Mahmood Reza Amiry-Moghaddam

• de Bellis, Manuela; Cibelli, Antonio; Mola, Maria Grazia; Pisani, Francesco; Barile, Barbara; Mastrodonato, Maria; Banitalebi, Shervin; Amiry-Moghaddam, Mahmood; Abbrescia, Pasqua; Frigeri, Antonio; Svelto, Maria & Nicchia, Grazia Paola (2020). Orthogonal arrays of particle assembly are essential for normal aquaporin-4 expression level in the brain. Glia.  ISSN 0894-1491. . doi: 10.1002/glia.23909 Full text in Research Archive.
• Hoddevik, Eystein Hellstrøm; Rao, Shreyas Balachandra; Rahmani, Soulmaz; Boldt, Henning Bunsow; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood (2020). Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain. Brain Structure and Function.  ISSN 1863-2653.  225, s 805- 816 . doi: 10.1007/s00429-020-02036-3 Full text in Research Archive.
• Katoozi, Shirin; Shreyas, Rao; Skauli, Nadia; Froehner, Stanley C.; Ottersen, Ole Petter; Adams, Marv & Amiry-Moghaddam, Mahmood (2020). Functional specialization of retinal Müller cell endfeet depends on an interplay between two syntrophin isoforms. Molecular Brain.  ISSN 1756-6606.  13 . doi: 10.1186/s13041-020-00581-w Full text in Research Archive. Show summary

  Retinal Müller cells are highly polarized macroglial cells with accumulation of the aquaporin-4 (AQP4) water channel and the inwardly rectifying potassium channel Kir4.1 at specialized endfoot membrane domains abutting microvessels and corpus vitreum. Proper water and potassium homeostasis in retina depends on these membrane specializations. Here we show that targeted deletion of β1-syntrophin leads to a partial loss of AQP4 from perivascular Müller cell endfeet and that a concomitant deletion of both α1- and β1-syntrophin causes a near complete loss of AQP4 from both perivascular and subvitreal endfoot membranes. α1-syntrophin is normally very weakly expressed in Müller cell endfeet but β1-syntrophin knockout mice display an increased amount of α1-syntrophin at these sites. We suggest that upregulation of perivascular α1-syntrophin restricts the effect of β1-syntrophin deletion. The present findings indicate that β1-syntrophin plays an important role in maintaining the functional polarity of Müller cells and that α1-syntrophin can partially substitute for β1-syntrophin in AQP4 anchoring. Functional polarization of Müller cells thus depends on an interplay between two syntrophin isoforms.

• Katoozi, Shirin; Skauli, Nadia; Rahmani, Soulmaz; Deshpande, Tushar; Ezan, Pascal; Palazzo, Claudia; Steinhäuser, Christian; Frigeri, Antonio; Cohen-Salmon, Martine; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood (2020). Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms. Cells.  ISSN 2073-4409. . doi: 10.3390/cells9020382 Full text in Research Archive. Show summary

  The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis. While AQP4 is mainly involved in water flux across the astrocytic endfeet membranes, astrocytic gap junctions provide syncytial coupling allowing intercellular exchange of water, ions, and other molecules. We have previously shown that mice with targeted deletion of Aqp4 display enhanced gap junctional coupling between astrocytes. Here, we investigate whether uncoupling of the astrocytic syncytium by deletion of the astrocytic connexins Cx43 and Cx30 affects AQP4 membrane localization and expression. By using quantitative immunogold cytochemistry, we show that deletion of astrocytic connexins leads to a substantial reduction of perivascular AQP4, concomitant with a down-regulation of total AQP4 protein and mRNA. Isoform expression analysis shows that while the level of the predominant AQP4 M23 isoform is reduced in Cx43/Cx30 double deficient hippocampal astrocytes, the levels of M1, and the alternative translation AQP4ex isoform protein levels are increased. These findings reveal a complex interdependence between AQP4 and connexins, which are both significantly involved in homeostatic functions and astrogliopathologies.

• Palazzo, Claudia; Abbrescia, Pasqua; Valente, Onofrio; Nicchia, Grazia Paola; Banitalebi, Shervin; Amiry-Moghaddam, Mahmood; Trojano, Maria & Frigeri, Antonio (2020). Tissue Distribution of the Readthrough Isoform of AQP4 Reveals a Dual Role of AQP4ex Limited. International Journal of Molecular Sciences.  ISSN 1422-0067.  21(4), s 1- 14 . doi: 10.3390/ijms21041531 Full text in Research Archive.
