Berit Flatø

• Marstein, Henriette; Godang, Kristin; Flatø, Berit; Sjaastad, Ivar; Bollerslev, Jens & Sanner, Helga (2021). Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study. Pediatric Rheumatology.  ISSN 1546-0096.  19(1), s 1- 11 . doi: 10.1186/s12969-021-00543-z Full text in Research Archive.
• Frid, Paula; Augdal, Thomas Angell; Larheim, Tore Arne; Halbig, Josefine Mareile; Rypdal, Veronika Gjertsen; Songstad, Nils Thomas; Rosén, Annika; Tylleskär, Karin; Berstad, Johanna Elisabeth Rykke; Flatø, Berit; Stoustrup, Peter; Rosendahl, Karen; Kirkhus, Eva Astrid & Nordal, Ellen Berit (2020). Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: A Norwegian 2-year prospective multicenter pilot study. Pediatric Rheumatology.  ISSN 1546-0096.  18:75, s 1- 16 . doi: 10.1186/s12969-020-00464-3 Full text in Research Archive.
• Frid, Paula; Baraniya, Divyashri; Halbig, Josefine Mareile; Rypdal, Veronika Gjertsen; Songstad, Nils Thomas; Rosén, Annika; Berstad, Johanna Elisabeth Rykke; Flatø, Berit; Alakwaa, Fadhl; Gil, Elisabeth Grut; Cetrelli, Lena Elisabet; Chen, Tsute; Al-hebshi, Nezar Noor; Nordal, Ellen Berit & Al-Haroni, Mohammed (2020). Salivary Oral Microbiome of Children With Juvenile Idiopathic Arthritis: A Norwegian Cross-Sectional Study. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  10, s 1- 13 . doi: 10.3389/fcimb.2020.602239 Full text in Research Archive.
• Malattia, Clara; Ruperto, Nicolino; Pederzoli, Silvia; Palmisani, Elena; Pistorio, Angela; Wouters, Carine; Dolezalova, Pavla; Flatø, Berit; Garay, Stella Maris; Giancane, Gabriella; Wells, Chris; Douglass, Wendy; Brunner, Hermine I.; De Benedetti, Fabrizio & Ravelli, Angelo (2020). Tocilizumab may slow radiographic progression in patients with systemic or polyarticular-course juvenile idiopathic arthritis: Post hoc radiographic analysis from two randomized controlled trials. Arthritis Research & Therapy.  ISSN 1478-6354.  22(1), s 1- 11 . doi: 10.1186/s13075-020-02303-y Full text in Research Archive.
• Barth, Zoltan; Schwartz, Thomas; Flatø, Berit; Aaløkken, Trond Mogens; Koller, Akos; Lund, May-Brith; Sjaastad, Ivar & Sanner, Helga (2019). The association between nailfold capillary density and pulmonary and cardiac involvement in medium-to long-standing juvenile dermatomyositis. Arthritis care & research.  ISSN 2151-464X.  71(4), s 492- 497 . doi: 10.1002/acr.23687 Full text in Research Archive.
• Berntsen, Kristin Schjander; Edvardsen, Elisabeth; Hansen, Bjørge Hermann; Flatø, Berit; Sjaastad, Ivar & Sanner, Helga (2019). Cardiorespiratory fitness in long-term juvenile dermatomyositis: A controlled, cross-sectional study of active/inactive disease. Rheumatology.  ISSN 1462-0324.  58(3), s 492- 501 . doi: 10.1093/rheumatology/key342 Full text in Research Archive. Show summary

  Objectives. To compare cardiorespiratory fitness (CRF) expressed as maximal oxygen uptake (VO2max) between patients with long-term JDM and controls and between patients with active and inactive disease, as well as to explore exercise limiting factors and associations between CRF and disease variables. Methods. JDM patients (n=45) and age- and gender-matched controls (n=45) performed a cardiopulmonary exercise test (CPET) on a treadmill until exhaustion. Physical activity was measured by accelerometers. Disease activity, damage and muscle strength/function were assessed by validated tools. Clinically inactive disease was defined according to PRINTO criteria. Results. The mean disease duration was 20.8 (S.D. 11.9) years and 29/45 (64%) patients had inactive disease. A low VO2max was found in 27% of patients vs 4% of controls (P = 0.006). The mean VO2max and maximal ventilation (VEmax) were lower in patients with active and inactive disease compared with controls. Patients with active disease also had lower maximal voluntary ventilation (MVV) compared with controls and lower VEmax and MVV compared with those with inactive disease. Patients with inactive disease had lower physical activity levels compared with controls. VO2max correlated negatively with disease damage in patients with inactive disease and positively with muscle strength/function in patients with active disease. Conclusion. CRF was lower in JDM patients, both with active and inactive disease, compared with controls after a mean 20 years disease duration. Cardiopulmonary exercise test results suggested different limiting factors contributing to the reduced CRF according to disease activity, including deconditioning in inactive disease and reduced ventilatory capacity in active disease. Further research is needed to verify this.

