Geir Hetland

Professor II - Department of Immunology
Image of Geir Hetland
Norwegian version of this page
Phone +47 22118878
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 4950 Nydalen 0424 OSLO

Publications

  • Fagerhol, Magne Kristoffer; Johnson, Egil; Tangen, Jon-Magnus; Hollan, Ivana; Mirlashari, Mohammad Reza; Nissen-Meyer, Lise Sofie Haug & Hetland, Geir (2020). NETs Analyzed by Novel Calprotectin-Based Assays in Blood Donors, and Patients With Multiple Myeloma or Rheumatoid Arthritis. A Pilot Study. Scandinavian Journal of Immunology.  ISSN 0300-9475.  91(5), s 1- 5 . doi: 10.1111/sji.12870 Full text in Research Archive. Show summary
  • Hetland, Geir; Tangen, Jon-Magnus; Mahmood, Faiza; Mirlashari, Mohammad Reza; Nissen-Meyer, Lise Sofie Haug; Nentwich, Ivo; Therkelsen, Stig Palm; Tjønnfjord, Geir Erland & Johnson, Egil (2020). Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies. Nutrients.  ISSN 2072-6643.  12(5) . doi: https://doi.org/10.3390/nu12051339 Full text in Research Archive.
  • Mahmood, Faiza; Hetland, Geir; Nentwich, Ivo; Mirlashari, Mohammad Reza; Ghiasvand, Reza & Nissen-Meyer, Lise Sofie Haug (2019). Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial. Nutrients.  ISSN 2072-6643.  11(10), s 1- 15 . doi: 10.3390/nu11102339 Full text in Research Archive.
  • Johnson, Egil; Therkelsen, Stig Palm; Nentwich, Ivo; Nissen-Meyer, Lise Sofie Haug & Hetland, Geir (2019). IgE-sensitization to food and inhalant allergens in IBD patients compared with normal blood donors at Oslo University Hospital, Norway. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  54(9), s 1107- 1110 . doi: 10.1080/00365521.2019.1663445
  • Tangen, Jon-Magnus; Holien, Toril; Mirlashari, Mohammad Reza; Misund, Kristine & Hetland, Geir (2017). Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™. BioMed Research International.  ISSN 2314-6133.  2017 . doi: 10.1155/2017/2059825 Full text in Research Archive.
  • Hetland, Geir; Eide, Dag Markus; Tangen, Jon-Magnus; Haugen, Mads Haugland; Mirlashari, Mohammad Reza & Paulsen, Jan Erik (2016). The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. PLOS ONE.  ISSN 1932-6203.  11(12) . doi: 10.1371/journal.pone.0167754 Full text in Research Archive.
  • Therkelsen, Stig Palm; Hetland, Geir; Lyberg, Torstein; Lygren, Idar & Johnson, Egil (2016). Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™ , in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study.. Scandinavian Journal of Immunology.  ISSN 0300-9475.  84(6), s 323- 331 . doi: 10.1111/sji.12476
  • Therkelsen, Stig Palm; Hetland, Geir; Lyberg, Torstein; Lygren, Idar & Johnson, Egil (2016). Effect of a medicinal agaricus blazei murill- based mushroom extract, andosan™, on symptoms, fatigue and quality of life in patients with ulcerative colitis in a randomized single-blinded placebo controlled study. PLOS ONE.  ISSN 1932-6203.  11(3) . doi: 10.1371/journal.pone.0150191 Full text in Research Archive.
  • Therkelsen, Stig Palm; Hetland, Geir; Lyberg, Torstein; Lygren, Idar & Johnson, Egil (2016). Effect of the medicinal agaricus blazei murill-based mushroom extract, andosantm, on symptoms, fatigue and quality of life in patients with Crohn's disease in a randomized single-blinded placebo controlled study. PLOS ONE.  ISSN 1932-6203.  11:e0159288(7) . doi: 10.1371/journal.pone.0159288 Full text in Research Archive.