• Prydz, Agnete; Stahl, Katja; Rahmani, Soulmaz; Skauli, Nadia; Skare, Øivind; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood (2020). Pro-inflammatory role of AQP4 in mice subjected to intrastriatal injections of the Parkinsonogenic toxin MPP. Cells.  ISSN 2073-4409.  9:2418(11) . doi: 10.3390/cells9112418 Full text in Research Archive. Show summary

  Aquaporin-4 (AQP4) is critically involved in brain water and volume homeostasis and has been implicated in a wide range of pathological conditions. Notably, evidence has been accrued to suggest that AQP4 plays a proinflammatory role by promoting release of astrocytic cytokines that activate microglia and other astrocytes. Neuroinflammation is a hallmark of Parkinson's disease (PD), and we have previously shown that astrocytes in substantia nigra (SN) are enriched in AQP4 relative to cortical astrocytes, and that their complement of AQP4 is further increased following treatment with the parkinsonogenic toxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Here, we investigated the effect of Aqp4 deletion on microglial activation in mice subjected to unilateral intrastriatal injection of 1-methyl-4-phenylpyridinium (MPP+, the toxic metabolite of MPTP). Our results show that MPP+ injections lead to a pronounced increase in the expression level of microglial activating genes in the ventral mesencephalon of wild type (WT) mice, but not Aqp4-/- mice. We also show, in WT mice, that MPP+ injections cause an upregulation of nigral AQP4 and swelling of astrocytic endfeet. These findings are consistent with the idea that AQP4 plays a pro-inflammatory role in Parkinson's disease, secondary to the dysregulation of astrocytic volume homeostasis.

• Vatnehol, Svein Are Sirirud; Hol, Per Kristian; Bjørnerud, Atle; Amiry-Moghaddam, Mahmood; Haglerød, Camilla & Storås, Tryggve (2020). Effect of drinking oxygenated water assessed by in vivo MRI relaxometry. Journal of Magnetic Resonance Imaging.  ISSN 1053-1807.  52(3), s 720- 728 . doi: 10.1002/jmri.27104 Full text in Research Archive.
• Amiry-Moghaddam, Mahmood (2019). AQP4 and the fate of gliomas. Cancer Research.  ISSN 0008-5472.  79(11), s 2810- 2811 . doi: 10.1158/0008-5472.CAN-19-1185 Full text in Research Archive.
• Formaggio, Francesco; Saracino, Emanuela; Mola, Maria Grazia; Rao, Shreyas Balachandra; Amiry-Moghaddam, Mahmood; Muccini, Michele; Zamboni, Roberto; Nicchia, Grazia Paola; Caprini, Marco & Benfenati, Valentina (2019). LRRC8A is essential for swelling-activated chloride current and for regulatory volume decrease in astrocytes.. The FASEB Journal.  ISSN 0892-6638.  33(1), s 101- 113 . doi: 10.1096/fj.201701397RR
• Rao, Shreyas Balachandra; Katoozi, Shirin; Skauli, Nadia; Froehner, Stanley C.; Ottersen, Ole Petter; Adams, Marvin E. & Amiry-Moghaddam, Mahmood (2019). Targeted deletion of β1-syntrophin causes a loss of Kir 4.1 from Müller cell endfeet in mouse retina. Glia.  ISSN 0894-1491.  67(6), s 1138- 1149 . doi: 10.1002/glia.23600 Full text in Research Archive.
• Vatnehol, Svein Are Sirirud; Hol, Per Kristian; Bjørnerud, Atle; Amiry-Moghaddam, Mahmood; Haglerød, Camilla Margrete & Storås, Tryggve (2019). Determination of oxygen r1 at 3 Tesla using samples with a concentration range of dissolved oxygen. Magnetic Resonance Materials in Physics, Biology and Medicine.  ISSN 0968-5243.  s 1- 7 . doi: 10.1007/s10334-019-00783-x Full text in Research Archive.
