Ingrid Agartz

• Almdahl, Ina S.; Martinussen, Liva Jenny; Agartz, Ingrid; Hugdahl, Kenneth & Korsnes, Maria Stylianou (2021). Inhibition of emotions in healthy aging: age‐related differences in brain network connectivity. Brain and Behavior.  ISSN 2162-3279. . doi: 10.1002/brb3.2052
• Barth, Claudia; Nerland, Stener; de Lange, Ann-Marie Glasø; Wortinger, Laura Anne; Hilland, Eva; Andreassen, Ole Andreas; Jørgensen, Kjetil Nordbø & Agartz, Ingrid (2021). In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders. Schizophrenia Bulletin.  ISSN 0586-7614. . doi: https://doi.org/10.1093/schbul/sbaa192
• Wortinger, Laura Anne; Jørgensen, Kjetil Nordbø; Barth, Claudia; Nerland, Stener; Smelror, Runar; Vaskinn, Anja; Ueland, Torill; Andreassen, Ole Andreas & Agartz, Ingrid (2021). Significant association between intracranial volume and verbal intellectual abilities in patients with schizophrenia and a history of birth asphyxia. Psychological Medicine.  ISSN 0033-2917. . doi: https://doi.org/10.1017/S0033291721000489
• Andreou, Dimitrios; Saetre, Peter; Milesson Fors, Björn; Nilsson, Björn Mikael; Kullberg, Joel; Jönsson, Erik Gunnar; Ebeling Barbier, Charlotte & Agartz, Ingrid (2020). Cardiac left ventricular ejection fraction in men and women with schizophrenia on long-term antipsychotic treatment. Schizophrenia Research.  ISSN 0920-9964.  s 226- 232 . doi: 10.1016/j.schres.2019.12.042 Full text in Research Archive.
• Bakke, Laura A Wortinger; Engen, Kristine; Barth, Claudia; Andreassen, Ole Andreas; Jørgensen, Kjetil Nordbø & Agartz, Ingrid (2020). Asphyxia at birth affects brain structure in patients on the schizophrenia-bipolar disorder spectrum and healthy participants. Psychological Medicine.  ISSN 0033-2917. . doi: 10.1017/S0033291720002779 Full text in Research Archive.
• Barth, Claudia; Jørgensen, Kjetil Nordbø; Wortinger, Laura Anne; Nerland, Stener; Jönsson, Erik Gunnar & Agartz, Ingrid (2020). Trajectories of brain volume change over 13 years in chronic schizophrenia.. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2020.05.014
• Barth, Claudia; Lonning, Vera Louise Hiorth; Gurholt, Tiril Pedersen; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Exploring white matter microstructure and the impact of antipsychotics in adolescent-onset psychosis.. PLOS ONE.  ISSN 1932-6203. . doi: 10.1371/journal.pone.0233684 Full text in Research Archive.
• Bohman, Hannes; Agartz, Ingrid; Mansouri, Shiva; Naessen, Tord & Lundberg, Mathias (2020). Preclinical atherosclerosis in adolescents with psychotic or bipolar disorders investigated with carotid high-frequency ultrasound. Brain and Behavior.  ISSN 2162-3279.  00:e01862, s 1- 10 . doi: 10.1002/brb3.1862 Full text in Research Archive.
• Ching, Christopher R. K.; Hibar, Derrek P.; Gurholt, Tiril Pedersen; Nunes, Abraham; Thomopoulos, Sophia I.; Abé, Chritsoph; Agartz, Ingrid; Brouwer, Rachel M.; Cannon, Dara M.; de Zwarte, Sonja M. C.; Eyler, Lisa T.; Favre, Pauline; Hajek, Tomas; Haukvik, Unn Kristin H.; Houenou, Josselin; Zeng, Ling-Li; Almeida, Jorge; Alnæs, Dag; Alonso-Lana, Silvia; Altimus, Cara; Bauer, Michael; Baune, Bernhard T.; Bearden, Carrie E.; Bellani, Marcella; Benedetti, Francesco; Berk, Michael; Bilderbeck, Amy C.; Blumberg, Hilary P.; Bøen, Erlend; Bollettini, Irene; del Mar Bonnin, Caterina; Brambilla, Paolo; Díaz-Zuluaga, Ana M.; Dima, Danai; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Fears, Scott C.; Jansen, Andreas; Kircher, Tilo T.J.; Knochel, Christian; Krämer, Bernd; Tamnes, Christian Krog; Thomaidis, Georgios V.; Upegui, Cristian Vargas; Veltman, Dick J; Wessa, Michele; Westlye, Lars Tjelta; Whalley, Heather C.; Wolf, Daniel H.; Thompson, Paul M & Andreassen, Ole Andreas (2020). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping.  ISSN 1065-9471. . doi: https://doi.org/10.1002/hbm.25098 Full text in Research Archive.
• Coleman, Jonathan R.I.; Gaspar, Helena A; Bryois, Julien; Byrne, Enda M; Forstner, Andreas J; Holmans, Peter A; de Leeuw, Christiaan A.; Mattheisen, Manuel; McQuillin, Andrew; Whitehead Pavlides, Jennifer M; Pers, Tune H; Ripke, Stephan; Stahl, Eli A.; Steinberg, Stacy; Trubetskoy, Vassily; Trzaskowski, Maciej; Wang, Yunpeng; Abbott, Liam; Abdellaoui, Abdel; Adams, Mark J; Nordin Adolfsson, Annelie; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Andlauer, Till F.M.; Anjorin, Adebayo; Anttila, Verneri; Van Der Auwera, Sandra; Awasthi, Swapnil; Bacanu, Silviu-Alin; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Beekman, Aartjan T.F.; Belliveau, Richard; Bøen, Erlend; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Ødegaard, Ketil Joachim; Stordal, Eystein; Vaaler, Arne; Andreassen, Ole Andreas & Breen, Gerome (2020). The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2019.10.015 Show summary

  Background: Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. Methods: To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424). Results: Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More loci from the Psychiatric Genomics Consortium analysis of major depression than from that for bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single-episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment-the relationship is positive in bipolar disorder but negative in major depressive disorder. Conclusions: The mood disorders share several genetic associations, and genetic studies of major depressive disorder and bipolar disorder can be combined effectively to enable the discovery of variants not identified by studying either disorder alone. However, we demonstrate several differences between these disorders. Analyzing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum.

• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 8 . doi: 10.1038/s41380-020-0664-1
• de Lange, Ann-Marie Glasø; Barth, Claudia; Kaufmann, Tobias; Maximov, Ivan; van der Meer, Dennis; Agartz, Ingrid & Westlye, Lars Tjelta (2020). Women's brain aging: effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer's disease. Human Brain Mapping.  ISSN 1065-9471.  s 1- 10 . doi: 10.1002/hbm.25180 Full text in Research Archive.
• de Zwarte, Sonja M. C.; Brouwer, Rachel M; Agartz, Ingrid; Alda, Martin; Alonso-Lana, Silvia; Bearden, Carrie E; Bertolino, Alessandro; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth E. L.; Cahn, Wiepke; Canales‐Rodríguez, Erick J.; Cannon, Dara M.; Cannon, Tyrone D.; Caseras, Xavier; Castro‐Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; de la Serna, Elena; del Mar Bonnin, Caterina; Demro, Caroline; Di Giorgio, Annabella; Doucet, Gaëlle E.; Eker, Mehmet Cagdas; Erk, Susanne; Fatjó-Vilas, Mar; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Fullerton, Janice M.; Glahn, David C.; Goghari, Vina M.; Goikolea, Jose M.; Goldman, Aaron L.; Gonul, Ali Saffet; Gruber, Oliver; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hidiroglu Ongun, Ceren; Hillegers, Manon H.J.; Houenou, Josselin; Pol, Hilleke E. Hulshoff; Hultman, Christina M.; Ingvar, Martin; Johansson, Viktoria; Jönsson, Erik Gunnar; Kane, Fergus; Andreassen, Ole Andreas & van Haren, Neeltje E. M. (2020). Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Human Brain Mapping.  ISSN 1065-9471. . doi: 10.1002/hbm.25206 Full text in Research Archive.
• Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O`Connell, Kevin; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Sowa, Piotr; Soininen, Hilkka; Steen, Vidar Martin; Vellas, Bruno; Tsolaki, Magda; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications.  ISSN 2041-1723.  11 . doi: 10.1038/s41467-020-17376-1 Full text in Research Archive. Show summary

  Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

• Engen, Kristine; Wortinger, Laura Anne; Jørgensen, Kjetil Nordbø; Lundberg, Mathias; Bohman, Hannes; Smelror, Runar; Myhre, Anne Margrethe; Jacobson, Leslie; Vincent, Angela & Agartz, Ingrid (2020). Autoantibodies to the N-methyl-D-aspartate receptor in adolescents with early onset psychosis and healthy controls. Frontiers in Psychiatry.  ISSN 1664-0640.  11:666, s 1- 7 . doi: 10.3389/fpsyt.2020.00666 Full text in Research Archive.
• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita; Hibar, DP; Lind, Penelope A.; Pizzagalli, Fabrizio; Ching, Christopher R.K.; McMahon, Mary Agnes B.; Shatokhina, Natalia; Zsembik, Leo C.P.; Thomopoulos, Sophia I.; Zhu, Alyssa H.; Strike, Lachlan T.; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Wolfers, Thomas; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Melle, Ingrid; Andreassen, Ole Andreas; Espeseth, Thomas; Jönsson, Erik Gunnar; Steen, Vidar Martin; Håberg, Asta; Trollor, Julian N.; Van Der Wee, Nic J.A.; Volzke, Henry; Walter, Henrik; Weber, Bernd; Weinberger, Daniel R.; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). The genetic architecture of the human cerebral cortex. Science.  ISSN 0036-8075.  367(6484) . doi: 10.1126/science.aay6690 Full text in Research Archive. Show summary

  INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.

• Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Lonning, Vera; Jönsson, Erik Gunnar; Pasternak, Ofer & Agartz, Ingrid (2020). Microstructural white matter and links with subcortical structures in chronic schizophrenia: A free-water imaging approach. Frontiers in Psychiatry.  ISSN 1664-0640.  11 . doi: 10.3389/fpsyt.2020.00056 Full text in Research Archive.
• Gurholt, Tiril Pedersen; Lonning, Vera Louise Hiorth; Nerland, Stener; Jørgensen, Kjetil Nordbø; Haukvik, Unn Kristin H.; Alloza, Clara; Arango, Celso; Barth, Claudia; Bearden, Carrie E.; Berk, Michael; Bohman, Hannes; Dandash, Orwa; Diaz-Caneja, Covadonga M.; Edbom, Carl T.; van Erp, Theo G.M.; Fett, Anne-Kathrin J.; Frangou, Sophia; Goldstein, Benjamin I; Grigorian, Anahit; Jahanshad, Neda; James, Anthony C.; Janssen, Joost; Johannessen, Cecilie Haggag; Karlsgodt, Katherine H. ; Kempton, Matthew J.; Kochunov, Peter; Krabbendam, Lydia; Kyriakopoulos, Marinos; Lundberg, Mathias; MacIntosh, Bradley J.; Rund, Bjørn Rishovd; Smelror, Runar; Sultan, Alysha; Tamnes, Christian Krog; Thomopoulos, Sophia I.; Vajdi, Ariana; Wedervang-Resell, Kirsten; Myhre, Anne Margrethe; Andreassen, Ole Andreas; Thompson, Paul M. & Agartz, Ingrid (2020). Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium. Human Brain Mapping.  ISSN 1065-9471.  s 1- 12 . doi: 10.1002/hbm.25212 Full text in Research Archive.
• Haatveit, Beathe Christin; Mørch-Johnsen, Lynn; Alnæs, Dag; Engen, Magnus Johan; Lyngstad, Siv Hege; Færden, Ann; Agartz, Ingrid; Ueland, Torill & Melle, Ingrid (2020). Divergent relationship between brain structure and cognitive functioning in patients with prominent negative symptomatology. Psychiatry Research : Neuroimaging.  ISSN 0925-4927. . doi: 10.1016/j.pscychresns.2020.111233 Full text in Research Archive.
• Haukvik, Unn Kristin H.; Gurholt, Tiril Pedersen; Nerland, Stener; Elvsåshagen, Torbjørn; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T.; Benedetti, Francesco; Berk, Michael; Bettella, Francesco; Bøen, Erlend; Bonnín, Caterina M.; Brambilla, Paolo; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Dandash, Orwa; Dannlowski, Udo; Delvecchio, Giuseppe; Díaz-Zuluaga, Ana M.; van Erp, Theo G.M.; Fatjó-Vilas, Mar; Foley, Sonya F.; Förster, Katharina; Fullerton, Janice M.; Goikolea, Jose M.; Grotegerd, Dominik; Gruber, Oliver; Haarman, Bartholomeus C. M.; Haatveit, Beathe; Hajek, Tomas; Hallahan, Brian; Harris, Mathew; Hawkins, Emma L.; Howells, Fleur M.; Hülsmann, Carina; Jahanshad, Neda; Jørgensen, Kjetil Nordbø; Kircher, Tilo; Krämer, Bernd; Krug, Axel; Kuplicki, Rayus; Lagerberg, Trine Vik; Lancaster, Thomas M.; Lenroot, Rhoshel K.; Lonning, Vera Louise Hiorth; López-Jaramillo, Carlos; Malt, Ulrik Fredrik; McDonald, Colm; McIntosh, Andrew M.; McPhilemy, Genevieve; van der Meer, Dennis; Melle, Ingrid; Melloni, Elisa M. T.; Mitchell, Philip B.; Nabulsi, Leila; Nenadic, Igor; Oertel, Viola; Oldani, Lucio; Opel, Nils; Otaduy, Maria C. G.; Overs, Bronwyn; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Radua, Joaquim; Rauer, Lisa; Redlich, Ronny; Repple, Jonathan; Rive, Maria M.; Roberts, Gloria; Ruhe, Henricus G.; Salminen, Lauren E.; Salvador, Raymond; Sarró, Salvador; Savitz, Jonathan; Schene, Aart H.; Sim, Kang; Soeiro-de-Souza, Marcio G.; Stäblein, Michael; Stein, Dan J.; Stein, Frederike; Tamnes, Christian Krog; Temmingh, Henk S.; Thomopoulos, Sophia I.; Veltman, Dick J.; Vieta, Eduard; Waltemate, Lena; Westlye, Lars Tjelta; Whalley, Heather C.; Sämann, Philipp G.; Thompson, Paul M.; Ching, Christopher; Andreassen, Ole Andreas & Agartz, Ingrid (2020). In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group. Human Brain Mapping.  ISSN 1065-9471.  s 1- 14 . doi: 10.1002/hbm.25249 Full text in Research Archive.
• Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Panizzon, Matthew S.; Andreassen, Ole Andreas; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Ikram, M. Arfan; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Melle, Ingrid; Nordvik, Jan Egil; Steen, Vidar Martin; Espeseth, Thomas; Håberg, Asta; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications.  ISSN 2041-1723.  11 . doi: 10.1038/s41467-020-18367-y Full text in Research Archive.
• Holleran, Laurena; Kelly, Sinead; Alloza, Clara; Agartz, Ingrid; Andreassen, Ole Andreas; Arango, Celso; Banaj, Nerisa; Calhoun, Vince; Cannon, Dara; Carr, Vaughan; Corvin, Aiden; Glahn, David C.; Gur, Ruben; Hong, Elliot; Hoschl, Cyril; Howells, Fleur M.; James, Anthony; Janssen, Joost; Kochunov, Peter; Lawrie, Stephen M.; Liu, Jingyu; Martinez, Covadonga; McDonald, Colm; Morris, Derek; Mothersill, David; Pantelis, Christos; Piras, Fabrizio; Potkin, Steven; Rasser, Paul E.; Roalf, David; Rowland, Laura; Satterthwaite, Theodore D.; Schall, Ulrich; Spalletta, Gianfranco; Spaniel, Filip; Stein, Dan J.; Uhlmann, Anne; Voineskos, Aristotle; Zalesky, Andrew; Van Erp, Theo G.M.; Turner, Jessica A.; Deary, Ian J.; Thompson, Paul M.; Jahanshad, Neda & Donohoe, Gary (2020). The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium. American Journal of Psychiatry.  ISSN 0002-953X. . doi: 10.1176/appi.ajp.2019.19030225
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva; Abrahamsen, Tore G; Nerhus, Mari; Wedervang-Resell, Kirsten; Lonning, Vera Louise Hiorth; Johannessen, Jarle; Steen, Nils Eiel; Agartz, Ingrid; Stenberg, Nina; Hundhausen, Thomas Eckhard; Mørkrid, Lars & Andreassen, Ole Andreas (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal.  ISSN 0892-6638.  34(6), s 8114- 8124 . doi: 10.1096/fj.201900855RRR
• Kamitaki, Nolan; Sekar, Aswin; Handsaker, Robert E; de Rivera,, Heather; Tooley,, Katherine; Morris,, David L.; Taylor, Kimberly E.; Whelan, Christopher W.; Tombleson, Philip; Olde Loohuis,, Loes M.; Boehnke, Michael; Kimberly, Robert P.; Kaufman, Kenneth M.; Harley, John B.; Langefeld, Carl D.; Seidman, Christine E.; Pato, Michele T.; Pato, Carlos N.; Ophoff, Roel A.; Graham, Robert R.; Criswell, Lindsey A.; McCarroll, Steven A.; Vyse, Timothy J.; Schizophrenia, Working Group of; Ripke, Stephan; Neale, Benjamin M.; Corvin, Aiden; Andreassen, Ole Andreas; Walters, James T. R.; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Huang, Hailiang; Collier, David A.; Pers, Tune H.; Farh, Kai-How; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Bruggeman, Richard; Amin, Farooq; Bigdeli, Tim B.; Black, Donald W.; Bevilacqua, Elizabeth; Bergen, Sarah E.; Alexander, Madeline; Bene, Judit; Belliveau Jr, Richard A.; Bacanu, Silviu A. & Buccola, Nancy G. (2020). Complement genes contribute sex-biased vulnerability in diverse disorders. Nature.  ISSN 0028-0836. . doi: 10.1038/s41586-020-2277-x
• Koenig, Julian; Abler, Birgit; Agartz, Ingrid; Åkerstedt, Torbjørn; Andreassen, Ole Andreas; Anthony, Mia; Bär, Karl-Jürgen; Bertsch, Katja; Brown, Rebecca C.; Brunner, Romuald; Carnevali, Luca; Critchley, Hugo D.; Cullen, Kathryn R.; De Geus, Eco J C; de la Cruz, Feliberto; Dziobek, Isabel; Ferger, Marc D.; Fischer, Håkan; Flor, Herta; Gaebler, Michael; Gianaros, Peter J; Giummarra, Melita J.; Greening, Steven G.; Guendelman, Simon; Heathers, James A. J.; Herpertz, Sabine C.; Hu, Mandy X.; Jentschke, Sebastian; Kaess, Michael; Kaufmann, Tobias; Klimes-Dougan, Bonnie; Koelsch, Stefan; Krauch, Marlene; Kumral, Deniz; Lamers, Femke; Lee, Tae-Ho; Lekander, Mats; Lin, Feng; Lotze, Martin; Makovac, Elena; Mancini, Matteo; Mancke, Falk; Månsson, Kristoffer N. T.; Manuck, Stephen B.; Mather, Mara; Meeten, Frances; Min, Jungwon; Mueller, Bryon A.; Muench, Vera; Nees, Frauke; Nga, Lin; Nilsonne, Gustav; Ordonez Acuna, Daniela; Osnes, Berge; Ottaviani, Cristina; Penninx, Brenda; Ponzio, Allison; Poudel, Govinda R.; Reinelt, Janis; Ren, Ping; Sakaki, Michiko; Schumann, Andy; Sørensen, Lin; Specht, Karsten; Straub, Joana; Tamm, Sandra; Thai, Michelle; Thayer, Julian F.; Ubani, Benjamin; van der Mee, Denise J.; van Velzen, Laura S.; Ventura-Bort, Carlos; Villringer, Arno; Watson, David R.; Wei, Luqing; Wendt, Julia; Schreiner, Melinda Westlund; Westlye, Lars Tjelta; Weymar, Mathias; Winkelmann, Tobias; Wu, Guo-Rong; Yoo, Hyun Joo & Quintana, Daniel (2020). Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis. Psychophysiology.  ISSN 0048-5772. . doi: 10.1111/psyp.13688 Full text in Research Archive. Show summary

  Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega‐analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.

• Lundberg, Mathias; Curbo, Sophie; Bohman, Hannes; Agartz, Ingrid; Ögren, Sven-Ove; Patrone, Cesare & Mansouri, Shiva (2020). Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy. Bioscience Reports.  ISSN 0144-8463.  40(1) . doi: 10.1042/BSR20193156 Full text in Research Archive.
• Rokicki, Jaroslav; Wolfers, Thomas; Nordhøy, Wibeke; Tesli, Natalia; Quintana, Daniel; Alnæs, Dag; Richard, Geneviève; de Lange, Ann-Marie Glasø; Lund, Martina Jonette; Norbom, Linn Christin Bonaventure; Agartz, Ingrid; Melle, Ingrid; Nærland, Terje; Selbæk, Geir; Persson, Karin Ester Torun; Nordvik, Jan Egil; Schwarz, Emanuel; Andreassen, Ole Andreas; Kaufmann, Tobias & Westlye, Lars Tjelta (2020). Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders. Human Brain Mapping.  ISSN 1065-9471.  s 1- 13 . doi: 10.1002/hbm.25323 Full text in Research Archive.
• Smelror, Runar; Rund, Bjørn Rishovd; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Wedervang-Resell, Kirsten; Andreassen, Ole Andreas; Ueland, Torill; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Negative and disorganized symptoms mediate the relationship between verbal learning and global functioning in adolescents with early-onset psychosis. European Child and Adolescent Psychiatry.  ISSN 1018-8827. . doi: 10.1007/s00787-020-01479-7 Full text in Research Archive.
• Tesli, Natalia; van der Meer, Dennis; Rokicki, Jaroslav; Storvestre, Guttorm Breivik; Røsæg, Cato; Jensen, Arvid; Hjell, Gabriela; Bell, Christina; Fischer-Vieler, Thomas; Tesli, Martin Steen; Andreassen, Ole Andreas; Melle, Ingrid; Agartz, Ingrid & Haukvik, Unn Kristin H. (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334. . doi: 10.1007/s00406-020-01098-y Full text in Research Archive.
• Thompson, Paul M.; Jahanshad, Neda; Ching, Christopher R.K.; Salminen, Lauren E.; Thomopoulos, Sophia I.; Bright, Joanna; Baune, Bernhard T.; Bertolin, Sara; Bralten, Janita; Bruin, Willem B.; Bulow, Robin; Chen, Jian; Chye, Yann; Dannlowski, Udo; de Kovel, Carolien G.F.; Donohoe, Gary; Eyler, Lisa T.; Faraone, Stephen V.; Favre, Pauline; Filippi, Courtney A.; Frodl, Thomas; Garijo, Daniel; Gil, Yolanda; Grabe, Hans J.; Grasby, Katrina L.; Hajek, Tomas; Han, Laura K.M.; Hatton, Sean N.; Hilbert, Kevin; Ho, Tiffany C.; Holleran, Laurena; Homuth, Georg; Hosten, Norbert; Houenou, Josselin; Ivanov, Iliyan; Jia, Tianye; Kelly, Sinead; Klein, Marieke; Kwon, Jun Soo; Laansma, Max A.; Leerssen, Jeanne; Lueken, Ulrike; Nunes, Abraham; O'Neill, Joseph; Opel, Nils; Piras, Fabrizio; Piras, Federica; Postema, Merel C.; Pozzi, Elena; Shatokhina, Natalia; Soriano-Mas, Carles; Spalletta, Gianfranco; Sun, Daqiang; Teumer, Alexander; Tilot, Amanda K.; Tozzi, Leonardo; van der Merwe, Celia; van Someren, Eus J.W.; van Wingen, Guido A.; Völzke, Henry; Walton, Esther; Wang, Lei; Winkler, Anderson M.; Wittfeld, Katharina; Wright, Margaret J.; Yun, Je-Yeon; Zhang, Guohao; Zhang-James, Yanli; Adhikari, Bhim M.; Agartz, Ingrid; Aghajani, Moji; Aleman, André; Althoff, Robert R.; Altmann, Andre; Andreassen, Ole Andreas; Baron, David A.; Bartnik-Olson, Brenda L.; Bas-Hoogendam, Janna Marie; Baskin-Sommers, Arielle R.; Bearden, Carrie E.; Berner, Laura A.; Boedhoe, Premika S.W.; Brouwer, Rachel M.; Buitelaar, Jan K.; Caeyenberghs, Karen; Cecil, Charlotte A.M.; Cohen, Ronald A.; Cole, James H.; Conrod, Patricia J.; De Brito, Stephane A.; de Zwarte, Sonja M.C.; Dennis, Emily L.; Desrivieres, Sylvane; Dima, Danai; Ehrlich, Stefan; Esopenko, Carrie; Fairchild, Graeme; Fisher, Simon E.; Fouche, Jean-Paul; Francks, Clyde; Frangou, Sophia; Franke, Barbara; Garavan, Hugh P.; Glahn, David C.; Groenewold, Nynke A.; Gurholt, Tiril Pedersen; Gutman, Boris A.; Hahn, Tim; Harding, Ian H.; Hernaus, Dennis; Hibar, Derrek P.; Hillary, Frank G.; Hoogman, Martine; Hulshoff Pol, Hilleke E.; Jalbrzikowski, Maria; Karkashadze, George A.; Klapwijk, Eduard T.; Knickmeyer, Rebecca C.; Kochunov, Peter; Koerte, Inga K.; Kong, Xiang-Zhen; Liew, Sook-Lei; Lin, Alexander P.; Logue, Mark W.; Luders, Eileen; Macciardi, Fabio; Mackey, Scott; Mayer, Andrew R.; McDonald, Carrie R.; McMahon, Agnes B.; Medland, Sarah E.; Modinos, Gemma; Morey, Rajendra A.; Mueller, Sven C.; Mukherjee, Pratik; Namazova-Baranova, Leyla; Nir, Talia M; Olsen, Alexander; Paschou, Peristera; Pine, Daniel S.; Pizzagalli, Fabrizio; Rentería, Miguel E.; Rohrer, Jonathan D.; Sämann, Philipp G.; Schmaal, Lianne; Schumann, Gunter; Shiroishi, Mark S.; Sisodiya, Sanjay M.; Smit, Dirk J.A.; Sønderby, Ida Elken; Stein, Dan J.; Stein, Jason L.; Tahmasian, Masoud; Tate, David F.; Turner, Jessica A.; van den Heuvel, Odile A; Van Der Wee, Nic J.A.; van der Werf, Ysbrand D.; van Erp, Theo G.M.; van Haren, Neeltje E.M.; van Rooij, Daan; van Velzen, Laura S.; Veer, Ilya M.; Veltman, Dick J.; Villalon-Reina, Julio E.; Walter, Henrik; Whelan, Christopher D.; Wilde, Elisabeth A.; Zarei, Mojtaba & Zelman, Vladimir (2020). ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry.  ISSN 2158-3188.  10:100, s 1- 28 . doi: 10.1038/s41398-020-0705-1 Full text in Research Archive.
• Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Doan, Nhat Trung; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  5(12), s 1095- 1103 . doi: 10.1016/j.bpsc.2020.06.014 Full text in Research Archive.
• Wedervang-Resell, Kirsten; Ueland, Thor; Aukrust, Pål; Friis, Svein; Holven, Kirsten Bjørklund; Johannessen, Cecilie Haggag; Lekva, Tove; Lonning, Vera Louise Hiorth; Smelror, Runar; Szabo, Attila; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis. Nature NPJ Schizophrenia.  ISSN 2334-265X.  6, s 1- 8 . doi: 10.1038/s41537-020-00112-5 Full text in Research Archive.
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders. Schizophrenia Research.  ISSN 0920-9964.  218, s 55- 62 . doi: 10.1016/j.schres.2020.03.006 Full text in Research Archive.
• Wierenga, Lara M.; Doucet, Gaëlle E.; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N.; Albajes-Eizagirre, Anton; Alnæs, Dag; Alpert, Kathryn I.; Andreassen, Ole Andreas; Anticevic, Alan; Gurholt, Tiril Pedersen; De Haan, Lieuwe; Haatveit, Beathe Christin; Jönsson, Erik Gunnar; Joska, John; Kalnin, Andrew J.; Klein, Marieke; Koenders, Laura; Kolskår, Knut-Kristian; van der Meer, Dennis; Menchon, José M.; Naaijen, Jilly; Nyberg, Lars; Oosterlaan, Jaap; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J.; Radua, Joaquim; Reif, Andreas; Richard, Geneviéve´; Weber, Bernd; Wen, Wei; West, John D.; Westlye, Lars Tjelta; Whalley, Heather C.; Williams, Steven Charles Rees; Wittfeld, Katharina; Wolf, Daniel H.; Wright, Margaret J.; Yoncheva, Yuliya N.; Zanetti, Marcus V.; Ziegler, Georg C.; de Zubicaray, Greig I.; Thompson, Paul M.; Crone, Eveline A.; Frangou, Sophia & Tamnes, Christian Krog (2020). Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping.  ISSN 1065-9471. . doi: 10.1002/hbm.25204 Full text in Research Archive.
• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob; Zhu, Zhaozhong; Tucker-Drob, Elliot M.; Nivard, Michel G.; Grotzinger, Andrew D.; Posthuma, Danielle; Yu, Dongmei; Stahl, Eli A.; Walters, Raymond K.; Anney, Richard J.L.; Duncan, Laramie E.; Ge, Tian; Belangero, Sintia I.; Cook, Edwin H.; Hoekstra, Pieter J.; Keski-Rahkonen, Anna; Kirov, George; Luykx, Jurjen J.; Rohde, Luis A.; Agerbo, Esben; Arranz, M.J.; Asherson, Philip; Bækvad-Hansen, Marie; Bellgrove, Mark A.; Belliveau Jr, Richard A.; Buitelaar, Jan; Bybjerg-Grauholm, Jonas; Casas, Miquel; Chambert, Kimberly; Cerrato, Felecia; Churchhouse, Claire; Cormand, Bru; Crosbie, Jennifer; Dalsgaard, Søren; Haavik, Jan; Hakonarson, Hakon; Hansen, Christine S.; Mors, Ole; Zayats, Tetyana; Bettella, Francesco; Hope, Sigrun; Hultman, Christina M.; Nærland, Terje; Bøen, Erlend; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Malt, Ulrik Fredrik; Melle, Ingrid; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Espeseth, Thomas; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Jönsson, Erik Gunnar; Andreassen, Ole Andreas; Agartz, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne & Joa, Inge (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell.  ISSN 0092-8674.  179(7), s 1469- 1482 . doi: 10.1016/j.cell.2019.11.020 Full text in Research Archive.
• Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry.  ISSN 2158-3188.  9 . doi: 10.1038/s41398-019-0432-7 Full text in Research Archive.
• Aas, Monica; Pizzagalli, Diego A.; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Ueland, Torill; Melle, Ingrid; Agartz, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas (2019). Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2019.01.011 Full text in Research Archive.
• Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav; Moberget, Torgeir; Bettella, Francesco; Agartz, Ingrid; Barch, Deanna M.; Bertolino, Alessandro; Brandt, Christine Lycke; Cervenka, Simon; Djurovic, Srdjan; Doan, Nhat Trung; Eisenacher, Sarah; Fatouros-Bergman, Helena; Flyckt, Lena; di Giorgio, Annabella; Haatveit, Beathe; Jönsson, Erik Gunnar; Kirsch, Peter; Lund, Martina Jonette; Meyer-Lindenberg, Andreas; Pergola, Giulio; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Quarto, Tiziana; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry.  ISSN 2168-6238.  76(7), s 739- 748 . doi: 10.1001/jamapsychiatry.2019.0257
• Bakke, Laura A. Wortinger; Engen, Kristine; Barth, Claudia; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Andreassen, Ole Andreas; Haukvik, Unn Kristin H.; Vaskinn, Anja; Ueland, Torill & Agartz, Ingrid (2019). Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants. Psychological Medicine.  ISSN 0033-2917.  s 1- 9 . doi: 10.1017/S0033291719002046
• Bless, Josef J; Hjelmervik, Helene; Torsheim, Torbjørn; Gudmundsen, Magne; Larøi, Frank; Holma, Irina; Arola, Anne; Korkeila, Jyrki; Hirnstein, Marco; Marquardt, Lynn Anne; Kusztrits, Isabella; Smelror, Runar; Agartz, Ingrid & Hugdahl, Kenneth (2019). Temporal Signatures of Auditory Verbal Hallucinations: An App-Based Experience Sampling Study. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2019.11.020 Full text in Research Archive.
• de Zwarte, Sonja M.C.; Brouwer, Rachel M.; Agartz, Ingrid; Alda, Martin; Aleman, André; Alpert, Kathryn I.; Bearden, Carrie E.; Bertolino, Alessandro; Bois, Catherine; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth E.L.; Cahn, Wiepke; Cannon, Dara M.; Cannon, Tyrone D.; Caseras, Xavier; Castro-Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; de la Serna, Elena; di Giorgio, Annabella; Doucet, Gaëlle E.; Eker, Mehmet Cagdas; Erk, Susanne; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Frankland, Andrew; Fullerton, Janice M.; Glahn, David C.; Goghari, Vina M.; Goldman, Aaron L.; Gonul, Ali Saffet; Gruber, Oliver; de Haan, Lieuwe; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hillegers, Manon H.J.; Hulshoff Pol, Hilleke E.; Hultman, Christina M.; Ingvar, Martin; Johansson, Viktoria; Jönsson, Erik Gunnar; Kane, Fergus; Kempton, Matthew J.; Koenis, Marinka M.G.; Kopecek, Miloslav; Krabbendam, Lydia; Krämer, Bernd; Lawrie, Stephen M.; Lenroot, Rhoshel K.; Marcelis, Machteld; Marsman, Jan-Bernard C.; Mattay, Venkata S.; McDonald, Colm; Meyer-Lindenberg, Andreas; Michielse, Stijn; Mitchell, Philip B.; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Najt, Pablo; Neilson, Emma; Newport, Jason; van Os, Jim; Overs, Bronwyn; Özerdem, Ayşegül; Picchioni, Marco M.; Richter, Anja; Roberts, Gloria; Aydogan, Aybala Saricicek; Schofield, Peter R.; Simsek, Fatma; Soares, Jair C.; Sugranyes, Gisela; Toulopoulou, Timothea; Tronchin, Giulia; Walter, Henrik; Wang, Lei; Weinberger, Daniel R.; Whalley, Heather C.; Yalin, Nefize; Andreassen, Ole Andreas; Ching, Christopher R.K.; van Erp, Theo G.M.; Turner, Jessica A.; Jahanshad, Neda; Thompson, Paul M.; Kahn, René S. & van Haren, Neeltje E.M. (2019). The association between familial risk and brain abnormalities is disease specific: An ENIGMA-relatives study of schizophrenia and bipolar disorder. Biological Psychiatry.  ISSN 0006-3223.  86(7), s 545- 556 . doi: 10.1016/j.biopsych.2019.03.985 Full text in Research Archive.
• Di Sero, Alessia; Jørgensen, Kjetil Nordbø; Nerland, Stener; Melle, Ingrid; Andreassen, Ole Andreas; Jovicich, Jorge & Agartz, Ingrid (2019). Antipsychotic treatment and basal ganglia volumes: Exploring the role of receptor occupancy, dosage and remission status. Schizophrenia Research.  ISSN 0920-9964.  208, s 114- 123 . doi: 10.1016/j.schres.2019.04.002
• Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Bøen, Erlend; Elvsåshagen, Torbjørn; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne; Ødegaard, Ketil Joachim; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, MacIej; Pers, Tune H; Holmans, Peter A.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E & Pedersen, Carsten Bøcker (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience.  ISSN 1662-4548.  13 . doi: 10.3389/fnins.2019.00220 Full text in Research Archive. Show summary

  Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.

• Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Donohoe, Gary; Gill, M; Corvin, A & Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics.  ISSN 0148-7299. . doi: 10.1002/ajmg.b.32716
• Hess, JL; Tylee, JS; Mattheisen, M; Agartz, Ingrid; Andreassen, Ole Andreas; Djurovic, Srdjan; Jönsson, Erik Gunnar; Melle, Ingrid; Holmans, P.; Faraone, Stephen V. & Glatt, Stephen J. (2019). A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry.  ISSN 1359-4184. . doi: 10.1038/s41380-019-0463-8
• Ing, Alex J.; Sämann, Philipp G.; Chu, Congying; Tay, Nicole; Biondo, Francesca; Robert, Gabriel; Jia, Tianye; Wolfers, Thomas; Desrivières, Sylvane; Banaschewski, Tobias; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Conrod, Patricia; Fadai, Tahmine; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Spechler, Philip A.; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Ittermann, Bernd; Kappel, Viola; Martinot, Jean-Luc; Meyer-Lindenberg, Andreas; Millenet, Sabina; Nees, Frauke; van Noort, Betteke; Orfanos, Dimitri Papadopoulos; Martinot, Marie-Laure Paillère; Penttilä, Jani; Poustka, Luise; Quinlan, Erin Burke; Smolka, Michael N.; Stringaris, Argyris; Struve, Maren; Veer, Ilya M.; Walter, Henrik; Whelan, Robert; Andreassen, Ole Andreas; Agartz, Ingrid; Lemaître, Hervé; Barker, Edward D.; Ashburner, John; Binder, Elisabeth; Buitelaar, Jan; Marquand, André; Robbins, Trevor W. & Schumann, Gunter (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour.  ISSN 2397-3374.  3(12), s 1306- 1318 . doi: 10.1038/s41562-019-0738-8
• Jiang, Wenhao; Andreassen, Ole Andreas; Agartz, Ingrid; Lagerberg, Trine Vik; Westlye, Lars Tjelta; Calhoun, Vince D. & Turner, Jessica A. (2019). Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder.. NeuroImage: Clinical.  ISSN 2213-1582.  s 1- 9 . doi: 10.1016/j.nicl.2019.101989 Full text in Research Archive.
• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience.  ISSN 1097-6256.  22(10), s 1617- 1623 . doi: 10.1038/s41593-019-0471-7 Full text in Research Archive.
• Mennigen, Eva; Jiang, Wenhao; Calhoun, Vince D; van Erp, Theo GM; Agartz, Ingrid; Ford, Judith M.; Mueller, Bryon A; Liu, Jingyuan & Turner, Jessica A (2019). Positive and general psychopathology associated with specific gray matter reductions in inferior temporal regions in patients with schizophrenia. Schizophrenia Research.  ISSN 0920-9964.  208, s 242- 249 . doi: 10.1016/j.schres.2019.02.010
• Mullins, Niamh; Bigdeli, Tim B.; Børglum, Anders D.; Coleman, Jonathan R.I.; Demontis, Ditte; Mehta, Divya; Power, Robert A.; Ripke, Stephan; Stahl, Eli A.; Starnawska, Anna; Anjorin, Adebayo; Corvin, Aiden; Sanders, Alan R.; Forstner, Andreas J.; Reif, Andreas; Koller, Anna C.; Świątkowska, Beata; Baune, Bernhard T.; Müller-Myhsok, Bertram; Penninx, Brenda W.J.H.; Pato, Carlos; Zai, Clement; Rujescu, Dan; Hougaard, David M.; Quested, Digby; Levinson, Douglas F.; Binder, Elisabeth B.; Byrne, Enda M.; Agerbo, Esben; Streit, Fabian; Mayoral, Fermin; Bellivier, Frank; Degenhardt, Franziska; Breen, Gerome; Morken, Gunnar; Turecki, Gustavo; Rouleau, Guy A.; Grabe, Hans J.; Völzke, Henry; Jones, Ian; Giegling, Ina; Agartz, Ingrid; Melle, Ingrid; Lawrence, Jacob; Walters, James T.R.; Strohmaier, Jana; Shi, Jianxin; Hauser, Joanna; Biernacka, Joanna M.; Vincent, John B.; Kelsoe, John; Strauss, John S.; Lissowska, Jolanta; Pimm, Jonathan; Smoller, Jordan W.; Guzman-Parra, José; Berger, Klaus; Scott, Laura J.; Jones, Lisa A.; Azevedo, M. Helena; Trzaskowski, Maciej; Kogevinas, Manolis; Rietschel, Marcella; Boks, Marco; Ising, Marcus; Grigoroiu-Serbanescu, Maria; Hamshere, Marian L.; Leboyer, Marion; Frye, Mark; Nöthen, Markus M.; Alda, Martin; Preisig, Martin; Nordentoft, Merete; Boehnke, Michael; O'Donovan, Michael C.; Owen, Michael J.; Pato, Michele T.; Renteriá, Miguel E.; Budde, Monika; Weissman, Myrna M.; Wray, Naomi R.; Bass, Nicholas; Craddock, Nicholas; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Mors, Ole; Gejman, Pablo V.; Sklar, Pamela; McGrath, Patrick; Hoffmann, Per; McGuffin, Peter; Lee, Phil H.; Mortensen, Preben Bo; Kahn, René S.; Ophoff, Roel A.; Adolfsson, Rolf; Van der Auwera, Sandra; Djurovic, Srdjan; Kloiber, Stefan; Heilmann-Heimbach, Stefanie; Jamain, Stéphane; Hamilton, Steven P.; McElroy, Susan L.; Lucae, Susanne; Cichon, Sven; Schulze, Thomas G.; Hansen, Thomas; Werge, Thomas; Air, Tracy M.; Nimgaonkar, Vishwajit; Appadurai, Vivek; Cahn, Wiepke; Milaneschi, Yuri; Fanous, Ayman H.; Kendler, Kenneth S.; McQuillin, Andrew & Lewis, Cathryn M. (2019). GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. American Journal of Psychiatry.  ISSN 0002-953X.  176(8), s 651- 660 . doi: 10.1176/appi.ajp.2019.18080957 Full text in Research Archive.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Gardsjord, Erlend Strand; Aas, Monica; Iversen, Trude; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Thor & Andreassen, Ole Andreas (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine.  ISSN 0033-2917.  49(10), s 1749- 1757 . doi: 10.1017/S0033291718004142 Show summary

  Background. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role

• Raballo, Andrea; Cicero, David C.; Kerns, John G.; Sanna, Sara; Pintus, Mirra; Agartz, Ingrid; Pintus, Elisa; Corrias, Irene; Lai, Veronica; Petretto, Donatella Rita; Carta, Mauro Giovanni & Preti, Antonio (2019). Tracking salience in young people: A psychometric field test of the Aberrant Salience Inventory (ASI). Early Intervention in Psychiatry.  ISSN 1751-7885.  13(1), s 64- 72 . doi: 10.1111/eip.12449
• Rahaman, MA; Turner, Jessica A.; Gupta, Cota Navin; Rachakonda, Srinivas; Chen, Jiayu; Liu, Jingyu; van Erp, Theo G.M.; Potkin, Steven; Ford, Judith; Mathalon, Daniel; Lee, Hyo Jong; Jiang, Wenhao; Mueller, Bryon A; Andreassen, Ole Andreas; Agartz, Ingrid; Sponheim, Scott R.; Mayer, Andrew Robert; Stephen, Julia; Jung, Rex E.; Canive, Jose; Bustillo, Juan R & Calhoun, Vince D. (2019). N-BiC: A Method for Multi-Component and Symptom Biclustering of Structural MRI Data: Application to Schizophrenia.. IEEE Transactions on Biomedical Engineering.  ISSN 0018-9294.  67(1), s 110- 121 . doi: 10.1109/TBME.2019.2908815
• Richards, Alexander L.; Pardiñas, Antonio F.; Frizzati, Aura; Tansey, Katherine E.; Lynham, Amy J.; Holmans, Peter; Legge, Sophie E.; Savage, Jeanne E.; Agartz, Ingrid; Andreassen, Ole Andreas; Blokland, Gabriella A. M.; Corvin, Aiden; Cosgrove, Donna; Degenhardt, Franziska; Djurovic, Srdjan; Espeseth, Thomas; Ferraro, Laura; Gayer-Anderson, Charlotte; Giegling, Ina; van Haren, Neeltje E.M.; Hartmann, Annette M.; Hubert, John J.; Jönsson, Erik Gunnar; Konte, Bettina; Lennertz, Leonhard; Olde Loohuis, Loes M.; Melle, Ingrid; Morgan, Craig; Morris, Derek W.; Murray, Robin M.; Nyman, Håkan; Ophoff, Roel A.; van Os, Jim; Petryshen, Tracey L.; Quattrone, Diego; Rietschel, Marcella; Rujescu, Dan; Rutten, Bart P. F.; Streit, Fabian; Strohmaier, Jana; Sullivan, Patrick F.; Sundet, Kjetil Søren; Wagner, Michael; Escott-Price, Valentina; Owen, Michael J.; Donohoe, Gary; O'Donovan, Michael C. & Walters, James T R (2019). The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. Schizophrenia Bulletin.  ISSN 0586-7614. . doi: 10.1093/schbul/sbz061 Show summary

