Karianne Wiger Gammelsrud

• Helset, Elin; Nordøy, Ingvild; Sporsem, Hilde Margrete; Bakke, Victoria Desiree; Bugge, Jan F; Gammelsrud, Karianne Wiger; Zucknick, Karola Manuela & Lippe, Elisabeth von der (2020). Factors increasing the risk of inappropriate vancomycin therapy in ICU patients: A prospective observational study. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  64(9), s 1295- 1304 . doi: 10.1111/aas.13658 Full text in Research Archive.
• Åkerlund, Anna; Jonasson, Emma; Matuschek, Erika; Serrander, Lena; Sundqvist, Martin; Kahlmeter, Gunnar; Dzajic, Esad; Hansen, Dennis Schrøder; Agergaard, Charlotte Nielsen; Patari-Sampo, Anu; Manninen, Raija; Gronroos, Juha O.; Rasigade, Jean-Philippe; Salka, Wael; Boyer, Pierre H.; Lebessi, Evangelia; Zapaniotis, Nikolaos; Petinaki, Efi; Spiliopoulou, Iris; Kolonitsiou, Fevronia; Helgason, Kristjan Orri; Brazil, Jean; Riccobono, Eleonora; Lo Cascio, Giuliana; Maccacaro, Laura; Kellokumpu, Pirkko-Liisa; Mjøen, Andreas Fossum; Tofteland, Ståle; Harbak, Berit; Hartzen, Susanne Hartvig; Hänsgen, Siri Haug; Gammelsrud, Karianne Wiger; Skolbekken, Unni; Michalsen, Nina Kristin; Brekken, Anita Løvås; Pedersen, Bodil; Guennigsman, Brian Albert; Lia, Astrid; Berg, Ann Kristin; Marco, Francesco; Pitart, Cristina; Egea, Pilar; Cortes-Cuevas, Jose Luis; Machuca, Jesus; Wietzke, Martin; Dammstrom, Magdalena; Granstrom, Roger; Corneliusson, Maria & Skarstedt, Marita (2020). EUCAST rapid antimicrobial susceptibility testing (RAST) in blood cultures: validation in 55 European laboratories. Journal of Antimicrobial Chemotherapy.  ISSN 0305-7453.  75(11), s 3230- 3238 . doi: 10.1093/jac/dkaa333 Show summary

  Objectives: When bloodstream infections are caused by resistant bacteria, rapid antimicrobial susceptibility testing (RAST) is important for adjustment of therapy. The EUCAST RAST method, directly from positive blood cultures, was validated in a multi-laboratory study in Europe. Methods: RAST was performed in 40 laboratories in northern Europe (NE) and 15 in southern Europe (SE) from clinical blood cultures positive for Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus or Streptococcus pneumoniae. Categorical results at 4, 6 and 8 h of incubation were compared with results for EUCAST standard 16-20 h disc diffusion. The method, preliminary breakpoints and the performance of the laboratories were evaluated. Results: The total number of isolates was 833/318 in NE/SE. The number of zone diameters that could be read (88%, 96% and 99%) and interpreted (70%, 81% and 85%) increased with incubation time (4, 6 and 8 h). The categorical agreement was acceptable, with total error rates in NE/SE of 2.4%/4.9% at 4 h, 1.1%/3.5% at 6 h and 1.1%/3.3% at 8 h. False susceptibility at 4, 6 and 8 h of incubation was below 0.3% and 1.1% in NE and SE, respectively, and the corresponding percentages for false resistance were below 1.9% and 2.8%. After fine-tuning breakpoints, more zones could be interpreted (73%, 89% and 93%), with only marginally affected error rates. Conclusions: The EUCAST RAST method can be implemented in routine laboratories without major investments. It provides reliable antimicrobial susceptibility testing results for relevant bloodstream infection pathogens after 4-6 h of incubation. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

• Knudsen, Per Kristian; Gammelsrud, Karianne Wiger; Alfsnes, Kristian; Steinbakk, Martin; Abrahamsen, Tore G; Müller, Fredrik & Bohlin, Jon (2018). Transfer of a bla CTX-M-1-carrying plasmid between different Escherichia coli strains within the human gut explored by whole genome sequencing analyses. Scientific Reports.  ISSN 2045-2322.  8(1) . doi: 10.1038/s41598-017-18659-2 Full text in Research Archive.
• Knudsen, Per Kristian; Brandtzæg, Petter; Høiby, Ernst Arne; Bohlin, Jon; Samuelsen, Ørjan; Steinbakk, Martin; Abrahamsen, Tore G; Müller, Fredrik & Gammelsrud, Karianne Wiger (2017). Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting. PLOS ONE.  ISSN 1932-6203.  12(11) . doi: 10.1371/journal.pone.0187618 Full text in Research Archive.
• Gammelsrud, Karianne Wiger; Knudsen, Per Kristian & Høiby, Ernst Arne (2016). A novel Direct MIC-gradient Strip Method to screen for antibiotic-resistant faecal Enterobacteriaceae. Journal of Microbiological Methods.  ISSN 0167-7012.  129, s 94- 97 . doi: 10.1016/j.mimet.2016.08.007 Show summary

  A novel method to detect resistant faecal Enterobacteriaceae was developed by applying MIC-gradient strips directly onto agar plates inoculated with faeces. The method provided the susceptibility pattern (MICs) of the dominant bacterial population directly on the plates and also detected smaller resistant subpopulations with a sensitivity of 1/105.

• Gammelsrud, Karianne Wiger; Langnes, Belinda; Gaustad, Peter; Ingebretsen, André; Høiby, Ernst Arne; Brandtzaeg, Petter & Sandven, Per (2012). Multilocus sequence typing of serial Candida albicans isolates from children with cancer, children with cystic fibrosis and healthy controls. Medical Mycology.  ISSN 1369-3786.  50(6), s 619- 626 . doi: 10.3109/13693786.2012.675088
• Kvakkestad, Kristin Marie; Gammelsrud, Karianne Wiger; Brandtzæg, Petter & Høiby, Ernst Arne (2012). Unchanged Antibiotic Susceptibility in Escherichia coli and Pseudomonas aeruginosa after Long-Term in vitro Exposure to Antineoplastic Drugs. Chemotherapy.  ISSN 0009-3157.  58(2), s 118- 122 . doi: 10.1159/000337058
• Gammelsrud, Karianne Wiger; Sandven, Per; Høiby, Ernst Arne; Sandvik, Leiv; Brandtzæg, Petter & Gaustad, Peter (2011). Colonization by Candida in children with cancer, children with cystic fibrosis, and healthy controls. Clinical Microbiology and Infection (CMI).  ISSN 1198-743X.  17(12), s 1875- 1881 . doi: 10.1111/j.1469-0691.2011.03528.x
• Høiby, Ernst Arne; Vestrheim, Didrik Frimann; Caugant, Dominique A & Gammelsrud, Karianne Wiger (2008). Bakteriell resistens mot antibiotika. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  128(21), s 2452- 2456

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• Lindemann, Paul Christoffer; Gammelsrud, Karianne Wiger; Löhr, Iren Høyland; Akselsen, Per Espen; Lindbæk, Morten & Sundsfjord, Arnfinn (2019). Valg av antibiotika - viktig endring i prøvesvar fra mikrobiologen. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  139(12) . doi: 10.4045/tidsskr.19.0339

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