Inga Katherina Kelpanides

• Kelpanides, Inga Katherina; Katzenschlager, Stephan; Skogvoll, Eirik; Tjelmeland, Ingvild Beathe Myrhaugen; Berner, Guro Grindheim & Alm-Kruse, Kristin [Show all 11 contributors for this article] (2024). Out-of-hospital cardiac arrest in children in Norway: A national cohort study, 2016–2021. Resuscitation Plus. 18. doi: 10.1016/j.resplu.2024.100662. Full text in Research Archive Show summary

  Aim Children constitute an important and distinct subgroup of out-of-hospital cardiac arrest (OHCA) patients. This population-based cohort study aims to establish current age-specific population incidence, precipitating causes, circumstances, and outcome of paediatric OHCA, to guide a focused approach to prevention and intervention to improve outcomes. Methods Data from the national Norwegian Cardiac Arrest Registry was extracted for the six-year period 2016–21 for persons aged <18 years. We present descriptive statistics for the population, resuscitation events, presumed causes, treatment, and outcomes, alongside age-specific incidence and total paediatric mortality rates. Results Three hundred and eight children were included. The incidence of OHCA was 4.6 per 100 000 child-years and markedly higher in children <1 year at 20.9 child-years. Leading causes were choking, cardiac and respiratory disease, and sudden infant death syndrome. Overall, 21% survived to 30 days and 18% to one year. Conclusion A registry-based approach enabled this study to delineate the characteristics and trajectories of OHCA events in a national cohort of children. Precipitating causes of paediatric OHCA are diverse compared to adults. Infants aged <1 year are at particularly high risk. Mortality is high, albeit lower than for adults in Norway. A rational community approach to prevention and treatment may focus on general infant care, immediate first aid by caretakers, and identification of vulnerable children by primary health providers. Cardiac arrest registries are a key source of knowledge essential for quality improvement and research into cardiac arrest in childhood.

• Katzenschlager, Stephan; Kelpanides, Inga Katherina; Ristau, Patrick; Huck, Matthias; Seewald, Stephan & Brenner, Sebastian [Show all 13 contributors for this article] (2023). Out-of-hospital cardiac arrest in children: an epidemiological study based on the German Resuscitation Registry identifying modifiable factors for return of spontaneous circulation. Critical Care. ISSN 1364-8535. 27(1). doi: 10.1186/s13054-023-04630-3. Full text in Research Archive Show summary

  Aim This work provides an epidemiological overview of out-of-hospital cardiac arrest (OHCA) in children in Germany between 2007 and 2021. We wanted to identify modifiable factors associated with survival. Methods Data from the German Resuscitation Registry (GRR) were used, and we included patients registered between 1st January 2007 and 31st December 2021. We included children aged between > 7 days and 17 years, where cardiopulmonary resuscitation (CPR) was started, and treatment was continued by emergency medical services (EMS). Incidences and descriptive analyses are presented for the overall cohort and each age group. Multivariate binary logistic regression was performed on the whole cohort to determine the influence of (1) CPR with/without ventilation started by bystander, (2) OHCA witnessed status and (3) night-time on the outcome hospital admission with return of spontaneous circulation (ROSC). Results OHCA in children aged < 1 year had the highest incidence of the same age group, with 23.42 per 100 000. Overall, hypoxia was the leading presumed cause of OHCA, whereas trauma and drowning accounted for a high proportion in children aged > 1 year. Bystander-witnessed OHCA and bystander CPR rate were highest in children aged 1–4 years, with 43.9% and 62.3%, respectively. In reference to EMS-started CPR, bystander CPR with ventilation were associated with an increased odds ratio for ROSC at hospital admission after adjusting for age, sex, year of OHCA and location of OHCA. Conclusion This study provides an epidemiological overview of OHCA in children in Germany and identifies bystander CPR with ventilation as one primary factor for survival. Trial registrations German Clinical Trial Register: DRKS00030989, December 28th 2022. Graphical Abstract

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• Kelpanides, Inga Katherina; Katzenschlager, Stephan; Tjelmeland, Ingvild Beathe Myrhaugen; Kramer-Johansen, Jo; Bossaert, Leo & Maurer, Holger [Show all 38 contributors for this article] (2025). Cardiac arrest in children: A Europe-wide epidemiological study on out-of-hospital cardiac arrest in children. A protocol for a subgroup analysis of the European registry of cardiac arrest THREE study. doi: 10.1016/j.resplu.2025.101081. Full text in Research Archive
• Katzenschlager, Stephan; Kelpanides, Inga Katherina; Skogvoll, Eirik; Grindheim, Guro; Wnent, Jan & Popp, Erik [Show all 10 contributors for this article] (2023). Paediatric out-of-hospital cardiac arrest: Time to update registries? Critical Care. ISSN 1364-8535. 27(1). doi: 10.1186/s13054-023-04582-8. Full text in Research Archive

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