  • Berven, Lise; Karppinen, Pernille Kristensen; Hetland, Geir & Samuelsen, Anne Berit C. (2015). The polar high molecular weight fraction of the agaricus blazei murill extract, andosan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells. Journal of Medicinal Food.  ISSN 1096-620X.  18(4), s 429- 438 . doi: 10.1089/jmf.2014.0018
  • Tangen, Jon-Magnus; Tierens, Anne; Caers, Jo; Binsfeld, Marilene; Olstad, Ole Kristoffer; Siebke, Anne-Marie; Wang, Junbai; Tjønnfjord, Geir Erland & Hetland, Geir (2015). Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study. BioMed Research International.  ISSN 2314-6133. . doi: 10.1155/2015/718539
  • Therkelsen, Stig Palm; Hetland, Geir; Johnson, Egil & Nentwich, Ivo (2015). AndosanTM-an anti-allergic and anti-inflammatory ingredint prepared from Agaricus blazei Mushroom. Journal of Clinical & Cellular Immunology.  ISSN 2155-9899.  6(2), s 1-10 . doi: 10.4172/2155-9899.1000320
  • Hetland, Geir; Tangen, Jon-Magnus & Tryggestad, Anne Merete Aaland (2014). Stimulation of human monocytic cells by the medicinal mushroom Agaricus blazei Murill induces expression of cell surface markers associated with activation and antigen presentation. Applied Scientific Reports.  ISSN 2054-9903. . doi: 10.7243/2054-9903-1-1
  • Hetland, Geir; Johnson, Egil; Eide, Dag Markus; Grinde, Bjørn; Samuelsen, Anne Berit C. & Wiker, Harald G (2013). Antimicrobial effects of beta-glucans and pectin and of the Agaricus blazei-based mushroom extract, AndoSanTM. Examples of mouse models for pneumococcal-, fecal bacterial-, and mycobacterial infections, In A. Mendez-Vilas (ed.),  Microbial pathogens and strategies for combating them: science, technology and education.  Formatex Research Center.  ISBN 978-84-942134-0-3.  Vol.2.  s 889 - 898 Full text in Research Archive.
  • Hetland, Geir; Tryggestad, Anne Merete Aaland; Espevik, Terje & Ryan, Liv (2013). The medicinal mushroom Agaricus blazei Murill promotes NF-B activation via stimulation of TLR2 and inhibits its activation via TLR4. Journal of Pharmaceutical and Biomedical Sciences.  ISSN 2230-7885.  29, s 753- 761
  • Johnson, Egil; Førland, Dag T.; Hetland, Geir; Sætre, Karin Lisbeth; Olstad, Ole Kristoffer & Lyberg, Torstein (2012). Effect of AndoSan (TM) on expression of adhesion molecules and production of reactive oxygen species in human monocytes and granulocytes in vivo. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  47(8-9), s 984- 992 . doi: 10.3109/00365521.2012.660544
  • Førland, Dag T.; Johnson, Egil; Sætre, Karin Lisbeth; Lyberg, Torstein; Lygren, Idar & Hetland, Geir (2011). Effect of an Extract Based on the Medicinal Mushroom Agaricus blazei Murill on Expression of Cytokines and Calprotectin in Patients with Ulcerative Colitis and Crohn's disease. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(1), s 66- 75 . doi: 10.1111/j.1365-3083.2010.02477.x
  • Hetland, Geir; Johnson, Egil; Lyberg, Torstein & Kvalheim, Gunnar (2011). The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation. Advances in Pharmacological Sciences.  ISSN 1687-6334. . doi: 10.1155/2011/157015
  • Bertelsen, Randi Jacobsen; Instanes, Christine; Granum, Berit; Carlsen, Karin C. Lødrup; Hetland, Geir; Carlsen, Kai-Håkon; Mowinckel, Petter & Løvik, Martinus (2010). Gender differences in indoor allergen exposure and association with current rhinitis. Clinical and Experimental Allergy.  ISSN 0954-7894.  40(9), s 1388- 1397 . doi: 10.1111/j.1365-2222.2010.03543.x
  • Førland, Dag T.; Johnson, Egil; Tryggestad, Anne Merete Aaland; Lyberg, Torstein & Hetland, Geir (2010). An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vitro. Cytokine.  ISSN 1043-4666.  49(3), s 245- 250 . doi: 10.1016/j.cyto.2009.09.002
  • Ellertsen, Linda Kathrine & Hetland, Geir (2009). An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. Clinical and Molecular Allergy.  ISSN 1476-7961.  7 . doi: 10.1186/1476-7961-7-6
