Jørgen Wesche

Professor II - Division of Biochemistry
Image of Jørgen Wesche
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Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1112 Blindern 0317 OSLO

Academic interests

Our group is investigating mechanisms involved in the development and progression of sarcomas, with focus on cell biology and genomics. The Norwegian Radium Hospital is a national centre of competence on this kind of tumours, and our research is done in collaboration with our clinical colleagues.

We aim to unravel new oncogenic mechanisms in sarcomas. Genetic and proteomic screens in sarcoma cells and models lay the basis for the discovery of novel cancer cell programs that can be targeted.

Education

2001:  PhD: Dr. Philos, 01.03.2001
Faculty of Medicine, University of Oslo. Thesis title: “Translocation of proteins across cellular membranes. Entry of anthrax toxin, ricin and aFGF into cells”. Supervised by Prof. Sjur Olsnes, the Norwegian Radium Hospital.

1995: Ingénieur diplomé (Norwegian: “sivilingeniør”, 5 year study) in Biochemistry.
Institut National des Sciences Appliquées (INSA), Toulouse, France.

Current and previous positions

2017: Group leader, Dept. of Tumor Biology, the Norwegian Radium Hospital, OUS, Oslo
2005-2017:  Researcher, Department of Molecular Cell Biology, the Norwegian Radium Hospital, Oslo
2002-2005: Postdoctor, Department of Biochemistry, the Norwegian Radium Hospital, Oslo
2001-2002: Postdoctor, Subcellular Structure and Cellular Dynamics, Institut Curie, Paris
1995-2001: PhD-student, Department of Biochemistry, the Norwegian Radium Hospital, Oslo

