Ingrid Dieset

• Shafi, Dur E. Shahnaz; Jørgensen, Kjetil Nordbø; Bjella, Thomas; Nesvåg, Ragnar; Dieset, Ingrid & Melle, Ingrid [Show all 8 contributors for this article] (2024). Prescriptions of psychotropic and somatic medications among patients with severe mental disorders and healthy controls in a naturalistic study. Nordic Journal of Psychiatry. ISSN 0803-9488. doi: 10.1080/08039488.2024.2305806. Show summary

  Purpose Psychotropic and somatic medications are both used in treating severe mental disorders (SMDs). Realistic estimates of the prevalence of use across medication categories are needed. We obtained this in a clinical cohort of patients with SMD and healthy controls (HCs). Materials and methods Prescriptions filled at Norwegian pharmacies the year before and after admittance to the Thematically Organized Psychosis (TOP) study were examined in 1406 patients with SMD (mean age 32.5 years, 48.2% women) and 920 HC (34.1 years, 46.2% women). Using data from the Norwegian Prescription Database (NorPD), the number of users in different anatomical therapeutic chemical (ATC) categories was compared using logistic regression. Population estimates were used as reference data. Results Use of antipsychotics (N05A), antiepileptics (N03A), antidepressants (N06A), anxiolytics (N05B), hypnotics and sedatives (N05C), anticholinergics (N04A), psychostimulants, attention deficit hyperactivity disorder and nootropic agents (N06B) and drugs for addiction disorders (N07B) was significantly more prevalent in patients with SMD than HC. Use of diabetes treatment (A10), antithrombotic drugs (B01), beta blockers (C07), lipid modifiers (C10), and thyroid and endocrine therapeutics (H03) was also more prevalent in patients with SMD, but with two exceptions somatic medication use was comparable to the general population. Among HC, there was low prevalence of use for most medication categories. Conclusion Patients were using psychiatric medications, but also several types of somatic medications, more often than HC. Still, somatic medication use was mostly not higher than in the general population. The results indicate that HC had low use of most medication types.

• Reponen, Elina Johanna; Ueland, Thor; Rokicki, Jaroslav; Bettella, Francesco; Aas, Monica & Werner, Maren Caroline Frogner [Show all 10 contributors for this article] (2023). Polygenic risk for schizophrenia and bipolar disorder in relation to cardiovascular biomarkers. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-023-01591-0. Full text in Research Archive Show summary

  Individuals with schizophrenia and bipolar disorder are at an increased risk of cardiovascular disease (CVD), and a range of biomarkers related to CVD risk have been found to be abnormal in these patients. Common genetic factors are a putative underlying mechanism, alongside lifestyle factors and antipsychotic medication. However, the extent to which the altered CVD biomarkers are related to genetic factors involved in schizophrenia and bipolar disorder is unknown. In a sample including 699 patients with schizophrenia, 391 with bipolar disorder, and 822 healthy controls, we evaluated 8 CVD risk biomarkers, including BMI, and fasting plasma levels of CVD biomarkers from a subsample. Polygenic risk scores (PGRS) were obtained from genome-wide associations studies (GWAS) of schizophrenia and bipolar disorder from the Psychiatric Genomics Consortium. The CVD biomarkers were used as outcome variables in linear regression models including schizophrenia and bipolar disorder PGRS as predictors, age, sex, diagnostic category, batch and 10 principal components as covariates, controlling for multiple testing by Bonferroni correction for the number of independent tests. Bipolar disorder PGRS was significantly (p = 0.03) negatively associated with BMI after multiple testing correction, and schizophrenia PGRS was nominally negatively associated with BMI. There were no other significant associations between bipolar or schizophrenia PGRS, and other investigated CVD biomarkers. Despite a range of abnormal CVD risk biomarkers in psychotic disorders, we only found a significant negative association between bipolar disorder PGRS and BMI. This has previously been shown for schizophrenia PGRS and BMI, and warrants further exploration.

