June Helen Myklebust

• Spasevska, Ivana; Sharma, Ankush; Steen, Chloe Beate; Josefsson, Sarah Elisabet; Blaker, Yngvild Nuvin & Kolstad, Arne [Show all 26 contributors for this article] (2023). Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma. Blood Advances. ISSN 2473-9529. 7(23), p. 7216–7230. doi: 10.1182/bloodadvances.2023010158. Full text in Research Archive
• Casey, Nicholas Paul; Klee, Clara Helena; Bøthun, Anne Fåne; Caulier, Benjamin William; Graczyk-Jarzynka, Agnieszka & Krawczyk, Marta [Show all 17 contributors for this article] (2023). Efficient chimeric antigen receptor targeting of a central epitope of CD22. Journal of Biological Chemistry. ISSN 0021-9258. 299(7). doi: 10.1016/j.jbc.2023.104883. Full text in Research Archive
• Huse, Kanutte; Bai, Baoyan; Hilden, Vera Irene; Bollum, Lise Kristin; Våtsveen, Thea Kristin & Munthe, Ludvig Andre [Show all 10 contributors for this article] (2022). Mechanism of CD79A and CD79B support for IgM+ B cell fitness through B cell receptor surface expression. Journal of Immunology. ISSN 0022-1767. 209(10), p. 2042–2053. doi: 10.4049/jimmunol.2200144. Show summary

  he BCR consists of surface-bound Ig and a heterodimeric signaling unit comprised of CD79A and CD79B. Upon cognate Ag recognition, the receptor initiates important signals for B cell development and function. The receptor also conveys Ag-independent survival signals termed tonic signaling. Although the requirement of a CD79A/CD79B heterodimer for BCR complex assembly and surface expression is well established based on mice models, few studies have investigated this in human mature B cells. In this study, we found that human tonsillar B cells with high surface expression of IgM or IgG had potentiated BCR signaling compared with BCRlow cells, and high IgM expression in germinal center B cells was associated with reduced apoptosis. We explored the mechanism for IgM surface expression by CRISPR/Cas9-induced deletion of CD79A or CD79B in four B lymphoma cell lines. Deletion of either CD79 protein caused loss of surface IgM in all cell lines and reduced fitness in three. From two cell lines, we generated stable CD79A or CD79B knockout clones and demonstrated that loss of CD79A or CD79B caused a block in N-glycan maturation and accumulation of immature proteins, compatible with retention of BCR components in the endoplasmic reticulum. Rescue experiments with CD79B wild-type restored surface expression of CD79A and IgM with mature glycosylation, whereas a naturally occurring CD79B G137S mutant disrupting CD79A/CD79B heterodimerization did not. Our study highlights that CD79A and CD79B are required for surface IgM expression in human B cells and illuminates the importance of the IgM expression level for signaling and fitness.

• Rye, Inga Hansine; Huse, Kanutte; Josefsson, Sarah Elisabet; Kildal, Wanja; Danielsen, Håvard Emil Greger & Schlichting, Ellen [Show all 28 contributors for this article] (2021). Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression. Molecular Oncology. ISSN 1574-7891. 16(1), p. 88–103. doi: 10.1002/1878-0261.13047. Full text in Research Archive
• Spasevska, Ivana & Myklebust, June Helen (2021). What it takes to transform a T cell. Cancer Research. ISSN 0008-5472. 81(12), p. 3160–3161. doi: 10.1158/0008-5472.CAN-21-0784.
• Oksvold, Morten Pedersen; Berglund, Ulrika Warpman; Gad, Helge; Bai, Baoyan; Stokke, Trond & Rein, Idun Dale [Show all 14 contributors for this article] (2021). Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-85613-8. Full text in Research Archive
• Steen, Chloé Beate; Luca, Bogdan A.; Esfahani, Mohammad S.; Azizi, Armon; Sworder, Brian J. & Nabet, Barzin Y. [Show all 16 contributors for this article] (2021). The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma. Cancer Cell. ISSN 1535-6108. 39(10), p. 1422–1437. doi: 10.1016/j.ccell.2021.08.011.
