Vision
The brain is the seat of dynamic, experience-based reorganization of neural pathways and refinement of synapses throughout life, under both physiological and pathological conditions. The combination of synaptic plasticity and adult neurogenesis provides a foundation for brain functions such as memory and learning. Furthermore, brain plasticity is essential for the opportunity for recovery and adaptation after brain insults. Indeed, plasticity is a prerequisite for the myriad of brain functions that arise in response to changing environments and demands.
We use cutting edge technology in confocal-, two-photon- and electron microscopy, dynamic optical recording techniques, genetic modifications in animal models, molecular imaging, two-electrode voltage clamp electrophysiology in Xenopus Laevis oocytes, extracellular recordings in brain slices, optogenetics, experimental embryology, stem cell technology and neurochemistry. By combining our efforts we will go beyond state-of-the-art neuroscience to gain insight into mechanisms sustaining brain plasticity and thus pave the way for future therapies.