• Berntsen, Kristin Schjander; Raastad, Truls; Marstein, Henriette; Kirkhus, Eva Astrid; Merckoll, Else; Cumming, Kristoffer Toldnes; Flatø, Berit; Sjaastad, Ivar & Sanner, Helga (2019). Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis; a Controlled Cross-Sectional Study. Arthritis & Rheumatology.  ISSN 2326-5191. . doi: 10.1002/art.41174 Full text in Research Archive.
• Consolaro, Alessandro; Giancane, Gabriella; Alongi, Alessandra; van Dijkhuizen, Evert Hendrik Pieter; Aggarwal, Amita; Al-Mayouf, Sulaiman M.; Bovis, Francesca; De Inocencio, Jaime; Demirkaya, Erkan; Flatø, Berit; Foell, Dirk; Garay, Stella Maris; Lazăr, Călin; Lovell, Daniel J.; Montobbio, Carolina; Miettunen, Päivi; Mihaylova, Dimitrina; Nielsen, Susan; Orban, Ilonka; Rumba-Rozenfelde, Ingrida; Magalhães, Claudia Saad; Shafaie, Nahid; Susic, Gordana; Trachana, Maria; Wulffraat, Nico; Pistorio, Angela; Martini, Alberto; Ruperto, Nicolino & Ravelli, Angelo (2019). Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study. The Lancet Child and Adolescent Health.  ISSN 2352-4642.  3(4), s 255- 263 . doi: 10.1016/S2352-4642(19)30027-6 Full text in Research Archive.
• Hetlevik, Siri Opsahl; Flatø, Berit; Aaløkken, Trond Mogens; Samersaw-Lund, May Brit; Reiseter, Silje; Mynarek, Georg; Nordal, Ellen Berit; Rygg, Marite & Lilleby, Vibke (2019). Pulmonary manifestations and progression of lung disease in juvenile-onset mixed connective tissue disease. Journal of Rheumatology.  ISSN 0315-162X.  46(1), s 93- 100 . doi: 10.3899/jrheum.180019 Full text in Research Archive.
• Marstein, Henriette; Schwartz, Thomas; Aaløkken, Trond M; Samersaw-Lund, May Brit; Flatø, Berit; Sjaastad, Ivar & Sanner, Helga (2019). Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross-sectional study of long-term disease. Rheumatology.  ISSN 1462-0324.  59(8), s 1862- 1870 . doi: 10.1093/rheumatology/kez531 Full text in Research Archive.
• NOMELAND, BIRGIT; Hetlevik, Siri Opsahl; Sanner, Helga; Barth, Zoltan; Schwartz, Thomas; Flatø, Berit; Lilleby, Vibke & Sjaastad, Ivar (2019). Cardiac function is impaired in longstanding juvenile-onset mixed connective tissue disease - a controlled study. Journal of Rheumatology.  ISSN 0315-162X.  46(7), s 739- 747 . doi: 10.3899/jrheum.180526 Full text in Research Archive.
• Tollisen, Anita; Flatø, Berit; Selvaag, Anne Marit G; Aasland, Astrid; Ingebrigtsen, Trude; Sagen, Joakim & Lerdal, Anners Vetle (2019). Treatment Satisfaction with and Adherence to Disease-Modifying Antirheumatic Drugs in Adult Patients with Juvenile Idiopathic Arthritis.. Arthritis care & research.  ISSN 2151-464X. . doi: 10.1002/acr.24113
• Tollisen, Anita; Selvaag, Anne Marit G; Aasland, Astrid; Lerdal, Anners & Flatø, Berit (2019). Longitudinal Health Status from Early Disease to Adulthood and Associated Prognostic Factors in Juvenile Idiopathic Arthritis.. Journal of Rheumatology.  ISSN 0315-162X.  46(10), s 1335- 1344 . doi: 10.3899/jrheum.180948
• Barth, Zoltan; NOMELAND, BIRGIT; Flatø, Berit; Koller, Akos; Sjaastad, Ivar & Sanner, Helga (2018). Assessment of Microvascular Abnormalities by Nailfold Capillaroscopy in Juvenile Dermatomyositis After Medium- to Long-Term Followup. Arthritis care & research.  ISSN 2151-464X.  70(5), s 768- 776 . doi: 10.1002/acr.23338
• Aulie, Hanne Aaserud; Estensen, Mette-Elise; Selvaag, Anne Marit G; Lilleby, Vibke; Flatø, Berit & Aakhus, Svend (2018). Arterial properties in adults with long-lasting active juvenile idiopathic arthritis compared to healthy controls.. Pediatric Rheumatology.  ISSN 1546-0096.  16(85) . doi: 10.1186/s12969-018-0302-5 Full text in Research Archive.
• Flatø, Berit; Rygg, Marite; Nordal, Ellen Berit; Røisland, Mona; Ødegård, Hanne Beate; Hoftun, Gry Børmark; Songstad, Nils Thomas; Consolaro, Alessandro; Bovis, Francesca & Ruperto, Nicolino (2018). The Norwegian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR). Rheumatology International.  ISSN 0172-8172.  38, s 291- 298 . doi: 10.1007/s00296-018-3963-y Full text in Research Archive.
• Barth, Zoltan; Witzcak, Birgit; Flatø, Berit; Koller, Akos; Sjaastad, Ivar & Sanner, Helga (2017). Microvascular Abnormalities Assessed by Nailfold Capillaroscopy In Juvenile Dermatomyositis After Medium to Long-Term Follow-Up. Arthritis Care and Research.  ISSN 0893-7524. . doi: 10.1002/acr.23338
• Augestad, Linnea B.; Hammarström, Clara Louise; Flatø, Berit & Bjerre, Anna Kristina (2017). Nyreaffeksjon ved systemisk vaskulitt hos barn. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(19) . doi: 10.4045/tidsskr.16.0592
• Berntsen, Kristin Schjander; Tollisen, Anita; Schwartz, Thomas; Kirkhus, Eva; Aaløkken, Trond Mogens; Samersaw-Lund, May Brit; Flatø, Berit; Sjaastad, Ivar & Sanner, Helga (2017). Submaximal exercise capacity in juvenile dermatomyositis after longterm disease: The contribution of muscle, lung, and heart involvement. Journal of Rheumatology.  ISSN 0315-162X.  44(6), s 827- 834 . doi: 10.3899/jrheum.160997
• Frid, Paula Hanna Therese; Nordal, Ellen Berit; Bovis, Francesca; Giancane, Gabriella; Larheim, Tore Arne; Rygg, Marite; Pires Marafon, Denise; De Angelis, Donato; Palmisani, Elena; J Murray, Kevin; Oliveira, Sheila; Simonini, Gabriele; Corona, Fabrizia; Davidson, Joyce; Foster, Helen; Steenks, Michel H.; Flatø, Berit; Zulian, Francesco; Baildam, Eileen M.; Saurenmann, Rotraud K.; Lahdenne, Pekka; Ravelli, Angelo; Martini, Alberto; Pistorio, Angela & Ruperto, Nicolino (2017). Temporomandibular Joint Involvement in Association With Quality of Life, Disability, and High Disease Activity in Juvenile Idiopathic Arthritis. Arthritis care & research.  ISSN 2151-464X.  69(5), s 677- 686 . doi: 10.1002/acr.23003
• Selvaag, Anne Marit G; Kirkhus, Eva; Törnqvist, Lena; Lilleby, Vibke; Aulie, Hanne Aaserud & Flatø, Berit (2017). Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration. Pediatric Rheumatology.  ISSN 1546-0096.  15 . doi: 10.1186/s12969-017-0151-7
• Tollisen, Anita; Selvaag, Anne Marit G; Aulie, Hanne Aaserud; Lilleby, Vibke; Aasland, Astrid; Lerdal, Anners & Flatø, Berit (2017). Physical functioning, pain, and health-related quality of life in adults with juvenile idiopathic arthritis: a longitudinal 30-year followup study. Arthritis care & research.  ISSN 2151-464X.  70(5), s 741- 749 . doi: 10.1002/acr.23327
• Anderson, Joseph H.; Anderson, K.R.; Aulie, Hanne Aaserud; Crowson, C.S.; Mason, T.G.; Ardoin, S.P.; Reed, Ann M. & Flatø, Berit (2016). Juvenile idiopathic arthritis and future risk for cardiovascular disease: a multicenter study. Scandinavian Journal of Rheumatology.  ISSN 0300-9742.  45(4), s 299- 303 . doi: 10.3109/03009742.2015.1126345
• Barth, Zoltan; NOMELAND, BIRGIT; Schwartz, Thomas; Gjesdal, Knut; Flatø, Berit; Koller, Akos; Sanner, Helga & Sjaastad, Ivar (2016). In juvenile dermatomyositis, heart rate variability is reduced, and associated with both cardiac dysfunction and markers of inflammation: a cross-sectional study median 13.5 years after symptom onset. Rheumatology.  ISSN 1462-0324.  55(3), s 535- 543 . doi: 10.1093/rheumatology/kev376 Show summary

  Objectives. Low heart rate variability (HRV) is a well-established predictor of cardiac death. The aim of this study was to investigate arrhythmias and HRV in patients with JDM, and associations between HRV and inflammatory markers, echocardiographic measurements and disease parameters. Methods. Fifty-five patients with JDM were examined 2–34 years (median 13.5 years) after disease onset, and compared with 55 age and sex matched controls. Holter ECG monitoring and echocardiography were analysed blinded to patient information. Arrhythmia and HRV (six parameters) were analysed by standard software, finally adjudicated by an experienced cardiologist. Markers of inflammation (ESR, high sensitivity (hs)CRP and cytokines) were analysed. Disease activity and organ damage were assessed by clinical examination at follow-up and retrospectively by chart review. Results. In two out of six HRV parameters, JDM patients had lower values than controls. No difference in arrhythmias was found between the groups. In patients, but not in controls, there were significant negative correlations between five out of six HRV parameters, and ESR and hsCRP (Spearman correlation coefficient, −0.306 to −0.470; P, 0.023 to <0.001). Also, in patients, negative correlations were found between three out of six HRV parameters and systolic and diastolic function. Active disease and low HRV were associated. Patients with hsCRP in the highest quartile (Q4) had lower HRV in all parameters compared with those in pooled Q1–3 (P < 0.001). Conclusion. JDM patients had reduced HRV, which was associated with elevated inflammatory markers, active disease and reduced myocardial function. This suggests reduced vagal control of the heart; further studies are needed to determine whether this is also associated with cardiac morbidity or mortality.

