Ragnhild Eskeland

Associate Professor
Image of Ragnhild Eskeland
Norwegian version of this page
Phone (+47) 22 85 14 57
Room 2260 Domus Medica
Visiting address Domus Medica Songsvannsveien 9 0317 Oslo
Postal address Postal Box 1112 Biochemistry 0317 OSLO

Current position

Associate Professor, IMB, MedFak. The Eskeland group will move spring 2019

Responsible for projects:

-Chromatin loops and functions (#262484 Norges Forskningsråd 2017-2020)    

-Safe Medication in Pregnancy (PI, PharmaTox Research Initiative; MatNat Faculty, UiO, IBV Anders Jahre Fund, Wedel Jarlsbergs Fond and Nansenfondene, 2016-2019)

-Centre for Cancer Cell Reprogramming (PI, NoE Norges Forskningsråd 2018-2027) 

Research Interests

My areas of scientific interest are the regulation of gene expression through higher order chromatin structure and nuclear organization during development and in cancer. My team focuses on the role of protein complexes in epigenetic regulation of chromatin structure during embryonic stem cell differentiation and in cancer cells. We use imaging and biochemical methods such as Fluorescence in situ hybridization (FISH), Hi-C, ATAC-seq, ChIP and in vitro nucleosome assembly.

For more info visit Chromatin Biology group.


Work experience

Principal Investigator (June 2014- Aug 2018) Universitetet i Oslo, Department of Biosciences.

Associate professor II (Jan 2014  - Jan 2016) Department of Molecular Biology, University of Bergen (20 percent)

Postdoktor (Sept 2010 - May 2014) Universitetet i Oslo, Department of Biosciences. Group Head: Prof. Odd Stokke Gabrielsen

Career Development Fellow (Jan 2007- Aug 2010) MRC Human Genetics Unit, Edinburgh, Scotland. Group head: Prof. Wendy A. Bickmore


PhD (Nov. 2002 - Dec. 2006) Adolf-Butenandt Institute, Ludwig-Maximillians University of Munich, Germany. Group head: Prof. Axel Imhof. Thesis: “Histone H3 lysine 9 methylation: A signature for chromatin function”. In this period I was enrolled in the International Graduate Program: “Protein Dynamics in Health and Disease” and a member of the Elite Network of Bavaria.

Master (Candidatus Scientiarum) (Jan. 2000- Dec. 2002) Sars International Centre for Marine Molecular Biology and University of Bergen, Norway. Group head: Prof. Eric Thompson and UiB supervisor Prof. Rein Aasland. Thesis:“Characterization of linker and core histones in the Urochordate Oikopleura dioica”

ERASMUS Exchange Programme (Sept. 1999 – Jan. 2000) Chemistry and Physiology, University of Aberdeen, Scotland.

Cand. Mag. (Aug. 1997 – Jan. 2000) Molecular Biology and Chemistry, Faculty of Natural Sciences, University of Bergen, Norway


Prof. Philippe Collas, Institute of Basic Medical Sciences, University of Oslo

Dr. Tiziana Bonaldi, European Institute of Oncology, Italy

Prof. Kerstin Bystricky, University of Toulouse, France

Dr. Duncan Sproul, MRC Medical Research Council, IGMM, University of Edinburgh

PharmaTox, Endringsmiljø, MatNat, UiO. Leiar Prof. Hedvig Nordeng 

CanCell, Centre of Excellence, UiO

Prof. Vessela Kristensen, Oslo University Hospital, Norway

Dr. Jose Garcia Perez, University of Edinburgh, UK

Dr. Anthony Mathelier, NCMM, Norway

Dr. Thomas Fleischer, OUS, Norway

Ass. Prof. Jonas Paulsen, IBV, UiO, Oslo

Dr. Bernd Thiede, IBV, UiO, Oslo.

Tags: Epigenetics, Chromatin, Nuclear organisation, Stem cells


Williamson I, Berlivet S, Eskeland R, Boyle S, Illingworth RS, Paquette D, Dostie J, Bickmore WA. Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization. Genes Dev. 2014 Dec 15;28(24):2778-91. doi: 10.1101/gad.251694.114.

Taylor G, Eskeland R, Hekimoglu-Balkan B, Pradeepa M, Bickmore WA. H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction. Genome Res. 2013 Dec;23(12):2053-65. doi: 10.1101/gr.155028.113. Epub 2013 Aug 29.

Lund E, Oldenburg A, Delbarre E, Freberg C, Duband-Goulet I, Eskeland R, Buendia B, Collas P. Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Res. 2013 Oct;23(10):1580-9. doi: 10.1101/gr.159400.113. Epub 2013 Jul 16.

D. Greiner, T. Bonaldi, R. Eskeland, E. Roemer and A. Imhof (2013). Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases". Nature Chemical Biology. Feb 15;9(3):137.

