Ragnhild Eskeland

Associate Professor - Chromatin Biology Group
Image of Ragnhild Eskeland
Norwegian version of this page
Phone +47-22854213
Room 2303A IBV /2260 IMB
Username
Visiting address Kristine Bonnevies Hus Blindernveien 31 0371 Oslo & Domus Medica Songsvannsveien 9 0317 Oslo
Postal address Postboks 1112 Biokjemi 0317 OSLO

Current position

Associate Professor, IMB, MedFak. The Eskeland group will move spring 2019

Responsible for projects:

-Chromatin loops and functions (#262484 Norges Forskningsråd 2017-2020)    

-Safe Medication in Pregnancy (PI, PharmaTox Research Initiative; MatNat Faculty, UiO, IBV Anders Jahre Fund, Wedel Jarlsbergs Fond and Nansenfondene, 2016-2019)

-Centre for Cancer Cell Reprogramming (PI, NoE Norges Forskningsråd 2018-2027) 

Research Interests

My areas of scientific interest are the regulation of gene expression through higher order chromatin structure and nuclear organization during development and in cancer. My team focuses on the role of protein complexes in epigenetic regulation of chromatin structure during embryonic stem cell differentiation and in cancer cells. We use imaging and biochemical methods such as Fluorescence in situ hybridization (FISH), ChIP and in vitro nucleosome assembly.

Groupmembers:

Beata Nadratowska-Wesolowska (Researcher, NFR) 

Ignacio Cuervo (PhD student)

Martin Falck (PhD student, PharmaTox)

Naima Azouzi (Postdoc, NFR)

Melanie Engelfriet (Engineer)

Guro Cecilie Mustorp (Master student)

Marie Rogne (Researcher, CanCell)

Ankush Sharma (Postdoc, MatNat)

Nils Labba (PhD student, PharmaTox)

Mohamed I. M. Abdelhalim (Master student)

Aruna Abraham (Master student)

Hallvard Austin Wæhler (Master student)

Tasmia Jinnurine (Master student)

Alumnis:

Madeleine Lystad Fosslie (PhD defended 27.10.2016)

Gema Escribano Serrano (Erasmus student)

Antonio Mora (Bioinformatician)

Teaching

Work experience

Principal Investigator (June 2014- Aug 2018) Universitetet i Oslo, Department of Biosciences.

Associate professor II (Jan 2014  - Jan 2016) Department of Molecular Biology, University of Bergen (20 percent)

Postdoktor (Sept 2010 - May 2014) Universitetet i Oslo, Department of Biosciences. Group Head: Prof. Odd Stokke Gabrielsen

Career Development Fellow (Jan 2007- Aug 2010) MRC Human Genetics Unit, Edinburgh, Scotland. Group head: Prof. Wendy A. Bickmore

 

Education

Cand. Mag. (Aug. 1997 – Jan. 2000) Molecular Biology and Chemistry, Faculty of Natural Sciences, University of Bergen, Norway

ERASMUS Exchange Programme (Sept. 1999 – Jan. 2000) Chemistry and Physiology, University of Aberdeen, Scotland.

Master (Candidatus Scientiarum) (Jan. 2000- Dec. 2002) Sars International Centre for Marine Molecular Biology and University of Bergen, Norway. Group head: Prof. Eric Thompson and UiB supervisor Prof. Rein Aasland. Thesis:“Characterization of linker and core histones in the Urochordate Oikopleura dioica”

PhD (Nov. 2002 - Dec. 2006) Adolf-Butenandt Institute, Ludwig-Maximillians University of Munich, Germany. Group head: Prof. Axel Imhof. Thesis: “Histone H3 lysine 9 methylation: A signature for chromatin function”. In this period I was enrolled in the International Graduate Program: “Protein Dynamics in Health and Disease” and a member of the Elite Network of Bavaria.

