Michael Rory Daws

Professor - Division of Anatomy
Image of Michael Rory Daws
Norwegian version of this page
Phone +47 22851151
Room 2503
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1105 Blindern 0317 Oslo


  • Teaching in MED1100 (module 1) and MED2200 (module 2):
    • immunology
    • cell biology
    • histology
    • anatomy
  • Research
    • receptors of the innate immune system, and their role in autoimmunity and cancer


I completed my PhD at the University of Newcastle-upon-Tyne i 1995. My first postdoctoral period was in Umeå in the north of Sweden, where I worked with NK cells under the supervision of Charles Sentman. After this, I spent 6 years in San Francisco in the lab of Bill Seaman, before I came to Oslo in 2004. Here I worked together with Bent Rolstad, John Torgils Vaage, Erik Dissen and Sigbjørn Fossum. Since 2015 I have had a full professor position.


  • Bjørnsen, Elisabeth Gyllensten; Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Henden, Camilla; Sæther, Per Christian; Boysen, Preben; Daws, Michael Rory & Dissen, Erik (2019). B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines. European Journal of Immunology.  ISSN 0014-2980.  49(1), s 54- 65 . doi: 10.1002/eji.201847746 Full text in Research Archive. Show summary
  • Daws, Michael Rory; Nakken, Britt; Lobato, Pascual Ana; Josien, Regis; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With Fc?RI? and Is Expressed by Myeloid Cell Subsets in the Rat. Frontiers in Immunology.  ISSN 1664-3224.  10, s 1060 . doi: 10.3389/fimmu.2019.01060 Full text in Research Archive. Show summary
  • Jendresen, Charlotte Bille; Daws, Michael Rory & Nilsson, Lars (2018). An improved CPRG colorimetric ligand-receptor signal transduction assay based on beta-galactosidase activity in mammalian BWZ-reporter cells. Journal of pharmacological and toxicological methods.  ISSN 1056-8719.  90, s 67- 75 . doi: 10.1016/j.vascn.2017.11.004 Full text in Research Archive.
  • Jendresen, Charlotte Bille; Årskog, Vibeke Helen; Daws, Michael Rory & Nilsson, Lars (2017). The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. Journal of Neuroinflammation.  ISSN 1742-2094.  14:59, s 1- 13 . doi: 10.1186/s12974-017-0835-4
  • Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian; Bjørnsen, Elisabeth Gyllensten; Pende, Daniela; Fossum, Sigbjørn; Daws, Michael Rory & Dissen, Erik (2017). The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer Cells. Journal of Immunology.  ISSN 0022-1767.  198(7), s 2556- 2567 . doi: 10.4049/jimmunol.1600930
  • Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik; Fossum, Sigbjørn & Daws, Michael Rory (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLOS ONE.  ISSN 1932-6203.  8(2) . doi: 10.1371/journal.pone.0057406
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology.  ISSN 0014-2980.  43(12), s 3167- 3174 . doi: 10.1002/eji.201343752
  • Daws, Michael Rory; Dai, Kezheng; Zinöcker, Severin; Naper, Christian; Kveberg, Lise; Hedrich, Hans J; Rolstad, Bent & Vaage, John Torgils (2012). Identification of an MHC Class I Ligand for the Single Member of a Killer Cell Lectin-like Receptor Family, KLRH1. Journal of Immunology.  ISSN 0022-1767.  189(11), s 5178- 5184 . doi: 10.4049/jimmunol.1201983 Show summary
  • Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics.  ISSN 0093-7711.  63(12), s 809- 820 . doi: 10.1007/s00251-011-0553-5
  • Shegarfi, Hamid; Dai, Kezheng; Daws, Michael Rory; Ryan, James C.; Vaage, John Torgils; Rolstad, Bent & Naper, Christian (2011). The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages. Journal of Leukocyte Biology.  ISSN 0741-5400.  89(4), s 617- 623 . doi: 10.1189/jlb.1010593
  • Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics.  ISSN 0093-7711.  62(8), s 521- 530 . doi: 10.1007/s00251-010-0455-y
  • Kveberg, Lise; Dai, Kezheng; Westgaard, Ingunn Hagen; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2009). Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. European Journal of Immunology.  ISSN 0014-2980.  39(2), s 541- 551 . doi: 10.1002/eji.200838891
  • Humphrey, MB; Daws, Michael Rory; Spusta, SC; Niemi, EC; Torchia, JA; Lanier, LL; Seaman, WE & Nakamura, MC (2006). TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Journal of Bone and Mineral Research.  ISSN 0884-0431.  21, s 237- 245