• Vatnehol, Svein Are Sirirud; Hol, Per Kristian; Bjørnerud, Atle; Amiry-Moghaddam, Mahmood; Haglerød, Camilla Margrete & Storås, Tryggve (2019). Precision of T1-relaxation time measurements in the hepatic portal vein: influence of measurement technique and sequence parameters.. Magnetic Resonance Materials in Physics, Biology and Medicine.  ISSN 0968-5243.  32(3), s 359- 368 . doi: 10.1007/s10334-018-00731-1
• Moen, Ingrid; Ugland, Hege; Strömberg, Niklas; Sjöström, Eva; Karlsson, Anders; Ringstad, Lovisa; Bysell, Helena; Amiry-Moghaddam, Mahmood & Haglerød, Camilla (2018). Development of a novel in situ gelling skin dressing: Delivering high levels of dissolved oxygen at pH 5.5.. Health Science Reports.  ISSN 2398-8835.  13(1), s 101- 113 . doi: 10.1002/hsr2.57
• Stahl, Katja; Rahmani, Soulmaz; Prydz, Agnete; Skauli, Nadia; MacAulay, Nanna; Mylonakou, Maria-Niki; Torp, Reidun; Skare, Øivind; Berg, Torill; Leergaard, Trygve Brauns; Paulsen, Ragnhild Elisabeth; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood (2018). Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PLOS ONE.  ISSN 1932-6203.  13(3) . doi: 10.1371/journal.pone.0194896 Full text in Research Archive. Show summary

  More than 90% of the cases of Parkinson’s disease have unknown etiology. Gradual loss of dopaminergic neurons of substantia nigra is the main cause of morbidity in this disease. External factors such as environmental toxins are believed to play a role in the cell loss, although the cause of the selective vulnerability of dopaminergic neurons remains unknown. We have previously shown that aquaglyceroporin AQP9 is expressed in dopaminergic neurons and astrocytes of rodent brain. AQP9 is permeable to a broad spectrum of substrates including purines, pyrimidines, and lactate, in addition to water and glycerol. Here we test our hypothesis that AQP9 serves as an influx route for exogenous toxins and, hence, may contribute to the selective vulnerability of nigral dopaminergic (tyrosine hydroxylase-positive) neurons. Using Xenopus oocytes injected with Aqp9 cRNA, we show that AQP9 is permeable to the parkinsonogenic toxin 1-methyl-4-phenylpyridinium (MPP+). Stable expression of AQP9 in HEK cells increases their vulnerability to MPP+ and to arsenite—another parkinsonogenic toxin. Conversely, targeted deletion of Aqp9 in mice protects nigral dopaminergic neurons against MPP+ toxicity. A protective effect of Aqp9 deletion was demonstrated in organotypic slice cultures of mouse midbrain exposed to MPP+ in vitro and in mice subjected to intrastriatal injections of MPP+ in vivo. Seven days after intrastriatal MPP+ injections, the population of tyrosine hydroxylase-positive cells in substantia nigra is reduced by 48% in Aqp9 knockout mice compared with 67% in WT littermates. Our results show that AQP9 –selectively expressed in catecholaminergic neurons—is permeable to MPP+ and suggest that this aquaglyceroporin contributes to the selective vulnerability of nigral dopaminergic neurons by providing an entry route for parkinsonogenic toxins. To our knowledge this is the first evidence implicating a toxin permeable membrane channel in the pathophysiology of Parkinson’s disease.

• Hoddevik, Eystein Hellstrøm; Khan, Faraz Hameed; Rahmani, Soulmaz; Ottersen, Ole Petter; Boldt, Henning Bunsow & Amiry-Moghaddam, Mahmood (2017). Factors determining the density of AQP4 water channel molecules at the brain-blood interface. Brain Structure and Function.  ISSN 1863-2653.  222(4), s 1753- 1766 . doi: 10.1007/s00429-016-1305-y Full text in Research Archive.
• Katoozi, Shirin; Skauli, Nadia; Rahmani, Soulmaz; Camassa, Laura Maria Azzurra; Boldt, Henning Bunsow; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood (2017). Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions. Brain Structure and Function.  ISSN 1863-2653.  s 1- 14 . doi: 10.1007/s00429-017-1448-5
• Prydz, Agnete; Stahl, Katja; Puchades, Maja Amedjkouh; Davarpaneh, Nina; Nadeem, Maria; Ottersen, Ole Petter; Gundersen, Vidar & Amiry-Moghaddam, Mahmood (2017). Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice. Neuroscience.  ISSN 0306-4522.  359, s 258- 266 . doi: 10.1016/j.neuroscience.2017.07.029