• Köksal, Hakan; Dillard, Pierre; Juzeniene, Asta; Kvalheim, Gunnar; Smeland, Erlend B. & Myklebust, June Helen [Show all 8 contributors for this article] (2021). Combinatorial CAR design improves target restriction. Journal of Biological Chemistry. ISSN 0021-9258. 296:100116, p. 1–13. doi: 10.1074/jbc.RA120.016234. Full text in Research Archive
• Majzner, Robbie G.; Rietberg, Skyler P.; Sotillo, Elena; Dong, Rui; Vachharajani, Vipul T. & Labanieh, Louai [Show all 20 contributors for this article] (2020). Tuning the antigen density requirement for car T-cell activity. Cancer Discovery. ISSN 2159-8274. 10(5), p. 702–723. doi: 10.1158/2159-8290.CD-19-0945.
• Wise, Jillian; Nakken, Sigve; Steen, Chloe Beate; Vodak, Daniel; Trøen, Gunhild & Johannessen, Bjarne [Show all 24 contributors for this article] (2020). Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Advances. ISSN 2473-9529. 4(9), p. 1859–1866. doi: 10.1182/bloodadvances.2019001325. Show summary

  • Diagnostic and relapse diffuse large B-cell lymphoma (DLBCL) biopsies reveal increased mutational burden/loss of heterozygosity in HLA-A. • Serially sampled tumor biopsies provide insight into therapeutic targets and evolutionary divergence in relapsed/refractory DLBCL.

• Bai, Baoyan; Myklebust, June Helen & Wälchli, Sébastien (2020). Gene editing in B-lymphoma cell lines using CRISPR/Cas9 technology. Methods in molecular biology. ISSN 1064-3745. 2115, p. 445–454. doi: 10.1007/978-1-0716-0290-4_25.
• Steen, Chloe Beate; Leich, Ellen; Myklebust, June Helen; Lockmer, Sandra; Wise, Jillian & Wahlin, Björn Engelbrekt [Show all 14 contributors for this article] (2019). A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy. Haematologica. ISSN 0390-6078. 104(10), p. 460–464. doi: 10.3324/haematol.2018.209080. Full text in Research Archive
• Köksal, Hakan; Dillard, Pierre; Josefsson, Sarah Elisabet; Maggadottir, Solrun Melkorka; Pollmann, Sylvie Mireille & Fåne, Anne [Show all 16 contributors for this article] (2019). Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma. Blood Advances. ISSN 2473-9529. 3(8), p. 1230–1243. doi: 10.1182/bloodadvances.2018029678. Full text in Research Archive
• Josefsson, Sarah Elisabet; Beiske, Klaus; Blaker, Yngvild Nuvin; Førsund, Mette S; Holte, Harald & Østenstad, Bjørn [Show all 15 contributors for this article] (2019). TIGIT and PD-1 mark intratumoral T cells with reduced effector function in B-cell non-Hodgkin lymphoma. Cancer immunology research. ISSN 2326-6066. 7(3), p. 355–362. doi: 10.1158/2326-6066.CIR-18-0351. Full text in Research Archive
• Huse, Kanutte; Wogsland, Cara Ellen; Polikowsky, Hannah G.; Diggins, Kirsten E.; Smeland, Erlend B & Myklebust, June [Show all 7 contributors for this article] (2019). Human Germinal Center B Cells Differ from Naive and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Cytometry Part A. ISSN 1552-4922. 95(4), p. 442–449. doi: 10.1002/cyto.a.23737.
• Mensali, Nadia; Dillard, Pierre; Hebeisen, Michael; Lorenz, Susanne; Theodossiou, Theodossis & Myhre, Marit Renee [Show all 12 contributors for this article] (2019). NK cells specifically TCR-dressed to kill cancer cells. EBioMedicine. ISSN 2352-3964. 40, p. 106–117. doi: 10.1016/j.ebiom.2019.01.031. Full text in Research Archive
• Holte, Harald; Beiske, Klaus; Boyle, Merrill; Trøen, Gunhild; Blaker, Yngvild Nuvin & Myklebust, June [Show all 13 contributors for this article] (2018). The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy. British Journal of Haematology. ISSN 0007-1048. p. 1–10. doi: 10.1111/bjh.15518.
