Nils Eiel Steen

• Winterton, Adriano; Bettella, Francesco; Beck, Dani; Gurholt, Tiril Pedersen; Steen, Nils Eiel & Rødevand, Linn Nilsen [Show all 9 contributors for this article] (2022). The oxytocin signalling gene pathway contributes to the association between loneliness and cardiometabolic health. Psychoneuroendocrinology. ISSN 0306-4530. doi: 10.1016/j.psyneuen.2022.105875.
• Ormerod, Monica Bettina E. Greenwood; Ueland, Thor; Werner, Maren Caroline Frogner; Hjell, Gabriela; Rødevand, Linn Nilsen & Sæther, Linn Sofie [Show all 14 contributors for this article] (2022). Composite immune marker scores associated with severe mental disorders and illness course. Brain, Behavior, & Immunity - Health. ISSN 2666-3546. doi: 10.1016/j.bbih.2022.100483.
• Gjerde, Priyanthi Borgen; Steen, Synne Wollen; Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Reponen, Elina Johanna & Andreassen, Ole [Show all 8 contributors for this article] (2022). Lifetime Cannabis Use Is Not Associated With Negative Beliefs About Medication in Patients With First Treatment Psychosis. Frontiers in Psychiatry. ISSN 1664-0640. 13. doi: 10.3389/fpsyt.2022.824051. Full text in Research Archive
• Hjell, Gabriela; Szabo, Attila; Mørch-Johnsen, Lynn Egeland; Holst, Rene; Tesli, Natalia & Bell, Christina [Show all 18 contributors for this article] (2022). Interleukin-18 signaling system links to agitation in severe mental disorders. Psychoneuroendocrinology. ISSN 0306-4530. 140:105721, p. 1–8. doi: 10.1016/j.psyneuen.2022.105721. Full text in Research Archive
• Trubetskoy, Vassily; Pardiñas, Antonio F.; Qi, Ting; Panagiotaropoulou, Georgia; Awasthi, Swapnil & Bigdeli, Tim B. [Show all 434 contributors for this article] (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. ISSN 0028-0836. 604(7906), p. 502–508. doi: 10.1038/s41586-022-04434-5.
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Show all 15 contributors for this article] (2022). Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis. Translational Psychiatry. ISSN 2158-3188. 12(1). doi: 10.1038/s41398-022-01811-6.
• Beck, Dani; de Lange, Ann-Marie Glasø; Alnæs, Dag; Maximov, Ivan; Pedersen, Mads Lund & Leinhard, Olof Dahlqvist [Show all 20 contributors for this article] (2022). Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults. NeuroImage: Clinical. ISSN 2213-1582. 33. doi: 10.1016/j.nicl.2022.102949. Full text in Research Archive
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Show all 15 contributors for this article] (2022). Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 116. doi: 10.1016/j.pnpbp.2022.110511. Full text in Research Archive
• Johansen, Ingrid Torp; Steen, Nils Eiel; Haram, Marit; Rødevand, Linn ; Werner, Maren Caroline Frogner & Lunding, Synve Hoffart [Show all 12 contributors for this article] (2022). Sex differences in antipsychotic-related triglyceride levels are associated with metabolic hormone differences in patients with severe mental disorders. Schizophrenia Research. ISSN 0920-9964. 243, p. 55–63. doi: 10.1016/j.schres.2022.02.015. Full text in Research Archive
• Rokicki, Jaroslav; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; van der Meer, Dennis; Bahrami, Shahram & Sartorius, Alina [Show all 14 contributors for this article] (2022). Oxytocin receptor expression patterns in the human brain across development. Neuropsychopharmacology. ISSN 0893-133X. doi: 10.1038/s41386-022-01305-5.
• Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia & Smeland, Olav Bjerkehagen [Show all 12 contributors for this article] (2021). Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 112. doi: 10.1016/j.pnpbp.2021.110408. Full text in Research Archive
• Winterton, Adriano; Bettella, Francesco; de Lange, Ann-Marie Glasø; Haram, Marit; Steen, Nils Eiel & Westlye, Lars Tjelta [Show all 8 contributors for this article] (2021). Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01725-9. Full text in Research Archive
• Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid & Andreou, Dimitrios [Show all 31 contributors for this article] (2021). Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation. Brain, Behavior, and Immunity. ISSN 0889-1591. 99, p. 299–306. doi: 10.1016/j.bbi.2021.10.017. Full text in Research Archive Show summary

  Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI are not known yet. Recently, dyslipidemia has been linked to systemic inflammasome activation, and elevated atherogenic lipid ratios have been shown to correlate with circulating levels of inflammatory biomarkers in SMI. It is, however, not yet known if increased systemic cholesterol load leads to inflammasome activation in these patients. Methods We tested the hypothesis that patients with SCZ and BD display higher circulating levels compared to healthy individuals of key members of the IL-18 system using a large patient cohort (n = 1632; including 737 SCZ and 895 BD), and healthy controls (CTRL; n = 1070). In addition, we assessed associations with coronary artery disease risk factors in SMI, focusing on relevant inflammasome-related, neuroendocrine, and lipid markers. Results We report higher baseline levels of circulating IL-18 system components (IL-18, IL-18BPA, IL-18R1), and increased expression of inflammasome-related genes (NLRP3 and NLRC4) in the blood of patients relative to CTRL. We demonstrate a cholesterol dyslipidemia pattern in psychotic disorders, and report correlations between levels of blood cholesterol types and the expression of inflammasome system elements in SMI. Conclusions Based on these results, we suggest a role for inflammasome activation/dysregulation in SMI. Our findings further the understanding of possible underlying inflammatory mechanisms and may expose important therapeutic targets in SMI.

• Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine V.; Steen, Nils Eiel; Andreassen, Ole A. & Steen, Vidar M. [Show all 7 contributors for this article] (2021). Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients. Frontiers in Psychiatry. ISSN 1664-0640. 12. doi: 10.3389/fpsyt.2021.723158. Full text in Research Archive
• Valstad, Mathias; Roelfs, Daniel; Slapø, Nora Berz; Timpe, Clara Marie Fides; Rai, Ahsan & Matziorinis, Anna Maria [Show all 24 contributors for this article] (2021). Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin. ISSN 0586-7614. 47(6), p. 1751–1760. doi: 10.1093/schbul/sbab049. Full text in Research Archive
• Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar; Wedervang-Resell, Kirsten & Nerland, Stener [Show all 25 contributors for this article] (2021). Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness. Psychological Medicine. ISSN 0033-2917. p. 1–10. doi: 10.1017/S0033291721003056. Full text in Research Archive
• Bigseth, Therese Torgersen; Engh, John; Egeland, Jens; Andersen, Eivind; Andreassen, Ole & Bang-Kittilsen, Gry [Show all 15 contributors for this article] (2021). Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms. BMC Psychiatry. ISSN 1471-244X. 21(1), p. 1–10. doi: 10.1186/s12888-021-03522-6. Full text in Research Archive
• Beck, Dani; de Lange, Ann-Marie G.; Pedersen, Mads L.; Alnæs, Dag; Maximov, Ivan & Voldsbekk, Irene [Show all 18 contributors for this article] (2021). Cardiometabolic risk factors associated with brain age and accelerate brain ageing. Human Brain Mapping. ISSN 1065-9471. p. 1–21. doi: 10.1002/hbm.25680. Full text in Research Archive
• Wiström, Erik David; O'Connell, Kevin Sean; Karadag, Naz; Bahrami, Shahram; Hindley, Guy Frederick Lanyon & Lin, Aihua [Show all 14 contributors for this article] (2021). Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci. Addiction. ISSN 0965-2140. doi: 10.1111/add.15680. Full text in Research Archive
• O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Cheng, Weiqiu [Show all 16 contributors for this article] (2021). Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes. Biological Psychiatry. ISSN 0006-3223. p. 1–11. doi: 10.1016/j.biopsych.2021.07.007. Full text in Research Archive
• Birkenæs, Viktoria; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Høegh, Margrethe Collier; Haram, Marit & Werner, Maren Caroline Frogner [Show all 14 contributors for this article] (2021). Telomeres are shorter and associated with number of suicide attempts in affective disorders. Journal of Affective Disorders. ISSN 0165-0327. 295, p. 1032–1039. doi: 10.1016/j.jad.2021.08.135.
• Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr & Shadrin, Alexey [Show all 13 contributors for this article] (2021). Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking. Translational Psychiatry. ISSN 2158-3188. 11:466, p. 1–10. doi: 10.1038/s41398-021-01576-4. Full text in Research Archive
• Engh, John; Ueland, Thor; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål & Boye, Birgitte [Show all 27 contributors for this article] (2021). Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study. Schizophrenia Bulletin. ISSN 0586-7614. p. 1–10. doi: 10.1093/schbul/sbab106.
