June Helen Myklebust

Associate Professor - Institute for Cancer Research
Image of June Helen Myklebust
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Visiting address Ullernchausseen 70 OUS Radiumhospitalet 0372 Oslo
Postal address Postboks 4950 Nydalen OUS, Rikshospitalet 0424 Oslo

Publications

  • Köksal, Hakan; Dillard, Pierre; Juzeniene, Asta; Kvalheim, Gunnar; Smeland, Erlend B. & Myklebust, June Helen [Show all 8 contributors for this article] (2021). Combinatorial CAR design improves target restriction. Journal of Biological Chemistry. ISSN 0021-9258. 296, p. 1–13. doi: 10.1074/jbc.RA120.016234.
  • Majzner, Robbie G.; Rietberg, Skyler P.; Sotillo, Elena; Dong, Rui; Vachharajani, Vipul T. & Labanieh, Louai [Show all 20 contributors for this article] (2020). Tuning the antigen density requirement for car T-cell activity. Cancer Discovery. ISSN 2159-8274. 10(5), p. 702–723. doi: 10.1158/2159-8290.CD-19-0945.
  • Wise, Jillian; Nakken, Sigve; Steen, Chloe Beate; Vodak, Daniel; Trøen, Gunhild & Johannessen, Bjarne [Show all 24 contributors for this article] (2020). Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Advances. ISSN 2473-9529. 4(9), p. 1859–1866. doi: 10.1182/bloodadvances.2019001325.
  • Bai, Baoyan; Myklebust, June Helen & Wälchli, Sébastien (2020). Gene editing in B-lymphoma cell lines using CRISPR/Cas9 technology. Methods in molecular biology. ISSN 1064-3745. 2115, p. 445–454. doi: 10.1007/978-1-0716-0290-4_25.
  • Steen, Chloe Beate; Leich, Ellen; Myklebust, June Helen; Lockmer, Sandra; Wise, Jillian & Wahlin, Björn Engelbrekt [Show all 14 contributors for this article] (2019). A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy. Haematologica. ISSN 0390-6078. 104(10), p. 460–464. doi: 10.3324/haematol.2018.209080. Full text in Research Archive
  • Köksal, Hakan; Dillard, Pierre; Josefsson, Sarah Elisabet; Maggadottir, Solrun Melkorka; Pollmann, Sylvie Mireille & Fåne, Anne [Show all 16 contributors for this article] (2019). Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma. Blood Advances. ISSN 2473-9529. 3(8), p. 1230–1243. doi: 10.1182/bloodadvances.2018029678. Full text in Research Archive
  • Josefsson, Sarah Elisabet; Beiske, Klaus; Blaker, Yngvild Nuvin; Førsund, Mette S; Holte, Harald & Østenstad, Bjørn [Show all 15 contributors for this article] (2019). TIGIT and PD-1 mark intratumoral T cells with reduced effector function in B-cell non-Hodgkin lymphoma. Cancer immunology research. ISSN 2326-6066. 7(3), p. 355–362. doi: 10.1158/2326-6066.CIR-18-0351. Full text in Research Archive
  • Huse, Kanutte; Wogsland, Cara Ellen; Polikowsky, Hannah G.; Diggins, Kirsten E.; Smeland, Erlend B & Myklebust, June [Show all 7 contributors for this article] (2019). Human Germinal Center B Cells Differ from Naive and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Cytometry Part A. ISSN 1552-4922. 95(4), p. 442–449. doi: 10.1002/cyto.a.23737.
  • Mensali, Nadia; Dillard, Pierre; Hebeisen, Michael; Lorenz, Susanne; Theodossiou, Theodossis & Myhre, Marit Renee [Show all 12 contributors for this article] (2019). NK cells specifically TCR-dressed to kill cancer cells. EBioMedicine. ISSN 2352-3964. 40, p. 106–117. doi: 10.1016/j.ebiom.2019.01.031. Full text in Research Archive
  • Holte, Harald; Beiske, Klaus; Boyle, Merrill; Trøen, Gunhild; Blaker, Yngvild Nuvin & Myklebust, June [Show all 13 contributors for this article] (2018). The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy. British Journal of Haematology. ISSN 0007-1048. p. 1–10. doi: 10.1111/bjh.15518.
