I joined Institute of Clinical Medicine, Division of Cancer Medicine at Faculty of Medicine of University of Oslo as a Researcher on research work related to “Integrative multi-omics analyses for precision medicine in B-cell lymphoma”.
My research work during postdoc at Dept of Biosciences/Dept of Informatics at University of Oslo ,was on understanding regulome and identifying key components and interaction playing a role during development and in Cancer. I majorly employed integrative inferences on scRNA and scATAC sequencing data, bulk RNAseq/CHiP seq studies along with Network analysis. Complex systems are of keen interest to me and my focus to develop Novel and robust methodology for integrative inferences to understand complex biological systems at the epigenomic, genetic and proteomic level.
Before joining UiO, I was working at the Department of Molecular Genetics at Erasmus Medical Centre, Rotterdam as a postdoctoral researcher, where my main focus was on integrative inferences using network studies on Single-cell genomics. Apart from this, I developed pipelines for cell segmentation, tracking, and isolation for images obtained from one of its kind in-house built Ultrawide field of View Microscope (UFOV).
I also won visiting CASyM (Co-ordinating Actions Systems Medicine across Europe) EU-FP7 grant as a postdoctoral research associate to work on the project related to epigenome modulation in Cancer at Institute of Clinical Physiology, National Research Council of Italy, Siena in collaboration with Center for Computational Sciences of University of Miami. I did a PhD in Computational Biology from the Second University of Naples on Interactomic analysis of Intrinsically disordered proteins.
I´m keenly interested in integrative inferences on multi-omics data to identify hidden patterns and early warning signals at a system level for early detection of diseases in individual patients.
- Piplani, Honit; Marek-Iannucci, Stefanie; Sin, Jon; Hou, Jean; Takahashi, Toshimasa; Sharma, Ankush; de Freitas Germano, Juliana; Waldron, Richard T; Saadaeijahromi, Hannaneh; Song, Yang; Gulla, Aiste; Wu, Bechien; Lugea, Aurelia; Andres, Allen M; Gaisano, Herbert Y; Gottlieb, Roberta A & Pandol, Stephen J (2019). Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis. Biochimica et Biophysica Acta - Molecular Basis of Disease. ISSN 0925-4439. 1865(11), s 1- 14 . doi: 10.1016/j.bbadis.2019.08.006 Full text in Research Archive.