Ragnhild Eskeland

Associate Professor
Image of Ragnhild Eskeland
Norwegian version of this page
Phone (+47) 22 85 14 57
Room 2260 Domus Medica
Visiting address Domus Medica Songsvannsveien 9 0317 Oslo
Postal address Postal Box 1112 Biochemistry 0317 OSLO

Current position

Associate Professor, IMB, MedFak. The Eskeland group will move spring 2019

Responsible for projects:

-Chromatin loops and functions (#262484 Norges Forskningsråd 2017-2021)    

-Safe Medication in Pregnancy (PI, PharmaTox Research Initiative; MatNat Faculty, UiO, IBV Anders Jahre Fund, Wedel Jarlsbergs Fond and Nansenfondene, 2016-2019)

-Centre for Cancer Cell Reprogramming (PI, NoE Norges Forskningsråd 2018-2027) 

Research Interests

My areas of scientific interest are the regulation of gene expression through higher order chromatin structure and nuclear organization during development and in cancer. My team focuses on the role of protein complexes in epigenetic regulation of chromatin structure during embryonic stem cell differentiation and in cancer cells. We use imaging and biochemical methods such as Fluorescence in situ hybridization (FISH), Hi-C, ATAC-seq, ChIP and in vitro nucleosome assembly.

For more info visit Chromatin Biology group.


Work experience

Principal Investigator (June 2014- Aug 2018) Universitetet i Oslo, Department of Biosciences.

Associate professor II (Jan 2014  - Jan 2016) Department of Molecular Biology, University of Bergen (20 percent)

Postdoktor (Sept 2010 - May 2014) Universitetet i Oslo, Department of Biosciences. Group Head: Prof. Odd Stokke Gabrielsen

Career Development Fellow (Jan 2007- Aug 2010) MRC Human Genetics Unit, Edinburgh, Scotland. Group head: Prof. Wendy A. Bickmore


PhD (Nov. 2002 - Dec. 2006) Adolf-Butenandt Institute, Ludwig-Maximillians University of Munich, Germany. Group head: Prof. Axel Imhof. Thesis: “Histone H3 lysine 9 methylation: A signature for chromatin function”. In this period I was enrolled in the International Graduate Program: “Protein Dynamics in Health and Disease” and a member of the Elite Network of Bavaria.

Master (Candidatus Scientiarum) (Jan. 2000- Dec. 2002) Sars International Centre for Marine Molecular Biology and University of Bergen, Norway. Group head: Prof. Eric Thompson and UiB supervisor Prof. Rein Aasland. Thesis:“Characterization of linker and core histones in the Urochordate Oikopleura dioica”

ERASMUS Exchange Programme (Sept. 1999 – Jan. 2000) Chemistry and Physiology, University of Aberdeen, Scotland.

Cand. Mag. (Aug. 1997 – Jan. 2000) Molecular Biology and Chemistry, Faculty of Natural Sciences, University of Bergen, Norway


Prof. Philippe Collas, Institute of Basic Medical Sciences, University of Oslo

Dr. Tiziana Bonaldi, European Institute of Oncology, Italy

Prof. Kerstin Bystricky, University of Toulouse, France

PharmaTox, Endringsmiljø, MatNat, UiO. Lead by Prof. Hedvig Nordeng 

CanCell, Centre of Excellence, UiO

Prof. Vessela Kristensen, Oslo University Hospital, Norway

Dr. Jose Garcia Perez, University of Edinburgh, UK

Dr. Anthony Mathelier, NCMM, Norway

Dr. Thomas Fleischer, OUS, Norway

Ass. Prof. Jonas Paulsen, IBV, UiO, Oslo

Dr. Bernd Thiede, IBV, UiO, Oslo.