Williamson I, Eskeland R, Lettice LA, Hill AE, Boyle S, Grimes GR, Hill RE, Bickmore WA (2012). Anterior-posterior differences in HoxD chromatin topology in limb development. Development Sep;139(17):3157-67.

di Pietro M, Lao-Sirieix P, Boyle S, Cassidy A, Castillo D, Saadi A, Eskeland R, Fitzgerald RC. Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus. Proc Natl Acad Sci U S A. 2012 May 17. [Epub ahead of print]

Illingworth RS, Botting CH, Grimes GR, Bickmore WA*, Eskeland R* (2012). PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. PLoS One. 2012;7(4):e34848. Epub 2012 Apr 9. * Co-corresponding authors

Endoh M; Endo T. A.; Endoh T; Isono K; Sharif J; Ohara O; Toyoda T; Ito T; Eskeland R; Bickmore W. A.; Vidal M; Bernstein B. E.; Koseki H. Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. (2012). PLoS Genetics. 8(7):e1002774.

R. Eskeland, E. Freyer, M. Leeb, A. Wutz, W.A. Bickmore (2011). Histone Acetylation and the Maintenance of Chromatin Compaction by Polycomb Repressive Complexes. Cold Spring Harb Symp Quant Biol. 2010;75:71-8. 

R. Eskeland, M. Leeb, G. Grimes, C. Kress, S. Boyle, D. Sproul, N. Gilbert, Y. Fan, A. I. Skoultchi, A. Wutz and W. A. Bickmore (2010). Ring1B compact chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell. 38(3):452-64.

M. Lavigne, R. Eskeland, S. Azebi, H. Fan, B. Bourachot, R. E. Kingston, A. Imhof and C. Muchardt (2009). Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. PLoS Genet.  .Dec;5(12):e1000769

J. Abel, R. Eskeland, G. D. Raffa, E. Kremmer, A. Imhof (2009). Drosophila HP1c is regulated by an auto-regulatory feed back loop through its binding partner Woc. PLoS One. 4(4):e5089.

R. Eskeland, A. Eberharter and A. Imhof (2007). HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Molecular and Cellular Biology, 27(2):453-65.

M. Stabell, R. Eskeland, M. Bjørkmo, J. Larson, R. B. Aalen, A. Imhof and A. Lambertson (2006). The Drosophila G9a gene encodes a multicatalytic histone methyltransferase required for normal development. Nucleic Acids Research, 34(16):4609-21

D. Greiner, T. Bonaldi, R. Eskeland, E. Roemer and A. Imhof (2005). Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nature Chemical Biology, 1:143-5

R. Eskeland#, B. Czermin#, J. Boeke, T. Bonaldi, J. T. Regula, and A. Imhof (2004). The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity. Biochemistry, 43(12):3740-9. # These authors contributed equally 

