [Vis alle 14 forfattere av denne artikkelen] (2022). Domain-specific cognitive course in schizophrenia: Group- and individual-level changes over 10 years. Schizophrenia Research: Cognition. ISSN 2215-0013. 30, s. 1–8. doi: 10.1016/j.scog.2022.100263.
• Engen, Magnus Johan; Vaskinn, Anja; Melle, Ingrid; Færden, Ann; Lyngstad, Siv Hege & Flaaten, Camilla Bärthel [Vis alle 12 forfattere av denne artikkelen] (2022). Cognitive and Global Functioning in Patients With First-Episode Psychosis Stratified by Level of Negative Symptoms. A 10-Year Follow-Up Study. Frontiers in Psychiatry. ISSN 1664-0640. 13:841057, s. 1–13. doi: 10.3389/fpsyt.2022.841057. Fulltekst i vitenarkiv
• Flaaten, Camilla Bärthel; Melle, Ingrid; Gardsjord, Erlend Strand; Bjella, Thomas; Engen, Magnus Johan & Vaskinn, Anja [Vis alle 13 forfattere av denne artikkelen] (2022). Course of intellectual functioning in schizophrenia and bipolar disorder: A 10-year follow-up study. Psychological Medicine. ISSN 0033-2917. s. 1–9. doi: 10.1017/S0033291721004645. Fulltekst i vitenarkiv
• Ihler, Henrik Myhre; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Melle, Ingrid & Romm, Kristin Lie (2021). Exploring the relationship between recency and frequency of cannabis use and diminished expression and apathy as two dimensions of negative symptoms in first episode psychosis. A one-year follow-up study. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2021.08.004. Fulltekst i vitenarkiv
• Haatveit, Beathe Christin; Mørch-Johnsen, Lynn; Alnæs, Dag; Engen, Magnus Johan; Lyngstad, Siv Hege & Færden, Ann [Vis alle 9 forfattere av denne artikkelen] (2020). Divergent relationship between brain structure and cognitive functioning in patients with prominent negative symptomatology. Psychiatry Research : Neuroimaging. ISSN 0925-4927. doi: 10.1016/j.pscychresns.2020.111233. Fulltekst i vitenarkiv
• Engen, Magnus Johan; Lyngstad, Siv Hege; Ueland, Torill; Simonsen, Carmen Elisabeth; Vaskinn, Anja & Smeland, Olav Bjerkehagen [Vis alle 11 forfattere av denne artikkelen] (2020). Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls. Translational Psychiatry. ISSN 2158-3188. 10:416, s. 1–9. doi: 10.1038/s41398-020-01094-9. Fulltekst i vitenarkiv
• Lyngstad, Siv Hege; Bettella, Francesco; Aminoff, Sofie Ragnhild; Athanasiu, Lavinia; Andreassen, Ole Andreas & Færden, Ann [Vis alle 7 forfattere av denne artikkelen] (2020). Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 141(5), s. 452–464. doi: 10.1111/acps.13167. Fulltekst i vitenarkiv
• Lyngstad, Siv Hege; Gardsjord, Erlend Strand; Engen, Magnus Johan; Haatveit, Beathe ; Ihler, Henrik Myhre & Wedervang-Resell, Kirsten [Vis alle 9 forfattere av denne artikkelen] (2020). Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-020-01112-3. Fulltekst i vitenarkiv
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag & Reponen, Elina Johanna [Vis alle 13 forfattere av denne artikkelen] (2019). Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms. Psychoneuroendocrinology. ISSN 0306-4530. 112:104513, s. 1–7. doi: 10.1016/j.psyneuen.2019.104513. Fulltekst i vitenarkiv
• Engen, Magnus Johan; Simonsen, Carmen Elisabeth; Melle, Ingrid; Færden, Ann; Lyngstad, Siv Hege & Haatveit, Beathe [Vis alle 8 forfattere av denne artikkelen] (2019). Cognitive functioning in patients with first-episode psychosis stratified by level of negative symptoms: A 1-year follow-up study. Psychiatry Research. ISSN 0165-1781. 281, s. 1–7. doi: 10.1016/j.psychres.2019.112554.
• Lyngstad, Siv Hege; Gardsjord, Erlend Strand; Simonsen, Carmen Elisabeth; Engen, Magnus Johan; Romm, Kristin Lie & Melle, Ingrid [Vis alle 7 forfattere av denne artikkelen] (2018). Consequences of persistent depression and apathy in first-episode psychosis ? A one-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 86, s. 60–66. doi: 10.1016/j.comppsych.2018.07.015.
• Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg & Dieset, Ingrid [Vis alle 10 forfattere av denne artikkelen] (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research. ISSN 0165-1781. 267, s. 140–147. doi: 10.1016/j.psychres.2018.05.065. Fulltekst i vitenarkiv
• Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr & Lagerberg, Trine Vik [Vis alle 12 forfattere av denne artikkelen] (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research. ISSN 0920-9964. 197, s. 253–260. doi: 10.1016/j.schres.2017.10.042. Fulltekst i vitenarkiv Vis sammendrag

  Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.

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