• Constantin, Tamás; Foeldvari, Ivan; Vojinovic, Jelena; Horneff, Gerd; Burgos-Vargas, Ruben; Nikishina, Irina; Akikusa, Jonathan D.; Avcin, Tadej; Chaitow, Jeffrey; Koskova, Elena; Lauwerys, Bernard R.; Penades, Inmaculada Calvo; Flatø, Berit; Gamir, Maria Luz; Huppertz, Hans-Iko; Raad, Juan Jose Jaller; Jarosova, Katerina; Anton, Jordi; Macku, Marie; Otero Escalante, William J.; Rutkowska-Sak, Lidia; Trauzeddel, Ralf; Velez-Sanchez, Patricia J.; Wouters, Carine; Wajdula, Joseph; Zang, Chuanbo; Bukowski, Jack; Woodworth, Deborah; Vlahos, Bonnie; Martini, Alberto & Ruperto, Nicolino (2016). Two-year efficacy and safety of etanercept in pediatric patients with extended oligoarthritis, enthesitisrelated arthritis, or psoriatic arthritis. Journal of Rheumatology.  ISSN 0315-162X.  43(4), s 816- 824 . doi: 10.3899/jrheum.150430
• Evensen, Kristin; Aulie, Hanne Aaserud; Rønning, Ole M.; Flatø, Berit & Russell, David (2016). Carotid atherosclerosis in adult patients with persistently active juvenile idiopathic arthritis compared with healthy controls. Journal of Rheumatology.  ISSN 0315-162X.  43(4), s 810- 815 . doi: 10.3899/jrheum.150499 Show summary

  Objective. Juvenile idiopathic arthritis (JIA) is the most common inflammatory rheumatic disease in childhood. It is regarded as a systemic inflammatory disease with possible increased risk of cardiovascular disease (CVD). The aim of this study was to assess carotid intima-media thickness (IMT) and carotid stenosis as surrogate measures for CVD in adults with longterm active JIA and healthy age- and sex-matched controls. Methods. Seventy-five patients with JIA (age 28–45 yrs) with persistently active disease at least 15 years after disease onset were reexamined after a median of 29 years and compared with 75 matched controls. Patients and controls were examined by color duplex ultrasound of the carotid arteries to compare carotid IMT and carotid stenosis in the 2 groups. Results. Patients with JIA did not have increased carotid IMT values compared with the controls (mean ± SD: 0.56 mm ± 0.09 vs 0.58 mm ± 0.07, p = 0.289). Patients with a higher disease activity indicated by the Juvenile Arthritis Disease Activity Score value above the median value had increased carotid IMT compared with the patients with a lower value, but not statistically different compared with controls. No carotid stenoses were detected in patients or controls. Conclusion. We found similar carotid IMT values in adult patients with JIA and controls.

• Finkel, Terri H.; Li, Jin; Wei, Zhi; Wang, Wei; Zhang, Haitao; Behrens, Edward M.; Reuschel, Emma L.; Limou, Sophie; Wise, Carol; Punaro, Marilynn; Becker, Mara L.; Munro, Jane E.; Flatø, Berit; Førre, Øystein Thorleiv; Thompson, Susan D.; Langefeld, Carl D.; Glass, David N.; Glessner, Joseph T.; Kim, Cecilia E.; Frackelton, Edward; Shivers, Debra K.; Thomas, Kelly A.; Chiavacci, Rosetta M.; Hou, Cuiping; Xu, Kexiang; Snyder, James; Qiu, Haijun; Mentch, Frank; Wang, Kai; Winkler, Cheryl A.; Lie, Benedicte Alexandra; Ellis, Justine A. & Hakonarson, Hakon (2016). Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility. BMC Medical Genetics.  ISSN 1471-2350.  17(1) . doi: 10.1186/s12881-016-0285-3
• Hetlevik, Siri Opsahl; Flatø, Berit; Rygg, Marite; Nordal, Ellen Berit; Brunborg, Cathrine; Hetland, Helene & Lilleby, Vibke (2016). Long-term outcome in juvenile-onset mixed connective tissue disease: a nationwide Norwegian study. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  76(1), s 159- 165 . doi: 10.1136/annrheumdis-2016-209522
• Kirkhus, Eva; Arvidsson, Linda Zamoline; Smith, Hans-Jørgen; Flatø, Berit; Hetlevik, Siri Opsahl & Larheim, Tore Arne (2016). Disk abnormality coexists with any degree of synovial and osseous abnormality in the temporomandibular joints of children with juvenile idiopathic arthritis. Pediatric Radiology.  ISSN 0301-0449.  46(3), s 331- 341 . doi: 10.1007/s00247-015-3493-7 Show summary

  Background MRI manifestation of temporomandibular joint arthritis is frequently reported in children with juve- nile idiopathic arthritis. However, little attention has been paid to temporomandibular joint disk abnormalities. Objective To assess combinations of MRI findings in the symptomatic temporomandibular joint in children with ju- venile idiopathic arthritis with focus on disk abnormalities. Materials and methods This was a retrospective study of 46 patients with juvenile idiopathic arthritis, mean age 12 years (range: 5-17 years). Mean disease duration was 70 months (standard deviation: 61 months). MR images of 92 tempo- romandibular joints were scored for thickness of abnormal- ly enhancing synovium (synov itis), joint effusion, bone marrow oedema, abnormal bone shape, bone erosion and disk abnormalities. Results The 92 temporomandibular joints were categorized as A: No synovitis and normal bone shape (30/92; 33%), B: Synovitis and normal bone shape (14/92: 15%), C: Synovi- tis and abnormal bone shape (38/92; 41%) and D: No syno- vitis but abnormal bone shape (10/92; 11%). Thirty-six of the 46 patients (78%) had synovitis and 33/46 (72%) had abnormal bone shape, most frequently in combination (30/ 46; 65%). Disk abnormalities (flat disk, fragmented disk, adherent disk and displaced disk) were found in 29/46 pa- tients (63%). Disk abnormalities were found in all catego- ries of juvenile idiopathic arthritis involved temporoman- dibular joints (B: 8/14 [57%]; C: 25/38 [66%] and D: 7/10 [70%]). Disk displacement was found in half of the joints (7/14) in category B. Synovitis was most pronounced in this category. Conclusion Disk abnormalities were frequent. Disk displace- ment also occurred in joints with early temporomandibular joint arthritis, i.e., with normal bone shape. Other disk abnor- malities were found in joints with bone abnormalities. Atten- tion should be paid to disk abnormalities both in early and long-standing temporomandibular joint arthritis in children with juvenile idiopathic arthritis

• Kirkhus, Eva; Gunderson, Ragnhild B.; Smith, Hans-Jørgen; Flatø, Berit; Hetlevik, Siri Opsahl; Larheim, Tore Arne & Arvidsson, Linda Zamoline (2016). Temporomandibular joint involvement in childhood arthritis: comparison of ultrasonography-assessed capsular width and MRI-assessed synovitis. Dentomaxillofacial Radiology.  ISSN 0250-832X.  45(8) . doi: 10.1259/dmfr.20160195 Show summary

