Marie Rogne

• Caglayan, Safak; Hashim, Adnan; Cieslar-Pobuda, Artur; Jensen, Vidar; Behringer, Sidney; Talug, Burcu; Chu, Dinh Toi; Pecquet, Christian; Rogne, Marie; Brech, Andreas; Brorson, Sverre Henning; Nagelhus, Erlend Arnulf; Hannibal, Luciana; Boschi, Antonella; Tasken, Kjetil & Staerk, Judith (2020). Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation. iScience.  ISSN 2589-0042.  23(6) . doi: 10.1016/j.isci.2020.101154 Full text in Research Archive. Show summary

  Optic atrophy 1 (OPA1), a GTPase at the inner mitochondrial membrane involved in regulating mitochondrial fusion, stability, and energy output, is known to be crucial for neural development: Opa1 heterozygous mice show abnormal brain development, and inactivating mutations in OPA1 are linked to human neurological disorders. Here, we used genetically modified human embryonic and patient-derived induced pluripotent stem cells and reveal that OPA1 haploinsufficiency leads to aberrant nuclear DNA methylation and significantly alters the transcriptional circuitry in neural progenitor cells (NPCs). For instance, expression of the forkhead box G1 transcription factor, which is needed for GABAergic neuronal development, is repressed in OPA1+/− NPCs. Supporting this finding, OPA1+/− NPCs cannot give rise to GABAergic interneurons, whereas formation of glutamatergic neurons is not affected. Taken together, our data reveal that OPA1 controls nuclear DNA methylation and expression of key transcription factors needed for proper neural cell specification.

• Fuglerud, Bettina Maria; Ledsaak, Marit; Rogne, Marie; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2018). The pioneer factor activity of c-Myb involves recruitment of p300 and induction of histone acetylation followed by acetylation-induced chromatin dissociation. Epigenetics & Chromatin.  ISSN 1756-8935.  11(1) . doi: 10.1186/s13072-018-0208-y Full text in Research Archive.
• Rogne, Marie; Chu, Dinh Toi; Küntziger, Thomas M.; Mylonakou, Maria-Niki; Collas, Philippe & Tasken, Kjetil (2018). OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells. Molecular Biology of the Cell.  ISSN 1059-1524.  29(12), s 1487- 1501 . doi: 10.1091/mbc.E17-09-0538 Full text in Research Archive.
• Rogne, Marie; Svärd, Oksana; Madsen-Østerbye, Julia-Kristina Jensen; Hashim, Adnan; Tjønnfjord, Geir Erland & Staerk, Judith (2018). Cytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia. Journal of Cellular and Molecular Medicine.  ISSN 1582-1838.  22(5), s 2846- 2855 . doi: 10.1111/jcmm.13579 Full text in Research Archive.
• Rogne, Marie & Tasken, Kjetil (2014). Compartmentalization of cAMP signaling in adipogenesis, lipogenesis and lipolysis. Hormone and Metabolic Research.  ISSN 0018-5043.  46(12), s 833- 840 . doi: 10.1055/s-0034-1389955
• Rogne, Marie & Tasken, Kjetil (2013). Cell signalling analyses in the functional genomics era. New Biotechnology.  ISSN 1871-6784.  30(3), s 333- 338 . doi: 10.1016/j.nbt.2013.01.003
• Aksaas, Anne Kristin; Larsen, Anja C V; Rogne, Marie; Rosendal, Ken Roger; Kvissel, Anne Katrine & Skålhegg, Bjørn Steen (2011). G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. Journal of Molecular Signaling.  ISSN 1750-2187.  6, s 1- 14 . doi: 10.1186/1750-2187-6-10
• Rogne, Marie; Stokka, Anne Jorunn; Tasken, Kjetil; Collas, Philippe & Kuntziger, Thomas Michel (2009). Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. Human Molecular Genetics.  ISSN 0964-6906.  18(5), s 978- 987 . doi: 10.1093/hmg/ddn425
• Kuntziger, Thomas Michel; Rogne, Marie; Folstad, Rikke Lise & Collas, Philippe (2006). Association of PP1 with its regulatory subunit AKAP149 is regulated by serine phosphorylation flanking the RVXF motif of AKAP149. Biochemistry.  ISSN 0006-2960.  45(18), s 5868- 5877
• Rogne, Marie; Landsverk, Bjarnason Helga; Eynde, A.V.; Beullens, Monique; Bollen, M.; Collas, Philippe & Kuntziger, Thomas Michel (2006). The KH-Tudor domain of A-Kinase anchoring protein 149 mediates RNA-dependent self-association. Biochemistry.  ISSN 0006-2960.  45(50), s 14980- 14989
• Landsverk, Bjarnason Helga; Rogne, Marie; Bollen, M.; Kuntziger, Thomas Michel & Collas, Philippe (2005). PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochemical Journal.  ISSN 0264-6021.  15, s 709- 17

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