• Huang, Wei; Li, Qing; Amiry-Moghaddam, Mahmood; Hokama, Madoka; Sardi, Sylvia H.; Nagao, Masashi; Warman, Matthew L. & Olsen, Bjørn Reino (2016). Critical endothelial regulation by LRP5 during retinal vascular development. PLOS ONE.  ISSN 1932-6203.  11:e0152833(3) . doi: 10.1371/journal.pone.0152833
• Nakayama, Shin; Amiry-Moghaddam, Mahmood; Ottersen, Ole Petter & Bhardwaj, Anish (2016). Conivaptan, a Selective Arginine Vasopressin V<sub>1a</sub> and V<sub>2</sub> Receptor Antagonist Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4. Neurocritical Care.  ISSN 1541-6933.  24(2), s 273- 282 . doi: 10.1007/s12028-015-0236-4
• Nakayama, Shin; Migliati, Elton; Amiry-Moghaddam, Mahmood; Ottersen, Ole Petter & Bhardwaj, Anish (2016). Osmotherapy with hypertonic saline attenuates global cerebral edema following experimental cardiac arrest via perivascular pool of aquaporin-4. Critical Care Medicine.  ISSN 0090-3493.  44(8), s e702- e710 . doi: 10.1097/CCM.0000000000001671
• Camassa, Laura Maria Azzurra; Lunde, Lisa Kristina; Hoddevik, Eystein Hellstrøm; Stensland, Maria; Boldt, Henning Bunsow; De Souza, Gustavo Antonio; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood (2015). Mechanisms underlying AQP4 accumulation in astrocyte endfeet. Glia.  ISSN 0894-1491.  63(11), s 2073- 2091 . doi: 10.1002/glia.22878
• Magdolenova, Zuzana; Drlickova, Martina; Henjum, Kristi; Pran, Elise Rundén; Tulinska, Jana; Bilanicova, Dagmar; Pojana, Giulio; Kazimirova, Alena; Barancokova, Magdalena; Kuricova, Miroslava; Liskova, Aurelia; Staruchova, Marta; Ciampor, Fedor; Vara, Ivo; Lorenzo, Yolanda Corrales; Collins, Andrew Richard; Rinna, Alessandra; Fjellbø, Lise Marie; Volkova, Katarina; Marcomini, Antonio; Amiry-Moghaddam, Mahmood & Dusinska, Maria (2015). Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles. Nanotoxicology.  ISSN 1743-5390.  9(1), s 44- 56 . doi: 10.3109/17435390.2013.847505
• Ricanek, Petr; Lunde, Lisa Kristina; Frye, Stephan Alfons; Støen, Mari; Nygård, Ståle; Morth, Jens Preben; Rydning, Andreas; Vatn, Morten H; Amiry-Moghaddam, Mahmood & Tonjum, Tone (2015). Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease. Clinical and Experimental Gastroenterology.  ISSN 1178-7023.  8, s 49- 67 . doi: 10.2147/CEG.S70119
• Lunde, Lisa Kristina; Camassa, Laura Maria Azzurra; Hoddevik, Eystein Hellstrøm; Khan, Faraz Hameed; Ottersen, Ole Petter; Boldt, Henning Bunsow & Amiry-Moghaddam, Mahmood (2014). Postnatal development of the molecular complex underlying astrocyte polarization. Brain Structure and Function.  ISSN 1863-2653.  220(4), s 2087- 2101 . doi: 10.1007/s00429-014-0775-z
• Alvestad, Silje; Hammer, Janniche; Hoddevik, Eystein Hellstrøm; Skare, Øivind; Sonnewald, Ursula; Amiry-Moghaddam, Mahmood & Ottersen, Ole Petter (2013). Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy. Epilepsy Research.  ISSN 0920-1211.  105(1-2), s 30- 41 . doi: 10.1016/j.eplepsyres.2013.01.006
• Amiry-Moghaddam, Mahmood & Ottersen, Ole Petter (2013). Immunogold cytochemistry in neuroscience. Nature Neuroscience.  ISSN 1097-6256.  16(7), s 798- 804 . doi: 10.1038/nn.3418
• Nagelhus, Erlend Arnulf; Amiry-Moghaddam, Mahmood; Bergersen, Linda Hildegard; Bjaalie, Jan G.; Eriksson, Jens; Gundersen, Vidar; Leergaard, Trygve Brauns; Morth, Jens Preben; Storm-Mathisen, Jon; Torp, Reidun; Walhovd, Kristine B & Tønjum, Tone (2013). The glia doctrine: Addressing the role of glial cells in healthy brain ageing. Mechanisms of Ageing and Development.  ISSN 0047-6374.  134(10), s 449- 459 . doi: 10.1016/j.mad.2013.10.001
• Nuruddin, Syed; Wojniusz, Slawomir; Ropstad, Erik; Krogenæs, Anette; Evans, Neil P.; Robinson, Jane E.; Solbakk, Anne-Kristin; Amiry-Moghaddam, Mahmood & Haraldsen, Ira Hebold (2013). Peri-pubertal gonadotropin-releasing hormone analog treatment affects hippocampus gene expression without changing spatial orientation in young sheep. Behavioural Brain Research.  ISSN 0166-4328.  242, s 9- 16 . doi: 10.1016/j.bbr.2012.12.027
