Academic interests
- Anaesthetic pharmacology
- Pain medicine
- Pharmacoepidemiology
Teaching
- Anaesthesia, intensive care medicine, and emergency medicine in the following courses:
Background
- 2021: Specialist clinical pharmacologist
- 2018: Specialist anaesthetist
- 2009: Medical graduate
Tags:
Anestesiologi,
Farmakologi
Publications
-
-
Torp, Henrik Andreas & Laake, Jon Henrik
(2026).
Legemiddelassosiert akutt nyreskade hos kritisk syke pasienter.
Tidsskrift for Den norske legeforening (Tidsskriftet).
ISSN 0029-2001.
146(1),
p. 46–49.
doi:
10.4045/tidsskr.25.0410.
Full text in Research Archive
-
Torp, Henrik Andreas; Skurtveit, Svetlana Ondrasova; Gustavsen, Ingebjørg G.; Gran, Jon Michael & Rosseland, Leiv Arne
(2024).
Post-injury use of opioid analgesics in patients with traumatic injury: A registry-based study.
European Journal of Pain.
ISSN 1090-3801.
29(3).
doi:
10.1002/ejp.4743.
Full text in Research Archive
Show summary
Background Opioid analgesics are commonly used to treat acute and chronic pain following traumatic injury. Psychiatric comorbidity has been reported to be associated with increased pain and persistent opioid use. Our aims were to determine the extent of post-injury opioid use and assess whether pre-injury antidepressant, benzodiazepine, and z-hypnotic drug use is associated with increased post-injury opioid use. Methods Data on trauma patients aged 15 years and older included in the Oslo University Hospital Trauma Registry between 2005 and 2014 was linked to data from the Norwegian Prescription Database. We identified opioid dispensing within the first 90 and 365 days following trauma and determined subsequent persistent use. Multivariable logistic regression was applied to examine associations between pre- and post-injury drug use. Results 3912 of 11,057 patients (35.4%) had opioids dispensed within 90 days after trauma, and 4644 (42.0%) within 365 days. Among 9800 previously opioid-naïve, the proportions were 33.0% and 39.0%, respectively. One year after the first post-injury opioid dispensing, 9.6% of all opioid users and 4.5% of new users were defined as persistent users. Pre-injury benzodiazepine use and z-hypnotic use was associated with new persistent opioid use (adjusted odds ratio [aOR] 2.25; 95% confidence interval [CI] 1.47–3.45, and aOR 2.04; 95% CI 1.33–3.13, respectively), whereas pre-injury antidepressant use was not (aOR 1.49; 95% CI 0.97–2.30). Conclusions Opioid use after trauma is widespread. Development of persistent use is limited, particularly in previously opioid-naïve patients. Pre-injury benzodiazepine or z-hypnotic use seem to increase odds of new persistent use. Significance statement This large registry-based study adds to the body of knowledge on opioid use beyond in-hospital care in patients having sustained traumatic injury, a field which is scarcely investigated and not yet fully understood. It suggests that both previous drug therapy and the nature of opioid treatment initiation may affect outcome. This will help guide clinicians in selecting the appropriate pain management in this patient group.
-
Torp, Henrik Andreas; Skurtveit, Svetlana Ondrasova; Skaga, Nils Oddvar; Gustavsen, Ingebjørg; Gran, Jon Michael & Rosseland, Leiv Arne
(2021).
Pre-injury dispensing of psychoactive prescription drugs in a ten years trauma population: a retrospective registry analysis.
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.
29(1).
doi:
10.1186/s13049-021-00939-6.
Full text in Research Archive
-
Kvam, Ann Kristin; Torp, Henrik Andreas & Iversen, Per Ole
(2021).
Life-Threatening Acute Chest Syndrome in a
Patient With Sickle Cell Disease After Switching
From Hydroxyurea Therapy to Partial Exchange
Transfusions: A Case Report.
Cureus - Journal of Medical Science.
13(12).
doi:
10.7759/cureus.20236.