• Våtsveen, Thea Kristin; Myhre, Marit Renee; Steen, Chloe Beate; Wälchli, Sébastien; Lingjærde, Ole Christian & Bai, Baoyan [Show all 14 contributors for this article] (2018). Artesunate shows potent anti-tumor activity in B-cell lymphoma. Journal of Hematology & Oncology. ISSN 1756-8722. 11:23, p. 1–12. doi: 10.1186/s13045-018-0561-0. Full text in Research Archive
• Bollum, Lise Kristin; Huse, Kanutte; Oksvold, Morten Pedersen; Bai, Baoyan; Hilden, Vera Irene & Forfang, Lise [Show all 10 contributors for this article] (2017). BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLOS ONE. ISSN 1932-6203. 12(5). doi: 10.1371/journal.pone.0177188. Full text in Research Archive
• Inderberg, Else Marit ; Mensali, Nadia; Oksvold, Morten Pedersen; Fallang, Lars Egil; Fåne, Anne & Skorstad, Gjertrud [Show all 12 contributors for this article] (2017). Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 67(4), p. 525–536. doi: 10.1007/s00262-017-2105-9.
• Josefsson, Sarah Elisabet Göthberg; Huse, Kanutte; Kolstad, Arne; Beiske, Klaus; Pende, Daniela & Steen, Chloe Beate [Show all 13 contributors for this article] (2017). T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling. Clinical Cancer Research. ISSN 1078-0432. 24(4), p. 870–881. doi: 10.1158/1078-0432.CCR-17-2337. Full text in Research Archive
• Taraldsrud, Eli; Fevang, Børre; Jørgensen, Silje Fjellgård; Moltu, Kristine; Hilden, Vera Irene & Tasken, Kjetil [Show all 9 contributors for this article] (2017). Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. Journal of Autoimmunity. ISSN 0896-8411. 81, p. 110–119. doi: 10.1016/j.jaut.2017.04.004.
• Wogsland, Cara Ellen; Greenplate, Allison Rae; Kolstad, Arne; Myklebust, June; Irish, Jonathan Michael & Huse, Kanutte (2017). Mass cytometry of follicular lymphoma tumors reveals intrinsic heterogeneity in proteins including HLA-DR and a deficit in nonmalignant plasmablast and germinal center B-cell populations. Cytometry Part B: Clinical Cytometry. ISSN 1552-4949. 92(1), p. 79–87. doi: 10.1002/cyto.b.21498.
• Myklebust, June; Brody, Joshua; Kohrt, Holbrook E.; Kolstad, Arne; Czerwinski, Debra K & Waelchli, Sebastien [Show all 15 contributors for this article] (2017). Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling. Blood. ISSN 0006-4971. 129(6), p. 759–770. doi: 10.1182/blood-2016-05-718494.
• Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje Fjellgård; Lingjærde, Ole Christian; Olweus, Johanna & Myklebust, June [Show all 7 contributors for this article] (2017). Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology. ISSN 1521-6616. 175, p. 69–74. doi: 10.1016/j.clim.2016.11.014. Show summary

  Patients with common variable immunodeficiency (CVID) constitute a clinically and immunologically heterogeneous group characterized by B-cell dysfunction with hypogammaglobulinemia and defective immunoglobulin class switch of unknown etiology. Current classification systems are insufficient to achieve precise disease management. Characterization of signaling pathways essential for B-cell differentiation and class switch could provide new means to stratify patients. We evaluated constitutive and induced signaling by phospho-specific flow cytometry in 26 CVID patients and 18 healthy blood donors. Strong responses were induced both in CVID and healthy donor B cells upon activation. In contrast, constitutive phosphorylation levels of STAT3,-5,-6, Erk, PLC-γ and Syk were significantly increased in CVID B cells only. Hierarchical clustering revealed a subgroup of CVID patients with elevated constitutive phosphorylation of Syk and PLC-γ. All these patients had non-infectious complications, indicating that a distinct phosphorylation pattern of kinases in B cells identifies a clinically important subgroup of CVID patients.

• Holm, Kristine Lillebø; Indrevær, Randi Larsen; Myklebust, June; Kolstad, Arne; Moskaug, Jan Øivind & Naderi, Elin Hallan [Show all 7 contributors for this article] (2016). Myeloid cell leukaemia 1 has a vital role in retinoic acid-mediated protection of Toll-like receptor 9-stimulated B cells from spontaneous and DNA damage-induced apoptosis. Immunology. ISSN 0019-2805. 149(1), p. 62–73. doi: 10.1111/imm.12629.
