Asbjørn Otto Christophersen

Associate Professor - Division of Anatomy

Norwegian version of this page

Email a.o.christophersen@medisin.uio.no

Phone +47 22851203

Username

Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO

Postal address Postboks 1105 Blindern 0317 Oslo

Other affiliations Institutt for pedagogikk (Student)

Download business card

Teaching

Immunology
Anatomy

Background

Education

2015: PhD, Department of Immunology, University of Oslo
2008: MD, Eberhad Karls Universität Tübingen, Germany

Current and Previous Positions

From 2024: Resident physician (50%) | Department of Rheumatology, Dermatology and Infectious Diseases, Oslo University Hospital - Rikshospitalet
From 2022: Associate Professor | Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo (100% position, 80% leave 2022-2023, 50% leave from January 2024 to specialize in rheumatology
2020-2023: Resident physician (100%) | Department of Rheumatology, Dermatology and Infectious Diseases, Oslo University Hospital - Rikshospitalet; Department of Rheumatology, Diakonhjemmet Hospital; Department of Internal Medicine, Lovisenberg Hospital (Oslo)
From 2016: Postdoctoral Fellow | Department of Immunology and KG Jebsen Coeliac Disease Research Centre, University of Oslo
2016-2017: Postdoctoral Fellow | Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, USA (Mark M. Davis lab)
2010-2015: PhD Candidate | Department of Immunology, University of Oslo
2008-2010: Medical Internship

Fellowships and Awards

Oslo University Hospital: Excellent article award for the first half-year of 2019 (first author)
The Julia Bodmer Award (2019)
Oslo University Hospital: Excellent article award for the second half-year of 2017 (last author)
Scientia Fellowship (2016-2018)
Fulbright Scholarship (2016-2017)
Unger-Vetlesen Medical Fund (2016-2017)
Fondsstiftelsen, Oslo University Hospital (2016-2017)
BIOTEK2021, The Research Council of Norway, Commercialization grant (2014-2016)
UEG Journal Best Paper Award (2015)
The South-Eastern Norway Regional Healthy Authority, Innovation grant (2013-2014)