Publications

  • Szybowska, Patrycja Maria; Kostas, Michal Janusz; Wesche, Jørgen; Wiedlocha, Antoni & Haugsten, Ellen Margrethe (2019). Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway. Cells.  ISSN 2073-4409.  8(6), s 1- 18 . doi: 10.3390/cells8060518 Full text in Research Archive.
  • Fafílek, Bohumil; Bálek, Lukáš; Bosakova, Michaela Kunova; Vařecha, Miroslav; Nita, Alexandru; Gregor, Tomas; Gudernovǎ, Iva; Krenova, Jitka; Ghosh, Somadri; Piskáček, Martin; Jonatova, Lucie; Cernohorsky, Nicole H.; Zieba, Jennifer T.; Kostas, Michal Janusz; Haugsten, Ellen Margrethe; Wesche, Jørgen; Erneux, Christophe; Trántirek, Lukáš; Krakow, Deborah & Krejčí, Pavel (2018). The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases. Science Signaling.  ISSN 1945-0877.  11:eaap8608(548), s 1- 15 . doi: 10.1126/scisignal.aap8608 Full text in Research Archive.
  • Kostas, Michal Janusz; Haugsten, Ellen Margrethe; Zhen, Yan; Sørensen, Vigdis; Szybowska, Patrycja Maria; Fiorito, Elisa; Lorenz, Susanne; Jones, Nina; De Souza, Gustavo Antonio; Wiedlocha, Antoni & Wesche, Jørgen (2018). Protein Tyrosine Phosphatase Receptor Type G (PTPRG) controls Fibroblast Growth Factor Receptor (FGFR) 1 activity and influences sensitivity to FGFR kinase inhibitors. Molecular & Cellular Proteomics.  ISSN 1535-9476.  17(5), s 850- 870 . doi: 10.1074/mcp.RA117.000538 Full text in Research Archive. Show summary
  • Zhen, Yan; Haugsten, Ellen Margrethe; Singh, Sachin Kumar & Wesche, Jørgen (2018). Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4. Biochemistry.  ISSN 0006-2960.  57(26), s 3807- 3816 . doi: 10.1021/acs.biochem.8b00120 Show summary
  • Haugsten, Ellen Margrethe; Sørensen, Vigdis; Kunova Bosakova, Michaela; De Souza, Gustavo Antonio; Krejci, Pavel; Wiedlocha, Antoni & Wesche, Jørgen (2016). Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport. Journal of Proteome Research.  ISSN 1535-3893.  15(10), s 3841- 3855 . doi: 10.1021/acs.jproteome.6b00652
  • Haugsten, Ellen Margrethe; Brech, Andreas; Liestøl, Knut; Norman, Jim C. & Wesche, Jørgen (2014). Photoactivation Approaches Reveal a Role for Rab11 in FGFR4 Recycling and Signalling. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  15(6), s 665- 683 . doi: 10.1111/tra.12168
  • Nadratowska-Wesolowska, Beata; Haugsten, Ellen Margrethe; Zakrzewska, Malgorzata; Jakimowicz, Piotr; Zhen, Yan; Pajdzik, Dorota; Wesche, Jørgen & Wiedlocha, Antoni (2014). RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789. Oncogene.  ISSN 0950-9232.  33(40), s 4823- 4836 . doi: 10.1038/onc.2013.425
  • Oppelt, Angela; Haugsten, Ellen Margrethe; Zech, Tobias; Danielsen, Håvard Emil; Sveen, Anita; Lobert, Viola Helene; Skotheim, Rolf Inge & Wesche, Jørgen (2014). PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. Biochemical Journal.  ISSN 0264-6021.  461(3), s 383- 390 . doi: 10.1042/BJ20140132
  • Oppelt, Angela; Lobert, Viola Helene; Haglund, Kaisa; Mackey, Ashley M.; Rameh, Lucia E.; Liestøl, Knut; Schink, Kay Oliver; Pedersen, Nina Marie; Wenzel, Eva; Haugsten, Ellen Margrethe; Brech, Andreas; Rusten, Tor Erik; Stenmark, Harald Alfred & Wesche, Jørgen (2013). Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Reports.  ISSN 1469-221X.  14(1), s 57- 64 . doi: 10.1038/embor.2012.183
  • Zakrzewska, Malgorzata; Haugsten, Ellen Margrethe; Nadratowska-Wesolowska, Beata; Oppelt, Angela; Hausott, Barbara; Jin, Yixin; Otlewski, Jacek; Wesche, Jørgen & Wiedlocha, Antoni (2013). ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser(777) Inhibits Signaling. Science Signaling.  ISSN 1945-0877.  6(262) . doi: 10.1126/scisignal.2003087
  • Haugsten, Ellen Margrethe; Zakrzewska, Malgorzata; Brech, Andreas; Pust, Sascha; Olsnes, Sjur; Sandvig, Kirsten & Wesche, Jørgen (2011). Clathrin- and Dynamin-Independent Endocytosis of FGFR3-Implications for Signalling. PLOS ONE.  ISSN 1932-6203.  6(7) . doi: 10.1371/journal.pone.0021708