• Blaker, Yngvild Nuvin; Spetalen, Signe; Eide, Marianne Brodtkorb; Lingjærde, Ole Christian; Beiske, Klaus & Østenstad, Bjørn [Show all 13 contributors for this article] (2016). The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. British Journal of Haematology. ISSN 0007-1048. 175(1), p. 102–114. doi: 10.1111/bjh.14201.
• Rein, Idun Dale; Stokke, Caroline; Jalal, Marwa; Myklebust, June; Patzke, Sebastian & Stokke, Trond (2015). New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX. Cell Cycle. ISSN 1538-4101. 14(20), p. 3261–3269. doi: 10.1080/15384101.2015.1087617. Full text in Research Archive
• Oksvold, Morten Pedersen; Duyvestyn, Johanna M.; Dagger, Samantha A.; Taylor, Samuel J.; Forfang, Lise & Myklebust, June [Show all 8 contributors for this article] (2015). The targeting of human and mouse B lymphocytes by dasatinib. Experimental Hematology. ISSN 0301-472X. 43(5), p. 352–363.e4. doi: 10.1016/j.exphem.2015.01.008.
• Blix, Egil Støre; Kildal, Anders Benjamin; Bertelsen, Eirin Listau; Waage, Anders; Myklebust, June & Kolstad, Arne [Show all 7 contributors for this article] (2015). Content of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyeloma. Biology of Blood and Marrow Transplantation. ISSN 1083-8791. 21(5), p. 840–847. doi: 10.1016/j.bbmt.2014.12.027. Full text in Research Archive
• Brodtkorb, Marianne; Lingjærde, Ole Christian; Huse, Kanutte; Trøen, Gunhild; Hystad, Marit Elise & Hilden, Vera Irene [Show all 12 contributors for this article] (2014). Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma. Blood. ISSN 0006-4971. 123(7), p. 1051–1054. doi: 10.1182/blood-2013-07-512392.
• Green, Michael R.; Gentles, Andrew J.; Nair, Ramesh V.; Irish, Jonathan M.; Kihira, Shingo & Liu, Chih Long [Show all 13 contributors for this article] (2013). Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood. ISSN 0006-4971. 121(9), p. 1604–1611. doi: 10.1182/blood-2012-09-457283.
• Myklebust, June; Irish, Jonathan M.; Brody, Joshua; Czerwinski, Debra K; Houot, Roch & Kohrt, Holbrook E. [Show all 13 contributors for this article] (2013). High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood. ISSN 0006-4971. 121(8), p. 1367–1376. doi: 10.1182/blood-2012-04-421826.
• Arita, Adriana; McFarland, Daniel C.; Myklebust, June; Parekh, Samir; Petersen, Bruce & Gabrilove, Janice [Show all 7 contributors for this article] (2013). Signaling pathways in lymphoma: pathogenesis and therapeutic targets. Future Oncology. ISSN 1479-6694. 9(10), p. 1549–1571. doi: 10.2217/fon.13.113.
• Blix, Egil Støre; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Forfang, Lise & Tierens, Anne [Show all 8 contributors for this article] (2012). Phospho-spesific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma. BMC Cancer. ISSN 1471-2407. 12(478). doi: 10.1186/1471-2407-12-478. Full text in Research Archive
• Bakkebø, Maren; Huse, Kanutte; Hilden, Vera Irene; Forfang, Lise; Myklebust, June & Smeland, Erlend B [Show all 7 contributors for this article] (2012). SARA is dispensable for functional TGF-beta signaling. FEBS Letters. ISSN 0014-5793. 586(19), p. 3367–3372. doi: 10.1016/j.febslet.2012.07.027.
• Huse, Kanutte; Bakkebø, Maren; Waelchli, Sebastien; Oksvold, Morten Pedersen; Hilden, Vera Irene & Forfang, Lise [Show all 11 contributors for this article] (2012). Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma. PLOS ONE. ISSN 1932-6203. 7(10). doi: 10.1371/journal.pone.0046117. Full text in Research Archive
• Tkacz-Stachowska, Kinga Magda; Lund-Andersen, Christin; Velissarou, Angeliki; Myklebust, June; Stokke, Trond & Syljuåsen, Randi G. (2011). The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells. Radiotherapy and Oncology. ISSN 0167-8140. 101(1), p. 24–27. doi: 10.1016/j.radonc.2011.05.060.