  • Våtsveen, Thea Kristin; Myhre, Marit Renee; Steen, Chloe Beate; Wälchli, Sébastien; Lingjærde, Ole Christian & Bai, Baoyan [Show all 14 contributors for this article] (2018). Artesunate shows potent anti-tumor activity in B-cell lymphoma. Journal of Hematology & Oncology. ISSN 1756-8722. 11:23, p. 1–12. doi: 10.1186/s13045-018-0561-0. Full text in Research Archive
  • Bollum, Lise Kristin; Huse, Kanutte; Oksvold, Morten Pedersen; Bai, Baoyan; Hilden, Vera Irene & Forfang, Lise [Show all 10 contributors for this article] (2017). BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLOS ONE. ISSN 1932-6203. 12(5). doi: 10.1371/journal.pone.0177188. Full text in Research Archive
  • Inderberg, Else Marit ; Mensali, Nadia; Oksvold, Morten Pedersen; Fallang, Lars Egil; Fåne, Anne & Skorstad, Gjertrud [Show all 12 contributors for this article] (2017). Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 67(4), p. 525–536. doi: 10.1007/s00262-017-2105-9.
  • Josefsson, Sarah Elisabet Göthberg; Huse, Kanutte; Kolstad, Arne; Beiske, Klaus; Pende, Daniela & Steen, Chloe Beate [Show all 13 contributors for this article] (2017). T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling. Clinical Cancer Research. ISSN 1078-0432. 24(4), p. 870–881. doi: 10.1158/1078-0432.CCR-17-2337. Full text in Research Archive
  • Taraldsrud, Eli; Fevang, Børre; Jørgensen, Silje Fjellgård; Moltu, Kristine; Hilden, Vera Irene & Tasken, Kjetil [Show all 9 contributors for this article] (2017). Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. Journal of Autoimmunity. ISSN 0896-8411. 81, p. 110–119. doi: 10.1016/j.jaut.2017.04.004.
  • Wogsland, Cara Ellen; Greenplate, Allison Rae; Kolstad, Arne; Myklebust, June; Irish, Jonathan Michael & Huse, Kanutte (2017). Mass cytometry of follicular lymphoma tumors reveals intrinsic heterogeneity in proteins including HLA-DR and a deficit in nonmalignant plasmablast and germinal center B-cell populations. Cytometry Part B: Clinical Cytometry. ISSN 1552-4949. 92(1), p. 79–87. doi: 10.1002/cyto.b.21498.
  • Myklebust, June; Brody, Joshua; Kohrt, Holbrook E.; Kolstad, Arne; Czerwinski, Debra K & Waelchli, Sebastien [Show all 15 contributors for this article] (2017). Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling. Blood. ISSN 0006-4971. 129(6), p. 759–770. doi: 10.1182/blood-2016-05-718494.
  • Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje Fjellgård; Lingjærde, Ole Christian; Olweus, Johanna & Myklebust, June [Show all 7 contributors for this article] (2017). Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology. ISSN 1521-6616. 175, p. 69–74. doi: 10.1016/j.clim.2016.11.014.
  • Holm, Kristine Lillebø; Indrevær, Randi Larsen; Myklebust, June; Kolstad, Arne; Moskaug, Jan Øivind & Naderi, Elin Hallan [Show all 7 contributors for this article] (2016). Myeloid cell leukaemia 1 has a vital role in retinoic acid-mediated protection of Toll-like receptor 9-stimulated B cells from spontaneous and DNA damage-induced apoptosis. Immunology. ISSN 0019-2805. 149(1), p. 62–73. doi: 10.1111/imm.12629.