• Reponen, Elina Johanna; Tesli, Martin Steen; Dieset, Ingrid; Steen, Nils Eiel; Vedal, Trude Seselie Jahr & Szabo, Attila [Show all 12 contributors for this article] (2021). Adiponectin Is Related to Cardiovascular Risk in Severe Mental Illness Independent of Antipsychotic Treatment. Frontiers in Psychiatry. ISSN 1664-0640. 12. doi: 10.3389/fpsyt.2021.623192. Full text in Research Archive
• Rødevand, Linn ; Bahrami, Shahram; Frei, Oleksandr; Chu, Yunhan; Shadrin, Alexey A. & O'Connell, Kevin Sean [Show all 14 contributors for this article] (2021). Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01527-z. Full text in Research Archive
• Aas, Monica; Ueland, Torill; Mørch, Ragni Helene; Laskemoen, Jannicke Fjæra; Lunding, Synve Hoffart & Reponen, Elina Johanna [Show all 11 contributors for this article] (2021). Physical activity and childhood trauma experiences in patients with schizophrenia or bipolar disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. 22(8), p. 637–645. doi: 10.1080/15622975.2021.1907707. Full text in Research Archive
• Lunding, Synve Hoffart; Simonsen, Carmen Elisabeth; Aas, Monica; Rødevand, Linn ; Werner, Maren Caroline Frogner & Laskemoen, Jannicke Fjæra [Show all 13 contributors for this article] (2021). Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control. European psychiatry. ISSN 0924-9338. 64(1). doi: 10.1192/j.eurpsy.2021.14. Full text in Research Archive
• Gurholt, Tiril Pedersen; Kaufmann, Tobias; Frei, Oleksandr; Alnæs, Dag; Haukvik, Unn Kristin H. & van der Meer, Dennis [Show all 17 contributors for this article] (2021). Population-based body–brain mapping links brain morphology with anthropometrics and body composition. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01414-7. Full text in Research Archive
• Osete, Jordi Requena; Akkouh, Ibrahim; Reis de Assis, Denis; Szabo, Attila; Frei, Evgeniia & Hughes, Timothy [Show all 10 contributors for this article] (2021). Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-021-01164-4. Full text in Research Archive
• Fjukstad, Katrine Kveli; Athanasiu, Lavinia; Bahrami, Shahram; O`Connell, Kevin; van der Meer, Dennis & Bettella, Francesco [Show all 11 contributors for this article] (2021). Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study. The Pharmacogenomics Journal. ISSN 1470-269X. 21, p. 574–585 . doi: 10.1038/s41397-021-00234-8.
• Bahrami, Shahram; Shadrin, Alexey A.; Frei, Oleksandr; O`Connell, Kevin; Bettella, Francesco & Krull, Florian [Show all 15 contributors for this article] (2021). Genetic loci shared between major depression and intelligence with mixed directions of effect. Nature Human Behaviour. ISSN 2397-3374. p. 1–9. doi: 10.1038/s41562-020-01031-2.
• Rødevand, Linn ; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman & Shadrin, Alexey A. [Show all 18 contributors for this article] (2021). Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-020-01142-4. Full text in Research Archive Show summary

  Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, SMDs, and CVD risk factors remain unknown. Here we explored overlapping genetic architecture and genetic loci shared between SMDs, loneliness, and CVD risk factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), loneliness and CVD risk factors using bivariate causal mixture mode (MiXeR), which estimates the total amount of shared variants, and conditional false discovery rate to evaluate overlap in specific loci. We observed substantial genetic overlap between SMDs, loneliness and CVD risk factors, beyond genetic correlation. We identified 149 loci jointly associated with loneliness and SMDs (MD n = 67, SCZ n = 54, and BD n = 28), and 55 distinct loci jointly associated with loneliness and CVD risk factors. A total of 153 novel loneliness loci were found. Most of the shared loci possessed concordant effect directions, suggesting that genetic risk for loneliness may increase the risk of both SMDs and CVD. Functional analyses of the shared loci implicated biological processes related to the brain, metabolic processes, chromatin and immune system. Altogether, the study revealed polygenic overlap between loneliness, SMDs and CVD risk factors, providing new insights into their shared genetic architecture and common genetic mechanisms.