• Promeneur, Dominique; Lunde, Lisa Kristina; Amiry-Moghaddam, Mahmood & Agre, Peter (2013). Protective role of brain water channel AQP4 in murine cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  110(3), s 1035- 1040 . doi: 10.1073/pnas.1220566110
• Rutkovskiy, Arkady; Bliksøen, Marte; Hillestad, Vigdis; Amin, Mubashar Mohammad; Czibik, Gabor Tamas; Valen, Guro; Vaage, Ingvar Jarle; Amiry-Moghaddam, Mahmood & Stensløkken, Kåre-Olav (2013). Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia, and cardioplegia. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  56, s 22- 33 . doi: 10.1016/j.yjmcc.2012.12.002
• Kielland, Anders; Camassa, Laura Maria Azzurra; Døhlen, Gaute; Munthe, Ludvig Andre; Blomhoff, Rune; Amiry-Moghaddam, Mahmood & Carlsen, Harald (2012). Activity in Perinatal Brain During Infectious and Hypoxic-Ischemic Insults revealed by a Reporter Mouse. Brain Pathology.  ISSN 1015-6305.  22(4), s 499- 510 . doi: 10.1111/j.1750-3639.2011.00548.x
• Kielland, Anders; Camassa, Laura Maria Azzurra; Døhlen, Gaute; Munthe, Ludvig Andre; Blomhoff, Rune; Amiry-Moghaddam, Mahmood & Carlsen, Harald (2012). NF-kappa B Activity in Perinatal Brain During Infectious and Hypoxic-Ischemic Insults Revealed by a Reporter Mouse. Brain Pathology.  ISSN 1015-6305.  22(4), s 499- 510 . doi: 10.1111/j.1750-3639.2011.00548.x
• Rutkovskiy, Arkady; Stensløkken, Kåre-Olav; Mariero, Lars Henrik; Skrbic, Biljana; Amiry-Moghaddam, Mahmood; Hillestad, Vigdis; Valen, Guro; Perreault, Marie-Claude; Ottersen, Ole Petter; Gullestad, Lars; Dahl, Christen Peder & Vaage, Ingvar Jarle (2012). Aquaporin-4 in the heart: expression, regulation and functional role in ischemia. Basic Research in Cardiology.  ISSN 0300-8428.  107, s 280 . doi: 10.1007/s00395-012-0280-6
• Benfenati, Valentina; Caprini, Marco; Dovizio, Melania; Mylonakou, Maria-Niki; Ferroni, Stefano; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood (2011). An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(6), s 2563- 2568 . doi: 10.1073/pnas.1012867108
• Jacobsen, Øyvind; Maekawa, Hiroaki; Ge, Nien-Hui; Gorbitz, Carl Henrik; Rongved, Pål; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood & Klaveness, Jo (2011). Stapling of a 3(10)-Helix with Click Chemistry. Journal of Organic Chemistry.  ISSN 0022-3263.  76(5), s 1228- 1238 . doi: 10.1021/jo101670a
• Stahl, Katja; Mylonakou, Maria-Niki; Skare, Øivind; Amiry-Moghaddam, Mahmood & Torp, Reidun (2011). Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease. Brain Research.  ISSN 0006-8993.  1378, s 105- 118 . doi: 10.1016/j.brainres.2010.12.090
• Yang, Jing; Lunde, Lisa Kristina; Nuntagij, Paworn; Oguchi, Tomohiro; Camassa, Laura Maria Azzurra; Nilsson, Lars N. G.; Lannfelt, L.; Xu, Y; Amiry-Moghaddam, Mahmood; Ottersen, Ole Petter & Torp, Reidun (2011). Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease.  ISSN 1387-2877. . doi: 10.3233/JAD-2011-110725
• Berle, Magnus Foldal; Wester, Knut; Ulvik, Rune Johan; Haaland, Øystein Ariansen; Kroksveen, Ann Cathrine; Amiry-Moghaddam, Mahmood; Berven, Frode & Helland, Christian Andre (2010). Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults. Cerebrospinal Fluid Research.  ISSN 1743-8454.  7(1)
• Helland, Christian Andre; Aarhus, Mads; Knappskog, Per Morten; Olsson, Lisa K; Lund-Johansen, Morten; Amiry-Moghaddam, Mahmood Reza & Wester, Knut (2010). Increased NKCC1 expression in arachnoid cysts supports secretory basis for cyst formation. Experimental Neurology.  ISSN 0014-4886.  224(2), s 424- 428 . doi: 10.1016/j.expneurol.2010.05.002
• Liu, Xiaoqin; Nakayama, Shin; Amiry-Moghaddam, Mahmood Reza; Ottersen, Ole Petter & Bhardwaj, Anish (2010). Arginine-Vasopressin V-1 but not V-2 Receptor Antagonism Modulates Infarct Volume, Brain Water Content, and Aquaporin-4 Expression Following Experimental Stroke. Neurocritical Care.  ISSN 1541-6933.  12(1), s 124- 131 . doi: 10.1007/s12028-009-9277-x
