Trygve Brauns Leergaard

Professor - Division of Anatomy
Image of Trygve Brauns Leergaard
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Phone +47 22851052
Room L-169
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Visiting address Dept. of Anatomy Domus Medica Gaustad Sognsvannsveien 9 0372 Oslo
Postal address Postboks 1105 Blindern 0317 Oslo

Academic interests

  • Neuroanatomy, brain connectivity mapping
  • Morphological phenotyping
  • Neuroinformatics and digital brain atlasing
  • Histological validation of neuroimaging methods

Courses taught

MEDSEM3A – macroscopic anatomy

IMB9345 – Neuroscience data integration through use of digital brain atlases

Background

  • MD, University of Leiden, The Netherlands, 1996
  • PhD, University of Oslo, Neuroscience, 2000

Work experience

  • 2006- : Deputy group leader, Neural Systems and Graphics Computing Laboratory, Experimental Division, Institute of Basic Medical Sciences, University of Oslo
  • 2004- : Deputy associate professor, Department of anatomy, Institute of Basic Medical Sciences, University of Oslo
  • 2002-2003: Research fellow, Department of Radiology, Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Harvard Medical School, Boston, USA
  • 2001-2003: Postdoc fellow, Department of  Anatomy, Institute of Basic Medical Sciences, University of Oslo

Positions held

  • Guest Associate Editor, Frontiers in Neuroinformatics (2010-2011)
  • Member semester board (semesterutvalg) MEDSEM3A (2008- ), Faculty of Medicine, University of Oslo
  • Member advisory board (programrådet), The Faculty of Medicine, University of Oslo (2009- )
  • Key advisor for high throughput tissue processing unit at the Institute of Basic Medical Sciences, University of Oslo

Collaboration

  • Anders M. Dale, University of California, San Diego, USA
  • G. Allan Johnson, Center for In Vivo Microscopy, Duke University Medical Center, USA
  • Annemie Van der Linden, Bio-Imaging lab, University of Antwerp, Belgium
  • Stephan von Hörsten, Experimental Therapy, Friedrich-Alexander University, Erlangen, Germany
  • Jan Sijbers, Vision Lab, Department of Physics, University of Antwerp, Belgium
  • Menno P. Witter, The Kavli Institute for Systems Neuroscience & Centre for the Biology of Memory, Norwegian University of Science and Technology (NTNU), Trondheim
Tags: Brain and nervous system, Diagnostic imaging and intervention, Heart, Vasculature and lungs, Neuroanatomy, Cerebellum, Basal ganglia, Neurodegenerative disease models