  • Blaker, Yngvild Nuvin; Spetalen, Signe; Eide, Marianne Brodtkorb; Lingjærde, Ole Christian; Beiske, Klaus & Østenstad, Bjørn [Show all 13 contributors for this article] (2016). The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. British Journal of Haematology. ISSN 0007-1048. 175(1), p. 102–114. doi: 10.1111/bjh.14201.
  • Rein, Idun Dale; Stokke, Caroline; Jalal, Marwa; Myklebust, June; Patzke, Sebastian & Stokke, Trond (2015). New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX. Cell Cycle. ISSN 1538-4101. 14(20), p. 3261–3269. doi: 10.1080/15384101.2015.1087617. Full text in Research Archive
  • Oksvold, Morten Pedersen; Duyvestyn, Johanna M.; Dagger, Samantha A.; Taylor, Samuel J.; Forfang, Lise & Myklebust, June [Show all 8 contributors for this article] (2015). The targeting of human and mouse B lymphocytes by dasatinib. Experimental Hematology. ISSN 0301-472X. 43(5), p. 352–363.e4. doi: 10.1016/j.exphem.2015.01.008.
  • Blix, Egil Støre; Kildal, Anders Benjamin; Bertelsen, Eirin Listau; Waage, Anders; Myklebust, June & Kolstad, Arne [Show all 7 contributors for this article] (2015). Content of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyeloma. Biology of Blood and Marrow Transplantation. ISSN 1083-8791. 21(5), p. 840–847. doi: 10.1016/j.bbmt.2014.12.027.
  • Brodtkorb, Marianne; Lingjærde, Ole Christian; Huse, Kanutte; Trøen, Gunhild; Hystad, Marit Elise & Hilden, Vera Irene [Show all 12 contributors for this article] (2014). Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma. Blood. ISSN 0006-4971. 123(7), p. 1051–1054. doi: 10.1182/blood-2013-07-512392.
  • Green, Michael R.; Gentles, Andrew J.; Nair, Ramesh V.; Irish, Jonathan M.; Kihira, Shingo & Liu, Chih Long [Show all 13 contributors for this article] (2013). Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood. ISSN 0006-4971. 121(9), p. 1604–1611. doi: 10.1182/blood-2012-09-457283.
  • Myklebust, June; Irish, Jonathan M.; Brody, Joshua; Czerwinski, Debra K; Houot, Roch & Kohrt, Holbrook E. [Show all 13 contributors for this article] (2013). High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood. ISSN 0006-4971. 121(8), p. 1367–1376. doi: 10.1182/blood-2012-04-421826.
  • Arita, Adriana; McFarland, Daniel C.; Myklebust, June; Parekh, Samir; Petersen, Bruce & Gabrilove, Janice [Show all 7 contributors for this article] (2013). Signaling pathways in lymphoma: pathogenesis and therapeutic targets. Future Oncology. ISSN 1479-6694. 9(10), p. 1549–1571. doi: 10.2217/fon.13.113.
  • Blix, Egil Støre; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Forfang, Lise & Tierens, Anne [Show all 8 contributors for this article] (2012). Phospho-spesific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma. BMC Cancer. ISSN 1471-2407. 12(478). doi: 10.1186/1471-2407-12-478. Full text in Research Archive
  • Bakkebø, Maren; Huse, Kanutte; Hilden, Vera Irene; Forfang, Lise; Myklebust, June & Smeland, Erlend B [Show all 7 contributors for this article] (2012). SARA is dispensable for functional TGF-beta signaling. FEBS Letters. ISSN 0014-5793. 586(19), p. 3367–3372. doi: 10.1016/j.febslet.2012.07.027.
  • Huse, Kanutte; Bakkebø, Maren; Waelchli, Sebastien; Oksvold, Morten Pedersen; Hilden, Vera Irene & Forfang, Lise [Show all 11 contributors for this article] (2012). Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma. PLOS ONE. ISSN 1932-6203. 7(10). doi: 10.1371/journal.pone.0046117. Full text in Research Archive
  • Tkacz-Stachowska, Kinga Magda; Lund-Andersen, Christin; Velissarou, Angeliki; Myklebust, June; Stokke, Trond & Syljuåsen, Randi G. (2011). The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells. Radiotherapy and Oncology. ISSN 0167-8140. 101(1), p. 24–27. doi: 10.1016/j.radonc.2011.05.060.