  • Chen, TT; Li, L; Chung, DH; Allen, CDC; Torti, SV; Torti, FM; Cyster, JG; Chen, C; Brodsky, FM; Niemi, EC; Nakamura, MC; Seaman, WE & Daws, Michael Rory (2005). TIM-2 is expressed on B-cells and in liver and kidney, and is a receptor for H-ferritin endocytosis. Journal of Experimental Medicine (JEM).  ISSN 0022-1007.  202, s 955- 965
  • Humphrey, MB; Ogasawara, K; Yao, W; Spusta, SC; Daws, Michael Rory; Lane, NE; Lanier, LL & Nakamura, MC (2004). The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. Journal of Bone and Mineral Research.  ISSN 0884-0431.  19, s 224- 234
  • Chung, DH; Humphrey, MB; Nakamura, MC; Seaman, WE & Daws, Michael Rory (2003). CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Journal of Immunology.  ISSN 0022-1767.  171, s 6541- 6548
  • Daws, Michael Rory; Sullam, PM; Niemi, EC; Chen, TT & Seaman, WE (2003). Pattern recognition by TREM-2: binding of anionic ligands. Journal of Immunology.  ISSN 0022-1767.  171, s 594- 599
  • Chung, DH; Seaman, WE & Daws, Michael Rory (2002). Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. European Journal of Immunology.  ISSN 0014-2980.  32, s 59- 66
  • O'Connell, D; Becerril, B; Roy-Burman, A; Daws, Michael Rory & Marks, JD (2002). Phage versus phagemid libraries for generation of human monoclonal antibodies. Journal of Molecular Biology (JMB).  ISSN 0022-2836.  321, s 49- 56
  • Daws, Michael Rory; Lanier, LL; Seaman, WE & Ryan, JC (2001). Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. European Journal of Immunology.  ISSN 0014-2980.  31, s 783- 791
  • Karnbach, Claudia; Daws, Michael Rory; Niemi, EC & Nakamura, MC (2001). Immune rejection of a large sarcoma following cyclophosphamide and IL-12 treatment requires both NK and NK T cells and is associated with the induction of a novel NK T cell population. Journal of Immunology.  ISSN 0022-1767.  167, s 2569- 2576
  • Ryan, JC; Naper, Christian; Hayashi, Shigenari & Daws, Michael Rory (2001). Physiologic functions of activating natural killer (NK) complex-encoded receptors on NK cells. Immunological Reviews.  ISSN 0105-2896.  181, s 126- 137
  • Daws, Michael Rory; Eriksson, Mikael; Öberg, Linda; Ullén, Anders & Sentman, Charles L (1999). H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology.  ISSN 0019-2805.  97, s 656- 664
  • Cilio, CM; Daws, Michael Rory; Malashicheva, A; Sentman, Charles L & Holmberg, D (1998). Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes. Journal of Experimental Medicine (JEM).  ISSN 0022-1007.  188, s 1239- 1246
  • Westley, BR; Clayton, SJ; Daws, Michael Rory; Molloy, CA & May, FE (1998). Interactions between the oestrogen and insulin-like growth factor signalling pathways in the control of breast epithelial cell proliferation. Biochemical Society Symposium.  ISSN 0067-8694.  63, s 35- 44
  • Fahlén, Linda; Khoo, NK; Daws, Michael Rory & Sentman, Charles L (1997). Location-specific regulation of transgenic Ly49A receptors by major histocompatibility complex class I molecules. European Journal of Immunology.  ISSN 0014-2980.  27, s 2057- 2065
  • Daws, Michael Rory; Westley, BR & May, FE (1996). Paradoxical effects of overexpression of the type I insulin-like growth factor (IGF) receptor on the responsiveness of human breast cancer cells to IGFs and estradiol. Endocrinology.  ISSN 0013-7227.  137, s 1177- 1186

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  • Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth; Flornes, Line Mari; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2011). Oils and Health. Report to the Ministry of Health and Care Services.
  • Dahle, Maria Krudtaa & Daws, Michael Rory (2010). Regulation of activating CD300-receptors in human macrophage differentiation and inflammatory activation.
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn & Daws, Michael Rory (2010). Exploring expression and function of the rat Macrophage C-type Lectin, Clecsf8. Show summary
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin related molecules.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin-related molecules.
  • Zinöcker, Severin; Dai, Kezheng; Naper, Christian; Daws, Michael Rory; Rolstad, Bent & Vaage, John Torgils (2007). A novel reporter system to identify NK receptor-MHC ligand interactions.

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Published Apr. 13, 2011 2:41 PM - Last modified Dec. 4, 2019 2:23 PM