Publications

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  • Puchades, Maja ; Yates, Sharon Christine; Bjerke, Ingvild Elise; Groeneboom, Nicolaas; Csucs, Gergely & Leergaard, Trygve B. [Show all 7 contributors for this article] (2021). Implementing the QUINT workflow for spatial quantitative analysis of labelling in mice and rats.
  • Puchades, Maja ; Dickscheid, Timo & Leergaard, Trygve B. (2021). Hands-on Session V: Brain Atlases.
  • Reiten, Ingrid; Schlegel, Ulrike; Blixhavn, Camilla Hagen; Andersson, Krister Andreas; Aasebø, Ida Elisabeth Jørgensen & Yates, Sharon Christine [Show all 12 contributors for this article] (2020). Data sharing through the online EBRAINS platform: a new service for brain research.
  • Schlegel, Ulrike; Reiten, Ingrid; Aasebø, Ida Elisabeth Jørgensen; Blixhavn, Camilla Hagen; Zehl, Lyuba & Kjelsberg, Kasper [Show all 13 contributors for this article] (2020). EBRAINS data sharing: benefits and workflow.
  • Reiten, Ingrid; Schlegel, Ulrike; Aasebø, Ida Elisabeth Jørgensen; Blixhavn, Camilla Hagen; Zehl, Lyuba & Kjelsberg, Kasper [Show all 13 contributors for this article] (2020). Neuroscience community-gains from data sharing through the EBRAINS infrastructure.
  • Yates, Sharon Christine; Groeneboom, Nicolaas; Csucs, Gergely; Leergaard, Trygve B.; Kreshuk, Anna & Kutra, Dominik [Show all 8 contributors for this article] (2020). New functionalities i the QUINT workflow for brain atlas based image analysis.
  • Schlegel, Ulrike; Blixhavn, Camilla Hagen; Andersson, Krister Andreas; Yates, Sharon Christine; Øvsthus, Martin & Bjerke, Ingvild Elise [Show all 11 contributors for this article] (2019). Integrating and analysing heterogeneous rodent neuroscience data using three-dimensional brain reference atlases.
  • Andersson, Krister Andreas; Blixhavn, Camilla Hagen; Kleven, Heidi; Schlegel, Ulrike; Oliver, Schmid & Puchades, Maja [Show all 10 contributors for this article] (2019). EBRAINS fair data service: A novel infrastructure for making neuroscience data findable, accessible, interoperable, and reuseable.
  • Andersson, Krister Andreas; Blixhavn, Camilla Hagen; Kleven, Heidi; Zehl, Lyuba; Bjerke, Ingvild Elise & Schmid, Oliver [Show all 17 contributors for this article] (2019). Neuroinformatics platform for making neuroscience data Findable, Accessible, Interoperable, and Reuseable.
  • Andersson, Krister Andreas; Blixhavn, Camilla Hagen; Zehl, Lyuba; Zarfarnia, Sara; Köhnen, Stefan & Hilverling, Anna [Show all 19 contributors for this article] (2019). Resources for making neuroscience data FAIR. The Human Brain Project invites researchers to share, find, and use data via the new EBRAINS infrastructure.
  • Puchades, Maja ; Yates, Sharon Christine; Groeneboom, Nicolaas; Csúcs, Gergely; Leergaard, Trygve B. & Bjaalie, Jan G. (2019). Workflow for quantification and spatial analysis of labeling in large series of histological images from murine brains.
  • Blixhavn, Camilla Hagen; Andersson, Krister Andreas; Kleven, Heidi; Schlegel, Ulrike; Puchades, Maja & Bjaalie, Jan G. [Show all 7 contributors for this article] (2019). Find and explore rodent brain data using 3D atlases in the new EBRAINS infrastructure.
  • Blixhavn, Camilla Hagen; Andersson, Krister Andreas; Kleven, Heidi; Schlegel, Ulrike; Puchades, Maja & Bjaalie, Jan G. [Show all 7 contributors for this article] (2019). Infrastructure and workflow for integrating and navigating multi-scale and multi-modal murine neuroscience data using 3D digital brain reference atlases.
  • Yates, Sharon Christine; Groeneboom, Nicolaas; Csúcs, Gergely; Leergaard, Trygve B.; Puchades, Maja & Bjaalie, Jan G. (2019). Batch quantification and spatial analysis of labelling in microscopic rodent brain sections .