  • Ellertsen, Linda Kathrine; Storla, Dag G; Diep, Lien M; Brokstad, Karl A; Wiker, Harald G & Hetland, Geir (2009). Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy. BMC Infectious Diseases.  ISSN 1471-2334.  9 . doi: 10.1186/1471-2334-9-100
  • Johnson, Egil; Førland, Dag T.; Sætre, Lisbeth; Bernardshaw, S; Lyberg, Torstein & Hetland, Geir (2009). Effect of an Extract Based on the Medicinal Mushroom Agaricus blazei Murill on Release of Cytokines, Chemokines and Leukocyte Growth Factors in Human Blood Ex Vivo and In Vivo. Scandinavian Journal of Immunology.  ISSN 0300-9475.  69(3), s 242- 250 . doi: 10.1111/j.1365-3083.2008.02218.x
  • Ellertsen, Linda Kathrine; Hetland, Geir & Løvik, Martinus (2008). Specific IgE to respiratory allergens and IgG antibodies to Toxoplasma gondii and Streptococcus pneumoniae in norwegian military recruits. Scandinavian Journal of Immunology.  ISSN 0300-9475.  67(5), s 496- 500 . doi: 10.1111/j.1365-3083.2008.02090.x
  • Hetland, Geir; Johnson, Egil; Lyberg, T; Bernardshaw, S; Tryggestad, AMA & Grinde, Bjørn (2008). Effects of the medicinal mushroom Agaricus blazei murill on immunity, infection and cancer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 363- 370 . doi: 10.1111/j.1365-3083.2008.02156.x
  • Hetland, Geir; Johnson, Egil; Lyberg, Torstein; Bernardshaw, Soosaipillai; Tryggestad, AMA & Grinde, Bjørn (2008). Effects of the Medicinal Mushroom Agaricus blazei Mutill on Immunity, Infection and Cancer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 363- 370 . doi: 10.1111/j.1365-3083.2008.02156.x
  • Rydjord, Britt; Haanes, Jan Vilis; Strømsnes, Hege; Granum, Berit; Bolle, Roald; Nystad, Wenche & Hetland, Geir (2008). Mould-specific immunoglobulin antibodies quantified by flow cytometry reflect mould exposure in Norwegian children. Clinical and Experimental Allergy.  ISSN 0954-7894.  38(3), s 430- 437 . doi: 10.1111/j.1365-2222.2007.02905.x
  • Rydjord, Britt; Namork, Ellen; Nygaard, Unni Cecilie; Wiker, Harald G. & Hetland, Geir (2007). Quantification and characterisation of IgG binding to mould spores by flow cytometry and scanning electron microscopy. JIM - Journal of Immunological Methods.  ISSN 0022-1759.  323(2), s 123- 131 . doi: 10.1016/j.jim.2007.04.001
  • Bernardshaw, Soosaipillai; Hetland, Geir; Grinde, Bjørn & Johnson, Egil (2006). An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model of fecal peritonitis. Shock.  ISSN 1073-2322.  25(4), s 420- 425 . doi: 10.1097/01.shk.0000209526.58614.92
  • Ellertsen, Linda Kathrine; Hetland, Geir; Johnson, E. & Grinde, Bjørn (2006). Effect of a medicinal extract from Agaricus blazei Murill on gene expression in a human monocyte cell line as examined by microarrays and immuno assays. International Immunopharmacology.  ISSN 1567-5769.  6(2), s 133- 143 . doi: 10.1016/j.intimp.2005.07.007 Show summary
  • Grinde, Bjørn; Hetland, G. & Johnson, E. (2006). Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection. International Immunopharmacology.  ISSN 1567-5769.  6(8), s 1311- 1314 . doi: 10.1016/j.intimp.2006.04.005 Show summary
  • Ellertsen, Linda Katrine; Wiker, Harald G; Egeberg, NT & Hetland, Geir (2005). Allergic sensitization in tuberculosis and leprosy patients. International Archives of Allergy and Immunology.  ISSN 1018-2438.  138(3), s 217- 224 . doi: 10.1159/000088722 Show summary
  • Rydjord, Britt; Hetland, Geir & Wiker, Harald G (2005). Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. Scandinavian Journal of Immunology.  ISSN 0300-9475.  62(3), s 281- 288 Show summary
  • Instanes, Christine; Hetland, Geir; Berntsen, Sveinung; Løvik, Martinus & Nafstad, Per (2005). Allergens and endotoxin in settled dust from day-care centers and schools in Oslo, Norway. Indoor Air: International Journal of Indoor Environment and Health.  ISSN 0905-6947.  15(5), s 356- 362 . doi: 10.1111/j.1600-0668.2005.00381.x Show summary