  • Huse, Kanutte; Bakkebø, Maren Kolltveit; Oksvold, Morten Pedersen; Forfang, Lise; Hilden, Vera Irene & Stokke, Trond [Show all 8 contributors for this article] (2011). Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: Differential effects of BMP-6 and BMP-7. European Journal of Immunology. ISSN 0014-2980. 41(11), p. 3135–3145. doi: 10.1002/eji.201141558.
  • Alizadeh, Ash A.; Gentles, Andrew J.; Alencar, Alvaro J.; Liu, Chih Long; Kohrt, Holbrook E. & Houot, Roch [Show all 17 contributors for this article] (2011). Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. Blood. ISSN 0006-4971. 118(5), p. 1350–1358. doi: 10.1182/blood-2011-03-345272.
  • Chao, Mark P.; Alizadeh, AA; Tang, C; Myklebust, June; Varghese, B & Gill, S [Show all 20 contributors for this article] (2010). Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma. Cell. ISSN 0092-8674. 142(5), p. 699–713. doi: 10.1016/j.cell.2010.07.044.
  • Irish, Jonathan Michael; Myklebust, June; Alizadeh, Ash A.; Houot, Roch; Sharman, Jeff & Czerwinski, Debra K [Show all 8 contributors for this article] (2010). B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 127(29), p. 12747–12754. doi: 10.1073/pnas.1002057107.
  • Luo, RF; Zao, S; Tibshirani, Robert; Myklebust, June; Sanyal, M & Fernandez, Rosemary [Show all 13 contributors for this article] (2009). CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Human Pathology. ISSN 0046-8177. 41(2), p. 271–280. doi: 10.1016/j.humpath.2009.07.022.
  • Gentles, Andrew J.; Alizadeh, Ash A.; Lee, SI; Myklebust, June; Shachaf, CM & Shahbaba, B [Show all 9 contributors for this article] (2009). A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients. Blood. ISSN 0006-4971. 114(15), p. 3158–3166. doi: 10.1182/blood-2009-02-202465.
  • Houot, Roch; Goldstein, Matthew J.; Kohrt, Holbrook E.; Myklebust, June; Alizadeh, Ash A. & Lin, Jack T. [Show all 11 contributors for this article] (2009). Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by T-reg depletion. Blood. ISSN 0006-4971. 114(16), p. 3431–3438. doi: 10.1182/blood-2009-05-223958.
  • Hystad, ME; Myklebust, JH; Bø, Trond Hellem; Bo, TH; Sivertsen, EA & Rian, E [Show all 13 contributors for this article] (2007). Characterization of early stages of human B cell development by gene expression profiling. Journal of Immunology. ISSN 0022-1767. 179, p. 3662–3671.
  • Cabezón, T; Celis, JE; Skibshøj, I; Klingelhöfer, J; Grigorian, M.S. & Gromov, Pavel [Show all 11 contributors for this article] (2007). Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer. International Journal of Cancer. ISSN 0020-7136. 121(7), p. 1433–1444.
  • Sivertsen, Einar; Huse, Kanutte; Hystad, Marit Elise; Kersten, Christian; Smeland, Erlend B & Myklebust, June (2007). Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat Tag cells. European Journal of Immunology. ISSN 0014-2980. 37(10), p. 2937–2948.
  • Kersten, Christian; Dosen, Guri; Myklebust, June; Sivertsen, Einar; Hystad, Marit Elise & Smeland, Erlend B [Show all 7 contributors for this article] (2006). BMP-6 inhibits human bone marrow B lymphopoiesis - Upregulation of Id1 and Id3. Experimental Hematology. ISSN 0301-472X. 34(1), p. 72–81. doi: 10.1016/j.exphem.2005.09.010.