  BACKGROUND: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. METHODS: We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results were then meta-analyzed across all samples. A genome-wide association studies (GWAS) of cognition was conducted in schizophrenia cases. RESULTS: PRS for both population IQ (P = 4.39 x 10-28) and EA (P = 1.27 x 10-26) were positively correlated with cognition in those with schizophrenia. In contrast, there was no association between cognition in schizophrenia cases and PRS for schizophrenia (P = .39), BD (P = .51), or MDD (P = .49). No individual variant approached genome-wide significance in the GWAS. CONCLUSIONS: Cognition in schizophrenia cases is more strongly associated with PRS that index cognitive traits in the general population than PRS for neuropsychiatric disorders. This suggests the mechanisms of cognitive variation within schizophrenia are at least partly independent from those that predispose to schizophrenia diagnosis itself. Our findings indicate that this cognitive variation arises at least in part due to genetic factors shared with cognitive performance in populations and is not solely due to illness or treatment-related factors, although our findings are consistent with important contributions from these factors.

• Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J.; Stein, Jason L.; Scholz, Markus; Sargurupremraj, Muralidharan; Jahanshad, Neda; Roshchupkin, Gennady V.; Smith, Albert V.; Bis, Joshua C.; Jian, Xueqiu; Luciano, Michelle; Hofer, Edith; Teumer, Alexander; van der Lee, Sven J.; Yang, Jingyun; Yanek, Lisa R.; Lee, Tom V.; Li, Shuo; Hu, Yanhui; Koh, Jia Yu; Eicher, John D.; Desrivières, Sylvane; Arias-Vasquez, Alejandro; Chauhan, Ganesh; Athanasiu, Lavinia; Rentería, Miguel E.; Kim, Sungeun; Hoehn, David; Armstrong, Nicola J.; Chen, Qiang; Holmes, Avram J.; den Braber, Anouk; Kloszewska, Iwona; Andersson, Micael; Espeseth, Thomas; Grimm, Oliver; Abramovic, Lucija; Alhusaini, Saud; Milaneschi, Yuri; Papmeyer, Martina; Axelsson, Tomas; Ehrlich, Stefan; Roiz-Santiáñez, Roberto; Kraemer, Bernd; Håberg, Asta; Jones, Hannah J; Pike, G. Bruce; Stein, Dan J.; Stevens, Allison; Bralten, Janita; Vernooij, Meike W.; Harris, Tamara B.; Filippi, Irina; Witte, A Veronica; Guadalupe, Tulio; Wittfeld, Katharina; Mosley, Thomas H.; Becker, James T.; Hagenaars, Saskia P.; Saba, Yasaman; Cuellar-Partida, Gabriel; Amin, Najaf; Hilal, Saima; Nho, Kwangsik; Mirza-Schreiber, Nazanin; Arfanakis, Konstantinos; Becker, Diane M.; Ames, David; Goldman, Aaron L.; Lee, Phil H.; Boomsma, Dorret I.; Lovestone, Simon; Giddaluru, Sudheer; Le Hellard, Stephanie; Mattheisen, Manuel; Bohlken, Marc M.; Kasperaviciute, Dalia; Schmaal, Lianne; Lawrie, Stephen M.; Agartz, Ingrid; Walton, Esther; Tordesillas-Gutierrez, Diana; Davies, Gareth E.; Shin, Jean; Ipser, Jonathan C.; Vinke, Louis N.; Hoogman, Martine; Jia, Tianye; Burkhardt, Ralph; Klein, Marieke; Crivello, Fabrice; Janowitz, Deborah; Carmichael, Owen; Haukvik, Unn Kristin H.; Aribisala, Benjamin S.; Schmidt, Helena; Strike, Lachlan T.; Cheng, Ching-Yu; Risacher, Shannon L.; Putz, Benno; Fleischman, Debra A.; Assareh, Amelia A.; Mattay, Venkata S.; Buckner, Randy L.; Mecocci, Patrizia; Dale, Anders; Cichon, Sven; Boks, Marco P.; Matarin, Mar; Penninx, Brenda W.J.H.; Calhoun, Vince D.; Chakravarty, M. Mallar; Marquand, André F.; Macare, Christine; Kharabian Masouleh, Shahrzad; Oosterlaan, Jaap; Amouyel, Philippe; Hegenscheid, Katrin; Rotter, Jerome I.; Schork, Andrew J.; Liewald, David C.M.; de Zubicaray, Greig I.; Wong, Tien Yin; Shen, Li; Sämann, Philipp G.; Brodaty, Henry; Roffman, Joshua L.; de Geus, Eco J.C.; Tsolaki, Magda; Erk, Susanne; van Eijk, Kristel R.; Cavalleri, Gianpiero L.; Van Der Wee, Nic J.A.; McIntosh, Andrew M.; Gollub, Randy L.; Bulayeva, Kazima B.; Bernard, Manon; Richards, Jennifer S.; Himali, Jayandra J.; Loeffler, Markus; Rommelse, Nanda; Hoffmann, Wolfgang; Westlye, Lars Tjelta; Valdés Hernández, Maria C.; Hansell, Narelle K.; van Erp, Theo G.M.; Wolf, Christiane; Kwok, John B.J.; Vellas, Bruno; Heinz, Andreas; Olde Loohuis, Loes M.; Delanty, Norman; Ho, Beng-Choon; Ching, Christopher R.K.; Shumskaya, Elena; Singh, Baljeet; Hofman, Albert; Homuth, Georg; Psaty, Bruce M.; Bastin, Mark E.; Montgomery, Grant W.; Foroud, Tatiana M.; Reppermund, Simone; Hottenga, Jouke-Jan; Simmons, Andrew; Meyer-Lindenberg, Andreas; Cahn, Wiepke; Whelan, Christopher D; van Donkelaar, Marjolein M.J.; Yang, Qiong; Hosten, Norbert; Green, Robert C.; Thalamuthu, Anbupalam; Mohnke, Sebastian; Hulshoff Pol, Hilleke E.; Lin, Honghuang; Jack, Clifford R.; Schofield, Peter R.; Mühleisen, Thomas W.; Maillard, Pauline; Potkin, Steven G.; Wen, Wei; Fletcher, Evan; Toga, Arthur W.; Gruber, Oliver; Huentelman, Matthew; Davey Smith, George; Launer, Lenore J.; Nyberg, Lars; Jönsson, Erik Gunnar; Crespo-Facorro, Benedicto; Koen, Nastassja; Greve, Douglas N.; Uitterlinden, André G.; Weinberger, Daniel R.; Steen, Vidar Martin; Fedko, Iryna O.; Groenewold, Nynke A.; Niessen, Wiro J.; Toro, Roberto; Tzourio, Christophe; Longstreth, William T.; Ikram, M. Kamran; Smoller, Jordan W.; van Tol, Marie-Jose; Sussmann, Jessika E.; Paus, Tomáš; Lemaître, Hervé; Schroeter, Matthias L.; Mazoyer, Bernard; Andreassen, Ole Andreas; Holsboer, Florian; Depondt, Chantal; Veltman, Dick J.; Turner, Jessica A.; Pausova, Zdenka; Schumann, Gunter; van Rooij, Daan; Djurovic, Srdjan; Deary, Ian J.; McMahon, Katie L; Müller-Myhsok, Bertram; Brouwer, Rachel M.; Soininen, Hilkka; Pandolfo, Massimo; Wassink, Thomas H.; Cheung, Joshua W.; Wolfers, Thomas; Martinot, Jean-Luc; Zwiers, Marcel P.; Nauck, Matthias; Melle, Ingrid; Martin, Nicholas G.; Kanai, Ryota; Westman, Eric; Kahn, René S.; Sisodiya, Sanjay M.; White, Tonya; Saremi, Arvin; van Bokhoven, Hans; Brunner, Han G.; Völzke, Henry; Wright, Margaret J.; van `t Ent, Dennis; Nöthen, Markus M.; Ophoff, Roel A.; Buitelaar, Jan K.; Fernandéz, Guillén; Sachdev, Perminder S.; Rietschel, Marcella; van Haren, Neeltje E.M.; Fisher, Simon E.; Beiser, Alexa S.; Francks, Clyde; Saykin, Andrew J.; Mather, Karen A.; Romanczuk-Seiferth, Nina; Hartman, Catharina A.; DeStefano, Anita L; Heslenfeld, Dirk J.; Weiner, Michael W.; Walter, Henrik; Hoekstra, Pieter J.; Nyquist, Paul A.; Franke, Barbara; Bennett, David A.; Grabe, Hans J.; Johnson, Andrew D.; Chen, Christopher; van Duijn, Cornelia M.; Lopez, Oscar L.; Fornage, Myriam; Wardlaw, Joanna M.; Schmidt, Reinhold; DeCarli, Charles; De Jager, Philip L.; Villringer, Arno; Debette, Stéphanie; Gudnason, Vilmundur; Medland, Sarah E.; Shulman, Joshua M.; Thompson, Paul M.; Seshadri, Sudha; Ikram, M. Arfan; Doan, Nhat Trung & van der Meer, Dennis (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics.  ISSN 1061-4036.  51, s 1624- 1636 . doi: 10.1038/s41588-019-0511-y Full text in Research Archive. Show summary

  Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

• Schwarz, Emanuel; Doan, Nhat Trung; Pergola, Giulio; Westlye, Lars Tjelta; Kaufmann, Tobias; Wolfers, Thomas; Brecheisen, Ralph; Quarto, Tiziana; Ing, Alex J.; di Carlo, Pasquale; Gurholt, Tiril Pedersen; Harms, Robbert L.; Noirhomme, Quentin; Moberget, Torgeir; Agartz, Ingrid; Andreassen, Ole Andreas; Bellani, Marcella; Bertolino, Alessandro; Blasi, Giuseppe; Brambilla, Paolo; Buitelaar, Jan K.; Cervenka, Simon; Flyckt, Lena; Frangou, Sophia; Franke, Barbara; Hall, Jeremy; Heslenfeld, Dirk J.; Kirsch, Peter; McIntosh, Andrew M.; Nöthen, Markus M.; Papassotiropoulos, Andreas; de Quervain, Dominique J.F.; Rietschel, Marcella; Schumann, Gunter; Tost, Heike; Witt, Stephanie H.; Zink, Mathias & Meyer-Lindenberg, Andreas (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational Psychiatry.  ISSN 2158-3188.  9(12) . doi: 10.1038/s41398-018-0225-4 Full text in Research Archive.
• Smelror, Runar; Bless, Josef J; Hugdahl, Kenneth & Agartz, Ingrid (2019). Feasibility and Acceptability of Using a Mobile Phone App for Characterizing Auditory Verbal Hallucinations in Adolescents With Early-Onset Psychosis: Exploratory Study. Journal of Medical Internet Research.  ISSN 1438-8871.  3(2) . doi: 10.2196/13882 Full text in Research Archive.
• Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Byrne, Enda M.; Pers, Tune H.; Holmans, Peter A.; Richards, Alexander L.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P.; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miquel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Charney, Alxander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; Depaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartolomei, Claudia; Pedersen, Marianne Giørtz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tifany A.; Grove, Jakob; Guan, Weihua; Guzman-Parra, José; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica S.; Juréus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Mühleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P.S.; Oruc, Lilijana; Ösby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Céline S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sánchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Shannon Weickert, Cynthia; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav Bjerkehagen; Sobell, Janet L.; Søholm Hansen, Christine; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zöllner, Sebastian; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boehnke, Michael; Børglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tõnu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Gill, Michael; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, René S.; Kirov, George; Landén, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C; Ødegaard, Ketil Joachim; Owen, Michael J.; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribasés, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne; Vieta, Eduard; Vincent, John B.; Werge, Thomas; Nurnberger, John I.; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole Andreas; Kelsoe, John & Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics.  ISSN 1061-4036.  51(5), s 793- 803 . doi: 10.1038/s41588-019-0397-8 Full text in Research Archive.
• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail & Andreassen, Ole Andreas (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine.  ISSN 0033-2917.  17(2) . doi: 10.1017/S0033291719000400 Full text in Research Archive.
• Storvestre, Guttorm Breivik; Valnes, Lars Magnus; Jensen, Arvid; Nerland, Stener; Tesli, Natalia; Hymer, Knut-Erik; Røsæg, Cato; Server, Andres Alonso; Ringen, Petter Andreas; Jacobsen, Morten; Andreassen, Ole Andreas; Agartz, Ingrid; Melle, Ingrid & Haukvik, Unn Kristin H. (2019). A preliminary study of cortical morphology in schizophrenia patients with a history of violence. Psychiatry Research : Neuroimaging.  ISSN 0925-4927.  288, s 29- 36 . doi: 10.1016/j.pscychresns.2019.04.013 Full text in Research Archive.
• Tesli, Natalia; Westlye, Lars Tjelta; Storvestre, Guttorm Breivik; Gurholt, Tiril Pedersen; Agartz, Ingrid; Melle, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2019). White matter microstructure in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334. . doi: 10.1007/s00406-019-00988-0
• van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Cavalleri, Gianpiero L.; Ching, Christopher R.K.; Cichon, Sven; Ciufolini, Simone; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J.C.; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Delanty, Norman; den Braber, Anouk; Desrivieres, Sylvane; di Forti, Marta; Doherty, Joanne L.; Donohoe, Gary; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Håberg, Asta; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek; Hillegers, Manon H.J.; Hoffmann, Per; Holleran, Laurena; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jacquemont, Sébastien; Jahanshad, Neda; Jockwitz, Christiane; Johansson, Stefan; Jönsson, Erik Gunnar; Kikuchi, Masataka; Knowles, Emma E.M.; Kwok, John B.; Le Hellard, Stephanie; Linden, David E.J.; Liu, Jingyu; Lundervold, Arvid; Lundervold, Astri; Martin, Nicholas G.; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Moberget, Torgeir; Moreau, Clara; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nordvik, Jan Egil; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomáš; Pausova, Zdenka; Peralta, Juan M.; Pike, Bruce; Prieto, Carlos; Quinlan, Erin Burke; Reinbold, Céline Sonja; Reis Marques, Tiago; Rucker, James J.H.; Sachdev, Perminder S.; Sando, Sigrid Botne; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Steen, Vidar Martin; Stein, Dan J.; Strike, Lachlan T.; Tamnes, Christian Krog; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ülfarsson, Magnús Ö; van 't Ent, Dennis; van den Bree, Marianne B.M.; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Zayats, Tetyana; Dale, Anders; Djurovic, Srdjan; Agartz, Ingrid; Westlye, Lars Tjelta; Stefansson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry.  ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2019.3779 Show summary

  IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders

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• Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas; Bøen, Erlend; Còrdova Palomera, Aldo; Dale, Anders; Doan, Nhat Trung; Elvsåshagen, Torbjørn; Faraone, Stephen V.; Gurholt, Tiril Pedersen; Haavik, Jan; Høvik, Marie Farstad; Hugdahl, Kenneth; Jönsson, Erik Gunnar; Lundervold, Astri; Malt, Ulrik Fredrik; Nerland, Stener; Nordvik, Jan Egil; Plessen, Kerstin J.; Smelror, Runar; van den Heuvel, Odile A; van der Meer, Dennis; Lønning, Kjersti; Westlye, Lars Tjelta; Glahn, David C.; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E.; Thompson, Paul M. & Francks, Clyde (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  115(22), s E5154- E5163 . doi: 10.1073/pnas.1718418115
• Maier, Robert M.; Zhu, Zhihong; Lee, Sang Hong; Trzaskowski, Maciej; Ruderfer, Douglas M.; Stahl, Eli A.; Ripke, Stephan; Wray, Naomi R.; Yang, Jian; Visscher, Peter M.; Robinson, Matthew R.; Wang, Yunpeng; Elvsåshagen, Torbjørn; Djurovic, Srdjan; Agartz, Ingrid; Mattingsdal, Morten & Melle, Ingrid (2018). Improving genetic prediction by leveraging genetic correlations among human diseases and traits. Nature Communications.  ISSN 2041-1723.  9:989, s 1- 17 . doi: 10.1038/s41467-017-02769-6
• Mørch-Johnsen, Lynn Egeland; Agartz, Ingrid & Jensen, Jimmy Kristian (2018). The Neural Correlates of Negative Symptoms in Schizophrenia: Examples From MRI Literature. Clinical EEG and Neuroscience.  ISSN 1550-0594.  49(1), s 12- 17 . doi: 10.1177/1550059417746214
• Mørch-Johnsen, Lynn; Nerland, Stener; Jørgensen, Kjetil Nordbø; Osnes, Kåre; Hartberg, Cecilie Bhandari; Andreassen, Ole Andreas; Melle, Ingrid; Nesvåg, Ragnar & Agartz, Ingrid (2018). Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations. Bipolar Disorders.  ISSN 1398-5647.  20(7), s 647- 657 . doi: 10.1111/bdi.12627
• Ni, Guiyan; Gratten, Jacob; Wray, Naomi R.; Lee, Sang Hong; Agartz, Ingrid; Djurovic, Srdjan; Joa, Inge; Mattingsdal, Morten; Melle, Ingrid; Andreassen, Ole Andreas & Jönsson, Erik Gunnar (2018). Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-28160-z Full text in Research Archive.
• Nunes, Abraham; Schnack, Hugo G.; Ching, Christopher R.K.; Agartz, Ingrid; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T; Bøen, Erlend; Bonnin, Caterina del Mar; Busatto, Geraldo F.; Canales-Rodriguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Chaim-Avancini, Tiffany M.; Dannlowski, Udo; Díaz-Zuluaga, Ana M.; Dietsche, Bruno; Doan, Nhat Trung; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Emden, Daniel; Eyler, Lisa T.; Fatjó-Vilas, Mar; Favre, Pauline; Foley, Sonya F.; Fullerton, Janice M.; Glahn, David C.; Goikolea, Jose M.; Grotegerd, Dominik; Hahn, Tim; Henry, Chantal; Hibar, Derrek; Houenou, Josselin; Howells, Fleur M.; Jahanshad, Neda; Kaufmann, Tobias; Kenney, Joanne; Kircher, Tilo T.J.; Krug, Axel; Lagerberg, Trine Vik; Lenroot, Rhoshel K.; López-Jaramillo, Carlos; Machado-Vieira, Rodrigo; Malt, Ulrik Fredrik; McDonald, Colm; Mitchell, Philip B.; Mwangi, Benson; Nabulsi, Leila; Opel, Nils; Overs, Bronwyn J.; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Redlich, Ronny; Roberts, Gloria; Rosa, Pedro G.; Salvador, Raymond; Satterthwaite, Theodore D.; Soares, Jair C.; Stein, Dan J.; Temmingh, Henk S.; Trappenberg, Thomas; Uhlmann, Anne; van Haren, Neeltje E.M.; Vieta, Eduard; Westlye, Lars Tjelta; Wolf, Daniel H.; Yüksel, Dilara; Zanetti, Marcus V.; Andreassen, Ole Andreas; Thompson, Paul M. & Hájek, Tomás (2018). Using structural MRI to identify bipolar disorders ? 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry.  ISSN 1359-4184. . doi: 10.1038/s41380-018-0228-9 Full text in Research Archive.
• Psychiatric Genomics Consorti, Bipolar Sczhizophrenia; Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alxander W.; Ori, Anil P.S.; Domenici, Enrico; Di Florio, A; Papiol, S; Kalman, Janos; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Joa, Inge; Malt, Ulrik Fredrik; Mattingsdal, Morten; Melle, Ingrid; Morken, Gunnar; Nordentoft, Merete; Nordin, Annelie; Ødegaard, Ketil Joachim; Smeland, Olav Bjerkehagen; Stordal, Eystein; Vaaler, Arne; Wang, Yunpeng; Zheng, Xuebin; Zimprich, Fritz; Zöllner, Sebastian; Corvin, Aiden; Fanous, Ayman H.; Rietschel, Marcella; Gershon, Elliot S.; Schulze, Thomas G.; Cuellar-Barboza, Alfredo B.; Forstner, Andreas J.; Holmans, Peter A.; Nurnberger, John I.; Andreassen, Ole Andreas; Hong Lee, S; O'Donovan, Michael C.; Sullivan, Patrick F.; Ophoff, Roel A.; Wray, Naomi R.; Sklar, Pamela & Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.. Cell.  ISSN 0092-8674.  173(7), s 1705- 1715 . doi: 10.1016/j.cell.2018.05.046
• Smelror, Runar; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Kelleher, Ian; Cannon, Mary; DeRosse, Pamela; Malhotra, Anil K.; Karlsgodt, Katherine H. ; Andreassen, Ole Andreas; Lundberg, Mathias; Edbom, Tobias; Cleland, Neil; Ueland, Torill; Myhre, Anne Margrethe; Rund, Bjørn Rishovd & Agartz, Ingrid (2018). Healthy adolescent performance with standardized scoring tables for the MATRICS Consensus Cognitive Battery: A multisite study. Schizophrenia Bulletin.  ISSN 0586-7614.  45(4), s 773- 783 . doi: 10.1093/schbul/sby131
• Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Ueland, Torill; Lagerberg, Trine Vik; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-32355-9 Full text in Research Archive.
• van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 13 . doi: 10.1038/s41380-018-0262-7 Full text in Research Archive.
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• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; wenhao, jiang; Glahn, David C; Pearlson, Godfrey D; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Clark, Vincent P; Mueller, Bryon A; de Zwarte, Sonja M.C.; Ophoff, Roel A; Van Haren, Neeltje E M; Andreassen, Ole Andreas; Gurholt, Tiril Pedersen; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Calhoun, Vince D; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; tordesillas-guiterrez, diana; Loughland, Carmel M; Catts, Stanley; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans; Jablensky, Assen; Mowry, Bryan J.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; weickert, cynthia; Weickert, Thomas W.; Hong, Elliot; Kochunov, Peter; Gur, Raquel E; Gur, Ruben C; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel; Potkin, Steven G; Preda, Adrian; Fan, Fengmei; Ehrlich, Stefan; King, Margaret D.; De Haan, Lieuwe; Veltman, Dick J; Assogna, Francesca; Banaj, Nerisa; De Rossi, Pietro; Lorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; Pomarol-Clotet, Edith; Kelly, Sinéad; Ciufollini, Simone; Radua, Joaquim; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; schonborn-harrisberger, fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; bertolino, allessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Yun, Je-Yeon; Cannon, Dara M; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; fatouros-bergmann, helena; Flyckt, Lena; Farde, Lars; Cervenka, Simon; Agartz, Ingrid; Collste, Karin; Victorsson, Pauliina; Engberg, Göran; Erhardt, Sophie; Schwieler, Lilly; Malmqvist, Anna; Hedberg, Mikael; Orhan, Funda; Piehl, Fredrik; Rosa, Pedro GP; Serpa, Mauricio H; Zanetti, Marcus V; Hoschl, Cyril; Škoch, Antonín; Spaniel, Filip; Tomecek, David; McIntosh, Andrew M.; Whalley, Heather C; Knochel, Christian; oertel-knöchel, viola; Howells, Fleur M; Stein, Dan J.; Temmingh, Henk S.; Uhlmann, Anne; Lopez-Jaramillo, Carlos; Dima, Danai; Faskowitz, Joshua I; Gutman, Boris A; Jahanshad, Neda; Thompson, Paul M & Turner, Jessica A (2018). Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.10.003
• Walton, E; Hibar, Derrek; Van Erp, Theo G M; Potkin, Steven G; Roiz-Santiañez, Roberto; Crespo-Facorro, B; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn Egeland; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Jahanshad, Neda; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Spalletta, Gianfranco; Gur, Raquel E; Gur, Ruben C; Wolf, Daniel H.; Satterthwaite, TD; Beard, Lauren M.; Sommer, Iris E; Koops, Sanne; Gruber, Oliver; Richter, A; Krämer, Bernhard; Kelly, S; Donohoe, G; McDonald, C; Cannon, Dara M; Corvin, Aiden; Gill, M; Di Giorgio, Annabella; Bertolino, A; Lawrie, Stephen M; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, J A & Ehrlich, S (2018). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine.  ISSN 0033-2917.  48(1), s 82- 94 . doi: 10.1017/S0033291717001283 Full text in Research Archive.
• Wolfers, Thomas; Doan, Nhat Trung; Kaufmann, Tobias; Alnæs, Dag; Moberget, Torgeir; Agartz, Ingrid; Buitelaar, Jan K.; Ueland, Torill; Melle, Ingrid; Franke, Barbara; Andreassen, Ole Andreas; Beckmann, Christian F.; Westlye, Lars Tjelta & Marquand, André F. (2018). Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models. JAMA psychiatry.  ISSN 2168-6238.  75(11), s 1146- 1155 . doi: 10.1001/jamapsychiatry.2018.2467
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Full text in Research Archive.
• Aas, Monica; Kauppi, Karolina; Brandt, Christine Lycke; Tesli, Martin Steen; Kaufmann, Tobias; Steen, Nils Eiel; Agartz, Ingrid; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. Psychological Medicine.  ISSN 0033-2917.  47(4), s 669- 679 . doi: 10.1017/S0033291716002762

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• Fagerberg, Tomas; Söderman, Erik; Gustavsson, J. Petter; Agartz, Ingrid & Jönsson, Erik Gunnar (2019). Correction to: Stability of personality traits over a five-year period in Swedish patients with schizophrenia spectrum disorder and nonpsychotic individuals: A study using the Swedish universities scales of personality. BMC Psychiatry.  ISSN 1471-244X.  19(109) . doi: 10.1186/s12888-019-2086-7
• Jørgensen, Kjetil Nordbø; Nerland, Stener; Moberget, Torgeir; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Andreassen, Ole Andreas & Agartz, Ingrid (2019). Optimizing the T1/T2 ratio for analysis within and between subjects.
• Checa, Antonio; Malmqvist, Anna; Flyckt, Lena; Schwieler, Lilly; Samuelsson, Martin; Skogh, Elisabeth; Cervenka, Simon; Dahl, Marja-Liisa; Piehl, Fredrik & Agartz, Ingrid (2018). Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients. Schizophrenia Research.  ISSN 0920-9964.  199, s 438- 441 . doi: 10.1016/j.schres.2018.03.029
• Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D. Schizophrenia Research.  ISSN 0920-9964.  199, s 433- 435 . doi: 10.1016/j.schres.2018.03.011

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