  Objectives: Ultrasonography is an effective, low-cost, low-threshold and convenient diagnostic tool in childhood arthritis, but its value in temporomandibular joint (TMJ) involvement is not clear. The purpose of our study was to explore the reliability of ultrasonography to assess TMJ inflammation using contrast-enhanced MRI as reference standard, in order to deduce cut-off values for TMJ capsular width to detect enhanced synovial thickening (synovitis). Methods: 124 ultrasonography and MRI examinations in 55 patients [mean age 12.4 ± 3.5 years (±standard deviation)], the majority obtained within 1 day, were scored for subcondylar and condylar capsular width (ultrasonography images) and amount of synovitis (MR images). The correlations of these findings were calculated. A receiver operating characteristic (ROC) curve analysis, with MRI findings as reference standard, was obtained. Results: The correlation between ultrasonography-assessed capsular width and MRI-assessed amount of synovitis was moderate both at the subcondylar and condylar level [Spearman's rho (ρ): 0.483; p < 0.001 and 0.347; p < 0.001 respectively]. The ROC curve indicated the best discriminatory ability at the subcondylar level with an area under the curve of 0.77 (95% confidence interval 0.69–0.85) and a cut-off value of 1.2 mm (sensitivity 72%, specificity 70%) for the capsular width. Conclusions: A moderate correlation between ultrasonography-assessed capsular width and MRI-assessed synovitis was found in childhood arthritis with the best discriminatory ability at the subcondylar level. This indicates that ultrasonography may be a valuable diagnostic tool in the initial assessment of TMJ inflammation.

• Ruperto, Nicolino; Pistorio, Angela; Oliveira, Sheila; Zulian, Francesco; Cuttica, Ruben; Ravelli, Angelo; Fischbach, Michel; Magnusson, Bo; Sterba, Gary; Avcin, Tadej; Brochard, Karine; Corona, Fabrizia; Dressler, Frank; Gerloni, Valeria; Apaz, Maria T.; Bracaglia, Claudia; Cespedes-Cruz, Adriana; Cimaz, Rolando; Couillault, Gerard; Joos, Rik; Quartier, Pierre; Russo, Ricardo; Tardieu, Marc; Wulffraat, Nico; Bica, Blanca; Dolezalova, Pavla; Ferriani, Virginia; Flatø, Berit; Bernard-Medina, Ana G.; Herlin, Troels; Trachana, Maria T.; Meini, Antonella; Allain-Launay, Emma; Pilkington, Clarissa; Vargova, Veronika; Wouters, Carine; Angioloni, Simona & Martini, Alberto (2016). Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial.. The Lancet.  ISSN 0140-6736.  387(10019), s 671- 678 . doi: 10.1016/S0140-6736(15)01021-1
• Selvaag, Anne Marit G; Aulie, Hanne Aaserud; Lilleby, Vibke & Flatø, Berit (2016). Disease progression into adulthood and predictors of long-term active disease in juvenile idiopathic arthritis. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  75(1), s 190- 195 . doi: 10.1136/annrheumdis-2014-206034
• Stray-Pedersen, Asbjørg; Sorte, Hanne Sørmo; Samarakoon, Pubudu Saneth; Gambin, Tomasz; Chinn, Ivan K.; Akdemir, Zeynep H.C.; Erichsen, Hans Christian; Forbes, Lisa R.; Gu, Shen; Yuan, Bo; Jhangiani, Shalini N.; Muzny, Donna M.; Rødningen, Olaug Kristin; Sheng, Ying; Nicholas, S.; Noroski, Lenora M.; Seeborg, FO; Davis, Carla M.; Canter, Debra L.; Mace, Emily M.; Vece, Timothy J.; Allen, Carl E.; Abhyankar, Harshal A.; Boone, Philip M.; Beck, Christine R.; Wiszniewski, Wojciech; Fevang, Børre; Aukrust, Pål; Tjønnfjord, Geir Erland; Gedde-Dahl, Tobias Jr.; Hjorth-Hansen, Henrik; Dybedal, Ingunn; Nordøy, Ingvild; Jørgensen, Silje Fjellgård; Abrahamsen, Tore G; Øverland, Torstein; Bechensteen, Anne Grete; Skogen, Vegard; Osnes, Liv T. N.; Kulseth, Mari Ann; Prescott, Trine; Rustad, Cecilie; Heimdal, Ketil Riddervold; Belmont, John W.; Rider, Nicholas L.; Chinen, Javier; Cao, Tram N.; Smith, Eric A.; Caldirola, Maria Soledad; Bezrodnik, Liliana & Flatø, Berit (2016). Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749.  139(1), s 232- 245 . doi: 10.1016/j.jaci.2016.05.042
• Aulie, Hanne Aaserud; Estensen, Mette-Lise; Selvaag, Anne Marit G; Lilleby, Vibke; Murbræch, Klaus; Flatø, Berit & Aakhus, Svend (2015). Cardiac function in adult patients with juvenile idiopathic arthritis. Journal of Rheumatology.  ISSN 0315-162X.  42(9), s 1716- 1723 . doi: 10.3899/jrheum.141351
• Aulie, Hanne Aaserud; Selvaag, Anne Marit G; Günther, Anne; Lilleby, Vibke; Molberg, Øyvind; Hartmann, Anders; Holdaas, Hallvard & Flatø, Berit (2015). Arterial haemodynamics and coronary artery calcification in adult patients with juvenile idiopathic arthritis. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  74(8), s 1515- 1521 . doi: 10.1136/annrheumdis-2013-204804
• Chiaroni-Clarke, Rachel C.; Li, Yun R.; Munro, Jane E.; Chavez, Raul A.; Scurrah, Katrina J.; Pezic, Angela; Akikusa, Jonathan D.; Allen, Roger C.; Piper, Susan E.; Becker, Mara L.; Thompson, Susan D.; Lie, Benedicte Alexandra; Flatø, Berit; Førre, Øystein Thorleiv; Punaro, Marilynn; Wise, Carol; Saffery, Richard; Finkel, Terri H.; Hakonarson, Hakon; Ponsonby, Anne-Louise & Ellis, Justine A. (2015). The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females. Genes and Immunity.  ISSN 1466-4879.  16(7), s 495- 498 . doi: 10.1038/gene.2015.32
• Ellis, Justine A.; Scurrah, Katrina J.; Li, Yun R.; Ponsonby, Anne-Louise; Chavez, Raul A.; Pezic, Angela; Dwyer, Terence; Akikusa, Jonathan D.; Allen, Roger C.; Becker, Mara L.; Thompson, Susan D.; Lie, Benedicte Alexandra; Flatø, Berit; Førre, Øystein Thorleiv; Punaro, Marilynn; Wise, Carol; Finkel, Terri H.; Hakonarson, Hakon & Munro, Jane E. (2015). Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  145, s 113- 120 . doi: 10.1016/j.jsbmb.2014.10.012
• Li, Yun R.; Li, Jin; Zhao, Sihai D.; Bradfield, Jonathan P.; Mentch, Frank D.; Maggadóttir, Sólrún Melkorka; Hou, Cuiping; Abrams, Debra J.; Chang, Diana; Gao, Feng; Guo, Yiran; Wei, Zhi; Connolly, John J.; Cardinale, Christopher J.; Bakay, Marina; Glessner, Joseph T.; Li, Dong; Kao, Charlly; Thomas, Kelly A.; Qiu, Haijun; Chiavacci, Rosetta M.; Kim, Cecilia E.; Wang, Fengxiang; Snyder, James; Richie, Marylyn D.; Flatø, Berit; Førre, Øystein Thorleiv; Denson, Lee A.; Thompson, Susan D.; Becker, Mara L.; Guthery, Stephen L; Latiano, Anna; Perez, Elena; Resnick, Elena; Russell, Richard K.; Wilson, David C.; Silverberg, Mark S.; Annese, Vito; Lie, Benedicte Alexandra; Punaro, Marilynn; Dubinsky, Marla C.; Monos, Dimitri S.; Strisciuglio, Caterina; Staiano, Annamaria; Miele, Erasmo; Kugathasan, Subra; Ellis, Justine A.; Munro, Jane E.; Sullivan, Kathleen E.; Wise, Carol A.; Chapel, Helen; Cunningham-Rundles, Charlotte; Grant, Struan F.A.; Orange, Jordan S.; Sleiman, Patrick M.A.; Behrens, Edward M.; Griffiths, Anne M.; Satsangi, Jack; Finkel, Terri H.; Keinan, Alon; Prak, Eline T. Luning; Polychronakos, Constantin; Baldassano, Robert N.; Li, Hongzhe; Keating, Brendan J. & Hakonarson, Hakon (2015). Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nature Medicine.  ISSN 1078-8956.  21(9), s 1018- 1027 . doi: 10.1038/nm.3933
• Li, Yun R.; Zhao, Sihai D.; Li, Jin; Bradfield, Jonathan P.; Mohebnasab, Maede; Steel, Laura; Kobie, Julie; Abrams, Debra J.; Mentch, Frank D.; Glessner, Joseph T.; Guo, Yiran; Wei, Zhi; Connolly, John J.; Cardinale, Christopher J.; Bakay, Marina; Li, Dong; Maggadóttir, Sólrún Melkorka; Thomas, Kelly A.; Qui, Haijun; Chiavacci, Rosetta M.; Kim, Cecilia E.; Wang, Fengxiang; Snyder, James; Flatø, Berit; Førre, Øystein Thorleiv; Denson, Lee A.; Thompson, Susan D.; Becker, Mara L.; Guthery, Stephen L.; Latiano, Anna; Perez, Elena; Resnick, Elena; Strisciuglio, Caterina; Staiano, Annamaria; Miele, Erasmo; Silverberg, Mark S.; Lie, Benedicte Alexandra; Punaro, Marilynn; Russell, Richard K.; Wilson, David C.; Dubinsky, Marla C.; Monos, Dimitri S.; Annese, Vito; Munro, Jane E.; Wise, Carol; Chapel, Helen; Cunningham-Rundles, Charlotte; Orange, Jordan S.; Behrens, Edward M.; Sullivan, Kathleen E.; Kugathasan, Subra; Griffiths, Anne M.; Satsangi, Jack; Grant, Struan F.A.; Sleiman, Patrick M.A.; Finkel, Terri H.; Polychronakos, Constantin; Baldassano, Robert N.; Luning Prak, Eline T.; Ellis, Justine A.; Li, Hongzhe; Keating, Brendan J. & Hakonarson, Hakon (2015). Genetic sharing and heritability of paediatric age of onset autoimmune diseases. Nature Communications.  ISSN 2041-1723.  6:8442 . doi: 10.1038/ncomms9442
• Sanner, Helga; Schwartz, Thomas; Flatø, Berit; Vistnes, Reidun Maria; Christensen, Geir Arve & Sjaastad, Ivar (2014). Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage. PLOS ONE.  ISSN 1932-6203.  9(3) . doi: 10.1371/journal.pone.0092171
• Sanner, Helga; Sjaastad, Ivar & Flatø, Berit (2014). Disease activity and prognostic factors in juvenile dermatomyositis: A long-term follow-up study applying the Paediatric Rheumatology International Trials Organization criteria for inactive disease and the myositis disease activity assessment tool. Rheumatology.  ISSN 1462-0324.  53(9), s 1578- 1585 . doi: 10.1093/rheumatology/keu146
• Schwartz, Thomas; Sjaastad, Ivar; Flatø, Berit; Vistnes, Reidun Maria; Christensen, Geir Arve & Sanner, Helga (2014). In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with Cardiac dysfunction. Rheumatology (Sveits).  ISSN 0080-2727.  53, s 2214- 2222 . doi: 10.1093/rheumatology/keu256
• Schwartz, Thomas; Sanner, Helga; Gjesdal, Ola; Flatø, Berit & Sjaastad, Ivar (2013). In juvenile dermatomyositis cardiac systolic dysfunction is present after long-term follow-up, and is predicted by sustained early skin activity. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  73, s 1805- 1810 . doi: 10.1136/annrheumdis-2013-203279
• Eike, Morten Christoph; Skinningsrud, Beate; Ronninger, Marcus; Stormyr, Alice; Kvien, Tore Kristian; Joner, Geir; Njølstad, Pål Rasmus; Førre, Øystein Thorleiv; Flatø, Berit; Alfredsson, Lars; Padyukov, Leonid; Undlien, Dag Erik & Lie, Benedicte Alexandra (2012). CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations. Genes and Immunity.  ISSN 1466-4879.  13(5), s 431- 436 . doi: 10.1038/gene.2012.11 Show summary

