I joined the Institute of Clinical Medicine, Division of Cancer Medicine at the Faculty of Medicine of the University of Oslo as a Researcher on research work related to “Integrative multi-omics analyses for precision medicine in B-cell lymphoma”.
My research work during my postdoc at the Dept of Biosciences/Dept of Informatics at the University of Oslo, was on understanding regulome and identifying key components and interaction playing a role during development and in Cancer. I majorly employed integrative inferences on scRNA and scATAC sequencing data, bulk RNAseq/CHiP seq studies along with Network analysis. Complex systems are of keen interest to me and my focus to develop Novel and robust methodology for integrative inferences to understand complex biological systems at the epigenomic, genetic, and proteomic levels.
Before joining UiO, I was working at the Department of Molecular Genetics at Erasmus Medical Centre, Rotterdam as a postdoctoral researcher, where my main focus was on integrative inferences using network studies on Single-cell genomics. Apart from this, I developed pipelines for cell segmentation, tracking, and isolation for images obtained from one of its kind inhouse-built Ultrawide field of View Microscope (UFOV).
I also won visiting CASyM (Co-ordinating Actions Systems Medicine across Europe) EU-FP7 grant as a postdoctoral research associate to work on the project related to epigenome modulation in Cancer at the Institute of Clinical Physiology, National Research Council of Italy, Siena in collaboration with the Center for Computational Sciences of the University of Miami. I did a Ph.D. in Computational Biology from the Second University of Naples on Interactomic analysis of Intrinsically disordered proteins.
I´m keenly interested in integrative inferences on multi-omics data to identify hidden patterns and early warning signals at a system level for the early detection of diseases in individual patients.
- Sharma, A#., Colonna, G. System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration. Mol Diagn Ther 25, 9–27 (2021). https://doi.org/10.1007/s40291-020-00505-3
- Piplani H, Marek-Iannucci S., Sin J., Sin J., Hou J., Takahashi T., Sharma A., de Freitas Germano J et al., Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis, BBA - Molecular Basis of Disease (2019), https://doi.org/10.1016/j.bbadis.2019.08.006
- Rani, S., Sharma, A., Goel, M., "Analysis and characterization of chaperone protein repertoire in thermoacidophilic archaea Picrophilus torridus" Cell Stress and Chaperones (2018) 23: 1257. https://doi.org/10.1007/s12192-018-0933-y
- Sharma, A., Cinti, C., Capobianco, E., " Network-guided Target Controllability of Tumor Microenvironment in Phenotypically Characterized Osteosarcoma." Front. Immunol. 8:918. doi: 10.3389/fimmu.2017.00918
- Sharma, A., Capobianco, E., “Immuno-Oncology Networks: Elucidating the Influences of Osteosarcoma phenotypes.” Cancer Informatics. doi.org/10.1177/1176935117721691
- Gherardini L., Sharma, A., Capobianco E., Cinti C., “Targeting Cancer with Epi-Drugs: A Precision Medicine Perspective." Current Pharmaceutical Biotechnology 2016 17(10): 856–65
- Sharma, A., Ferraro MB., Maiorano F., Blanco FDV., Guarracino MR., “Rigidity and flexibility in protein-protein interaction networks: a case study on neuromuscular disorders”, arXiv:1402.2304v2
- Sharma, A., Costantini S., Colonna.G., “The protein-protein interaction network of the human Sirtuin family.” Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1834, Issue 10, October 2013, Pages 1998-2009 (also available at arXiv preprint arXiv:1302.6423v2)
- Costantini S., Sharma, A., Raucci R., Costantini M., Autiero I., Colonna G., "Genealogy of an ancient protein family: the Sirtuins, a family of disordered members" BMC Evolutionary Biology 2013, 13:60 doi:10.1186/1471-2148-13-60
- Raucci R., Rusolo F., Sharma, A., Colonna G., Castello G., Costantini S., “Functional and structural features of adipokine family" Cytokine, Volume 61, Issue 1, January 2013, Pages 1-14, http://dx.doi.org/10.1016/j.cyto.2012.08.036
- Sharma, A., Gautam VK., Costantini S., Paladino A., Colonna G., "Interactomic and pharmacological insights on human Sirt-1" Frontiers in Experimental Pharmacology and Drug Discovery Front Pharmacol. (2012) 3: 40.
- Miele M°., Sharma A°., Capone F., Raucci R., Guerriero E., Colonna G., Castello G., Di Stasio M., Costantini S., "CytReD: a database collecting human cytokinome information" Bioinformation (2011), 6(5): 207-208 °These Author contributed equally to this work
- Costantini S., Sharma A., Colonna G., "The value of the cytokinome profile" (Amit Nagar Eds) in Inflammatory Diseases / Book 3, ISBN 979-953-307-659-0, 2011. (Book Chapter)
Sharma, Ankush; Akshay, Akshay; Rogne, Marie & Eskeland, Ragnhild (2021). ShinyArchR.UiO: User-friendly, integrative and open-source tool for visualisation of single-cell ATAC-seq data using ArchR. Bioinformatics. ISSN 1367-4803. 38(3), p. 834–836. doi: 10.1093/bioinformatics/btab680. Full text in Research Archive Show summary
de Freitas Germano, Juliana; Sharma, Ankush; Stastna, Miroslava; Huang, Chengqun; Aniag, Marianne & Aceves, Angie [Show all 11 contributors for this article] (2021). Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy. International Journal of Molecular Sciences. ISSN 1661-6596. 22(16), p. 1–21. doi: 10.3390/ijms22168711. Full text in Research Archive
Sharma, Ankush & Colonna, Giovanni (2021). System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration. Molecular Diagnosis & Therapy. ISSN 1177-1062. 25(1), p. 9–27. doi: 10.1007/s40291-020-00505-3.
Piplani, Honit; Marek-Iannucci, Stefanie; Sin, Jon; Hou, Jean; Takahashi, Toshimasa & Sharma, Ankush [Show all 17 contributors for this article] (2019). Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis. Biochimica et Biophysica Acta - Molecular Basis of Disease. ISSN 0925-4439. 1865(11), p. 1–14. doi: 10.1016/j.bbadis.2019.08.006. Full text in Research Archive
Sharma, Ankush & Colonna, Giovanni (2021). Correction to: System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration (Molecular Diagnosis & Therapy, (2021), 25, 1, (9-27), 10.1007/s40291-020-00505-3). Molecular Diagnosis & Therapy. ISSN 1177-1062. 25(3). doi: 10.1007/s40291-021-00527-5.