  • von Linstow, Christian Ulrich; Yates, Sharon Christine; Leergaard, Trygve B.; Plank, A-C; von Hörsten, S. & Puchades, Maja [Show all 7 contributors for this article] (2018). Whole brain analysis of Huntingtin aggregates in the F344 transgenic rat model of Huntington’s disease.
  • Bjerke, Ingvild Elise; Øvsthus, Martin; Andersson, Krister Andreas; Bjaalie, Jan G. & Leergaard, Trygve B. (2018). Best practices for determining and documenting neuroanatomical locations in the rodent brain.
  • Blixhavn, Camilla Hagen; Andersson, Krister; Øvsthus, Martin; Bjerke, Ingvild Elise; Kleven, Heidi & Puchades, Maja [Show all 8 contributors for this article] (2018). Data integration through digital brain atlasing: Making diverse neuroscience data discoverable using Human Brain Project infrastructure.
  • Øvsthus, Martin; Bjerke, Ingvild Elise; Yates, Sharon Christine; Bjaalie, Jan G. & Leergaard, Trygve Brauns (2018). Mapping topographical organization in mouse brain subcortical axonal projections using Human Brain Project infrastructure.
  • Yates, Sharon Christine; Puchades, Maja ; kreshuk, anna; Kutra, Dominik; Leergaard, Trygve B. & Bjaalie, Jan G. [Show all 7 contributors for this article] (2018). HBP Analytic Workflow: from Microscopic Image Data to Extracted Features in Atlas Space.
  • Zehl, Lyuba; Zafarnia, Sara; Köhnen, Stefan; Andersson, Krister Andreas; Markovic, Milica & Legouée, Elodie [Show all 20 contributors for this article] (2018). Integrating neuroscientific data into a unified database: from individual experiments to a standardized metadata collection using the Human Brain Project Neuroinformatics Platform.
  • Zehl, Lyuba; Zafarnia, Sara; Köhnen, Stefan; Andersson, Krister Andreas; Markovic, Milica & Legouée, Elodie [Show all 20 contributors for this article] (2018). Integrating neuroscientific data into a unified database: from individual experiments to a standardized metadata collection using the Human Brain Project Neuroinformatics Platform.
  • Andersson, Krister Andreas; Blixhavn, Camilla Hagen; Zehl, Lyuba; Markovic, Milica; Kleven, Heidi & Zafarnia, Sara [Show all 15 contributors for this article] (2018). HBP Curation service: Share your data via the Neuroinformatics platform.
  • Leergaard, Trygve B. (2017). Building and using rodent brain reference atlases for integration of experimental data.
  • Coello, Sebastian Christopher; Leergaard, Trygve B. & Bjaalie, Jan G. (2017). Tackling the normalization of 2-D rodent histology sections in a 3-D coordinate space.
  • Timonidis, Nestor; Bakker, Rembrandt; Øvsthus, Martin; Garcia-Amado, M; Porrero, C & Leergaard, Trygve B. [Show all 8 contributors for this article] (2017). Towards predicting the full mesoconnectome based on data fusion.
  • Imad, Jala; Kleven, Heidi; Clascá, Francisco; Wennberg, Arvind Eirik; Osen, Kirsten Kjelsberg & Coello, Sebastian Christopher [Show all 11 contributors for this article] (2017). Enriching and adding detail to the Waxholm Space rat brain reference atlas.
  • Andersson, Krister Andreas; Bell, Simon; Bjerke, Ingvild Elise; Øvsthus, Martin; Blixhavn, Camilla Hagen & Kleven, Heidi [Show all 18 contributors for this article] (2017). Submitting data and metadata through the HBP Data Workbench: Concepts, data flows, policies, and best practices.
  • Leprince, Y; Coello, Sebastian Christopher; Csúcs, Gergely; Chervakov, P; Darine, Dmitri Aleksandrovitsj & Øvsthus, Martin [Show all 12 contributors for this article] (2017). Interactive tools for registering of 2D and 3D images to reference atlases.
  • Coello, Sebastian Christopher; Leergaard, Trygve B. & Bjaalie, Jan G. (2017). Tackling the normalization of 2-D rodent histology sections in a 3-D coordinate space.