• Færden, Ann; Rosenqvist, Christine; Håkansson, Mats; Strøm-Gundersen, Eline; Stav, Åshild & Svartsund, Jan [Show all 14 contributors for this article] (2022). Environmental Transformations Enhancing Dignity in an Acute Psychiatric Ward: Outcome of a User-Driven Service Design Project. Health Environments Research & Design Journal. ISSN 1937-5867. 16(2), p. 55–72. doi: 10.1177/19375867221136558.
• Eriksen, Bjørn Magne Sundsbø; Dieset, Ingrid; Lockertsen, Øyvind & Roaldset, John Olav (2022). The risk of not knowing – A predictive validity study of the “Don't know” scores on a violence screen in acute psychiatry. Psychiatry Research Communications. ISSN 2772-5987. 2(4), p. 1–7. doi: 10.1016/j.psycom.2022.100076.
• Hjell, Gabriela; Szabo, Attila; Mørch-Johnsen, Lynn Egeland; Holst, Rene; Tesli, Natalia & Bell, Christina [Show all 18 contributors for this article] (2022). Interleukin-18 signaling system links to agitation in severe mental disorders. Psychoneuroendocrinology. ISSN 0306-4530. 140:105721, p. 1–8. doi: 10.1016/j.psyneuen.2022.105721. Full text in Research Archive Show summary

  Objective Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to severe mental disorders and implicated in animal models of agitation. We investigated if levels of circulating inflammasome-related immune markers were associated with agitation in severe mental disorders. Methods Individuals with a psychotic or affective disorder (N = 660) underwent blood sampling and clinical characterization. Plasma levels of interleukin (IL)‐18, IL-18 binding protein (IL-18BP), IL-18 receptor 1 (IL-18R1), IL-18 receptor accessory protein (IL-18RAP), and IL-1 receptor antagonist (IL-1RA) were measured. Agitation levels were estimated with the Positive and Negative Syndrome Scale Excited Component. Multiple linear- and logistic regression were used to investigate the associations between agitation and the immune markers, while controlling for confounders. The influence of psychotic and affective symptoms was assessed in follow-up analyses. Results Agitation was positively associated with IL-18BP (β = 0.13, t = 3.41, p = 0.0007) after controlling for multiple confounders, including BMI, smoking, medication, and substance use. Adjustment for psychotic, manic, and depressive symptoms did not affect the results. There were no significant associations between agitation and the other investigated immune markers (IL-1RA (β = 0.06, t = 1.27, p = 0.20), IL-18 (β = 0.05, t = 1.25, p = 0.21), IL-18R1 (β = 0.04, t = 1.01, p = 0.31), IL-18RAP (odds ratio = 0.96, p = 0.30)). In a subsample (N = 463), we also adjusted for cortisol levels, which yielded unaltered results. Conclusion Our findings add to the accumulating evidence of immune system disturbances in severe mental disorders and suggest the IL-18 system as a part of the biological correlate of agitation independent of affective and psychotic symptoms.