  • Wesche, Jørgen; Haglund, Kaisa & Haugsten, Ellen Margrethe (2011). Fibroblast growth factors and their receptors in cancer. Biochemical Journal.  ISSN 0264-6021.  437, s 199- 213 . doi: 10.1042/BJ20101603
  • Haglund, Kaisa; Nezis, Jonnis P; Lemus Torres, Dafne; Grabbe, C; Wesche, Jørgen; Liestøl, Knut; Dikic, I; Stenmark, Harald Alfred & Palmer, R. Barton (2010). Cindr Interacts with Anillin to Control Cytokinesis in Drosophila melanogaster. Current Biology.  ISSN 0960-9822.  20(10), s 944- 950 . doi: 10.1016/j.cub.2010.03.068
  • Haugsten, Ellen Margrethe; Wiedlocha, Antoni; Olsnes, Sjur & Wesche, Jørgen (2010). Roles of Fibroblast Growth Factor Receptors in Carcinogenesis. Molecular Cancer Research.  ISSN 1541-7786.  8(11), s 1439- 1452 . doi: 10.1158/1541-7786.MCR-10-0168
  • Lobert, Viola Helene; Brech, Andreas; Pedersen, Nina Marie; Wesche, Jørgen; Oppelt, Angela; Malerød, Lene & Stenmark, Harald (2010). Ubiquitination of alpha 5 beta 1 lntegrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-lntegrin Complexes. Developmental Cell.  ISSN 1534-5807.  19(1), s 148- 159 . doi: 10.1016/j.devcel.2010.06.010
  • Zakrzewska, Malgorzata; Zhen, Yan; Wiedlocha, Antoni; Olsnes, Sjur & Wesche, Jørgen (2009). Size Limitation in Translocation of Fibroblast Growth Factor 1 Fusion Proteins across the Endosomal Membrane. Biochemistry.  ISSN 0006-2960.  48(30), s 7209- 7218 . doi: 10.1021/bi9007353
  • Haugsten, Ellen Margrethe; Malecki, Jedrzej M.; Bjørklund, Sunniva Maria Stordal; Olsnes, Sjur & Wesche, Jørgen (2008). Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. Molecular Biology of the Cell.  ISSN 1059-1524.  19, s 3390- 3403 . doi: 10.1091/mbc.E07-12-1219
  • Nilsen, Trine; Rosendal, Ken; Sørensen, Vigdis; Wesche, Jørgen; Olsnes, Sjur & Widocha, Antoni (2007). A nuclear export sequence located on a beta-strand in fibroblast growth factor-1. Journal of Biological Chemistry.  ISSN 0021-9258.  282(36), s 26245- 26256 . doi: 10.1074/jbc.M611234200
  • Sørensen, Vigdis; Wiedlocha, Antoni; Haugsten, Ellen Margrethe; Khnykin, Denis; Wesche, Jørgen & Olsnes, Sjur (2006). Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail. Journal of Cell Science.  ISSN 0021-9533.  119, s 4332- 4341
  • Wesche, Jørgen; Malecki, Jedrzej M.; Wiedlocha, Antoni; Skjerpen, Camilla Skiple; Claus, P & Olsnes, Sjur (2006). FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. Journal of Biological Chemistry.  ISSN 0021-9258.  281, s 11405- 11412
  • Haugsten, Ellen Margrethe; Sørensen, Vigdis; Olsnes, Sjur; Wesche, Jørgen & Brech, Andreas (2005). Different intracellular trafficking of FGF1 endocytosed by the four specific and homologous FGF receptors. Journal of Cell Science.  ISSN 0021-9533.  118, s 3869- 3881
  • Wesche, Jørgen; Malecki, Jedrzej M.; Wiedlocha, Antoni; Ehsani, Maryam; Nilsen, Trine; Marcinkowska, Ewa & Olsnes, Sjur (2005). Two nuclear localization signals required for transport from the cytosol to the, nucleus of externally added FGF-1 translocated into cells. Biochemistry (Moscow).  ISSN 0006-2979.  44
  • Wiedlocha, Antoni; Nilsen, Trine; Wesche, Jørgen; Sørensen, Vigdis; Malecki, M; Marcinkowska, Ewa & Olsnes, Sjur (2005). Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1. Molecular Biology of the Cell.  ISSN 1059-1524.  (16), s 794- 810
  • Malecki, Jedrzej; Wesche, Jørgen; Skjerpen, Camilla Skiple; Wiedlocha, Antoni & Olsnes, Sjur (2004). Translocation of FGF-1 and FGF-2 across Vesicular Membranes Occurs during G1-Phase by a Common Mechanism. Molecular Biology of the Cell.  ISSN 1059-1524.  15, s 804- 814

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  • Skjerpen, Camilla Skiple; Olsnes, Sjur & Wesche, Jørgen (2005). Translocation mechanism and cellular interaction partners of FGF-1 and FGF-2.

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Published Apr. 12, 2019 10:47 AM - Last modified Nov. 28, 2019 9:38 AM