Michael Rory Daws
Professor
-
Seksjon for anatomi

English version of this page
E-post
m.r.daws@medisin.uio.no
Telefon
+47 22851151
Rom
2503
Brukernavn
Besøksadresse
Sognsvannsveien 9
Domus Medica
0372 Oslo
Postadresse
Postboks 1105 Blindern
0317 Oslo
Arbeidsområder
- Undervisning i modul-1 og modul-2:
- immunologi
- cellebiologi
- histologi
- anatomi
- Forskning
- reseptorer av det medfødte immunsystemet, og deres rolle i autoimmunitet og kreft
Bakgrunn
Jeg fullførte doktorgrad ved "University of Newcastle-upon-Tyne" i 1995. Første postdoc-periode var i Umeå, hvor jeg jobbet med NK-celler under veiledning av Charles Sentman. Deretter ble det 6 år i San Francisco i labben til Bill Seaman, før jeg kom til Oslo i 2004. Her har jeg forsket sammen med Bent Rolstad, John Torgils Vaage, Erik Dissen, og Sigbjørn Fossum. Siden 2015 har jeg hatt fast stilling som professor i anatomi.
Publikasjoner
- N'Diaye, Marie; Brauner, Susanna; Flytzani, Sevasti; Kular, Lara; Warnecke, Andreas; Adzemovic, Milena Z.; Piket, Eliane; Min, Jin-Hong; Edwards, Will; Mela, Filia; Choi, Hoi Ying; Magg, Vera; James, Tojo; Lindén, Magdalena; Reichardt, Holger M.; Daws, Michael Rory; Van Horssen, Jack; Kockum, Ingrid; Harris, Robert A.; Olsson, Tomas; Guerreiro-Cacais, Andre O. & Jagodic, Maja (2020). C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation. Journal of Clinical Investigation. ISSN 0021-9738. 130(2), s 838- 852 . doi: 10.1172/JCI125857
- Bjørnsen, Elisabeth Gyllensten; Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Henden, Camilla; Sæther, Per Christian; Boysen, Preben; Daws, Michael Rory & Dissen, Erik (2019). B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines. European Journal of Immunology. ISSN 0014-2980. 49(1), s 54- 65 . doi: 10.1002/eji.201847746 Fulltekst i vitenarkiv. Vis sammendrag
- Daws, Michael Rory; Nakken, Britt; Lobato, Pascual Ana; Josien, Regis; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With Fc?RI? and Is Expressed by Myeloid Cell Subsets in the Rat. Frontiers in Immunology. ISSN 1664-3224. 10, s 1060 . doi: 10.3389/fimmu.2019.01060 Fulltekst i vitenarkiv. Vis sammendrag
- Jendresen, Charlotte Bille; Daws, Michael Rory & Nilsson, Lars (2018). An improved CPRG colorimetric ligand-receptor signal transduction assay based on beta-galactosidase activity in mammalian BWZ-reporter cells. Journal of pharmacological and toxicological methods. ISSN 1056-8719. 90, s 67- 75 . doi: 10.1016/j.vascn.2017.11.004 Fulltekst i vitenarkiv.
- Jendresen, Charlotte Bille; Årskog, Vibeke Helen; Daws, Michael Rory & Nilsson, Lars (2017). The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. Journal of Neuroinflammation. ISSN 1742-2094. 14:59, s 1- 13 . doi: 10.1186/s12974-017-0835-4
- Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian; Bjørnsen, Elisabeth Gyllensten; Pende, Daniela; Fossum, Sigbjørn; Daws, Michael Rory & Dissen, Erik (2017). The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer Cells. Journal of Immunology. ISSN 0022-1767. 198(7), s 2556- 2567 . doi: 10.4049/jimmunol.1600930
- Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik; Fossum, Sigbjørn & Daws, Michael Rory (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLOS ONE. ISSN 1932-6203. 8(2) . doi: 10.1371/journal.pone.0057406
- Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology. ISSN 0014-2980. 43(12), s 3167- 3174 . doi: 10.1002/eji.201343752
- Daws, Michael Rory; Dai, Kezheng; Zinöcker, Severin; Naper, Christian; Kveberg, Lise; Hedrich, Hans J; Rolstad, Bent & Vaage, John Torgils (2012). Identification of an MHC Class I Ligand for the Single Member of a Killer Cell Lectin-like Receptor Family, KLRH1. Journal of Immunology. ISSN 0022-1767. 189(11), s 5178- 5184 . doi: 10.4049/jimmunol.1201983 Vis sammendrag
- Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics. ISSN 0093-7711. 63(12), s 809- 820 . doi: 10.1007/s00251-011-0553-5
- Shegarfi, Hamid; Dai, Kezheng; Daws, Michael Rory; Ryan, James C.; Vaage, John Torgils; Rolstad, Bent & Naper, Christian (2011). The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages. Journal of Leukocyte Biology. ISSN 0741-5400. 89(4), s 617- 623 . doi: 10.1189/jlb.1010593
- Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics. ISSN 0093-7711. 62(8), s 521- 530 . doi: 10.1007/s00251-010-0455-y
- Kveberg, Lise; Dai, Kezheng; Westgaard, Ingunn Hagen; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2009). Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. European Journal of Immunology. ISSN 0014-2980. 39(2), s 541- 551 . doi: 10.1002/eji.200838891
- Humphrey, MB; Daws, Michael Rory; Spusta, SC; Niemi, EC; Torchia, JA; Lanier, LL; Seaman, WE & Nakamura, MC (2006). TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Journal of Bone and Mineral Research. ISSN 0884-0431. 21