Collaborators

Prof. Philippe Collas, Institute of Basic Medical Sciences, University of Oslo

Dr. Tiziana Bonaldi, European Institute of Oncology, Italy

Prof. Kerstin Bystricky, University of Toulouse, France

Dr. Duncan Sproul, MRC Medical Research Council, IGMM, University of Edinburgh, UK

PharmaTox, Strategic Research Initiative, Mat.Nat., UiO. Leader Prof. Hedvig Nordeng

Dr. Lucia Daxinger, Center for Human and Clinical Genetics, Leiden University Medical Center, The Nederlands

Dr. Stig Ove Bøe, Rikshospitalet, Norway

Prof. Vessela Kristensen, Oslo University Hospital and Ahus, Norway

Prof. Jose Garcia Perez, University of Edinburgh, UK

Tags: Epigenetics, Chromatin, Nuclear organisation, Stem cells

Publications

  • Fuglerud, Bettina Maria; Ledsaak, Marit; Rogne, Marie; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2018). The pioneer factor activity of c-Myb involves recruitment of p300 and induction of histone acetylation followed by acetylation-induced chromatin dissociation. Epigenetics & Chromatin.  ISSN 1756-8935.  11(1) . doi: 10.1186/s13072-018-0208-y
  • Rodriguez- Castañeda, Fernando; Lemma, Roza Berhanu; Cuervo Torre, Ignacio; Bengtsen, Mads; Moen, Lisa Marie; Ledsaak, Marit; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2018). The SUMO protease SENP1 and the chromatin remodeller CHD3 interact and jointly affect chromatin accessibility and gene expression. Journal of Biological Chemistry.  ISSN 0021-9258.  293(40), s 15439- 15454 . doi: 10.1074/jbc.RA118.002844 Full text in Research Archive. Show summary
  • Fleischer, Thomas; Tekpli, Xavier; Mathelier, Anthony; Wang, Shixiong; Nebdal, Daniel J.H.; Dhakal, Hari Prasad; Sahlberg, Kristine Kleivi; Schlichting, Ellen; Børresen-Dale, Anne-Lise; Borgen, Elin; Naume, Bjørn; Eskeland, Ragnhild; Frigessi, Arnoldo; Tost, Jörg; Rodriguez, Antoni Hurtado & Kristensen, Vessela N. (2017). DNA methylation at enhancers identifies distinct breast cancer lineages. Nature Communications.  ISSN 2041-1723.  8(1379) . doi: 10.1038/s41467-017-00510-x Full text in Research Archive.
  • Fuglerud, Bettina Maria; Lemma, Roza Berhanu; Wanichawan, Pimthanya; Sundaram, Arvind; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2017). A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. Nucleic Acids Research.  ISSN 0305-1048.  45(13), s 7681- 7696 . doi: 10.1093/nar/gkx364 Full text in Research Archive.
  • Gervin, Kristina; Nordeng, Hedvig Marie Egeland; Eskeland, Ragnhild; Paulsen, Ragnhild Elisabeth & Lyle, Robert (2017). Farmakoepigenetikk: Samspillet mellom legemidler og epigenetikk. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  125(8), s 30- 34 Full text in Research Archive.
  • Maclennan, Marie; García-Cañadas, Marta; Reichmann, Judith; Khazina, Elena; Wagner, Gabriele; Playfoot, Christopher J.; Salvador-Palomeque, Carmen; Mann, Abigail R.; Peressini, Paula; Sanchez, Laura; Dobie, Karen; Read, David; Hung, Chao-Chun; Eskeland, Ragnhild; Meehan, Richard R.; Weichenrieder, Oliver; García-Pérez, Jose Luis & Adams, Ian R. (2017). Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. eLIFE.  ISSN 2050-084X.  6:e26152, s 1- 32 . doi: 10.7554/eLife.26152 Full text in Research Archive.