• Reponen, Elina Johanna; Tesli, Martin Steen; Dieset, Ingrid; Steen, Nils Eiel; Vedal, Trude Seselie Jahr & Szabo, Attila [Show all 12 contributors for this article] (2021). Adiponectin Is Related to Cardiovascular Risk in Severe Mental Illness Independent of Antipsychotic Treatment. Frontiers in Psychiatry. ISSN 1664-0640. 12. doi: 10.3389/fpsyt.2021.623192. Full text in Research Archive
• Fjukstad, Katrine Kveli; Athanasiu, Lavinia; Bahrami, Shahram; O`Connell, Kevin; van der Meer, Dennis & Bettella, Francesco [Show all 11 contributors for this article] (2021). Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study. The Pharmacogenomics Journal. ISSN 1470-269X. 21, p. 574–585 . doi: 10.1038/s41397-021-00234-8.
• Dieset, Ingrid; Løvhaug, Lars; Selle, Morten Stefan; Kolseth, Asbjørn; Smeland, Olav Bjerkehagen & Færden, Ann (2021). Lessons learned from a cross-sectional survey among patients and staff in an acute psychiatric unit during an ongoing pandemic outbreak. Psychiatry Research. ISSN 0165-1781. 298, p. 1–3. doi: 10.1016/j.psychres.2021.113779. Full text in Research Archive
• Færden, Ann; Bølgen, Brita Rønbeck; Løvhaug, Lars; Thoresen, Christian & Dieset, Ingrid (2020). Patient satisfaction and acute psychiatric inpatient treatment. Nordic Journal of Psychiatry. ISSN 0803-9488. 74(8), p. 577–584. doi: 10.1080/08039488.2020.1764620.
• Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid & Bjella, Thomas [Show all 12 contributors for this article] (2020). Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder. Frontiers in Psychiatry. ISSN 1664-0640. 11, p. 1–10. doi: 10.3389/fpsyt.2020.00642. Full text in Research Archive
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica & Vedal, Trude Seselie Jahr [Show all 18 contributors for this article] (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry. ISSN 1664-0640. 11. doi: 10.3389/fpsyt.2020.00672. Full text in Research Archive Show summary

  Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interplay with dyslipidemia is a central driver in the pathogenesis of CVD. We hypothesize that evaluation of atherogenic lipid ratios together with inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis, could give novel information on immune-related mechanisms involved in early CVD risk in patients with psychotic disorders. Methods: As a measure for CVD risk we calculated atherogenic lipid ratios using established sex-specific cut-offs: Total cholesterol/high-density lipoprotein; HDL-c (TC/HDL) and triglyceride/HDL-c (TG/HDL) were evaluated in 571 schizophrenia (SCZ) and 247 bipolar disorder (BD) patients, and in 99 healthy controls (HC). In addition, as a measure of low-grade inflammation, we measured fasting plasma levels of nine stable atherogenic inflammatory markers in patients (SCZ, BD) and in HC. The elevated inflammatory markers and CVD risk in patients, as reflected by TC/HDL and TG/HDL, were further assessed in multivariable analyses adjusting for comorbid cardio-metabolic risk factors. Results: A markedly higher proportion (26%-31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses. Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies. Keywords: CVD risk; bipolar disorder; dyslipidemia; inflammatory biomarkers; schizophrenia.

• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr & Reponen, Elina Johanna [Show all 9 contributors for this article] (2019). Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(5), p. 464–471. doi: 10.1111/acps.13019. Full text in Research Archive
• Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias & Còrdova Palomera, Aldo [Show all 9 contributors for this article] (2019). Oxytocin pathway gene networks in the human brain. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-08503-8. Full text in Research Archive
• Kroken, Rune Andreas; Sommer, Iris Else Clara; Steen, Vidar Martin; Dieset, Ingrid & Johnsen, Erik (2019). Constructing the immune signature of schizophrenia for clinical use and research; an integrative review translating descriptives into diagnostics. Frontiers in Psychiatry. ISSN 1664-0640. 9:753, p. 1–16. doi: 10.3389/fpsyt.2018.00753. Full text in Research Archive
• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen & Matson, Wayne [Show all 13 contributors for this article] (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine. ISSN 0033-2917. 17(2). doi: 10.1017/S0033291719000400. Full text in Research Archive
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun & Hoseth, Eva Zsuzsanna [Show all 17 contributors for this article] (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine. ISSN 0033-2917. 49(10), p. 1749–1757. doi: 10.1017/S0033291718004142. Show summary

  Background. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role

• Rødevand, Linn ; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna & Mørch, Ragni Helene [Show all 12 contributors for this article] (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(4), p. 348–360. doi: 10.1111/acps.13008. Show summary

