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Research groups

For an overview of group leaders, please see the institute's department pages.

Molekyl

This research group is focused on transport and cycling of neurotransmitters and amino acids.

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The purpose of the research is a better understanding of the close interplay nutrition and atherosclerosis.

Bildet kan inneholde: medisinsk avbildning, radiologi, hjerne, computertomografi, radiografi.

Our overall goal is to increase our knowledge of adult brain plasticity and its roles in neurological and psychiatric disorders - and the same time bridge the gap between neurological and psychiatric research.

Microscopy-photo of organoids and oligodendrocytes

We study the cellular and metabolic mechanisms that shape brain development, vulnerability, and recovery.

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Our main focus is methodological research in causal inference and event history analysis with applications to observational and randomized studies in epidemiology and medicine.

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The main goal of the research group, is to elucidate the mechanisms involved in cAMP-mediated regulation of proliferation and apoptosis in cells of the immune system, in order to identify new targets for improved therapy of cancer

Human cell under microscope

We work on uncovering and understanding novel mechanisms of autophagy termination, using Drosophila as a model.

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Our lab investigates chromosome inheritance across biological scales, from the evolution of inheritance systems and chromosome organization to the molecular mechanisms of centromere function. By integrating structural, biochemical, and evolutionary approaches, we seek to uncover the fundamental principles that govern faithful chromosome inheritance.

Chromatin Biology Group picture

The chromatin biology group focuses on epigenetic regulation in stem cells and cancer.

Our overall aim is to understand how neuronal activity in the human brain is used for cognitive processes.

Bildet kan inneholde: smil, bord, deling, sommer, fritid.

We are an interdisciplinary group working within a variety of topics in healthcare, especially in cancer survivorship care for children and young adults. We use a range of methods, including quantitative, qualitative, and co-design, with the aim to develop new knowledge, interventions and tools that will help improve patient centred practice. 

Uncertainty is an inherent part of all scientific activity and the generally agreed framework for handling uncertainty is the use of probability. Our lab focuses on enabling and making inferences with the aid of probabilistic models, with a focus on evolutionary epidemiology of bacterial infectious diseases but also within a wider range of applications in life sciences, technology and engineering. 

How does the brain work?

We investigate processes in the brains of awake, behaving animals in order to  reveal mechanisms underlying perception, learning and memory.

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The goal of this research group is to understand the mechanisms by which a plant based dietary pattern mediates protective effects.

Portraits of collaborating researchers

We are assessing nutritional status in pediatric and adult patients with cancer and gastrointestinal disorders, and are doing dietary interventions with the purpose of improving their health and quality of life.

Members of the group

Our primary interest is to study dietary prevention of cholesterol-induced inflammation in early atherosclerosis.

Bildet kan inneholde: mat, frukt, naturlig mat, oransje, anlegg.

What we eat matters for the health of both people and the planet.

We aim to identify dietary challenges in the Norwegian population as well as environmental sustainability challenges in the Norwegian food pattern.

Our research is focused on development and evaluation of dietary assessment methods and dietary habits among children, adolescents and adults, and on associations between diet and various diseases.

Infographics

A key strategy for controlling cancer is to understand the risk factors and patterns within the population. 

Schematic figure depicting main strategies for treating cardiac illnesses

The laboratory for experimental cardiology aims to identify molecular mechanisms that regulates short term and long term cardiac function. The goal is to develop future treatment for cardiac disease.

Astrocytes in green and neurons in red in the hippocampus from an awake head-fixed mouse.

The research group GliaLab explores functions of astrocytes, the starshaped glial cells, in the healthy brain, sleep and in neurological disorders. 

Group image of the members in the research group

Our research is primarily focused on optimizing nutritional status among vulnerable population groups as well as among patients with chronic diseases. We reach out both domestically as well as to Southern Africa.

We study changes in proteoglycans in inflammation and obesity and in kidneys in relation to diabetes and atherosclerosis. We also work with nutrition and health for persons with intellectual disabilities

Medical doctors at work

A leading research group in the field of mental health and work among medical students and physicians.

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We want to improve our understanding of the pathophysiological events underlying acute ischemic injury of the heart and the subsequent remodelling which may lead to heart failure. We work towards identifying new therapeutic targets to reduce these injuries. We also work to improve organs for transplantation with focus in ischemia reperfusion injury.

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We are working on methodological problems related to analysis of high-dimensional data.

Science group

We study the cardiovascular control mechanisms in healthy subjects and patients. We investigate the interaction between  circulation and respiration, control of cerebral blood flow, and the interaction between endothelial and autonomic functions.

Group picture of members of the immunbiological laboratory

The focus of the Immunbiology Laboratory is immune receptor biology and how this relates to the molecular mechanisms involved in autoimmune disease and cancer.

Our overarching research goal is to better understand the roles of stress receptor signalling pathways in normal physiology, chronic inflammatory diseases, immunity, and cancer.

Our research is focused on quantitative mathematical studies of infectious diseases.

The research group aims at developing statistical methodology and software tools for evidence synthesis and comparative effectiveness research.

Bildet kan inneholde: organisme, font, linje, skråningen, terrestrisk plante.

Our lab studies how the brain turns sensory information into perceptions. The physical stimuli reaching our eyes and ears are very complex, yet our perception of the outer world appears rather simple. To understand how we are able to interact with the physical world so efficiently, we study the fundamental principles by which brain circuits operate.

We study

Our focus is to understand the role of intracellular lipid droplets and how alterations in these may lead to various lipid-mediated diseases.