  • Hetland, Geir; Granum, Berit; Groeng, Else-Carin & Løvik, Martinus (2001). Leptin does not influence the IgE response to ovalbumin in mice. Clinical Immunology.  ISSN 1521-6616.  101(1), s 8- 11
  • Hetland, G.; Samuelsen, A.B; Løvik, M.; Paulsen, B.S; Aaberge, Ingeborg Aase S.; Groeng, E.C & Michaelsen, Terje Einar (2000). Protective effect of Plantago major L. Pectin polysaccharide against systemic Streptococcus pneumoniae infection in mice. Scandinavian Journal of Immunology.  ISSN 0300-9475.  52(4), s 348- 355
  • Hetland, Geir; Ohno, N; Aaberge, Ingeborg Aase S. & Løvik, Martinus (2000). Protective effect of beta-glucan against systemic Streptococcus pneumoniae infection in mice. FEMS Immunology and Medical Microbiology.  ISSN 0928-8244.  27(2), s 111- 116
  • Ormstad, Heidi; Groeng, Else-Carin; Løvik, Martinus & Hetland, Geir (2000). The fungal cell wall component -1,3-glucan has an adjuvant effect on the allergic response to ovalbumin in mice. Journal of Toxicology and Environmental Health, Part A.  ISSN 1528-7394.  61, s 55- 67 . doi: 10.1080/00984100050116780

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  • Hetland, Geir; Biedron, Rafal; Hetland, Aleksander & Badmaev, Vladimir (2014). SanTM: An Optimal Biological Response Modifier and Health Promoting Ingredient Prepared from Agaricus blazei Mushroom. Nova Science Publishers, Inc..  ISBN 978-1-63117-130-7.  71 s.

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  • Hetland, Geir (2014). An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. Show summary
  • Hetland, Geir (2014). Kan den immunmodulerende soppen Agaricus blazei brukes mot multi-resistente infeksjoner?.
  • Hetland, Geir; Tangen, Jon-Magnus; Tierens, Anne; Kvalheim, Gunnar; Osnes, Liv T. N. & Tjønnfjord, Geir Erland (2013). The Agaricus blazei-based mushroom extract, AndosanTM,has immuno-suppressive and anti-inflammatory effects when used as supplement to multiple myeloma patients receiving high-dose chemotherapy and autologous bone marrow transplantation.
  • Hetland, Geir; Tangen, Jon-Magnus; Tryggestad, Anne Merete Aaland; Dyrhaug, Marianne & Kvalheim, Gunnar (2013). THE MEDICINAL MUSHROOM AGARICUS BLAZEI MURILL ACTIVATES NF-kappa B VIA TLR2 IN MONOCYTIC CELLS, INDUCES EXPANSION OF CD56+BUT NOT OTHER HSC, AND ACTIVATION OF HUMAN MONOCYTE-DERIVED DC IN VITRO. Cytotherapy.  ISSN 1465-3249.  15(4), s S36- S36
  • Hetland, Geir; Tangen, Jon-Magnus; Tryggestad, Anne Merete Aaland; Dyrhaug, Marianne & Kvalheim, Gunnar (2013). The medicinal mushroom Agaricus blazei Murill activates NF-KB via TLR2 in monocytic cells, activates MDDC and induces expansion of CD56+HSC but not other progenitor HSC in vitro. Bone Marrow Transplantation.  ISSN 0268-3369.  48, s S521- S521
  • Josefsen, Dag; Hetland, Geir; Blystad, Anne Kirsti; Fløisand, Yngvar & Kvalheim, Gunnar (2013). Successful use of plerixafor in hard to mobilize patients: following high dose therapy all patients developed fast and sustained engraftment with durable clinical responses. Bone Marrow Transplantation.  ISSN 0268-3369.  48, s S522- S522
  • Josefsen, Dag; Hetland, Geir; Blystad, Astrid; Fløisand, Yngvar & Kvalheim, Gunnar (2013). SUCCESSFUL USE OF PLERIXAFOR IN HARD TO MOBILIZE PATIENTS - FOLLOWING HIGH DOSE THERAPY ALL PATIENTS DEVELOPED FAST AND SUSTAINED ENGRAFTMENT WITH DURABLE CLINICAL RESPONSES. Cytotherapy.  ISSN 1465-3249.  15(4), s S24- S24
  • Josefsen, Dag; Hetland, Geir; Fløisand, Yngvar; Holte, Harald & Kvalheim, Gunnar (2013). The use of Plerixafor in hard-to-mobilize lymphoma and multiple myeloma patients not only provide sufficient numbers of Pbpcs to proceed to high dose therapy, but also have a positive impact on survival.