  • Sivertsen, Einar Andreas; Hystad, Marit Elise; Gutzkow, Kristine B; Døsen, Guri; Smeland, Erlend B & Blomhoff, Heidi Kiil [Show all 7 contributors for this article] (2006). PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells. British Journal of Haematology. ISSN 0007-1048. 135(1), p. 117–128.
  • Torlakovic, Emina; Malecka, A; Aasheim, HC; Tierens, Anne; Nesland, Jahn M & Smeland, Erlend B [Show all 9 contributors for this article] (2005). PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: Identification of PU.1 putative binding sites in the BCL-6 promotor. Journal of Pathology. ISSN 0022-3417. 206, p. 312–319.
  • Kersten, Christian; Sivertsen, Einar; Hystad, Marit Elise; Forfang, Lise; Smeland, Erlend B & Myklebust, June (2005). BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1. BMC Immunology. ISSN 1471-2172. 6. doi: 10.1186/1471-2172-6-9.
  • Torlakovic, Emina; Malecka, Agnieszka Maria; Myklebust, June Helen; Tierens, Anne; Åsheim, Hans-Christian & Smeland, Erlend B. [Show all 8 contributors for this article] (2005). PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: identification of PU.1 putative binding sites in the BCL-6 promotor. Journal of Pathology. ISSN 0022-3417. doi: 10.1002/path.1777.
  • Josefsen, Dag; Myklebust, June; Lømo, Jon; Sioud, Mouldy; Blomhoff, Heidi Kiil & Smeland, Erlend B (2000). Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells . Stem Cells. ISSN 1066-5099. 18(4), p. 261–272.
  • Jacobsen, Sten Eirik W.; Veiby, Ole-Petter; Myklebust, June; Okkenhaug, Cecilie & Lyman, S. (1996). Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha. Blood. ISSN 0006-4971. 87(12), p. 5016–5026.
  • Jacobsen, Sten Eirik W.; Okkenhaug, Cecilie; Myklebust, June; Veiby, Ole-Petter & Lyman, S. (1995). The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 181(4), p. 1357–1363. Full text in Research Archive

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  • Bai, Baoyan; Vodák, Daniel; Nakken, Sigve; Wise, Jillian; Blaker, Yngvild Nuvin & Lingjærde, Ole Christian [Show all 18 contributors for this article] (2019). Deep profiling of genetic aberrations and clonal evolution in follicular lymphoma. Blood. ISSN 0006-4971. 134(1), p. 20–20. doi: 10.1182/blood-2019-128403.
  • Blix, Egil Støre; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Tierens, Anne & Myklebust, June [Show all 7 contributors for this article] (2012). Altered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patients. British Journal of Haematology. ISSN 0007-1048. 159(5), p. 604–608. doi: 10.1111/bjh.12073.
  • Myklebust, June; Irish, Jonathan Michael; Brody, Joshua; Alizadeh, Ash A.; Czerwinski, Debra & Houot, Roch [Show all 9 contributors for this article] (2010). NF-kappa B Signaling In Response to CpG Stratifies Mantle Cell Lymphoma Patient Outcome. Blood. ISSN 0006-4971. 116(21), p. 67–68.
  • Huse, Kanutte; Bakkebø, Maren; Forfang, Lise; Hilden, Vera Irene; Smeland, Erlend B & Myklebust, June (2010). Bone Morphogenetic Proteins Inhibit CD40L-and IL-21-Induced Ig Production In Human B Cells: Differential Effects of BMP-6 and BMP-7. Blood. ISSN 0006-4971. 116(21), p. 729–729.
  • Myklebust, June; Irish, J.M.; Houot, Roch; Brody, Joshua; Czerwinski, Debra K & Alizadeh, Ash A. [Show all 8 contributors for this article] (2009). A Subpopulation of Follicular Lymphoma Tumor Infiltrating T Cells Shows Suppressed Common Gamma Chain Cytokine Signaling. Blood. ISSN 0006-4971. 114(22), p. 316–316.

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Published Sep. 17, 2013 11:40 AM - Last modified Jan. 11, 2018 8:07 AM