The complexity of medical knowledge and practices is growing. Our research group studies how we can effectively meet this challenge through new strategies in education and communication.

Image of a cancer cell with membrane ruffles and large vesicles - macropinosomes

We study how cells build and maintain membrane compartments, with a focus on macropinocytosis and vesicle identity. These processes control nutrient uptake, signalling, migration, and cellular defence, and they are frequently rewired in cancer and during infection. Our goal is to define the rules that make membrane trafficking robust, and to identify points where the system can be targeted therapeutically.

Our research group investigates how macronutrient metabolism can be used to regulate inflammation in cancer and autoimmunity.

We study how genes and lipids regulate diet induced metabolic diseases.

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The Laboratory for Molecular Neuroscience investigates molecular mechanisms involved in physiological processes such as cell volume regulation, gliovascular signaling, maintenance of the blood-brain-barrier integrity and role of the brain extracellular matrix in normal brain function.

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Natural killer (NK) cells eliminate cancer cells and cells infected with several viruses and bacteria, while sparing normal cells .

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The Laboratory of Neural Development  (NDEVOR) is dedicated to the study of the functional development of brain and spinal cord networks with special focus on motor and premotor circuitry.

NeSys group photo

NeSys is a computational neuroanatomy, neuroimaging, and neuroinformatics laboratory.

We study B cells, immunoglobulins, and adaptive immune receptor repertoires, with a particular focus on their role in multiple sclerosis and other neuroinflammatory diseases. We use samples from patients and healthy donors to investigate how B- and T-cell receptors shape immune responses that protect against or contribute to disease. Our work combines single-cell analysis, immunogenetics, and bioinformatics.

The Neurotransporter Group focuses on the transporter proteins moving transmitter amino acids (GABA, glutamate and glycine) across cell membranes, and on the roles of these transporters in normal brain physiology and disease.

Confocal picture of the spinal cord after lesion (top). Implantable Bluetooth transceiver. Photo: Jean-Luc Boulland, UiO 

We focus on mechanisms behind tissue damage and recovery after neurotrauma, particularly spinal cord injuries.

We also develop new strategies and prototypes of medical devices to restore lost function. 

Our research focuses on the nuclear envelope, the main line of defense for our genome.

The focus of this research group is to understand the roles of foods on growth, development, as well as prevention of life style diseases such as diabetes, and coronary heart disease. We are investigating the mechanisms of cellular transport and effects on cellular growth, function and metabolism of dietary lipids and other food constituents.

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Our research explores the link between dietary factors and various conditions and chronic diseases, with a special focus on healthy ageing and on breast and colon cancer.

Baby breastfeeding

The overall long-term objective of this research is to determine how to prevent metabolic disease and promote health in parous women.

Our primary research focus is to understand the biological mechanisms of fatty acids on human health. We utilize large scale datasets from controlled dietary intervention studies to define molecular profiles which can be used to predict and understand who some individuals responds better to intervention than others.

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Public Health Nutrition is the promotion of good health through primary prevention of nutrition-related illness in the population.

Our main research focus is on receptors that are expressed by cells of the innate immune system.

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Rapid advances in medical knowledge challenge both healthcare professionals and patients when making important decisions about treatment. The research group U-BET works at the intersection of evidence-based medicine and behavioral science to ensure that new research benefits patients faster.

Oil painting of a man holding a marble head

We explore the affective, cognitive, and neural basis of social behaviour and sensory experiences, using psychological, neuroscientific, and biological techniques.

Estimation of drug efficacy and synergistic effects in a drug combination experiment. The plots were generated with the R package bayesynergy v2.1 for an example data set from O'Neil et.al, 2016, DOI:10.1158/1535-7163.MCT-15-0843.

We develop methods to integrate multi-omics and other data, e.g. clinical data or drug characteristics, for predicting a patient's prognosis or treatment response. In this way we contribute to the development of novel cancer treatments.

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The research group aims at developing statistical methods for analyzing data with complex structure, high-dimensional and/or functional (intrinsically smooth)

The Collas lab

We investigate mechanisms by which genome organization and nuclear architecture pattern adipose stem cell fate, and cancer metastasis. We focus on the interplay between enhancer interactions, nuclear lamina-chromatin interactions, chromatin accessibility and transcription factor binding and activity. Our main model systems are Ⅰ) white and beige differentiation of adipose stem cells from healthy individuals and lipodystrophy patients, Ⅱ) in vitro models of EMT and Ⅲ) metastatic cancer cell lines.

Pen and paper, with statistical diagrams

Innovative computationally intensive inference for complex stochastic models in the life sciences. We develop statistical methodology motivated by specific problems in science, technology, industry and society.

Confocal imaging and patch clamp recordings.

My group studies how neurons in the mammalian brain communicate with each other at synapses. We use advanced electrophysiological, imaging and computer modeling techniques to analyze synaptic signaling mechanisms in presynaptic axons and postsynaptic dendrites.

Neurons of the brain communicate through contact points called synapses. This research group focuses on synapses and their highly developed capacities for structural and functional change.

Image contain pictures of five persons belonging to the group

The main focus of our research is regulation of adaptive immunity. We are particularly interested in signaling in activated and experienced T cells, as these cells influence individual susceptibility to autoimmune diseases as well as cancer. 

X-ray of a skull suffering from a stroke, affected area colorized in red

The goal of our research is to reduce the level of mortality and disability due to stroke by developing new diagnostic methods and treatment strategies.