• Migliati, Elton R.; Amiry-Moghaddam, Mahmood; Froehner, S.C.; Adams, Marvin E.; Ottersen, Ole Petter & Bhardwaj, Anish (2010). Na+-K+-2Cl(-) Cotransport Inhibitor Attenuates Cerebral Edema Following Experimental Stroke via the Perivascular Pool of Aquaporin-4. Neurocritical Care.  ISSN 1541-6933.  13(1), s 123- 131 . doi: 10.1007/s12028-010-9376-8
• Jacobsen, Øyvind; Klaveness, Jo; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood Reza & Rongved, Pål (2009). Synthesis of cyclic peptide analogues of the 3(10) helical Pro138-Gly144 segment of human aquaporin-4 by olefin metathesis. Organic and biomolecular chemistry.  ISSN 1477-0520.  7(8), s 1599- 1611 . doi: 10.1039/b823559g
• Liu, Xiaoqin; Nakayama, Shin; Amiry-Moghaddam, Mahmood Reza; Ottersen, Ole Petter & Bhardwaj, A (2009). Arginine-Vasopressin V(1) but not V (2) Receptor Antagonism Modulates Infarct Volume, Brain Water Content, and Aquaporin-4 Expression Following Experimental Stroke. Neurocritical Care.  ISSN 1541-6933. . doi: 10.1007/s12028-009-9277-x
• Mylonakou, Maria-Niki; Petersen, Petur Henry; Rinvik, Eric; Rojek, Aleksandra; Valdimarsdottir, Erla; Zelenin, S; Zeuthen, T; Nielsen, S; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood Reza (2009). Analysis of mice with targeted deletion of AQP9 gene provides conclusive evidence for expression of AQP9 in neurons. Journal of Neuroscience Research.  ISSN 0360-4012.  87(6), s 1310- 1322 . doi: 10.1002/jnr.21952
• Liu, Xiaoqin; Zhang, Wenri; Alkayed, Nabil; Froehner, Stanley C.; Adams, Marvin E.; Amiry-Moghaddam, Mahmood Reza; Ottersen, Ole Petter; Hurn, Patricia D. & Bhardwaj, Anish (2008). Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  28(12), s 1898- 1906 . doi: 10.1038/jcbfm.2008.83
• Zeynalov, E; Chen, CH; Froehner, SC; Adams, ME; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood Reza & Bhardwaj, A (2008). The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edema. Critical Care Medicine.  ISSN 0090-3493.  36, s 2634- 2640 . doi: 10.1097/CCM.0b013e3181847853
• Benfenati, Valentina; Amiry-Moghaddam, Mahmood Reza; Caprini, Melania; Mylonakou, Maria-Niki; Rapisarda, C; Ottersen, Ole Petter & Ferroni, S (2007). Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes. Neuroscience.  ISSN 0306-4522.  148(4), s 876- 892
• Bragg, AD; Amiry-Moghaddam, Mahmood; Ottersen, Ole Petter & Froehner, S.C. (2006). Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin. Glia.  ISSN 0894-1491.
• Bragg, AD; Amiry-Moghaddam, Mahmood Reza; Ottersen, Ole Petter; Adams, ME & Froehner, SC (2006). Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin. Glia.  ISSN 0894-1491.  53
• Frydenlund, Didrik Søli; Bhardwaj, A; Otsuka, T; Mylonakou, Maria-Niki; Yasumura, T; Davidson, KGV; Zeynalov, E; Skare, Øivind; Laake, Petter; Haug, Finn-Mogens Smejda; Rash, JE; Agre, P; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood Reza (2006). Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  103, s 13532- 13536
• Mathisen, Thomas Misje; Nagelhus, Erlend Arnulf; Juoleh, Bahareh; Torp, Reidun; Frydenlund, Didrik Søli; Mylonakou, Maria-Niki; Amiry-Moghaddam, Mahmood Reza; Covolan, Luciene; Utvik, Jo Kristian; Riber, Bjørg; Gujord, Karen Marie; Knutsen, Jorunn; Skare, Øivind; Laake, Petter; Davanger, Svend; Haug, Finn-Mogens Smejda; Rinvik, Eric & Ottersen, Ole Petter (2006). Postembedding Immunogold Cytochemistry of Membrane Molecules and Amino Acid Transmitters in the Central Nervous System, In L. Záborszky; F. Wouterlood & J.L. Lanciego (ed.),  Neuroanatomical Tract Tracing: Molecules, Neurons, & Systems.  Springer Science+Business Media B.V..  ISBN 0-387-28941-0.  3.  s 72 - 108
• Puwarawuttipanit, W; Bragg, AD; Frydenlund, Didrik Søli; Mylonakou, Maria-Niki; Nagelhus, Erlend Arnulf; Peters, MF; Kotchabhakdi, N; Adams, ME; Froenhner, SC; Haug, Finn-Mogens Smejda; Ottersen, Ole Petter & Amiry-Moghaddam, Mahmood Reza (2006). Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice. Neuroscience.  ISSN 0306-4522.  137, s 165- 175