- Humphrey, MB; Daws, Michael Rory; Spusta, SC; Niemi, EC; Torchia, JA; Lanier, LL; Seaman, WE & Nakamura, MC (2006). TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Journal of Bone and Mineral Research. ISSN 0884-0431. 21, s 237- 245
- Chen, TT; Li, L; Chung, DH; Allen, CDC; Torti, SV; Torti, FM; Cyster, JG; Chen, C; Brodsky, FM; Niemi, EC; Nakamura, MC; Seaman, WE & Daws, Michael Rory (2005). TIM-2 is expressed on B-cells and in liver and kidney, and is a receptor for H-ferritin endocytosis. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 202, s 955- 965
- Humphrey, MB; Ogasawara, K; Yao, W; Spusta, SC; Daws, Michael Rory; Lane, NE; Lanier, LL & Nakamura, MC (2004). The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. Journal of Bone and Mineral Research. ISSN 0884-0431. 19, s 224- 234
- Chung, DH; Humphrey, MB; Nakamura, MC; Seaman, WE & Daws, Michael Rory (2003). CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Journal of Immunology. ISSN 0022-1767. 171, s 6541- 6548
- Daws, Michael Rory; Sullam, PM; Niemi, EC; Chen, TT & Seaman, WE (2003). Pattern recognition by TREM-2: binding of anionic ligands. Journal of Immunology. ISSN 0022-1767. 171, s 594- 599
- Chung, DH; Seaman, WE & Daws, Michael Rory (2002). Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. European Journal of Immunology. ISSN 0014-2980. 32, s 59- 66
- O'Connell, D; Becerril, B; Roy-Burman, A; Daws, Michael Rory & Marks, JD (2002). Phage versus phagemid libraries for generation of human monoclonal antibodies. Journal of Molecular Biology (JMB). ISSN 0022-2836. 321, s 49- 56
- Daws, Michael Rory; Lanier, LL; Seaman, WE & Ryan, JC (2001). Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. European Journal of Immunology. ISSN 0014-2980. 31, s 783- 791
- Karnbach, Claudia; Daws, Michael Rory; Niemi, EC & Nakamura, MC (2001). Immune rejection of a large sarcoma following cyclophosphamide and IL-12 treatment requires both NK and NK T cells and is associated with the induction of a novel NK T cell population. Journal of Immunology. ISSN 0022-1767. 167, s 2569- 2576
- Ryan, JC; Naper, Christian; Hayashi, Shigenari & Daws, Michael Rory (2001). Physiologic functions of activating natural killer (NK) complex-encoded receptors on NK cells. Immunological Reviews. ISSN 0105-2896. 181, s 126- 137
- Daws, Michael Rory; Eriksson, Mikael; Öberg, Linda; Ullén, Anders & Sentman, Charles L (1999). H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology. ISSN 0019-2805. 97, s 656- 664
- Cilio, CM; Daws, Michael Rory; Malashicheva, A; Sentman, Charles L & Holmberg, D (1998). Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 188, s 1239- 1246
- Westley, BR; Clayton, SJ; Daws, Michael Rory; Molloy, CA & May, FE (1998). Interactions between the oestrogen and insulin-like growth factor signalling pathways in the control of breast epithelial cell proliferation. Biochemical Society Symposium. ISSN 0067-8694. 63, s 35- 44
- Fahlén, Linda; Khoo, NK; Daws, Michael Rory & Sentman, Charles L (1997). Location-specific regulation of transgenic Ly49A receptors by major histocompatibility complex class I molecules. European Journal of Immunology. ISSN 0014-2980. 27, s 2057- 2065
- Daws, Michael Rory; Westley, BR & May, FE (1996). Paradoxical effects of overexpression of the type I insulin-like growth factor (IGF) receptor on the responsiveness of human breast cancer cells to IGFs and estradiol. Endocrinology. ISSN 0013-7227. 137, s 1177- 1186
- Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth; Flornes, Line Mari; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2011). Oils and Health. Report to the Ministry of Health and Care Services.
- Nakken, Britt; Jensen, Wendi; Szodoray, Peter; Daws, Michael Rory & Fossum, Sigbjørn (2011). Role of the C-Type Lectin-Like Receptor Dcar1 in Oil Induced Arthritis. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s 375- 376
- Dahle, Maria Krudtaa & Daws, Michael Rory (2010). Regulation of activating CD300-receptors in human macrophage differentiation and inflammatory activation.
- Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn & Daws, Michael Rory (2010). Exploring expression and function of the rat Macrophage C-type Lectin, Clecsf8. Vis sammendrag
- Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin related molecules.
- Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn; Naper, Christian & Vaage, John Torgils (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin-related molecules.
- Zinöcker, Severin; Dai, Kezheng; Naper, Christian; Daws, Michael Rory; Rolstad, Bent & Vaage, John Torgils (2007). A novel reporter system to identify NK receptor-MHC ligand interactions.
- Daws, Michael Rory; Dai, K; Naper, C; Rolstad, Bent & Vaage, JT (2006). Identification of an MHC ligand for the rat natural killer cell receptor KLRH1. Tissue Antigens. ISSN 0001-2815. 67, s 444- 445
Publisert 13. apr. 2011 10:35
- Sist endret 4. des. 2019 14:30