  Expression of the major autoimmune risk loci DRB1 and DQB1 is regulated by the class II MHC (major histocompatibility complex) transactivator (CIITA), making the CIITA gene a strong autoimmune risk locus candidate. A CIITA promoter single-nucleotide polymorphism (SNP), rs3087456 (-168 A/G), has indeed been associated with several autoimmune diseases, including rheumatoid arthritis (RA). Recently, an intronic SNP rs8048002 has been suggested as a better susceptibility marker in Addison's disease. Therefore, we tested both SNPs in a panel of autoimmune diseases, consisting of Norwegian patients with RA (n=819), juvenile idiopathic arthritis (JIA; n=524), or type 1 diabetes (T1D; n=1211), and 2149 controls. We also included an independent Swedish RA cohort (n=2503) and controls (n=1416). Both rs3087456 and rs8048002 were significantly associated with RA (combined Norwegian and Swedish patients P(corrected)=0.012 and P(corrected)=0.0016, respectively), but not with JIA or T1D. Meta-analysis of 16 RA cohorts confirmed rs3087456 with only marginal significance (P=0.016). However, results were stronger in the Scandinavian subgroup (4 cohorts, P=3.8 × 10(-4)), indicating a population-dependent effect. A similar pattern was observed in a meta-analysis of rs8048002. Our results support involvement of CIITA in RA, but imply that this is population dependent and that the aetiological variant is yet to be discovered.