Full text in Research Archive
Show summary
Acute chest syndrome (ACS) is a severe form of vaso-occlusive crisis, which is a main feature of sickle cell disease (SCD), an inherited hemoglobinopathy. Traditionally, hydroxyurea has been the treatment of choice for SCD to prevent vaso-occlusive crises including ACS. However, hydroxyurea may be contraindicated, for example, in patients wanting to have children. We here present a young male with SCD who wanted to become a father and developed a life-threatening episode of ACS following discontinuation of hydroxyurea and switching to partial exchange blood transfusions. The patient, aged 32 years and originally from Bahrain, had been diagnosed with homozygous SCD, alpha-thalassemia, and glucose-6-phosphate dehydrogenase deficiency as a child. He had an episode of ACS with moderate severity in 2008, after which he started using hydroxyurea. From 2008 until the present, he did not experience any episodes of ACS. About six months before the present episode, he stopped using hydroxyurea and switched to partial exchange transfusions, aiming to keep hemoglobin S (HbS) below 30%. The interval between the transfusions was typically about seven to eight weeks. On the evening (day 1) before hospital admission, he developed typical symptoms and signs of vaso-occlusive crisis, and during the first day in the hospital (HbS about 55%), his pulmonary function deteriorated, and he also developed cerebral symptoms (somnolence and confusion). On suspicion of ACS, a full blood exchange transfusion was administered on day 3. He then gradually recovered clinically, and his laboratory values also normalized. He was discharged on day 10. Subsequent follow-up visits at the outpatient clinic the following month were unremarkable. Possibly, this severe episode of ACS was triggered by switching from hydroxyurea therapy to partial exchange transfusions with too long intervals between the transfusions. This novel case is a compelling reminder of the possible perils that may accompany the discontinuation of hydroxyurea, the best-documented therapy in SCD.
-
Torp, Henrik Andreas; Skurtveit, Svetlana Ondrasova; Skaga, Nils Oddvar; Gustavsen, Ingebjørg G.; Gran, Jon Michael & Rosseland, Leiv Arne
(2021).
Pre-injury dispensing of psychoactive prescription drugs in a ten years trauma population: a retrospective registry analysis.
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.
29.
doi:
10.1186/s13049-021-00939-6.
Full text in Research Archive
Show summary
Background The use of psychoactive prescription drugs is associated with increased risk of traumatic injury, and has negative impact on clinical outcome in trauma patients. Previous studies have focused on specific drugs or subgroups of patients. Our aim was to examine the extent of psychoactive drug dispensing prior to injury in a comprehensive population of trauma patients. Methods The Oslo University Hospital Trauma Registry provided data on all trauma patients admitted to the trauma centre between 2005 and 2014. We linked the data to Norwegian Prescription Database data from 2004. Opioids, benzodiazepines, z-hypnotics, gabapentinoids, and centrally acting sympathomimetics dispensed during the year before trauma of each patient were identified. We determined the pre-trauma annual prevalence of dispensing and mean annual cumulative defined daily doses (DDD) for each drug class, and compared results with corresponding figures in the general population, using standardised ratios. For each drug class, dispensing 14 days preceding trauma was analysed in patients sustaining severe injury and compared with patients sustaining non-severe injury. Results 12,713 patients (71% male) were included. Median age was 36 years. 4891 patients (38%) presented with severe injury (Injury Severity Score > 15). The ratio between annual prevalence of dispensed prescriptions for trauma patients and the general population, adjusted for age and sex, was 1.5 (95% confidence interval 1.4–1.6) for opioids, 2.1 (2.0–2.2) for benzodiazepines, 1.7 (1.6–1.8) for z-hypnotics, 1.9 (1.6–2.2) for gabapentinoids, and 1.9 (1.6–2.2) for centrally acting sympathomimetics. Compared with the general population, mean annual cumulative DDD of opioids and benzodiazepines dispensed to trauma patients were more than two and three times as high, respectively, in several age groups below 70 years. The prevalence of dispensing 14 days pre-trauma was higher in severely injured patients for opioids, benzodiazepines, and z-hypnotics compared with patients without severe injury. Conclusions Our results support previous findings that the prevalence of psychoactive drug use is high among trauma patients. In terms of both frequency and amounts, the pre-injury dispensing of psychoactive drugs to trauma patients supersedes that of the general population, especially in younger patients.
-
-
View all works in NVA
Published
Dec. 20, 2021 4:01 PM
- Last modified
Feb. 27, 2022 3:41 PM