• Warskulat, U; Borsch, E; Reinehr, R; Heller-Stilb, B; Monnighoff, I; Buchczyk, D; Donner, M; Flogel, U; Kappert, G; Soboll, S; Beer, S; Pfeffer, K; Marschall, HU; Gabrielsen, Marcus; Amiry-Moghaddam, Mahmood Reza; Ottersen, Ole Petter; Dienes, HP & Haussinger, DH (2006). Chronic liver disease is triggered by taurine transporter knockout in the mouse. The FASEB Journal.  ISSN 0892-6638.  20
• Amiry-Moghaddam, Mahmood Reza; Lindland, Heidi; Zelenin, S; Roberg, Bjørg Åse; Gundersen, BB; Petersen, Petur Henry; Rinvik, Eric; Torgner, Ingeborg Aasland & Ottersen, Ole Petter (2005). Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane. The FASEB Journal.  ISSN 0892-6638.  19, s 1459- 1467
• Eid, T; Lee, TSW; Thomas, Marion J.; Amiry-Moghaddam, Mahmood Reza; Bjørnsen, Lars Petter B. W.; Spencer, DD; Agre, P; Ottersen, Ole Petter & de Lanerolle, NC (2005). Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  102, s 1193- 1198
• Solbu, Tom Tallak; Boulland, Jean-Luc; Zahid, W; Bredahl, May Kristin Lyamouri; Amiry-Moghaddam, Mahmood Reza; Storm-Mathisen, Jon; Roberg, Bjørg Åse & Chaudhry, Farrukh Abbas (2005). Induction and targeting of the glutamine transporter SN1 to the basolateral membranes of cortical kidney tubule cells during chronic metabolic acidosis suggest a role in pH regulation. Journal of the American Society of Nephrology.  ISSN 1046-6673.  16
• Amiry-Moghadam, Mahmood Reza; Frydenlund, Didrik Søli & Ottersen, Ole Petter (2004). Anchoring of aquaporin-4 in brain: Molecular mechanisms and implications forthe physiology and pathophysiology of water transport. Neuroscience.  ISSN 0306-4522.  129(4), s 997- 1008
• Amiry-Moghadam, Mahmood Reza; Xue, R; Haug, Finn-Mogens Smejda; Neely, J.D.; Bhardwaj, A; Agre, P; Adams, ME; Froehner, SC; Mori, S. & Ottersen, Ole Petter (2004). Alpha syntrophin deletion removes the perivascular but not the endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. The FASEB Journal.  ISSN 0892-6638.  18(3), s 542- 544
• Amiry-Moghadam, Mahmood Reza; Otsuka, T; Hurn, PD; Traystman, RJ; Haug, Finn-Mogens Smejda; Froehner, SC; Adams, ME; Neely, J.D.; Agre, P.; Ottersen, Ole Petter & Bhardwaj, A (2003). An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  100(4), s 2106- 2111
• Amiry-Moghadam, Mahmood Reza & Ottersen, Ole Petter (2003). The molecular basis for water transport in brain. Nature Reviews Neuroscience.  ISSN 1471-003X.  4(12), s 991- 1001
• Amiry-Moghadam, Mahmood Reza; Williamson, A; Palomba, M; Eid, Tore; Lanerolle, NC de; Adams, ME; Nagelhus, Erlend Arnulf; Froehner, SC; Agre, P. & Ottersen, Ole Petter (2003). Delayed K+ clearance and intensified seizures associated with Aquaporin-4 mislocalization: Phenotypic defects in brains of alpha-syntrophin-null mice. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  100(23), s 13615- 13620
• Neely, J.D.; Amiry-Moghaddam, Mahmood; Ottersen, Ole Petter; Froehner, SC; Agre, P. & Adams, ME (2001). Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  98(24), s 14108- 14113
• Niermann, H.; Amiry-Moghaddam, Mahmood; Holthoff, K.; Witte, O.W. & Ottersen, Ole Petter (2001). A novel role of vasopressin in the brain: modulation of activity-dependent water flux in the neocortex. Journal of Neuroscience.  ISSN 0270-6474.  21(9), s 3045- 3051
• Elkjaer, M; Vajda, Z.; Nejsum, L.N.; Kwon, T.; Jensen, U.B.; Amiry-Moghaddam, Mahmood Reza & Frøkiaer, J. (2000). Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  s 1118- 1128
• Wen, H. Z.; Nagelhus, Erlend Arnulf; Amiry-Moghaddam, Mahmood; Agre, P.; Ottersen, Ole Petter & Nielsen, S.P. (1999). Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel. European Journal of Neuroscience.  ISSN 0953-816X.  11, s 935- 945
• Landsend, A. S.; Amiry-Moghaddam, Mahmood; Matsubara, Atsushi; Bergersen, Linda Hildegard; Usami, Shin-ichi; Wenthold, R.J. & Ottersen, Ole Petter (1997). Differential localization of _d glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. Journal of Neuroscience.  ISSN 0270-6474.  17, s 834- 842
• Landsend, Alf S.; Amiry-Moghaddam, Mahmood; Matsubara, Atsushi; Bergersen, Linda Hildegard; Usami, Shin-ichi; Wenthold, R.J. & Ottersen, Ole Petter (1997). Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. Journal of Neuroscience.  ISSN 0270-6474.