  Objective: While CVD risk has decreased in the general population during the last decade, the situation in patients with schizophrenia (SCZ) and bipolar disorder (BD) is unknown. Methods: We compared CVD risk factors in patients with SCZ and BD recruited from 2002‐2005 (2005 sample, N = 270) with patients recruited from 2006‐2017 (2017 sample, N = 1011) from the same catchment area in Norway. The 2017 sample was also compared with healthy controls (N = 922) and the general population (N range = 1285‐4587, Statistics Norway) from the same area and period. Results: Patients with SCZ and BD in the 2017 sample had significantly higher level of most CVD risk factors compared to healthy controls and the general population. There was no significant difference in the prevalence of CVD risk factors in SCZ between the 2005 and 2017 samples except a small increase in glucose in the 2017 sample. There were small‐to‐moderate reductions in hypertension, obesity, total cholesterol, low‐density lipoprotein, systolic and diastolic blood pressure in the BD 2017 sample compared to the 2005 sample. Conclusion: Despite major advances in health promotion during the past decade, there has been no reduction in the level of CVD risk factors in patients with SCZ and modest improvement in BD.

• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Show all 11 contributors for this article] (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, p. 87–95. doi: 10.1016/j.psyneuen.2019.01.001. Full text in Research Archive
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr & Steen, Vidar Martin [Show all 8 contributors for this article] (2018). Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(7), p. 795–802. doi: 10.1007/s00406-018-0897-z. Full text in Research Archive
• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna & Gran, Jon Michael [Show all 16 contributors for this article] (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139, p. 37–45. doi: 10.1111/acps.12971. Full text in Research Archive
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Show all 11 contributors for this article] (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, p. 74–81. doi: 10.1016/j.jpsychires.2018.09.014.
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun & Reponen, Elina Johanna [Show all 12 contributors for this article] (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2018.08.007. Full text in Research Archive
• Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg & Dieset, Ingrid [Show all 10 contributors for this article] (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research. ISSN 0165-1781. 267, p. 140–147. doi: 10.1016/j.psychres.2018.05.065. Full text in Research Archive
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun & Gardsjord, Erlend Strand [Show all 14 contributors for this article] (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports. ISSN 2045-2322. 8:5349, p. 1–8. doi: 10.1038/s41598-018-23703-w. Full text in Research Archive
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun & Gardsjord, Erlend Strand [Show all 14 contributors for this article] (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational Psychiatry. ISSN 2158-3188. 8:55, p. 1–10. doi: 10.1038/s41398-018-0102-1. Full text in Research Archive
• Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt & Schork, Andrew J. [Show all 18 contributors for this article] (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports. ISSN 2045-2322. 674(8), p. 1–8. doi: 10.1038/s41598-017-16481-4. Full text in Research Archive
• Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2018). Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics. European psychiatry. ISSN 0924-9338. 48, p. 71–78. doi: 10.1016/j.eurpsy.2017.04.001.
• Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr & Lagerberg, Trine Vik [Show all 12 contributors for this article] (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research. ISSN 0920-9964. 197, p. 253–260. doi: 10.1016/j.schres.2017.10.042. Full text in Research Archive Show summary

  Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.

• Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene & Gardsjord, Erlend Strand [Show all 11 contributors for this article] (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 82, p. 263–271. doi: 10.1016/j.pnpbp.2017.11.004.
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene & Reponen, Elina Johanna [Show all 13 contributors for this article] (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, Behavior, and Immunity. ISSN 0889-1591. 65, p. 342–349. doi: 10.1016/j.bbi.2017.06.005. Full text in Research Archive
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica & Nerhus, Mari [Show all 17 contributors for this article] (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 136(4), p. 400–408. doi: 10.1111/acps.12783.
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon & Kleinman, Joel Edward [Show all 19 contributors for this article] (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin. ISSN 0586-7614. 43(4), p. 881–890. doi: 10.1093/schbul/sbw183. Full text in Research Archive
• Quintana, Daniel; Dieset, Ingrid; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2017). Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders. Frontiers in Neuroendocrinology (FIN). ISSN 0091-3022. 45, p. 1–10. doi: 10.1016/j.yfrne.2016.12.004. Full text in Research Archive
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2016). Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. 18(6), p. 471–482. doi: 10.1080/15622975.2016.1245441.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2016). Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting. International journal of bipolar disorders. ISSN 2194-7511. 4(24). doi: 10.1186/s40345-016-0067-z. Full text in Research Archive
• Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2016). Metabolic abnormalities related to treatment with selective serotonin reuptake inhibitors in patients with schizophrenia or bipolar disorder. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 36(6), p. 615–620. doi: 10.1097/JCP.0000000000000582.
• Dieset, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2016). Somatic Comorbidity in Schizophrenia: Some Possible Biological Mechanisms Across the Life Span. Schizophrenia Bulletin. ISSN 0586-7614. 42(6), p. 1316–1319. doi: 10.1093/schbul/sbw028.
• Fountoulakis, Konstantinos N.; Chatzikosta, Isaia; Pastiadis, Konstantinos; Zanis, Prodromos; Kawohl, Wolfram & Kerkhof, Ad J.F.M. [Show all 48 contributors for this article] (2016). Relationship of suicide rates with climate and economic variables in Europe during 2000-2012. Annals of General Psychiatry. ISSN 1744-859X. 15:19, p. 1–6. doi: 10.1186/s12991-016-0106-2.
• Tesli, Martin Steen; Wirgenes, Katrine Verena; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia & Hoseth, Eva Zsuzsanna [Show all 14 contributors for this article] (2016). VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls. British Journal of Psychiatry. ISSN 0007-1250. 209(2), p. 114–120. doi: 10.1192/bjp.bp.115.161950.
• Nerhus, Mari; Berg, Akiah Ottesen; Kvitland, Levi Røstad; Dieset, Ingrid; Hope, Sigrun & Dahl, Sandra Rinne [Show all 11 contributors for this article] (2016). Low vitamin D is associated with negative and depressive symptoms in psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 178(1-3), p. 44–49. doi: 10.1016/j.schres.2016.08.024. Full text in Research Archive Show summary

  BACKGROUND: There are indications that low S-25(OH)D is associated with increased disease severity in psychotic disorder. Our first aim was to investigate the relations between low S-25(OH)D and positive, negative and depressive symptoms. Our second aim was to explore if associations between S-25(OH)D and symptoms were influenced by levels of inflammatory markers. METHODS: Participants (N=358) with a medical history of one or more psychotic episodes were recruited. Current symptomatology was assessed by The Structured Interview for the Positive and Negative Syndrome Scaleanalyzed by a five-factor model. The Calgary Depression Scale for Schizophrenia was used to assess depression and suicidal ideation. Blood samples were analyzed for S-25(OH)D, CRP, sTNF-R1, IL-Ra and OPG. We performed bivariate correlations and multiple regression models to evaluate the effect of S-25(OH)D on the outcomes. RESULTS: Low S-25(OH)D was significantly associated with negative symptoms (adjusted R2=0.113, F(6,357)=8.58, p<0.001) and with depression (adjusted R2=0.045, F(4,357)=5.233, p<0.001) when adjusting for possible confounding factors (i.e. gender, education, diagnose, hospitalization status, ethnicity, season and thyroid status). CRP was correlated with both S-25(OH)D (rho=-0.13, p=0.02) and negative symptoms (rho=0.14, p=0.01), but did not act as a mediator. The correlations between S-25(OH)D and the inflammatory markers sTNF-R1, IL-Ra and OPG were not significant. CONCLUSION: There is a strong association between low S-25(OH)D and higher negative and depressive symptoms in psychotic disorders. Randomized controlled trials should be performed to investigate the effect of vitamin D supplementation as adjuvant treatment strategy in patients with prominent negative or depressive symptoms.

• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica & Nerhus, Mari [Show all 15 contributors for this article] (2016). Inflammatory evidence for the psychosis continuum model. Psychoneuroendocrinology. ISSN 0306-4530. 67, p. 189–197. doi: 10.1016/j.psyneuen.2016.02.011.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2015). Serum level of venlafaxine is associated with better memory in psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 169(1-3), p. 386–392. doi: 10.1016/j.schres.2015.10.021.
• Hoseth, Eva Zsuzsanna; Westlye, Lars Tjelta; Hope, Sigrun; Dieset, Ingrid; Aukrust, Pål & Melle, Ingrid [Show all 11 contributors for this article] (2015). Association between cytokine levels, verbal memory and hippocampus volume in psychotic disorders and healthy controls. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 133(1), p. 53–62. doi: 10.1111/acps.12467. Full text in Research Archive
• Hope, Sigrun; Hoseth, Eva Zsuzsanna; Dieset, Ingrid; Mørch, Ragni Helene; Aas, Monica & Aukrust, Pål [Show all 13 contributors for this article] (2015). Inflammatory markers are associated with general cognitive abilities in schizophrenia and bipolar disorder patients and healthy controls. Schizophrenia Research. ISSN 0920-9964. 165(2-3), p. 188–194. doi: 10.1016/j.schres.2015.04.004.
• Dieset, Ingrid; Haukvik, Unn Kristin H.; Melle, Ingrid; Røssberg, Jan Ivar; Ueland, Thor & Hope, Sigrun [Show all 11 contributors for this article] (2015). Association between altered brain morphology and elevated peripheral endothelial markers — Implications for psychotic disorders . Schizophrenia Research. ISSN 0920-9964. 161(2-3), p. 222–228. doi: 10.1016/j.schres.2014.11.006.
• Ringen, Petter Andreas; Engh, John; Birkenæs, Astrid B.; Dieset, Ingrid & Andreassen, Ole A. (2014). Increased mortality in schizophrenia due to cardiovascular disease - a non-systematic review of epidemiology, possible causes and interventions. Frontiers in Psychiatry. ISSN 1664-0640. 5. doi: 10.3389/fpsyt.2014.00137. Full text in Research Archive
• Haram, Marit; Tesli, Martin Steen; Dieset, Ingrid; Steen, Nils Eiel; Røssberg, Jan Ivar & Djurovic, Srdjan [Show all 8 contributors for this article] (2014). An attempt to identify single nucleotide polymorphisms contributing to possible relationships between personality traits and oxytocin-related genes. Neuropsychobiology. ISSN 0302-282X. 69(1), p. 25–30. doi: 10.1159/000356965.
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Dieset, Ingrid; Aas, Monica & Nerhus, Mari [Show all 11 contributors for this article] (2014). Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders. Journal of Psychiatric Research. ISSN 0022-3956. 52(1), p. 57–62. doi: 10.1016/j.jpsychires.2014.01.017.
• Etain, B; Aas, Monica; Andreassen, Ole Andreas; Lorentzen, Steinar; Dieset, Ingrid & Gard, Sebastien [Show all 11 contributors for this article] (2013). Childhood Trauma Is Associated With Severe Clinical Characteristics of Bipolar Disorders. Journal of Clinical Psychology. ISSN 0021-9762. 74(10), p. 991–998. doi: 10.4088/JCP.13m08353.
• Hope, Sigrun; Ueland, Thor; Steen, Nils Eiel; Dieset, Ingrid; Lorentzen, Steinar & Berg, Akiah Ottesen [Show all 9 contributors for this article] (2013). Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophrenia Research. ISSN 0920-9964. 145(1-3), p. 36–42. doi: 10.1016/j.schres.2012.12.023.
• Dieset, Ingrid; Hope, Sigrun; Ueland, Thor; Bjella, Thomas; Agartz, Ingrid & Melle, Ingrid [Show all 9 contributors for this article] (2012). Cardiovascular risk factors during second generation antipsychotic treatment are associated with increased C-reactive protein. Schizophrenia Research. ISSN 0920-9964. 140(1-3), p. 169–174. doi: 10.1016/j.schres.2012.06.040.
• Dieset, Ingrid; Djurovic, Srdjan; Tesli, Martin Steen; Hope, Sigrun; Mattingsdal, Morten & Michelsen, Annika [Show all 14 contributors for this article] (2012). Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder. American Journal of Psychiatry. ISSN 0002-953X. 169(12), p. 1292–1300. doi: 10.1176/appi.ajp.2012.11091431. Show summary