  • Sharma, Ankush; Akshay, Akshay; Rogne, Marie & Eskeland, Ragnhild (2021). ShinyArchR.UiO: User-friendly, integrative and open-source tool for visualisation of single-cell ATAC-seq data using ArchR. Bioinformatics. ISSN 1367-4803. 38(3), p. 834–836. doi: 10.1093/bioinformatics/btab680.
  • Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2021). Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB. Scientific Reports. ISSN 2045-2322. 11(9008). doi: 10.1038/s41598-021-88516-w. Full text in Research Archive
  • Rodriguez- Castañeda, Fernando; Lemma, Roza Berhanu; Cuervo Torre, Ignacio; Bengtsen, Mads; Moen, Lisa Marie & Ledsaak, Marit [Show all 8 contributors for this article] (2018). The SUMO protease SENP1 and the chromatin remodeller CHD3 interact and jointly affect chromatin accessibility and gene expression. Journal of Biological Chemistry. ISSN 0021-9258. 293(40), p. 15439–15454. doi: 10.1074/jbc.RA118.002844. Full text in Research Archive
  • Fuglerud, Bettina Maria; Ledsaak, Marit; Rogne, Marie; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2018). The pioneer factor activity of c-Myb involves recruitment of p300 and induction of histone acetylation followed by acetylation-induced chromatin dissociation. Epigenetics & Chromatin. ISSN 1756-8935. 11(1). doi: 10.1186/s13072-018-0208-y. Full text in Research Archive
  • Gervin, Kristina; Nordeng, Hedvig Marie Egeland; Eskeland, Ragnhild; Paulsen, Ragnhild Elisabeth & Lyle, Robert (2017). Farmakoepigenetikk: Samspillet mellom legemidler og epigenetikk. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 125(8), p. 30–34. Full text in Research Archive
  • Fleischer, Thomas; Tekpli, Xavier; Mathelier, Anthony; Wang, Shixiong; Nebdal, Daniel J.H. & Dhakal, Hari Prasad [Show all 16 contributors for this article] (2017). DNA methylation at enhancers identifies distinct breast cancer lineages. Nature Communications. ISSN 2041-1723. 8(1379). doi: 10.1038/s41467-017-00510-x. Full text in Research Archive
  • Maclennan, Marie; García-Cañadas, Marta; Reichmann, Judith; Khazina, Elena; Wagner, Gabriele & Playfoot, Christopher J. [Show all 18 contributors for this article] (2017). Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. eLIFE. ISSN 2050-084X. 6:e26152, p. 1–32. doi: 10.7554/eLife.26152. Full text in Research Archive
  • Fuglerud, Bettina Maria; Lemma, Roza Berhanu; Wanichawan, Pimthanya; Sundaram, Arvind; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2017). A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. Nucleic Acids Research (NAR). ISSN 0305-1048. 45(13), p. 7681–7696. doi: 10.1093/nar/gkx364. Full text in Research Archive
  • Simovski, Boris; Vodak, Daniel; Gundersen, Sveinung; Domanska, Diana Ewa; Azab, Abdulrahman & Holden, Lars [Show all 25 contributors for this article] (2017). GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. GigaScience. ISSN 2047-217X. 6(7), p. 1–12. doi: 10.1093/gigascience/gix032. Full text in Research Archive
  • Ledsaak, Marit; Bengtsen, Mads; Molværsmyr, Ann-Kristin; Fuglerud, Bettina Maria; Matre, Vilborg & Eskeland, Ragnhild [Show all 7 contributors for this article] (2016). PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms. ISSN 1874-9399. 1859(5), p. 705–718. doi: 10.1016/j.bbagrm.2016.03.011.
  • Mora Ortiz, Antonio Carlos; Sandve, Geir Kjetil; Gabrielsen, Odd Stokke & Eskeland, Ragnhild (2015). In the loop: promoter-enhancer interactions and bioinformatics. Briefings in Bioinformatics. ISSN 1467-5463. doi: 10.1093/bib/bbv097.
  • Bengtsen, Mads; Klepper, Kjetil; Gundersen, Sveinung; Cuervo Torre, Ignacio; Drabløs, Finn & Hovig, Johannes Eivind [Show all 9 contributors for this article] (2015). c-Myb Binding Sites in Haematopoietic Chromatin Landscapes. PLOS ONE. ISSN 1932-6203. 10(7). doi: 10.1371/journal.pone.0133280. Full text in Research Archive
  • Lund, Eivind Gard; Oldenburg Ruppelt, Anja; Delbarre, Erwan; Freberg, Christel Taranger; Duband-Goulet, Isabelle & Eskeland, Ragnhild [Show all 8 contributors for this article] (2013). Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Research. ISSN 1088-9051. 23(10), p. 1580–1589. doi: 10.1101/gr.159400.113.
  • Collas, Philippe & Eskeland, Ragnhild (2013). Oslo Epigenetics Symposium 2012 Oslo, Norway, 8-9 November 2012. Epigenomics. ISSN 1750-1911. 5(1), p. 29–32. doi: 10.2217/EPI.12.76.
  • Chioda, Christina; Spada, Fabio; Eskeland, Ragnhild & Thompson, Eric (2004). Histone mRNAs do not accumulate during S phase of either mitotic or endoreduplicative cycles in the chordate Oikopleura dioica. Molecular and Cellular Biology. ISSN 0270-7306. 24(12), p. 5391–5403.
  • Chioda, Christina; Eskeland, Ragnhild & Thompson, Eric (2002). Histone gene complement, variant expression, and mRNA processing in a urochordate Oikopleura dioica that undergoes extensive polyploidization. Molecular Biology and Evolution (MBE). ISSN 0737-4038. 19, p. 2247–2260.

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  • Sletbakk, Marianne; Marthinsen, Kirsten; Hessen, Dag Olav; Håpnes, Arnodd; Eskeland, Ragnhild & Spurkland, Anne (2021). Bios 1 Biologi 1 (LK20) . Cappelen Damm AS. ISBN 9788202696566.
  • Slettebakk, Marianne; Håpenes, Arnodd; Hessen, Dag Olav; Eskeland, Ragnhild; Gjærevoll, Inger & Borge, Ole Johan (2019). BIOS 2. Cappelen Damm AS. ISBN 9788202604851.

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  • Haraldsen, Kirsten Borse; Rogne, Sissel; Eskeland, Ragnhild; Kjeldstad, Torunn; Olsbye, Unni & Røyne, Anja (2017). Panelsamtale: Hva nå? DAMER! 100 år med kvinner i realfagene ved UiO.
  • Eskeland, Ragnhild & Grini, Paul Eivind (2015). Epigenetikk – hadde Lamarck rett? In Hessen, Dag Olav; Lie, Thore & Stenseth, Nils Christian (Ed.), Mendels arv - Genetikkens æra. Gyldendal Norsk Forlag A/S. ISSN 978-82-05-45818-5. p. 182–215.

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Published Jan. 17, 2019 2:07 PM - Last modified June 23, 2021 12:15 PM