• Nielsen, S.P.; Nagelhus, Erlend Arnulf; Amiry-Moghaddam, Mahmood; Bourque, C.; Agre, P. & Ottersen, Ole Petter (1997). Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of Aquaporin-4 in rat brain. Journal of Neuroscience.  ISSN 0270-6474.  17, s 171- 180
• Nielsen, Søren; Nagelhus, Erlend Arnulf; Amiry-Moghaddam, Mahmood; Bourque, C.; Agre, P. & Ottersen, Ole Petter (1997). Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. Journal of Neuroscience.  ISSN 0270-6474.
• Amiry-Moghaddam, Mahmood Reza; Nagelhus, Erlend Arnulf; Agre, P.; Nielsen, S.P. & Ottersen, Ole Petter (1996). Taurine and water channels are colocalized in renal tubule cells and other tissues, In  Taurine 2.  Plenum Press.  2.  s 165 - 171
• Amiry-Moghaddam, Mahmood Reza; Nagelhus, Erlend Arnulf & Ottersen, Ole Petter (1994). Light- and electronmicroscopic distribution of taurine, an organic osmolyte, in rat renal tubule cells. Kidney International.  ISSN 0085-2538.  s 10- 22
• Nagelhus, Erlend Arnulf; Amiry-Moghaddam, Mahmood Reza; Lehmann, A. & Ottersen, Ole Petter (1994). Taurine as an organic osmolyte in the intact brain: immunocytochemical and biochemical studies. Advances in Experimental Medicine and Biology.  ISSN 0065-2598.  s 325- 334

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• Olsen, Bjørn Reino; Amiry-Moghaddam, Mahmood & Ottersen, Ole Petter (2015). Translational Medical Research, In Petter Laake; Haakon Breien Benestad & Bjørn Reino Olsen (ed.),  Research in Medical and Biological Sciences: From Planning and Preparation ot Grant Application and Publication..  Academic Press.  ISBN 978-0-12-799943-2.  Kapittel 7.  s 213 - 235
• Witoszek, Nina & Amiry-Moghaddam, Mahmood (2014). "Hijab, galgen og revolusjon". Dagbladet.  ISSN 0805-3766.
• Amiry-Moghaddam, Mahmood (2010). Aquaporin water channels in health and disease. The FEBS Journal.  ISSN 1742-464X.  277, s 5- 5
• Amiry-Moghaddam, Mahmood Reza; Hoddevik, Eystein Hellstrøm & Ottersen, Ole Petter (2010). AQUAPORINS: MULTIFARIOUS ROLES IN BRAIN. Neuroscience.  ISSN 0306-4522.  168(4), s 859- 861 . doi: 10.1016/j.neuroscience.2010.04.071
• Amiry-Moghaddam, Mahmood (2009). Aquaporin-4 water channels as new molecular targets in treatment of brain edema and stroke. Journal of the Neurological Sciences.  ISSN 0022-510X.  285, s S27- S27
• Amiry-Moghaddam, Mahmood Reza (2009). PHYSIOLOGICAL AND PATHOLOGICAL ROLES OF AQUAPORIN-4 IN THE BRAIN. Journal of Neurochemistry.  ISSN 0022-3042.  110, s 13- 13
• Liu, X; Zhang, WR; Alkayed, NJ; Hurn, PD; Froehner, SC; Marvin, AE; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood Reza & Bhardwaj, A (2008). Lack of gender-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke. Stroke.  ISSN 0039-2499.  39, s 672- 673

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