Sigbjørn Fossum

Image of Sigbjørn Fossum
Norwegian version of this page
Room 2361
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1110 Blindern 0317 Oslo
Other affiliations Natural Killer Cell group

Academic interests

  • Immunology
  • Molecular biology
  • Genetics
  • Evolution

Courses taught

  • Lectures in immunology, Medicine, 1. semester
  • Lectures and PBL in cell biology, Medicine, 2. semester

Background

  • Founded Immunobiological laboratory (together with colleague Bent Rolstad and engineer Wendi Jensen)
  • Professor, Anatomical Institute (now Department of Anatomy, Institute of Basic Medical Sciences) 1992 -
  • Research scholarship, Lecturer and senior lecturer, Anatomical Institute, 1973 - 1992
  • MD thesis 1983
  • Authorized physician, 1973
  • Internship 1971 - 73
  • Medical degree, University of Oslo, 1971

Positions held

  • Dean of Research, Medical Faculty, University of Oslo, 2007 - 2010. As Research Dean ex officio member and leader of various boards and committees
  • Head of the Department of Anatomy 2000 - 1, 2002 - 2003
  • Board member for the Biotechnology Center in Oslo, 1990 - 97
  • Member of the Medical faculty board, 1980-5 and 1993 - 7

Collaboration

  • Erik Dissen
  • Michael R. Daws
Tags: Genetics, Evolution, Molecular biology, Immune system

Publications

  • Daws, Michael Rory; Nakken, Britt; Lobato, Pascual Ana; Josien, Regis; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With Fc?RI? and Is Expressed by Myeloid Cell Subsets in the Rat. Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01060. Full text in Research Archive
  • Daws, Michael Rory; Nakken, Britt; Lobato Pascual, Ana; Regis, Josien; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat . Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01060.
  • Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian; Bjørnsen, Elisabeth Gyllensten; Pende, Daniela & Fossum, Sigbjørn [Show all 8 contributors for this article] (2017). The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer Cells. Journal of Immunology. ISSN 0022-1767. 198(7), p. 2556–2567. doi: 10.4049/jimmunol.1600930.
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology. ISSN 0014-2980. 43(12), p. 3167–3174. doi: 10.1002/eji.201343752.
  • Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik & Fossum, Sigbjørn [Show all 7 contributors for this article] (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLOS ONE. ISSN 1932-6203. 8(2). doi: 10.1371/journal.pone.0057406.
  • Sæther, Per Christian; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2011). Rat and Mouse CD94 Associate Directly with the Activating Transmembrane Adaptor Proteins DAP12 and DAP10 and Activate NK Cell Cytotoxicity. Journal of Immunology. ISSN 0022-1767. 187(12), p. 6365–6373. doi: 10.4049/jimmunol.1102345.
  • Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics. ISSN 0093-7711. 63(12), p. 809–820. doi: 10.1007/s00251-011-0553-5.
  • Kveberg, Lise; Dai, Kezheng; Inngjerdingen, Marit; Brooks, Colin G. ; Fossum, Sigbjørn & Vaage, John Torgils (2011). Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse. Immunogenetics. ISSN 0093-7711. 63(7), p. 429–436. doi: 10.1007/s00251-011-0520-1.
  • Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics. ISSN 0093-7711. 62(8), p. 521–530. doi: 10.1007/s00251-010-0455-y.
  • Orr, Mark T; Wu, Jun; Fang, Min; Sigal, Luis J.; Spee, Pieter & Egebjerg, Thomas [Show all 10 contributors for this article] (2010). Development and Function of CD94-Deficient Natural Killer Cells. PLOS ONE. ISSN 1932-6203. 5(11). doi: 10.1371/journal.pone.0015184.
  • Kveberg, Lise; Dai, Kezheng; Westgaard, Ingunn Hagen; Daws, Michael Rory; Fossum, Sigbjørn & Naper, Christian [Show all 7 contributors for this article] (2009). Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. European Journal of Immunology. ISSN 0014-2980. 39(2), p. 541–551. doi: 10.1002/eji.200838891.
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Hoelsbrekken, Sigurd Erik; Benjamin, J; Lanier, LL & Fossum, Sigbjørn [Show all 7 contributors for this article] (2008). KLRE/I1 and KLRE/I2: A novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. Journal of Immunology. ISSN 0022-1767. 181, p. 3177–3182.
  • Dissen, Erik; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian & Fossum, Sigbjørn (2008). NK cell receptors in rodents and cattle. Seminars in Immunology. ISSN 1044-5323. 20(6), p. 369–375.
  • Lorentzen, JC; Flornes, Line Marie; Eklow, C; Backdahl, L; Ribbhammar, U & Guo, JP [Show all 14 contributors for this article] (2007). Association of arthritis with a gene complex encoding C-type lectin-like receptors. Arthritis and Rheumatism. ISSN 0004-3591. 56, p. 2620–2632. doi: 10.1002/art.22813.
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Flornes, Line Marie; Hoelsbrekken, Sigurd Erik; Ryan, James C. & Fossum, Sigbjørn [Show all 7 contributors for this article] (2005). Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics. ISSN 0093-7711. 56.
  • Bryceson, Yenan T.; Torgersen, Knut Martin; Inngjerdingen, Marit; Berg, Siri Fuglem; Hoelsbrekken, Sigurd Erik & Fossum, Sigbjørn [Show all 7 contributors for this article] (2005). The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. European Journal of Immunology. ISSN 0014-2980. 35(4).
  • Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Immunogenetics. ISSN 0093-7711. 57(7), p. 479–486.
  • Nylenna, Øyvind; Naper, Christian; Vaage, John Torgils; Woon, P.Y.; Gauguier, D & Dissen, Erik [Show all 7 contributors for this article] (2005). The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. European Journal of Immunology. ISSN 0014-2980. 35.
  • Flornes, Line Marie; Bryceson, Yenan T.; Spurkland, Anne; Lorentzen, JC; Dissen, Erik & Fossum, Sigbjørn (2004). Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics. ISSN 0093-7711. 56, p. 506–517.
  • Westgaard, Ingunn Hagen; Berg, Siri F.; Vaage, John Torgils; Wang, Lawrence L; Yokoyama, Wayne M. & Dissen, Erik [Show all 7 contributors for this article] (2004). Rat NKp46 activates natural killer cell cytotoxicity and is associated with Fc{epsilon}RI{gamma} and CD3{zeta}. Journal of Leukocyte Biology. ISSN 0741-5400. 76, p. 1200–1206. doi: 10.1189/jlb.0903428.
  • Ribbhammar, Ulrica; Flornes, Line Marie; Bäckdahl, Liselotte; Luthman, Holger; Fossum, Sigbjørn & Lorentzen, Johnny (2003). High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes. Human Molecular Genetics. ISSN 0964-6906. 12, p. 2087–2096.
  • Hoelsbrekken, Sigurd E.; Nylenna, Øyvind; Sæther, Per Christian; Slettedal, Imer Ö; Ryan, James C. & Fossum, Sigbjørn [Show all 7 contributors for this article] (2003). Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. Journal of Immunology. ISSN 0022-1767. 170(5), p. 2259–2263.
  • Westgaard, Ingunn Hagen; Dissen, Erik; Torgersen, Knut Martin; Lazetic, Sascha; Lanier, Lewis L. & Phillips, JH [Show all 7 contributors for this article] (2003). The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 197(11), p. 1551–1561.
  • Berg, Siri Fuglem; Fossum, Sigbjørn & Dissen, Erik (1999). NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1. European Journal of Immunology. ISSN 0014-2980. 29, p. 2000–2006.
  • Berg, Siri Fuglem; Westgaard, Ingunn Hagen; Fossum, Sigbjørn & Dissen, Erik (1999). A rat gene homologous to human granule membrane protein 17 is expressed by natural killer cells, CD8+ T cells and a mast cell line. Immunogenetics. ISSN 0093-7711. 29, p. 815–818.
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. International Immunology. ISSN 0953-8178. 10, p. 379–385.
  • Westgaard, Ingunn Hagen; Berg, Siri Fuglem; Ørstavik, Sigurd; Fossum, Sigbjørn & Dissen, Erik (1998). Identification of a human member of the Ly-49 multigene family. European Journal of Immunology. ISSN 0014-2980. 28, p. 1839–1846.
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Two genes in the rat homologous to human NKG2. European Journal of Immunology. ISSN 0014-2980. 28, p. 444–450.
  • Dissen, Erik; Berg, Siri Fuglem; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1997). Molecular characterization of a gene in the rat homologous to human CD94. European Journal of Immunology. ISSN 0014-2980. 27, p. 2080–2086.
  • Dissen, Erik; Ryan, James C.; Seaman, W. E. & Fossum, Sigbjørn (1996). An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 183, p. 2197–2207.
  • Dissen, Erik & Fossum, Sigbjørn (1996). Chromosomal localization of the genes encoding rat CD4, CD8 and CD8. Immunogenetics. ISSN 0093-7711. 44, p. 312–314.
  • Dissen, Erik; Vaage, John T.; Tasken, Kjetil; Jahnsen, Tore; Rolstad, Bent & Fossum, Sigbjørn (1990). Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors. International Immunology. ISSN 0953-8178. 2(5), p. 453–461.