Lindeman, Ida; Høydahl, Lene Støkken; Christophersen, Asbjørn Otto; Risnes, Louise Fremgaard; Jahnsen, Jørgen & Lundin, Knut [Show all 8 contributors for this article] (2024). Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease. Cell reports. ISSN 2211-1247. 43(4). doi: 10.1016/j.celrep.2024.114045.
Chlubnova, Marketa; Christophersen, Asbjørn Otto; Sandve, Geir Kjetil Ferkingstad; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen & Dahal-Koirala, Shiva [Show all 7 contributors for this article] (2023). Identification of gluten T cell epitopes driving celiac disease. Science Advances. ISSN 2375-2548. 9(4), p. 1–8. doi: 10.1126/sciadv.ade5800. Full text in Research Archive
Li, Jing; Zaslavsky, Maxim; Su, Yapeng; Guo, Jing; Sikora, Michael J. & van Unen, Vincent [Show all 36 contributors for this article] (2022). KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science. ISSN 0036-8075. 376:eabi9591(6590), p. 1–15. doi: 10.1126/science.abi9591. Full text in Research Archive
Christophersen, Asbjørn Otto; Dahal-Koirala, Shiva; Chlubnova, Marketa; Jahnsen, Jørgen; Lundin, Knut & Sollid, Ludvig Magne (2022). Phenotype-Based Isolation of Antigen-Specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease. Advanced Science. ISSN 2198-3844. 9(10), p. 1–10. doi: 10.1002/advs.202104766. Full text in Research Archive
Christophersen, Asbjørn Otto; Zühlke, Stephanie; Lund, Eivind Gard; Snir, Omri; Dahal-Koirala, Shiva & Risnes, Louise Fremgaard [Show all 9 contributors for this article] (2021). Pathogenic T cells in celiac disease change phenotype on gluten challenge: Implications for T-cell-directed therapies. Advanced Science. ISSN 2198-3844. 8(21), p. 1–11. doi: 10.1002/advs.202102778.
Risnes, Louise Fremgaard; Eggesbø, Linn Margrethe; Zühlke, Stephanie; Dahal-Koirala, Shiva; Neumann, Ralf Stefan & Lundin, Knut Erik Aslaksen [Show all 8 contributors for this article] (2021). Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease. Mucosal Immunology. ISSN 1933-0219. 14(4), p. 842–851. doi: 10.1038/s41385-021-00385-8. Full text in Research Archive
Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Christophersen, Asbjørn; Lundin, Knut E. A. & Sandve, Geir Kjetil [Show all 8 contributors for this article] (2021). Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs. Frontiers in Immunology. ISSN 1664-3224. 12:639672, p. 1–13. doi: 10.3389/fimmu.2021.639672. Full text in Research Archive
Christophersen, Asbjørn (2019). Peptide-MHC class I and class II tetramers: From flow to mass cytometry. HLA. ISSN 2059-2302. p. 169–178. doi: 10.1111/tan.13789. Full text in Research Archive
Eggesbø, Linn Margrethe; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Lundin, Knut Erik Aslaksen; Christophersen, Asbjørn & Sollid, Ludvig Magne (2019). Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease. Mucosal Immunology. ISSN 1933-0219. p. 1–9. doi: 10.1038/s41385-019-0222-9. Full text in Research Archive
Zühlke, Stephanie; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva; Christophersen, Asbjørn; Sollid, Ludvig Magne & Lundin, Knut Erik Aslaksen (2019). CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease . United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 7(10), p. 1337–1344. doi: 10.1177/2050640619874183.
Christophersen, Asbjørn; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva & Sollid, Ludvig Magne (2019). Therapeutic and diagnostic implications of T cell scarring in celiac disease and beyond. Trends in Molecular Medicine. ISSN 1471-4914. 25(10), p. 836–852. doi: 10.1016/j.molmed.2019.05.009. Full text in Research Archive
Christophersen, Asbjørn; Lund, Eivind Gard; Snir, Omri; Solà, Elsa; Kanduri, Srinivasa Kalyana Chakravarthi & Dahal-Koirala, Shiva [Show all 15 contributors for this article] (2019). Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions. Nature Medicine. ISSN 1078-8956. 25(5), p. 734–737. doi: 10.1038/s41591-019-0403-9. Full text in Research Archive
Dahal-Koirala, Shiva; Ciacchi, Laura; Petersen, Jan; Risnes, Louise Fremgaard; Neumann, Ralf Stefan & Christophersen, Asbjørn [Show all 11 contributors for this article] (2018). Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes . Journal of Biological Chemistry. ISSN 0021-9258. 294(3), p. 941–952. doi: 10.1074/jbc.RA118.005736. Full text in Research Archive
Risnes, Louise Fremgaard; Christophersen, Asbjørn; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Sandve, Geir Kjetil & Sarna, Vikas Kumar [Show all 9 contributors for this article] (2018). Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease. Journal of Clinical Investigation. ISSN 0021-9738. 128(6), p. 2642–2650. doi: 10.1172/JCI98819. Full text in Research Archive
Tutturen, Astrid Elisabeth Voorham; Dørum, Siri; Clancy, Trevor; Reims, Henrik Mikael; Christophersen, Asbjørn & Lundin, Knut Erik Aslaksen [Show all 9 contributors for this article] (2018). Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry. American Journal of Pathology. ISSN 0002-9440. 188(7), p. 1563–1579. doi: 10.1016/j.ajpath.2018.03.017. Full text in Research Archive
Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Mørkrid, Lars; Qiao, Shuo Wang; Sollid, Ludvig Magne & Christophersen, Asbjørn (2017). HLA-DQ-gluten tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption. Gastroenterology. ISSN 0016-5085. 154(4), p. 886–896.e6. doi: 10.1053/j.gastro.2017.11.006. Full text in Research Archive
Christophersen, Asbjørn (2016). Ny blodprøve kan forenkle diagnostikk av cøliaki. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(6), p. 555–555. doi: 10.4045/tidsskr.16.0106.
Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Christophersen, Asbjørn; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen & Sollid, Ludvig Magne [Show all 7 contributors for this article] (2016). TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage. Mucosal Immunology. ISSN 1933-0219. 9(3), p. 587–596. doi: 10.1038/mi.2015.147. Full text in Research Archive
Christophersen, Asbjørn; Risnes, Louise Fremgaard; Bergseng, Elin; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2016). Healthy HLA-DQ2.5<sup>+</sup> subjects lack regulatory and memory T cells specific for immunodominant gluten epitopes of celiac disease. Journal of Immunology. ISSN 0022-1767. 196(6), p. 2819–2826. doi: 10.4049/jimmunol.1501152.
Sollid, Ludvig Magne; Iversen, Rasmus; Steinsbø, Øyvind; Qiao, Shuo Wang; Bergseng, Elin & Dørum, Siri [Show all 14 contributors for this article] (2015). Small bowel, celiac disease and adaptive immunity. Digestive Diseases. ISSN 0257-2753. 33(2), p. 115–121. doi: 10.1159/000369512.
Christophersen, Asbjørn; Raki, Melinda; Bergseng, Elin; Lundin, Knut E A; Jahnsen, Jørgen & Sollid, Ludvig Magne [Show all 7 contributors for this article] (2014). Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 2(4), p. 268–278. doi: 10.1177/2050640614540154.
Dørum, Siri; Bodd, Michael; Fallang, Lars-Egil; Bergseng, Elin; Christophersen, Asbjørn & Johansen, Marie Kongshaug [Show all 10 contributors for this article] (2014). HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes. Journal of Immunology. ISSN 0022-1767. 193(9), p. 4497–4506. doi: 10.4049/jimmunol.1301466.
Qiao, Shuo Wang; Christophersen, Asbjørn; Lundin, Knut E A & Sollid, Ludvig Magne (2014). Biased usage and preferred pairing of α-and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease. International Immunology. ISSN 0953-8178. 26(1), p. 13–19. doi: 10.1093/intimm/dxt037.

View all works in Cristin

Risnes, Louise Fremgaard; Eggesbø, Linn Margrethe; Christophersen, Asbjørn Otto & Sollid, Ludvig Magne (2021). Response to: “Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease”. Mucosal Immunology. ISSN 1933-0219. 14(5), p. 1216–1217. doi: 10.1038/s41385-021-00422-6.
Eggesbø, Linn Margrethe; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Lundin, Knut E. A.; Christophersen, Asbjørn Otto & Sollid, Ludvig Magne (2021). Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8<sup>+</sup> αβ T lymphocytes in untreated celiac disease. European Journal of Immunology. ISSN 0014-2980. 51(6), p. 1542–1545. doi: 10.1002/eji.202048974.

View all works in Cristin

Published Sep. 17, 2014 8:43 AM - Last modified Mar. 20, 2024 9:27 AM

Research groups

Immune Responses in Rheumatic Diseases