Tags: Epigenetics, Chromatin, Nuclear organisation, Stem cells


  • Samara, Athina; Spildrejorde, Mari; Sharma, Ankush; Falck, Martin ; Leithaug, Magnus & Modafferi, Stefania [Show all 11 contributors for this article] (2022). A multi-omics approach to visualize early neuronal differentiation from hESCs in 4D. iScience. ISSN 2589-0042.
  • Samara, Athina; Falck, Martin ; Spildrejorde, Mari; Leithaug, Magnus; Acharya, Ganesh & Lyle, Robert [Show all 7 contributors for this article] (2022). Robust neuronal differentiation of human embryonic stem cells for neurotoxicology. STAR Protocols. ISSN 2666-1667. doi: 10.1016/j.xpro.2022.101533.
  • Labba, Nils-Anders Johannes; Wæhler, Hallvard Austin; Houdaifi, Nora; Zosen, Denis; Haugen, Fred & Paulsen, Ragnhild Elisabeth Heimtun [Show all 8 contributors for this article] (2022). Paracetamol perturbs neuronal arborization and disrupts the cytoskeletal proteins SPTBN1 and TUBB3 in both human and chicken in vitro models. Toxicology and Applied Pharmacology. ISSN 0041-008X. 449. doi: 10.1016/j.taap.2022.116130.
  • Lemma, Roza Berhanu; Fleischer, Thomas; Martinsen, Emily; Ledsaak, Marit; Kristensen, Vessela N. & Eskeland, Ragnhild [Show all 8 contributors for this article] (2022). Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers. Epigenetics & Chromatin. ISSN 1756-8935. 15. doi: 10.1186/s13072-022-00444-9.
  • Sharma, Ankush; Akshay, Akshay; Rogne, Marie & Eskeland, Ragnhild (2021). ShinyArchR.UiO: user-friendly,integrative and open-source tool for visualization of single-cell ATAC-seq data using ArchR. Bioinformatics. ISSN 1367-4803. 38(3), p. 834–836. doi: 10.1093/bioinformatics/btab680. Full text in Research Archive
  • Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2021). Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB. Scientific Reports. ISSN 2045-2322. 11(9008). doi: 10.1038/s41598-021-88516-w. Full text in Research Archive
  • Rodriguez- Castañeda, Fernando; Lemma, Roza Berhanu; Cuervo Torre, Ignacio; Bengtsen, Mads; Moen, Lisa Marie & Ledsaak, Marit [Show all 8 contributors for this article] (2018). The SUMO protease SENP1 and the chromatin remodeller CHD3 interact and jointly affect chromatin accessibility and gene expression. Journal of Biological Chemistry. ISSN 0021-9258. 293(40), p. 15439–15454. doi: 10.1074/jbc.RA118.002844. Full text in Research Archive
  • Fuglerud, Bettina Maria; Ledsaak, Marit; Rogne, Marie; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2018). The pioneer factor activity of c-Myb involves recruitment of p300 and induction of histone acetylation followed by acetylation-induced chromatin dissociation. Epigenetics & Chromatin. ISSN 1756-8935. 11(1). doi: 10.1186/s13072-018-0208-y. Full text in Research Archive
  • Gervin, Kristina; Nordeng, Hedvig Marie Egeland; Eskeland, Ragnhild; Paulsen, Ragnhild Elisabeth & Lyle, Robert (2017). Farmakoepigenetikk: Samspillet mellom legemidler og epigenetikk. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 125(8), p. 30–34. Full text in Research Archive
  • Fleischer, Thomas; Tekpli, Xavier; Mathelier, Anthony; Wang, Shixiong; Nebdal, Daniel J.H. & Dhakal, Hari Prasad [Show all 16 contributors for this article] (2017). DNA methylation at enhancers identifies distinct breast cancer lineages. Nature Communications. ISSN 2041-1723. 8(1379). doi: 10.1038/s41467-017-00510-x. Full text in Research Archive
  • Maclennan, Marie; García-Cañadas, Marta; Reichmann, Judith; Khazina, Elena; Wagner, Gabriele & Playfoot, Christopher J. [Show all 18 contributors for this article] (2017). Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. eLIFE. ISSN 2050-084X. 6:e26152, p. 1–32. doi: 10.7554/eLife.26152. Full text in Research Archive
  • Fuglerud, Bettina Maria; Lemma, Roza Berhanu; Wanichawan, Pimthanya; Sundaram, Arvind; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2017). A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. Nucleic Acids Research (NAR). ISSN 0305-1048. 45(13), p. 7681–7696. doi: 10.1093/nar/gkx364. Full text in Research Archive
  • Simovski, Boris; Vodak, Daniel; Gundersen, Sveinung; Domanska, Diana Ewa; Azab, Abdulrahman & Holden, Lars [Show all 25 contributors for this article] (2017). GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. GigaScience. ISSN 2047-217X. 6(7), p. 1–12. doi: 10.1093/gigascience/gix032. Full text in Research Archive
  • Ledsaak, Marit; Bengtsen, Mads; Molværsmyr, Ann-Kristin; Fuglerud, Bettina Maria; Matre, Vilborg & Eskeland, Ragnhild [Show all 7 contributors for this article] (2016). PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms. ISSN 1874-9399. 1859(5), p. 705–718. doi: 10.1016/j.bbagrm.2016.03.011.
  • Mora Ortiz, Antonio Carlos; Sandve, Geir Kjetil; Gabrielsen, Odd Stokke & Eskeland, Ragnhild (2015). In the loop: promoter-enhancer interactions and bioinformatics. Briefings in Bioinformatics. ISSN 1467-5463. doi: 10.1093/bib/bbv097.
  • Bengtsen, Mads; Klepper, Kjetil; Gundersen, Sveinung; Cuervo Torre, Ignacio; Drabløs, Finn & Hovig, Johannes Eivind [Show all 9 contributors for this article] (2015). c-Myb Binding Sites in Haematopoietic Chromatin Landscapes. PLOS ONE. ISSN 1932-6203. 10(7). doi: 10.1371/journal.pone.0133280. Full text in Research Archive
  • Lund, Eivind Gard; Oldenburg Ruppelt, Anja; Delbarre, Erwan; Freberg, Christel Taranger; Duband-Goulet, Isabelle & Eskeland, Ragnhild [Show all 8 contributors for this article] (2013). Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Research. ISSN 1088-9051. 23(10), p. 1580–1589. doi: 10.1101/gr.159400.113.
  • Collas, Philippe & Eskeland, Ragnhild (2013). Oslo Epigenetics Symposium 2012 Oslo, Norway, 8-9 November 2012. Epigenomics. ISSN 1750-1911. 5(1), p. 29–32. doi: 10.2217/EPI.12.76.
  • Chioda, Christina; Spada, Fabio; Eskeland, Ragnhild & Thompson, Eric (2004). Histone mRNAs do not accumulate during S phase of either mitotic or endoreduplicative cycles in the chordate Oikopleura dioica. Molecular and Cellular Biology. ISSN 0270-7306. 24(12), p. 5391–5403.
  • Chioda, Christina; Eskeland, Ragnhild & Thompson, Eric (2002). Histone gene complement, variant expression, and mRNA processing in a urochordate Oikopleura dioica that undergoes extensive polyploidization. Molecular Biology and Evolution (MBE). ISSN 0737-4038. 19, p. 2247–2260.

