Nuclear Architecture in Adipose and Cancer Stem Cells
We are interested in understanding chromatin features that pattern 3D genome architecture during adipogenesis and breast cancer tumorigenesis.
The Collas lab 2019 (from left): Aurélie Nathalie Pascale Bellanger, Qiong Fan, Julia-Kristina Madsen-Østerbye, Thomas Germier, Sumithra Maud Taraldsen, Thomas Sæther, Philippe Collas, Coen Campsteijn, Louise Petersen, Tharvesh Moideen Liyakat Ali, Kristin Vekterud, Annemijn Arns, Nolwenn Briand, Anita Løvstad Sørensen, Evdokiia Potolitsyna, Sissel Eikvar, Annaëlle Brunet.
Cell fate decisions are programmed by multiple layers of regulation of gene expression involving chromatin modifications and a dynamic organization of the genome in the 3-dimensional cell nucleus space.
CollasLab is interested in understanding chromatin features that pattern 3D genome architecture during adipogenesis and breast cancer tumorigenesis.
To this end, we combine cell biological, biochemical, imaging, genomics and computational approaches.
- The 3-dimensional conformation of the genome
- Nuclear lamins and lipodystrophic laminopathies
- Nuclear envelope dynamics
- Nutritional regulation of transcription