  • Bjerke, Ingvild Elise; Andersson, Krister Andreas; Øvsthus, Martin; Puchades, Maja ; Bjaalie, Jan G. & Leergaard, Trygve B. (2017). Navigating the rodent brain: Best practice recommendations for determining and documenting spatial location for neuroscience data .
  • Yates, Sharon Christine; Puchades, Maja ; Coello, Sebastian Christopher; Kreshuk, Anna; Hartlage-Rübsamen, Maike & Rossner, Steffen [Show all 8 contributors for this article] (2017). Workflow for automated quantification and spatial analysis of labeling in microscoping rodent brain sections.
  • Yates, Sharon Christine; Puchades, Maja ; Coello, Sebastian Christopher; Kreshuk, Anna; Hartlage-Rübsamen, Maike & Rossner, Steffen [Show all 8 contributors for this article] (2017). Workflow for automated quantification and spatial analysis of labelling in microscoping rodent brain sections.
  • Puchades, Maja ; Csúcs, Gergely; Checinska, Martyna; Øvsthus, Martin; Bjerke, Ingvild Elise & Andersson, Krister [Show all 8 contributors for this article] (2017). Neuroinformatics tool and workflow for anchoring of serial histological images in rodent brain 3D space.
  • Imad, Jala; Osen, Kirsten Kjelsberg; Clascá, Francisco; Wennberg, Arvind E.; Coello, Sebastian Christopher & Csúcs, Gergely [Show all 9 contributors for this article] (2017). Enriching and Adding Detail to the Waxholm Space Rat Brain Reference Atlas.
  • Puchades, Maja ; Øvsthus, Martin; Bjerke, Ingvild Elise; Andersson, Krister; Csúcs, Gergely & Leergaard, Trygve Brauns [Show all 7 contributors for this article] (2017). Data integration through digital brain atlasing: semiautomatic spatial registration of serial histological images to rodent brain 3D reference atlases.
  • Bjerke, Ingvild Elise; Andersson, Krister; Øvsthus, Martin; Puchades, Maja ; Bjaalie, Jan G. & Leergaard, Trygve Brauns (2017). Determining and documenting the anatomical location of experimental neuroscience data: Best practice recommendations.
  • Andersson, Krister; Øvsthus, Martin; Bjerke, Ingvild Elise; Puchades, Maja ; Telefont, Martin & Jeff, Muller [Show all 9 contributors for this article] (2017). Data integration through digital brain atlasing: Human Brain Project infrastructure.
  • Leergaard, Trygve B. (2016). Navigating the rodent brain: An anatomist’s guide to assigning location to brain image data.
  • Puchades, Maja ; Bjerke, Ingvild Elise; Øvsthus, Martin; Andersson, Krister; Csúcs, Gergely & Leergaard, Trygve Brauns [Show all 7 contributors for this article] (2016). Spatial registration of serial histological image data to reference brain atlases.
  • Blackstad, Jan Sigurd Beddari; Osen, Kirsten Kjelsberg; Scharfman, HE; Storm-Mathisen, Jon; Blackstad, Theodor W. & Leergaard, Trygve Brauns (2015). Hippocampal mossy cells in mink (Neovison vison).
  • Schubert, N; Axer, M; Graessel, D; Schober, M; Huynh, A & Huysegoms, M [Show all 11 contributors for this article] (2015). 3D reconstructed fiber-, cyto- and receptorarchitecture of the rat brain transferred into the Waxholm Space atlas.
  • Puchades, Maja Amedjkouh; Darine, Dmitri Aleksandrovitsj; Csúcs, Gergely; Lillehaug, Sveinung; Leergaard, Trygve Brauns & Bjaalie, Jan G. (2015). Feeding rodent brain data to computational models through HBP spatial atlas templates and knowledge graph portal.
  • Leergaard, Trygve Brauns (2015). Hjerneforskning i den digitale tidsalder: Fremtidens hjerneatlas.
  • Leergaard, Trygve Brauns; Lillehaug, Sveinung; Yetman, Michael J.; Jankowsky, Joanna L. & Bjaalie, Jan G. (2014). Interactive brainwide atlas of tetracycline responsive trans-activator promoter mouse lines.
  • Leergaard, Trygve Brauns; Coello, Christopher; Papp, Eszter Agnes; Ragan, Tim & Bjaalie, Jan G. (2014). Registration of serial two-photon data to rodent brain Waxholm Space. Frontiers in Neuroinformatics. ISSN 1662-5196. doi: 10.3389/conf.fninf.2014.18.00059
