Projects

  • The role of activating NK cell receptors in cancer and virus infection.
    The aim of this project is to identify receptor-ligand interactions relevant for innate immune control of intracellular infection as well as early stages of neoplastic transformation. Specifically, ongoing efforts investigate what molecules can be recognized by the three activating receptors NKp46, NKp44 and NKp30, and which mechanisms underlie the expression of such ligand molecules in virus infection and cancer.
  • Identification of ligands for activating members of the human KIR family of receptors.
    The KIR multigene familiy was molecularly cloned in 1995, and has been extensively studied. In spite of these efforts, the functional role of activating KIR family members is still unknown.
  • Functional analysis of the KLRE/I receptor family. We recently discovered the KLRE/I1 and KLRE/2 receptors, and are searching for their ligands and functional significance.
Published Feb. 22, 2011 6:28 PM - Last modified Aug. 21, 2025 10:04 PM
E-mail this page