  • Simovski, Boris; Vodak, Daniel; Gundersen, Sveinung; Domanska, Diana Ewa; Azab, Abdulrahman; Holden, Lars; Holden, Marit; Grytten, Ivar; Rand, Knut Dagestad; Drabløs, Finn; Johansen, Morten; Mora Ortiz, Antonio Carlos; Lund-Andersen, Christin; Fromm, Bastian; Eskeland, Ragnhild; Gabrielsen, Odd Stokke; Ferkingstad, Egil; Nakken, Sigve; Bengtsen, Mads; Nederbragt, Alexander Johan; Thorarensen, Hildur Sif; Akse, Johannes Andreas; Glad, Ingrid Kristine; Hovig, Johannes Eivind & Sandve, Geir Kjetil (2017). GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. GigaScience.  ISSN 2047-217X.  6(7), s 1- 12 . doi: 10.1093/gigascience/gix032 Full text in Research Archive. Show summary
  • Ledsaak, Marit; Bengtsen, Mads; Molværsmyr, Ann-Kristin; Fuglerud, Bettina Maria; Matre, Vilborg; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2016). PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms.  ISSN 1874-9399.  1859(5), s 705- 718 . doi: 10.1016/j.bbagrm.2016.03.011
  • Bengtsen, Mads; Klepper, Kjetil; Gundersen, Sveinung; Cuervo Torre, Ignacio; Drabløs, Finn; Hovig, Johannes Eivind; Sandve, Geir Kjetil F.; Gabrielsen, Odd Stokke & Eskeland, Ragnhild (2015). c-Myb Binding Sites in Haematopoietic Chromatin Landscapes. PLoS ONE.  ISSN 1932-6203.  10(7) . doi: 10.1371/journal.pone.0133280 Full text in Research Archive. Show summary
  • Mora Ortiz, Antonio Carlos; Sandve, Geir Kjetil; Gabrielsen, Odd Stokke & Eskeland, Ragnhild (2015). In the loop: promoter-enhancer interactions and bioinformatics. Briefings in Bioinformatics.  ISSN 1467-5463. . doi: 10.1093/bib/bbv097 Show summary
  • Collas, Philippe & Eskeland, Ragnhild (2013). Oslo Epigenetics Symposium 2012 Oslo, Norway, 8-9 November 2012. Epigenomics.  ISSN 1750-1911.  5(1), s 29- 32 . doi: 10.2217/EPI.12.76
  • Lund, Eivind Gard; Oldenburg Ruppelt, Anja; Delbarre, Erwan; Freberg, Christel Taranger; Duband-Goulet, Isabelle; Eskeland, Ragnhild; Buendia, Brigitte & Collas, Philippe (2013). Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Research.  ISSN 1088-9051.  23(10), s 1580- 1589 . doi: 10.1101/gr.159400.113
  • Chioda, Christina; Spada, Fabio; Eskeland, Ragnhild & Thompson, Eric (2004). Histone mRNAs do not accumulate during S phase of either mitotic or endoreduplicative cycles in the chordate Oikopleura dioica. Molecular and Cellular Biology.  ISSN 0270-7306.  24(12), s 5391- 5403 Show summary
  • Chioda, Christina; Eskeland, Ragnhild & Thompson, Eric (2002). Histone gene complement, variant expression, and mRNA processing in a urochordate Oikopleura dioica that undergoes extensive polyploidization. Molecular biology and evolution.  ISSN 0737-4038.  19, s 2247- 2260 Show summary

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  • Haraldsen, Kirsten Borse; Rogne, Sissel; Eskeland, Ragnhild; Kjeldstad, Torunn; Olsbye, Unni & Røyne, Anja (2017). Panelsamtale: Hva nå? DAMER! 100 år med kvinner i realfagene ved UiO. Show summary
  • Eskeland, Ragnhild & Grini, Paul Eivind (2015). Epigenetikk – hadde Lamarck rett?, I: Dag Olav Hessen; Thore Lie & Nils Christian Stenseth (red.),  Mendels arv - Genetikkens æra.  Gyldendal Norsk Forlag A/S.  ISBN 978-82-05-45818-5.  8.  s 182 - 215

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Published Jan. 17, 2019 2:07 PM - Last modified June 5, 2019 9:46 AM