  • Leergaard, Trygve Brauns; Coello, Christopher; Papp, Eszter Agnes; Ragan, Tim & Bjaalie, Jan G. (2014). Registration of serial two-photon data to rodent brain Waxholm Space.
  • Leergaard, Trygve Brauns & Bjaalie, Jan G. (2014). Infrastructure for digital atlasing of mouse and rat brain: Rodent Brain WorkBench.
  • Leergaard, Trygve Brauns; Yetman, Michael J.; Lillehaug, Sveinung; Bjaalie, Jan G. & Jankowsky, Joanna L. (2014). Transgene expression in the neuropsin tTA driver line is not restricted to the entorhinal cortex.
  • Papp, Eszter Agnes; Leergaard, Trygve Brauns; Csucs, Gergely; Darine, Dmitri Aleksandrovitsj & Bjaalie, Jan G. (2014). Workflow for integration and analysis of histological data in rodent brain Waxholm Space.
  • Papp, Eszter Agnes; Leergaard, Trygve Brauns; Csucs, Gergely; Darine, Dmitri Aleksandrovitsj & Bjaalie, Jan G. (2014). Workflow for integration and analysis of histological data in rodent brain Waxholm Space. Frontiers in Neuroinformatics. ISSN 1662-5196. doi: 10.3389/conf.fninf.2014.18.00060
  • Leergaard, Trygve Brauns (2014). Navigating the rodent brain by digital atlasing.
  • Leergaard, Trygve Brauns; Lillehaug, Sveinung; Papp, Eszter Agnes; Coello, Christopher; Ragan, Tim & Bjaalie, Jan G. (2014). Waxholm Space atlas template enriched with serial two-photon and histological data.
  • Bjaalie, Jan G. & Leergaard, Trygve Brauns (2014). Neuroscience in the information ages: Brain atlasing goes digital. META. ISSN 1890-1956. p. 14–17.
  • Bjaalie, Jan G.; Papp, Eszter Agnes; Kjonigsen, LJ; Johnson, GA; Witter, Menno & Leergaard, Trygve Brauns (2013). Waxholm Space Atlas of the rat brain with detailed hippocampal subdivisions.
  • Syverstad, Gry-Helen Enger; Lillehaug, Sveinung; Nilsson, Lars N. G.; Bjaalie, Jan G.; Leergaard, Trygve B. & Torp, Reidun (2013). Spatial distribution and variance of amyloid-beta load in middle-aged transgenic Alzheimer’s disease mice with both the Artic and Swedish AβPP mutations.
  • Syverstad, Gry-Helen Enger; Nuruddin, Syed; Lillehaug, Sveinung; Leergaard, Trygve B.; Haraldsen, Ira Hebold & Torp, Reidun (2013). Targeting gonadotroping-releasing hormone in Alzheimer’s disease.
  • Papp, Eszter Agnes; Leergaard, Trygve Brauns; Johnson, G. Allan & Bjaalie, Jan G. (2012). First generation Waxholm atlas of the Sprague-Dawley rat brain.
  • Papp, Eszter Agnes; Leergaard, Trygve B.; Jiang, Yi; Johnson, G. Allan & Bjaalie, Jan G. (2011). Multimodal digital atlas of the rat brain: data integration in a high resolution volumetric template. Frontiers in Neuroinformatics. ISSN 1662-5196. doi: 10.3389/conf.fninf.2011.08.00013
  • Moene, Ivar Andre; Darine, Dmitri Aleksandrovitsj; Ramachandran, Muthuraja; Leergaard, Trygve Brauns & Bjaalie, Jan G. (2011). Rodent Brain Navigator: database and atlas system for microscopy and imaging data. Frontiers in Neuroinformatics. ISSN 1662-5196. doi: 10.3389/conf.fninf.2011.08.00159
  • Kjønigsen, Lisa Jannicke; Leergaard, Trygve Brauns; Witter, Menno & Bjaalie, Jan G. (2011). Three-dimensional atlas framework for mapping of projections from the entorhinal cortex to the hippocampal formation in rat. Frontiers in Neuroinformatics. ISSN 1662-5196. doi: 10.3389/conf.fninf.2011.08.00129
  • Papp, Eszter Agnes; Bjaalie, Jan G. & Leergaard, Trygve Brauns (2018). MR-basert atlas av rottehjernen for integrasjon av bildedata. Faculty of Medicine, University of Oslo. ISSN 978-82-8377-194-7. Full text in Research Archive

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Published Apr. 13, 2011 2:40 PM - Last modified Mar. 15, 2019 2:38 PM

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