  • Josefsen, Dag; Hetland, Geir; Fløisand, Yngvar; Holte, Harald & Kvalheim, Gunnar (2013). The use of Plerixafor in hard-to-mobilize lymphoma and multiple myeloma patients not only provide sufficient numbers of Pbpcs to proceed to high dose therapy, but also have a positive impact on survival. Blood.  ISSN 0006-4971.
  • Josefsen, Dag; Hetland, Geir; Holte, Harald & Kvalheim, Gunnar (2012). Up-front use of plerixafor combined with chemotherapy and G-CSF in hard-to-mobilise lymphoma patients gives a satisfactory yield of CD34 cells within 1-2 days of apheresis and shows a sustained engraftment following high-dose therapy. Bone Marrow Transplantation.  ISSN 0268-3369.  47, s S238- S239
  • Hetland, Geir; Tryggestad, Anne Merete Aaland; Espevik, Terje; Ryan, Liv; Tangen, Jon-Magnus; Johnson, Egil & Kvalheim, Gunnar (2010). The Medicinal and Antitumor Mushroom, Agaricus Blazei Murill, Activates NF-kappa B Via TLR2 but Not TLR4 In Monocytic Cells, and Stimulates Monocyte-Derived Dendritic Cells (MDDC) to Increased Cell Surface Marker Expression and Cytokine Production, and May Thus Have Adjuvant Effect In MDDC Cancer Vaccines. Blood.  ISSN 0006-4971.  116(21), s 1594- 1594
  • Hetland, Geir; Tryggestad, Anne Merete Aaland; Espevik, Terje; Ryan, Liv; Tangen, Jon-Magnus; Johnson, Egil & Kvalheim, Gunnar (2010). The medicinal and antitumour mushroom, agaricus blazei murill, activates NF-KB via TLR2 in monocytic cells and induces expression of cell surface markers and production of cytokines in human monocyte-derived dendritic cells (MDDC) in vitro. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 65- 65
  • Ellertsen, Linda Kathrine & Hetland, Geir (2009). The relationship between allergy and microbial exposure. Epidemiological and experimental studies. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. No.846.
  • Førland, Dag T.; Hetland, Geir; Lyberg, Torstein; Sætre, Lisbeth; Lygren, Idar & Johnson, Egil (2009). Oral intake of an extract based on the medicinal mushroom agaricus blazei murill alters levels of fecal calprotectin and pro-inflammatory cytokines in patients with ulcerative colitis and crohn’s disease.
  • Førland, Dag T.; Johnson, Egil; Tryggestad, Anne Merete; Lyberg, Torstein & Hetland, Geir (2009). The edible mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells (MDDC) to cytokine production in vitro.
  • Rydjord, Britt & Hetland, Geir (2008). Mould-specific IgG antibodies, mould exposure and airway symptoms. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. No.654.
  • Hetland, G.; Rydjord, Britt; Svenningsen, V. & Wiker, H. G. (2006). Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. Vox Sanguinis.  ISSN 0042-9007.  91, s 73- 73
  • Vegarud, Gerd; Devold, Tove Gulbrandsen; Hetland, Geir & Jonassen, Christine (2006). Geitmelk, hoppemeløk og helseeffekter. Show summary

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Published Dec. 16, 2013 2:52 PM - Last modified June 4, 2014 10:33 AM