Johanne Tracey Jacobsen

• Nakandakari-Higa, Sandra; Walker, Sarah; Canesso, Maria C. C.; van der Heide, Verena; Chudnovskiy, Aleksey & Kim, Dong-Yoon [Show all 18 contributors for this article] (2024). Universal recording of immune cell interactions in vivo. Nature. ISSN 0028-0836. 627(8003), p. 399–406. doi: 10.1038/s41586-024-07134-4.
• Graca, Luis; Jacobsen, Johanne Tracey & Kumar, Saumya (2023). The expanding family of T follicular regulatory cells. Science immunology. ISSN 2470-9468. 8(82). doi: 10.1126/sciimmunol.adg7526.
• Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Haabeth, Ole Audun; Løset, Geir Åge & Braathen, Ranveig [Show all 10 contributors for this article] (2019). B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(51), p. 25850–25859. doi: 10.1073/pnas.1902836116. Full text in Research Archive Show summary

  The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4+ T cells. It is not known if naive B cells spontaneously display pId:MHCII in vivo or if BCR ligation is required for expression, thereby enabling collaboration between Id+ B cells and Id-specific T cells. Here, using a mouse model, we show that naive B cells do not express readily detectable levels of pId:MHCII. However, BCR ligation by Ag dramatically increases physical display of pId:MHCII, leading to activation of Id-specific CD4+ T cells, extrafollicular T-B cell collaboration and some germinal center formation, and production of Id+ IgG. Besides having implications for immune regulation, the results may explain how persistent activation of self-reactive B cells induces the development of autoimmune diseases and B cell lymphomas.

• Andersen, Tor Kristian; Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Fauskanger, Marte & Tveita, Anders Aune [Show all 8 contributors for this article] (2019). Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. npj Vaccines. ISSN 2059-0105. 4:9, p. 1–13. doi: 10.1038/s41541-019-0101-0. Full text in Research Archive
• Jacobsen, Johanne Tracey; Mesin, Luka; Markoulaki, Styliani; Schiepers, Ariën; Cavazzoni, Cecilia B. & Bousbaine, Djenet [Show all 8 contributors for this article] (2018). One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 215(10), p. 2686–2695. doi: 10.1084/jem.20172064. Full text in Research Archive
• Ersching, Jonatan; Efeyan, Alejo; Mesin, Luka; Jacobsen, Johanne Tracey; Pasqual, Giulia & Grabiner, Brian C [Show all 9 contributors for this article] (2017). Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Immunity. ISSN 1074-7613. 46(6), p. 1045–1058.e6. doi: 10.1016/j.immuni.2017.06.005.
• Van Elssen, Catharina H.M.J.; Rashidian, Mohammad; Vrbanac, Vladimir; Wucherpfennig, Kai W.; El Habre, Zeina & Sticht, Jana [Show all 14 contributors for this article] (2017). Noninvasive imaging of human immune responses in a human xenograft model of graft-versus-host disease. Journal of Nuclear Medicine. ISSN 0161-5505. 58(6), p. 1003–1008. doi: 10.2967/jnumed.116.186007.
• Rashidian, Mohammad; Keliher, Edmund J.; Bilate, Angelina M.; Duarte, Joao N.; Wojtkiewicz, Gregory R. & Jacobsen, Johanne Tracey [Show all 11 contributors for this article] (2015). Noninvasive imaging of immune responses. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 112(19), p. 6146–6151. doi: 10.1073/pnas.1502609112.
• Jacobsen, Johanne Tracey; Haabeth, Ole Audun; Tveita, Anders; Schjetne, Karoline W; Munthe, Ludvig Andre & Bogen, Bjarne (2014). Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells. Journal of Immunology. ISSN 0022-1767. 192(9), p. 4174–4183. doi: 10.4049/jimmunol.1302359.
• Jacobsen, Johanne Tracey; Gjerstad, Vibeke Sundvold; Skjeldal, Frode Miltzow; Andersen, Jan Terje; Abrahamsen, Greger & Bakke, Oddmund [Show all 8 contributors for this article] (2013). B-cell tolerance to the B-cell receptor variable regions. European Journal of Immunology. ISSN 0014-2980. 43(10), p. 2577–2587. doi: 10.1002/eji.201243203.
• Jacobsen, Johanne Tracey; Lunde, Elin; Gjerstad, Vibeke Sundvold; Munthe, Ludvig Andre & Bogen, Bjarne (2010). The cellular mechanism by which complementary Id(+) and anti-Id antibodies communicate: T cells integrated into idiotypic regulation. Immunology and Cell Biology. ISSN 0818-9641. 88(5), p. 515–522. doi: 10.1038/icb.2009.118.

View all works in Cristin

• Jacobsen, Johanne Tracey; Schjetne, Karoline W; Munthe, Ludvig Andre & Bogen, Bjarne (2012). Naive anti-Id B cells and Id-specific CD4(+) T cells collaborate efficiently to non infectious antigens in the absence of dendritic cells. Journal of Immunology. ISSN 0022-1767. 188.
• Jacobsen, Johanne Tracey; Schjetne, Karoline W; Munthe, Ludvig Andre & Bogen, Bjarne (2011). New Immunoglobulin Knock-in Mice for Idiotype (Id)-Driven T-B Collaboration. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 388–388.

View all works in Cristin