Ingeborg Haug Steinholt

• Jalava, Karoliina; Sallinen, Ville; Lampela, Hanna; Malmi, Hanna; Steinholt, Ingeborg Haug & Augestad, Knut Magne [Show all 8 contributors for this article] (2025). Role of Preoperative Antibiotic Treatment While Awaiting Appendectomy: The PERFECT-Antibiotics Randomized Clinical Trial. JAMA Surgery. ISSN 2168-6254. 160(7), p. 745–754. doi: 10.1001/jamasurg.2025.1212. Full text in Research Archive
• Jalava, Karoliina; Sallinen, Ville; Lampela, Hanna; Malmi, Hanna; Steinholt, Ingeborg Haug & Augestad, Knut Magne [Show all 8 contributors for this article] (2023). Role of preoperative in-hospital delay on appendiceal perforation while awaiting appendicectomy (PERFECT): a Nordic, pragmatic, open-label, multicentre, non-inferiority, randomised controlled trial. The Lancet. ISSN 0140-6736. 402(10412), p. 1552–1561. doi: 10.1016/S0140-6736(23)01311-9. Full text in Research Archive
• Sgrò, A.; Blanco-Colino, R.; Ahmed, W.U.R; Brindl, N.; Gujjuri, R.R. & Lapolla, P. [Show all 51 contributors for this article] (2023). EuroSurg Collaborative. Safety and efficacy of intraperitoneal drain placement after emergency colorectal surgery: An international, prospective cohort study. Colorectal Disease. ISSN 1462-8910. 25, p. 2043–2053. doi: 10.1111/codi.16737. Full text in Research Archive Show summary

  Abstract Aim: Intraperitoneal drains are often placed during emergency colorectal surgery. However, there is a lack of evidence supporting their use. This study aimed to describe the efficacy and safety of intraperitoneal drain placement after emergency colorectal surgery. Method: COMPlicAted intra-abdominal collectionS after colorectal Surgery (COMPASS) is a prospective, international, cohort study into which consecutive adult patients undergoing emergency colorectal surgery were enrolled (from 3 February 2020 to 8 March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included rate and time-to-diagnosis of postoperative intraperitoneal collections, rate of surgical site infections (SSIs), time to discharge and 30-day major postoperative complications (Clavien–Dindo III–V). Multivariable logistic and Cox proportional hazards regressions were used to estimate the independent association of the outcomes with drain placement. Results: Some 725 patients (median age 68.0 years; 349 [48.1%] women) from 22 countries were included. The drain insertion rate was 53.7% (389 patients). Following multivariable adjustment, drains were not significantly associated with reduced rates (odds ratio [OR] = 1.56, 95% CI: 0.48–5.02, p = 0.457) or earlier detection (hazard ratio [HR] = 1.07, 95% CI: 0.61–1.90, p = 0.805) of collections. Drains were not significantly associated with worse major postoperative complications (OR = 1.26, 95% CI: 0.67–2.36, p = 0.478), delayed hospital discharge (HR = 1.11, 95% CI: 0.91–1.36, p = 0.303) or increased risk of SSIs (OR = 1.61, 95% CI: 0.87–2.99, p = 0.128). Conclusion: This is the first study investigating placement of intraperitoneal drains following emergency colorectal surgery. The safety and clinical benefit of drains remain uncertain. Equipoise exists for randomized trials to define the safety and efficacy of drains in emergency colorectal surgery.

• Sgrò, A; Blanco-Colino, R; Ahmed, WUR; Brindl, N; Gujjuri, RR & Lapolla, P [Show all 49 contributors for this article] (2022). Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study. British Journal of Surgery. ISSN 0007-1323. 109, p. 520–529. doi: 10.1093/bjs/znac069. Full text in Research Archive

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