Sophie Emilie Bresson

Academic interests

Current work focuses on Persistent Organic Pollutants as causes of inflammation. Particular in regards to intestinal inflammation and pancreatic beta-cells.

Courses taught

• MED1100 (https://www.uio.no/studier/emner/medisin/med/MED1100/)

Background

M.Sc. and B.Sc. in Molecular Biomedicine from University of Copenhagen, Denmark.

Previous occupation as Assistant Lecturer, at University of Copenhagen. Teaching Cell Biology and Medical Genetics.

Research background in diabetes, pancreatic beta-cells, protein folding, Endoplasmic reticulum function, protein degradation and molecular inflammation

Positions held

• PhD student (current)

https://orcid.org/0000-0002-8623-2237

Selected publications

• Bresson, Sophie E., Scott Isom, Elizabeth T. Jensen, Sandra Huber, Youssef Oulhote, Joseph Rigdon, James Lovato, Angela D. Liese, Catherine Pihoker, Dana Dabelea, Shelley Ehrlich, and Jérôme Ruzzin. "Associations between Persistent Organic Pollutants and Type 1 Diabetes in Youth." Environ Int. 2022 Mar 16;163:107175. doi: 10.1016/j.envint.2022.107175. Epub ahead of print. PMID: 35303528. (Link).
• Argon Y, Bresson SE, Marzec MT, Grimberg A. "Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production." Cells. 2020 Aug 6;9(8):1844. doi: 10.3390/cells9081844. PMID: 32781621; PMCID: PMC7465916.(Link)
• Khilji MS, Bresson SE, Verstappen D, Pihl C, Andersen PAK, Agergaard JB, Dahlby T, Bryde TH, Klindt K, Nielsen CK, Walentinsson A, Zivkovic D, Bousquet MP, Tyrberg B, Richardson SJ, Morgan NG, Mandrup-Poulsen T, Marzec MT. "The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets." Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E892-E900. doi: 10.1152/ajpendo.00372.2019. Epub 2020 Apr 7. PMID: 32255680.(Link)
• Khilji MS, Verstappen D, Dahlby T, Burstein Prause MC, Pihl C, Bresson SE, Bryde TH, Keller Andersen PA, Klindt K, Zivkovic D, Bousquet-Dubouch MP, Tyrberg B, Mandrup-Poulsen T, Marzec MT. "The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β." PLoS One. 2020 Feb 13;15(2):e0222432. doi: 10.1371/journal.pone.0222432. PMID: 32053590; PMCID: PMC7018053.(Link)
• Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT. "Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling." Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22. PMID: 30670477; PMCID: PMC6425875.(Link)