  OBJECTIVE: Immunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, and genome-wide association studies (GWAS) point to the major histocompatibility complex, a region that contains many immune-related genes. One of the strongest candidate risk genes for schizophrenia and bipolar disorder is the NOTCH4 gene within the major histocompatibility complex. The authors investigated the NOTCH4 gene expression in individuals with bipolar disorder and schizophrenia relative to healthy comparison subjects and identified putative expression quantitative trait loci in and around the NOTCH4 gene. METHOD: The authors measured and compared NOTCH4 mRNA in whole blood in 690 individuals (479 patients and 211 healthy comparison subjects) and adjusted for a range of confounders. The authors also genotyped 20 single-nucleotide polymorphisms (SNPs) and investigated possible associations between expression quantitative trait loci and NOTCH4 expression. RESULTS: The authors found a strong association between NOTCH4 expression and bipolar disorder after adjusting for a range of confounders and multiple testing. In addition, seven SNPs within the NOTCH4 gene region were associated with enhanced NOTCH4 mRNA levels. Three of these expression quantitative trait loci were independent (not in linkage disequilibrium). CONCLUSIONS: The results indicate that the association between NOTCH4 DNA markers and bipolar disorder is related to altered function at the mRNA level, supporting the notion that NOTCH4 pathways are involved in the pathophysiology of bipolar disorder.

• Hope, Sigrun; Dieset, Ingrid; Agartz, Ingrid; Steen, Nils Eiel; Ueland, Thor & Melle, Ingrid [Show all 8 contributors for this article] (2011). Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. Journal of Psychiatric Research. ISSN 0022-3956. 45(12), p. 1608–1616. doi: 10.1016/j.jpsychires.2011.08.003.

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• Eriksen, Bjørn Magne Sundsbø; Dieset, Ingrid; Lockertsen, Øyvind & Roaldset, John Olav (2022). A study of associations between lack of information on risk factors and future violence.
• Roaldset, John Olav; Eriksen, Bjørn Magne Sundsbø; Lockertsen, Øyvind & Dieset, Ingrid (2022). Don't know scores in risk assessment instruments – Should they be ignored, or should they be considered as risk factors?
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Show all 11 contributors for this article] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.
• Dieset, Ingrid (2013). Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder: Future Studies Response. American Journal of Psychiatry. ISSN 0002-953X. 170(5), p. 561–561. doi: 10.1176/appi.ajp.2013.12121529r.
• Hope, Sigrun; Melle, Ingrid; Ueland, Thor; Lorentzen, Steinar; Steen, Nils Eiel & Berg, Akiah Ottesen [Show all 10 contributors for this article] (2011). INTERLEUKIN 1 RECEPTOR ANTAGONIST AND TUMOR NECROSIS FACTOR RECEPTOR 1 ARE ASSOCIATED WITH GENERAL SEVERITY AND PSYCHOTIC SYMPTOMS IN SCHIZOPHRENIA AND BIPOLAR DISORDER. Schizophrenia Bulletin. ISSN 0586-7614. 37, p. 115–116.

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