• Huse, Kanutte; Bakkebø, Maren Kolltveit; Oksvold, Morten Pedersen; Forfang, Lise; Hilden, Vera Irene & Stokke, Trond [Show all 8 contributors for this article] (2011). Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: Differential effects of BMP-6 and BMP-7. European Journal of Immunology. ISSN 0014-2980. 41(11), p. 3135–3145. doi: 10.1002/eji.201141558.
• Alizadeh, Ash A.; Gentles, Andrew J.; Alencar, Alvaro J.; Liu, Chih Long; Kohrt, Holbrook E. & Houot, Roch [Show all 17 contributors for this article] (2011). Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. Blood. ISSN 0006-4971. 118(5), p. 1350–1358. doi: 10.1182/blood-2011-03-345272.
• Chao, Mark P.; Alizadeh, AA; Tang, C; Myklebust, June; Varghese, B & Gill, S [Show all 20 contributors for this article] (2010). Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma. Cell. ISSN 0092-8674. 142(5), p. 699–713. doi: 10.1016/j.cell.2010.07.044.
• Irish, Jonathan Michael; Myklebust, June; Alizadeh, Ash A.; Houot, Roch; Sharman, Jeff & Czerwinski, Debra K [Show all 8 contributors for this article] (2010). B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 127(29), p. 12747–12754. doi: 10.1073/pnas.1002057107.
• Luo, RF; Zao, S; Tibshirani, Robert; Myklebust, June; Sanyal, M & Fernandez, Rosemary [Show all 13 contributors for this article] (2009). CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Human Pathology. ISSN 0046-8177. 41(2), p. 271–280. doi: 10.1016/j.humpath.2009.07.022.
• Gentles, Andrew J.; Alizadeh, Ash A.; Lee, SI; Myklebust, June; Shachaf, CM & Shahbaba, B [Show all 9 contributors for this article] (2009). A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients. Blood. ISSN 0006-4971. 114(15), p. 3158–3166. doi: 10.1182/blood-2009-02-202465.
• Houot, Roch; Goldstein, Matthew J.; Kohrt, Holbrook E.; Myklebust, June; Alizadeh, Ash A. & Lin, Jack T. [Show all 11 contributors for this article] (2009). Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by T-reg depletion. Blood. ISSN 0006-4971. 114(16), p. 3431–3438. doi: 10.1182/blood-2009-05-223958.
• Hystad, ME; Myklebust, JH; Bø, Trond Hellem; Bo, TH; Sivertsen, EA & Rian, E [Show all 13 contributors for this article] (2007). Characterization of early stages of human B cell development by gene expression profiling. Journal of Immunology. ISSN 0022-1767. 179, p. 3662–3671.
• Cabezón, T; Celis, JE; Skibshøj, I; Klingelhöfer, J; Grigorian, M.S. & Gromov, Pavel [Show all 11 contributors for this article] (2007). Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer. International Journal of Cancer. ISSN 0020-7136. 121(7), p. 1433–1444.
• Sivertsen, Einar; Huse, Kanutte; Hystad, Marit Elise; Kersten, Christian; Smeland, Erlend B & Myklebust, June (2007). Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat Tag cells. European Journal of Immunology. ISSN 0014-2980. 37(10), p. 2937–2948.
• Kersten, Christian; Dosen, Guri; Myklebust, June; Sivertsen, Einar; Hystad, Marit Elise & Smeland, Erlend B [Show all 7 contributors for this article] (2006). BMP-6 inhibits human bone marrow B lymphopoiesis - Upregulation of Id1 and Id3. Experimental Hematology. ISSN 0301-472X. 34(1), p. 72–81. doi: 10.1016/j.exphem.2005.09.010.
• Sivertsen, Einar Andreas; Hystad, Marit Elise; Gutzkow, Kristine B; Døsen, Guri; Smeland, Erlend B & Blomhoff, Heidi Kiil [Show all 7 contributors for this article] (2006). PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells. British Journal of Haematology. ISSN 0007-1048. 135(1), p. 117–128.