• Nordang, Gry Beate Namløs; Viken, Marte K; Amundsen, Svanstrøm Silja; Sanchez, Elena S.; Flatø, Berit; Førre, Øystein Thorleiv; Martin, Javier; Kvien, Tore Kristian & Lie, Benedicte Alexandra (2012). Interferon regulatory factor 5 gene polymorphism confers risk to several rheumatic diseases and correlates with expression of alternative thymic transcripts. Rheumatology.  ISSN 1462-0324.  51(4), s 619- 626 . doi: 10.1093/rheumatology/ker364
• Ruperto, Nicolino; Brunner, Hermine I; Quartier, Pierre; Constantin, Tamás; Wulffraat, Nico; Horneff, Gerd; Brik, Riva; McCann, Liza; Kasapcopur, Ozgur; Rutkowska-Sak, Lidia; Schneider, Rayfel; Berkun, Yackov; Calvo, Inmaculada; Erguven, Muferet; Goffin, Laurence; Hofer, Michael; Kallinich, Tilmann; Oliveira, Sheila; Uziel, Yosef; Viola, Stefania; Nistala, Kiran; Wouters, Carine; Cimaz, Rolando; Ferrandiz, Manuel A; Flatø, Berit; Gamir, Maria Luz; Kone-Paut, Isabelle; Grom, Alexei; Magnusson, Bo; Ozen, Seza; Sztajnbok, Flavio; Lheritier, Karine; Abrams, Ken; Kim, Dennis; Martini, Alberto & Lovell, Daniel J. (2012). Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis. New England Journal of Medicine.  ISSN 0028-4793.  367(25), s 2396- 2406 . doi: 10.1056/NEJMoa1205099
• Tollisen, Anita; Sanner, Helga; Flatø, Berit & Wahl, Astrid (2012). Quality of Life in Adults With Juvenile-Onset Dermatomyositis: A Case-Control Study. Arthritis Care and Research.  ISSN 0893-7524.  64(7), s 1020- 1027 . doi: 10.1002/acr.21637
• Kirkhus, Eva; Flatø, Berit; Riise, Øystein Rolandsen; Reiseter, Tor & Smith, Hans-Jørgen (2011). Differences in MRI findings between subgroups of recent-onset childhood arthritis. Pediatric Radiology.  ISSN 0301-0449.  41(4), s 432- 440 . doi: 10.1007/s00247-010-1897-y
• Sanner, Helga; Aaløkken, Trond Mogens; Gran, Jan Tore; Sjaastad, Ivar; Johansen, Bjørn & Flatø, Berit (2011). Pulmonary outcome in juvenile dermatomyositis: a case-control study. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  70(1), s 86- 91 . doi: 10.1136/ard.2010.131433
• Schwartz, Thomas; Sanner, Helga; Husebye, Trygve Guttorm; Flatø, Berit & Sjaastad, Ivar (2011). Cardiac dysfunction in juvenile dermatomyositis - a case control study. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  70(5), s 766- 771 . doi: 10.1136/ard.2010.137968
• Staalesen, Yndis; Nordvåg, Bjørn-Yngvar; Stanghelle, Johan K; Røisland, Mona; Winther, Anne; Pajunen, Pär-Arne; Garen, Torhild Oddveig & Flatø, Berit (2011). Efficacy of rehabilitation for patients with ankylosing spondylitis: Comparison of a four-week rehabilitation programme in a Mediterranean and a Norwegian setting. Journal of Rehabilitation Medicine.  ISSN 1650-1977.  43(6), s 534- 542 . doi: 10.2340/16501977-0804
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2010). Craniofacial growth disturbance is related to temporomandibular joint abnormality in patients with juvenile idiopathic arthritis, but normal facial profile was also found at the 27-year follow-up. Scandinavian Journal of Rheumatology.  ISSN 0300-9742.  39(5), s 373- 379 . doi: 10.3109/03009741003685624
• Arvidsson, Linda Zamoline; Smith, Hans-Jørgen; Flatø, Berit & Larheim, Tore Arne (2010). Temporomandibular Joint Findings in Adults with Long-standing Juvenile Idiopathic Arthritis: CT and MR Imaging Assessment. Radiology.  ISSN 0033-8419.  256(1), s 191- 200 . doi: 10.1148/radiol.10091810
• Fjeld, Morten; Arvidsson, Linda Zamoline; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2010). Relationship between disease course in the temporomandibular joints and mandibular growth rotation in patients with juvenile idiopathic arthritis followed from childhood to adulthood. Pediatric Rheumatology.  ISSN 1546-0096.  (8), s 13 . doi: 10.1186/1546-0096-8-13
• Lien, Gunhild; Ueland, Thor; Godang, Kristin; Selvaag, Anne Marit G; Førre, Øystein Thorleiv & Flatø, Berit (2010). Serum levels of osteoprotegerin and receptor activator of nuclear factor -kappa B ligand in children with early juvenile idiopathic arthritis: a 2-year prospective controlled study. Pediatric Rheumatology.  ISSN 1546-0096.  8 . doi: 10.1186/1546-0096-8-30
• Ruperto, Nicolino; Pistorio, Angela; Ravelli, Angelo; Rider, Lisa G.; Pilkington, Clarissa; Oliveira, Sheila; Wulffraat, Nico; Espada, Graciela; Garay, Stella; Cuttica, Ruben; Hofer, Michael; Quartier, Pierre; Melo-Gomes, Jose; Reed, Ann M.; Wierzbowska, Malgorzata; Feldman, Brian M.; Harjacek, Miroslav; Huppertz, Hans-Iko; Nielsen, Susan; Flatø, Berit; Lahdenne, Pekka; Michels, Harmut; Murray, Kevin J.; Punaro, Lynn; Rennebohm, Robert; Russo, Ricardo; Balogh, Zsolt; Rooney, Madeleine; Pachman, Lauren M.; Wallace, Carol; Hashkes, Philip; Lovell, Daniel J.; Giannini, Edward H.; Gare, Boel Andersson & Martini, Alberto (2010). The Paediatric Rheumatology International Trials Organisation Provisional Criteria for the Evaluation of Response to Therapy in Juvenile Dermatomyositis. Arthritis Care and Research.  ISSN 0893-7524.  62(11), s 1533- 1541 . doi: 10.1002/acr.20280
• Sanner, Helga; Aaløkken, Trond Mogens; Gran, Jan Tore; Sjaastad, Ivar; Johansen, Bjørn & Flatø, Berit (2010). Pulmonary outcome in juvenile dermatomyositis: a case-controll study. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  70, s 86- 91 . doi: 10.1136/ard.2010.131433
• Sanner, Helga; Kirkhus, Eva; Merckoll, Else; Tollisen, Anita; Røisland, Mona; Lie, Benedicte Alexandra; Taraldsrud, Eli; Gran, Jan Tore & Flatø, Berit (2010). Long-Term Muscular Outcome and Predisposing and Prognostic Factors in Juvenile Dermatomyositis: A Case-Control Study. Arthritis Care and Research.  ISSN 0893-7524.  62(8), s 1103- 1111 . doi: 10.1002/acr.20203
• Skinningsrud, Beate; Lie, Benedicte; Husebye, Eystein S; Kvien, Tore K; Førre, Øystein; Flatø, Berit; Stormyr, Alice; Joner, Geir; Njølstad, Pål R; Egeland, Thore & Undlien, Dag E. (2010). A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  69(8), s 1471- 1474 . doi: 10.1136/ard.2009.114934
• Østlie, Ingrid Landgraff; Johansson, Inger Signe; Aasland, Astrid; Flatø, Berit & Möller, Anders (2010). Self-rated physical and psychosocial health in a cohort of young adults with juvenile idiopathic arthritis. Scandinavian Journal of Rheumatology.  ISSN 0300-9742.  39(4), s 318- 325 . doi: 10.3109/03009740903505213 Show summary

  Objective: To explore self-rated physical and psychosocial health in a cohort of young adults with juvenile idiopathic arthritis (JIA) 18.3 years after symptom onset, make comparisons with population-based data, and illuminate possible predictors of self-rated health. Methods: Of a baseline cohort of 84 patients with JIA, 55 (65.5%) answered the self-administered questionnaires of the Health Assessment Questionnaire (HAQ), the Visual Analogue Scale (VAS) of pain, fatigue, and illness, the Medical Outcomes Study 36-item Short Form Health Survey (SF-36), and the General Health Questionnaire (GHQ-30). Telephone interviews were conducted with 51/55 patients. Population-based norm-data of SF-36 were used for comparison. Results: Significantly impaired physical health but no difference in psychosocial health was found as compared to the general Norwegian population. The level of education was significantly higher whereas no difference was found in employment status as compared to norm-data. Pain was a significant correlate of the education level. Predictors of physical impairment were physical disability and pain, whereas psychiatric distress and female sex were predictors of mental ill-health. Conclusion: Physical disability does not seem to have a negative influence on the patients? functioning psychosocially.

