Digital Public Defence: Sindre Lee-Ødegård Sindre Lee-Ødegård at Institute for Basic Medical Sciences will be defending the thesis “Molecular links between physical activity and insulin sensitivity in men” for the degree of Dr.Philos. (Doctor Philosophiae).

The University of Oslo is closed and the public defence will be held as a video conference over Zoom.

The defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.


Click here to participate in the digital public defence 

Download Zoom here

Digital Trial Lecture - chosen topic - time and place

See Digital Trial Lecture on a chosen topic

Digital Trial Lecture - given topic - time and place

See Digital Trial Lecture on a given topic

Adjudication committee

  • First opponent: Professor Saveiro Cinti, University of Politecnica delle Marche, Italy
  • Second opponent: Professor Gunnar Mellgren, University of Bergen
  • Third member and chair of the evaluation committee: Professor Kristin Austlid Tasken, University of Oslo

Chair of the Defence

Professor Emeritus Tore Henriksen, University of Oslo

Principal Supervisor

Professor Christian A. Drevon, University of Oslo


The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. Insulin resistance is a key pathophysiological processes involved in diabetes mellitus type 2, one of the most prevalent and costly non-infectious diseases. Physical exercise is a cornerstone in preventing and treating diabetes mellitus type 2 by its substantial effects on insulin resistance. We analysed normal weight normoglycemic and overweight dysglycemic men before and after acute, long-term and acute upon long-term intensive exercise, focusing on three key insulin target tissues: skeletal muscle, liver, and white adipose, as well as blood. We considered the critical and underappreciated role of tissue crosstalk in whole body insulin action, especially the non-cell autonomous factors proposed to induce insulin resistance, including inflammatory mediators, sulphur- and branched-chain amino acids, adipokines, and hepatokines.

Additional information

Contact the research support staff.

Published Apr. 27, 2020 10:02 AM - Last modified May 11, 2020 12:33 PM