• Torlakovic, Emina; Malecka, A; Aasheim, HC; Tierens, Anne; Nesland, Jahn M & Smeland, Erlend B [Show all 9 contributors for this article] (2005). PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: Identification of PU.1 putative binding sites in the BCL-6 promotor. Journal of Pathology. ISSN 0022-3417. 206, p. 312–319.
• Kersten, Christian; Sivertsen, Einar; Hystad, Marit Elise; Forfang, Lise; Smeland, Erlend B & Myklebust, June (2005). BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1. BMC Immunology. ISSN 1471-2172. 6. doi: 10.1186/1471-2172-6-9.
• Torlakovic, Emina; Malecka, Agnieszka Maria; Myklebust, June Helen; Tierens, Anne; Åsheim, Hans-Christian & Smeland, Erlend B. [Show all 8 contributors for this article] (2005). PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: identification of PU.1 putative binding sites in the BCL-6 promotor. Journal of Pathology. ISSN 0022-3417. doi: 10.1002/path.1777.
• Josefsen, Dag; Myklebust, June; Lømo, Jon; Sioud, Mouldy; Blomhoff, Heidi Kiil & Smeland, Erlend B (2000). Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells . Stem Cells. ISSN 1066-5099. 18(4), p. 261–272.
• Jacobsen, Sten Eirik W.; Veiby, Ole-Petter; Myklebust, June; Okkenhaug, Cecilie & Lyman, S. (1996). Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha. Blood. ISSN 0006-4971. 87(12), p. 5016–5026.
• Jacobsen, Sten Eirik W.; Okkenhaug, Cecilie; Myklebust, June; Veiby, Ole-Petter & Lyman, S. (1995). The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 181(4), p. 1357–1363. Full text in Research Archive

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• Cui, Xueyan; Myklebust, June Helen; Munthe, Ludvig A; Schjesvold, Fredrik Hellem; Tjønnfjord, Geir Erland & Stavik, Benedicte [Show all 7 contributors for this article] (2022). Single-cell sequencing reveals procoagulant microenvironment in precursor stages of multiple myeloma .
• Cui, Xueyan; Myklebust, June Helen; Munthe, Ludvig A.; Schjesvold, Fredrik Hellem; Tjønnfjord, Geir Erland & Sandset, Per Morten [Show all 7 contributors for this article] (2022). Low expression of coagulation inhibitors in the immune microenvironment in precursor stages of multiple myeloma. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379.
• Bai, Baoyan; Vodák, Daniel; Nakken, Sigve; Wise, Jillian; Blaker, Yngvild Nuvin & Lingjærde, Ole Christian [Show all 18 contributors for this article] (2019). Deep profiling of genetic aberrations and clonal evolution in follicular lymphoma. Blood. ISSN 0006-4971. 134(1), p. 20–20. doi: 10.1182/blood-2019-128403.
• Blix, Egil Støre; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Tierens, Anne & Myklebust, June [Show all 7 contributors for this article] (2012). Altered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patients. British Journal of Haematology. ISSN 0007-1048. 159(5), p. 604–608. doi: 10.1111/bjh.12073.
• Myklebust, June; Irish, Jonathan Michael; Brody, Joshua; Alizadeh, Ash A.; Czerwinski, Debra & Houot, Roch [Show all 9 contributors for this article] (2010). NF-kappa B Signaling In Response to CpG Stratifies Mantle Cell Lymphoma Patient Outcome. Blood. ISSN 0006-4971. 116(21), p. 67–68.
• Huse, Kanutte; Bakkebø, Maren; Forfang, Lise; Hilden, Vera Irene; Smeland, Erlend B & Myklebust, June (2010). Bone Morphogenetic Proteins Inhibit CD40L-and IL-21-Induced Ig Production In Human B Cells: Differential Effects of BMP-6 and BMP-7. Blood. ISSN 0006-4971. 116(21), p. 729–729.
• Myklebust, June; Irish, J.M.; Houot, Roch; Brody, Joshua; Czerwinski, Debra K & Alizadeh, Ash A. [Show all 8 contributors for this article] (2009). A Subpopulation of Follicular Lymphoma Tumor Infiltrating T Cells Shows Suppressed Common Gamma Chain Cytokine Signaling. Blood. ISSN 0006-4971. 114(22), p. 316–316.

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