• Skinningsrud, Beate; Lie, Benedicte Alexandra; Husebye, Eystein; Kvien, TK; Førre, Øystein Thorleiv; Flatø, Berit; Stormyr, Alice; Joner, Geir; Njølstad, Pål R.; Egeland, Thore & Undlien, Dag Erik (2009). A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-CCP negative rheumatoid arthritis. Annals of the Rheumatic Diseases.  ISSN 0003-4967. . doi: 10.1136/ard.2009.114934
• Arvidsson, Linda Zamoline; Flatø, Berit & Larheim, Tore Arne (2009). Radiographic TMJ abnormalities in patients with juvenile idiopathic arthritis followed for 27 years. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics.  ISSN 1079-2104.  108(1), s 114- 123 . doi: 10.1016/j.tripleo.2009.03.012
• Flatø, Berit; Lien, Gunhild; Smerdel-Ramoya, A & Vinje, Odd (2009). Juvenile Psoriatic Arthritis: Longterm Outcome and Differentiation from Other Subtypes of Juvenile Idiopathic Arthritis. Journal of Rheumatology.  ISSN 0315-162X.  36(3), s 642- 650 . doi: 10.3899/jrheum.080543
• Sanner, Helga; Gran, Jan Tore; Sjaastad, Ivar & Flatø, Berit (2009). Cumulative organ damage and prognostic factors in juvenile dermatomyositis: a cross-sectional study median 16.8 years after symptom onset. Rheumatology.  ISSN 1462-0324.  48(12), s 1541- 1547 . doi: 10.1093/rheumatology/kep302
• Staalesen Strumse, Yndis A; Nordvåg, Bjørn-Yngvar; Stanghelle, Johan K; Røisland, Mona; Winther, Anne; Pär-Arne, Pajunen; Garen, Torhild & Flatø, Berit (2009). The efficacy of rehabilitation for patients with rheumatoid arthritis. A comparison between a four week rehabilitation programme in warm and cold climate. Scandinavian Journal of Rheumatology.  ISSN 0300-9742.  38(1), s 28- 37 . doi: 10.1080/03009740802304549 Show summary

  Abstract Objectives To investigate the long term effect (week 16) of a 4-week rehabilitation programme for patients with rheumatoid arthritis (RA), and to compare the effect of this intervention given in a Mediterranean or a Norwegian climate. Methods A randomised, controlled, parallel group design, where 124 RA patients applying for rehabilitation were randomized to a rehabilitation programme either in Norway or in a Mediterranean climate. The participants were examined clinically immediately before (week 0) and after (week 4) the rehabilitation period as well as in week 16 and answered a mailed questionnaire in week 28. The 28-Joint Disease Activity Score (DAS28), American College of Rheumatology (ACR) response and physical tests were used to measure clinical response. Results The baseline DAS28 value 4.45(1.16) was reduced by -0.95 (1.05) in the Mediterranean climate and the baseline DAS28 value 4.18 (1.17) was reduced by -0.37(0.92) in the Norwegian climate at week 16 (p=0.003). An ACR20 improvement was achieved in 25% of the patients treated in the Mediterranean climate and 15% of those treated in the Norwegian climate. Sustained improvement in all ACR core components at week 16 and in patient’s assessment of health status at week 28 was found in the patients treated in the Mediterranean climate only. Tests of physical function, the 6-Minute Walk Test (6MWT) and the Timed Up and Go (TUG) showed comparable improvements in patients treated in both climates. Conclusions RA patients have positive immediate effects on disease activity, physical function, and symptoms during a 4-week rehabilitation programme. The effects on disease activity and symptoms are larger and better maintained at least 3 months after rehabilitation in a warm than in a cold climate.

• Østlie, Ingrid Landgraff; Aasland, Astrid; Johansson, Inger Signe; Flatø, Berit & Möller, Anders (2009). A longitudinal follow-up study of physical and psychosocial health in young adults with chronic childhood arthritis. Clinical and Experimental Rheumatology.  ISSN 0392-856X.  27(6), s 1039- 1046 Show summary

  Objective: The aim was to describe physical and psychosocial health status in a second follow-up of a cohort of patients with chronic childhood arthritis, to compare results from the present study with the first follow-up, and to explore the course of physical and psychosocial functioning from baseline. Methods: At a median of 18.3 years after symptom onset 55 patients answered the self-administered questionnaires Health Assessment Questionnaire Disability Index (HAQ-DI), Visual Analogue Scales (VAS) of pain, fatigue and illness, and General Health Questionnaire (GHQ) 30-item version. Results from the current study were compared to first follow-up median 8.7 years after symptom onset, and the course of physical and psychosocial function from baseline was discussed. Results: At second follow-up, 38% reported HAQ-DI above 0 indicating physical disability, 22% had a GHQ-30 score in the clinical range indicating psychiatric distress, and fatigue seemed to be an overarching aspect of the health status. Pain was an important correlate of physical disability at first and second follow-up. At second follow-up psychiatric distress was a significant correlate of pain and fatigue, indicating a relation to disease severity. The association between psychosocial functioning and chronic family difficulties observed at first follow-up is not evident at second follow-up. Conclusions: The favourable physical and psychosocial outcome reported at first follow-up seems to persist. However, arthritis-related ill-health is still evident in a considerable proportion of the patients, indicating a constant impact of the disease on every-day life of the individual.

• Reikvam, A; Hexeberg, Sofie; Kvien, Tore K.; Slordal, L; Aabakken, Lars; Engebretsen, Lars; Flatø, Berit; Idsø, N; Johansen, Villy; Kalstad, Synnøve; Madsen, Steinar; Mikkelsen, Knut; Os, Ingrid & Ræder, Johan (2006). Klinisk bruk av COX-hemmere - en konsensus. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  126(5), s 591- 595
• Reikvam, Åsmund; Hexeberg, Sofie; Kvien, Tore Kristian; Slørdal, Lars; Aabakken, Lars; Engebretsen, Lars; Flatø, Berit; Idsø, Njål; Johnsen, Villy; Kalstad, Synnøve; Madsen, Steinar; Mikkelsen, Knut; Revmatismesykehuset, Lillehammer; Os, Ingrid & Ræder, Johan (2006). Klinisk bruk av COX-hemmere - en konsensus. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  126(5), s 591- 595
• Lien, Gunnhild; Selvaag, AM; Flatø, Berit; Haugen, Margaretha & Førre, Ø (2005). O A two-year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis. Arthritis and Rheumatism.  ISSN 0004-3591.  52(3), s 833- 840
• Lilleby, Vibke; Lien, Gunnhild; Frøsli, Katrine; Haugen, Margaretha; Flatø, Berit & Førre, Ø (2005). Frequency of osteopenia in children and young adults with childhood-onset systemic lupus erythematosus. Arthritis and Rheumatism.  ISSN 0004-3591.  52(7), s 2051- 2059