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  • Marianne, Sletbakk; Arnodd, Håpnes; Eskeland, Ragnhild; Dag Olav, Hessen & Kristin, Martinsen (2022). Bios 2 Biologi 2 (LK20) . Cappelen Damm Akademisk. ISBN 9788202743253. 432 p.
  • Sletbakk, Marianne; Marthinsen, Kirsten; Hessen, Dag Olav; Håpnes, Arnodd; Eskeland, Ragnhild & Spurkland, Anne (2021). Bios 1 Biologi 1 (LK20) . Cappelen Damm AS. ISBN 9788202696566.
  • Slettebakk, Marianne; Håpenes, Arnodd; Hessen, Dag Olav; Eskeland, Ragnhild; Gjærevoll, Inger & Borge, Ole Johan (2019). BIOS 2. Cappelen Damm AS. ISBN 9788202604851.

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  • Haraldsen, Kirsten Borse; Rogne, Sissel; Eskeland, Ragnhild; Kjeldstad, Torunn; Olsbye, Unni & Røyne, Anja (2017). Panelsamtale: Hva nå? DAMER! 100 år med kvinner i realfagene ved UiO.
  • Eskeland, Ragnhild & Grini, Paul Eivind (2015). Epigenetikk – hadde Lamarck rett? In Hessen, Dag Olav; Lie, Thore & Stenseth, Nils Christian (Ed.), Mendels arv - Genetikkens æra. Gyldendal Norsk Forlag A/S. ISSN 978-82-05-45818-5. p. 182–215.

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Published Jan. 17, 2019 2:07 PM - Last modified Feb. 3, 2022 2:05 PM