View all works in Cristin

  • Wisløff, Finn Georg B & Fossum, Sigbjørn (2012). Forskning viser at ... Vurdering og formidling av medisinske forskningsresultater. Gyldendal Akademisk. ISBN 978-82-05-42551-4. 359 p.

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  • Nakken, Britt; Jensen, Wendi; Szodoray, Peter; Daws, Michael Rory & Fossum, Sigbjørn (2011). Role of the C-Type Lectin-Like Receptor Dcar1 in Oil Induced Arthritis. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 375–376.
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn & Daws, Michael Rory (2010). Exploring expression and function of the rat Macrophage C-type Lectin, Clecsf8.
  • Kveberg, Lise; Fossum, Sigbjørn & Vaage, John Torgils (2009). Phylogenetic and functional conservation of the NKR-P1G receptor in rat and mouse.
  • Kveberg, Lise; Dai, Kezheng; Martinsen, Stine; Fossum, Sigbjørn & Vaage, John Torgils (2009). Phylogenetic and functional conservation of the NKR-P1G NK receptor in rat and mouse.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn & Naper, Christian [Show all 7 contributors for this article] (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin related molecules.
  • Kveberg, Lise; Westgaard, Ingunn Hagen; Dai, Kezheng; Daws, Michael Rory; Fossum, Sigbjørn & Naper, Christian [Show all 7 contributors for this article] (2007). The NKR-P1 family of receptors in rat recognizes C-type lectin-related molecules.
  • Rolstad, Bent & Fossum, Sigbjørn (1999). Natural killer celler, enfant terrible i immunologien. NBS-nytt. ISSN 0801-3535. 23, p. 7–13.
  • Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth & Flornes, Line Mari [Show all 9 contributors for this article] (2011). Oljer og helse - et pilotprosjekt. Kartlegging av oljeeksponering, genetiske faktorer og sykdom hos pasienter som ble utredet for mulig arbeidsrelatertsykdom. Statens Arbeidsmiljøinstitutt. ISSN 1502-0932. Årgang 12(Nr. 1).

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Published Apr. 13, 2011 2:41 PM - Last modified May 27, 2011 4:42 PM