View all works in Cristin

• Tollisen, Anita; Selvaag, Anne Marit; Ingebrigtsen, Trude Miljeteig; Aasland, Astrid; Lerdal, Anners & Flatø, Berit (2018). Treatment satisfaction in patients with juvenile idiopathic arthritis.
• Hetlevik, Siri Opsahl; Aaløkken, Trond Mogens; Lund, M B; Flatø, Berit; Nordal, Ellen Berit; Rygg, Marite & Lilleby, Vibke (2017). Pulmonary manifestations in juvenile onset mixed connective tissue disease after longterm disease duration – a Norwegian case-control study..
• Barth, Zoltan; Witzcak, Birgit; Schwartz, Thomas; Gjesdal, Knut; Flatø, Berit; Koller, A'kos; Sanner, Helga & Sjaastad, Ivar (2015). Heart rate variability is related to inflammation and cardiac function in juvenile dermatomyositis.
• Barth, Zoltan; Witzcak, Birgit; Schwartz, Thomas; Gjesdal, Knut; Flatø, Berit; Koller, A'kos; Sjaastad, Ivar & Sanner, Helga (2015). Heart rate variability is related to inflammation and cardiac function in juvenile dermatomyositis.
• Hetlevik, Siri Opsahl; Flatø, Berit; Nordal, Ellen Berit; Rygg, Marite & Lilleby, Vibke (2015). Long term outcome and clinical characteristics in childhood-onset mixed connective tissue disease – a Norwegian nationwide study. Annual European Congress of Rheumatology, Fiera di Roma, Rome, Italy, 10 - 13 June 2015. Annals of the Rheumatic Diseases.  ISSN 0003-4967.  74, s 184 . doi: 10.1136
• Johnsson, Anders Carl G.; Flatø, Berit; Knudsen, Per Kristian & Lilleby, Vibke (2015). Clinical outcome in a Norwegian cohort of patients with chronic recurrent multifocal osteomyelitis. Scandinavian Journal of Rheumatology.  ISSN 0300-9742.  44(6), s 513- 514 . doi: 10.3109/03009742.2015.1055514
• Tollisen, Anita; Selvaag, Anne Marit; Aulie, Hanne Aaserud; Lerdal, Anners & Flatø, Berit (2015). Health Related Quality of Life in Adults with JIA - a 30 Year Longitudinal Study.
• Witzcak, Birgit; Godang, Kristin; Schwartz, Thomas; Flatø, Berit; Bollerslev, Jens; Sjaastad, Ivar & Sanner, Helga (2015). In adults with juvenile onset dermatomyositis, visceral adipose tissue is increased compared with controls, and is associated with serum lipids.
• Lilleby, Vibke; Haydon, Joanna; Sanner, Helga; Krossness, B.K.; Ringstad, Geir Andre & Flatø, Berit (2014). Severe macrophage activation syndrome and central nervous system involvement in juvenile dermatomyositis. Scandinavian Journal of Rheumatology.  ISSN 0300-9742.  43(2), s 171- 173 . doi: 10.3109/03009742.2013.863968
• Aulie, Hanne Aaserud; Selvaag, Anne Marit G; Lilleby, Vibke; Molberg, Øyvind; Hartmann, Anders; Holdaas, Hallvard & Flatø, Berit (2013). Increased Pulse Wave Velocity In Juvenile Idiopathic Arthritis Patients Compared To Controls From The General Population. Arthritis and Rheumatism.  ISSN 0004-3591.  65, s S1142- S1142
• Selvaag, Anne Marit G; Aulie, Hanne Aaserud; Lilleby, Vibke & Flatø, Berit (2013). Disease Progression Into Adulthood In Patients With Juvenile Idiopathic Arthritis - a Longitudinal 30 Year Follow-Up Study. Arthritis and Rheumatism.  ISSN 0004-3591.  65, s S1142- S1143
• Schwartz, Thomas; Sjaastad, Ivar; Flatø, Berit; Vistnes, Reidun Maria; Christensen, Geir Arve & Sanner, Helga (2012). Monocyte Chemoattractant Protein-1 and Eotaxin Are Associated with Parameters of Cardiac Dysfunction in Juvenile Dermatomyositis. Arthritis and Rheumatism.  ISSN 0004-3591.  64(10), s S381- S381
• Stray-Pedersen, Asbjørg; Sorte, Hanne Sørmo; Rødningen, Olaug Kristin; Lyle, Robert; Gonzaga-Jauregui, C G; Hanson, C I; Noroski, L M; Nicholas, S.; Erichsen, Hans Christian; Abrahamsen, Tore G; Flatø, Berit; Osnes, Liv T. N.; Heimdal, Ketil Riddervold; Undlien, Dag Erik; Lupski, J.R & Shearer, W T (2012). THE UTILITY OF EXOME SEQUENCING IN PRIMARY IMMUNODEFICIENCY DISEASES AND IMMUNODYSREGULATIVE DISORDERS. Journal of Clinical Immunology.  ISSN 0271-9142.  32(Supp. 1), s 184- 185
• Sanner, Helga & Flatø, Berit (2011). Outcomes and prognostic factors in juvenile dermatomyositis. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. 1064.
• Schwartz, Thomas; Sanner, Helga; Husebye, EE; Flatø, Berit & Sjaastad, Ivar (2011). Cardiac dysfunction in juvenile dermatomyositis - a case control study.
• Schwartz, Thomas; Sanner, Helga; Vistnes, Reidun Maria; Christensen, Geir Arve; Flatø, Berit & Sjaastad, Ivar (2011). Increased levels of MCP-1 and eotaxin are associated with cardiac dysfunction in juvenile dermatomyositis.
• Staalesen, Yndis & Flatø, Berit (2011). The efficacy of rehabilitation in warm and cold climates for patients with rheumatic and neurological diseases : three randomised controlled studies. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. 1127.
• Tollisen, Anita; Sanner, Helga; Flatø, Berit & Wahl, Astrid Klopstad (2011). Health-related Quality of Life in Adults with Juvenile Dermatomyositis. Clinical and Experimental Rheumatology.  ISSN 0392-856X.  29(2), s 389- 389
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2010). Relationship between disease course in the temporomandibular joints and mandibular growth rotation in patients with juvenile idiopathic arthritis followed from childhood to adulthood.
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2009). Associations between CT and MRI assessments of the temporomandibular joint and craniofacial growth disturbances: a 27 year follow-up of patients with juvenile idiopathic arthritis.
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2009). Temporomandibular joint involvement and craniofacial morphology in 60 adult patients with juvenile idiopathic arthritis.
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2009). Temporomandibular joint involvement and craniofacial morphology in 60 adult patients with juvenile idiopathic arthritis.
• Arvidsson, Linda Zamoline; Flatø, Berit; Vinje, Odd & Larheim, Tore Arne (2007). A longitudinal TMJ study of JIA and healthy controls.
• Arvidsson, Linda Zamoline; Smith, Hans-Jørgen; Flatø, Berit; Vinje, Odd & Larheim, Tore Arne (2005). TMJ abnormalities in juvenile arthritis: 25 years follow-up.

View all works in Cristin