• Bigseth, Therese Torgersen; Fredriksen, Mats; Egeland, Jens; Andersen, Eivind; Andreassen, Ole Andreas & Bang-Kittilsen, Gry [Show all 15 contributors for this article] (2021). Elevated levels of soluble urokinase plasminogen activator receptor as a low-grade inflammation marker in schizophrenia: A case-control study. Schizophrenia Research. ISSN 0920-9964. 228, p. 190–192. doi: 10.1016/j.schres.2020.11.051.
• Aas, Monica; Ueland, Torill; Inova, Amina; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder. Frontiers in Psychiatry. ISSN 1664-0640. doi: 10.3389/fpsyt.2020.00391. Full text in Research Archive
• Winterton, Adriano; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Improving the precision of intranasal oxytocin research. Nature Human Behaviour. ISSN 2397-3374. p. 1–10. doi: 10.1038/s41562-020-00996-4.
• Winterton, Adriano; Rødevand, Linn ; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Associations of loneliness and social isolation with cardiovascular and metabolic health: A systematic review and meta-analysis protocol. Systematic Reviews. ISSN 2046-4053. 9(1). doi: 10.1186/s13643-020-01369-8. Full text in Research Archive
• Benjamin, Silje Beatrice Rognås; Valstad, Mathias; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Moberget, Torgeir & Winterton, Adriano [Show all 14 contributors for this article] (2020). Heart rate variability is associated with disease severity in psychosis spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 00:110108, p. 1–8. doi: 10.1016/j.pnpbp.2020.110108. Full text in Research Archive
• Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars ; Inderhaug, Elin; Hughes, Timothy & Steen, Nils Eiel [Show all 10 contributors for this article] (2020). Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, Behavior, and Immunity. ISSN 0889-1591. 87, p. 634–644. doi: 10.1016/j.bbi.2020.02.008. Full text in Research Archive
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica & Vedal, Trude Seselie Jahr [Show all 18 contributors for this article] (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry. ISSN 1664-0640. 11. doi: 10.3389/fpsyt.2020.00672. Full text in Research Archive
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart & Rødevand, Linn Nilsen [Show all 12 contributors for this article] (2020). Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders. Schizophrenia Research. ISSN 0920-9964. 218, p. 55–62. doi: 10.1016/j.schres.2020.03.006. Full text in Research Archive
• Hjell, Gabriela; Mørch-Johnsen, Lynn; Holst, René; Tesli, Natalia; Bell, Christina & Lunding, Synve Hoffart [Show all 13 contributors for this article] (2020). Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior. ISSN 2162-3279. 10(9). doi: 10.1002/brb3.1751. Full text in Research Archive
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva & Abrahamsen, Tore G [Show all 16 contributors for this article] (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal. ISSN 0892-6638. 34(6), p. 8114–8124. doi: 10.1096/fj.201900855RRR.
• Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen & Frei, Oleksandr [Show all 22 contributors for this article] (2020). Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci. Biological Psychiatry. ISSN 0006-3223. 89(3), p. 227–235. doi: 10.1016/j.biopsych.2020.01.026. Full text in Research Archive
• Hjelseng, Ingrid Varvin; Vaskinn, Anja; Ueland, Torill; Lunding, Synve Hoffart; Reponen, Elina Johanna & Steen, Nils Eiel [Show all 8 contributors for this article] (2020). Childhood Trauma Is Associated With Poorer Social Functioning in Severe Mental Disorders Both During an Active Illness Phase and in Remission . Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2020.03.015.
• Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey A.; O`Connell, Kevin; Frei, Oleksandr & Bettella, Francesco [Show all 13 contributors for this article] (2020). Shared genetic loci between body mass index and major psychiatric disorders: A genome-wide association study. JAMA psychiatry. ISSN 2168-6238. 77(5), p. 503–512. doi: 10.1001/jamapsychiatry.2019.4188.
• O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr & Bettella, Francesco [Show all 24 contributors for this article] (2019). Identification of genetic loci shared between ADHD, intelligence and educational attainment . Biological Psychiatry. ISSN 0006-3223. 87(12), p. 1052–1062. doi: 10.1016/j.biopsych.2019.11.015. Full text in Research Archive
• O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Frei, Oleksandr [Show all 20 contributors for this article] (2019). Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Molecular Psychiatry. ISSN 1359-4184. p. 1–11. doi: 10.1038/s41380-019-0613-z. Full text in Research Archive
• Ringen, Petter Andreas; Reponen, Elina Johanna; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Steen, Nils Eiel & Melle, Ingrid (2019). Predictors for antipsychotic dosage change in the first year of treatment in schizophrenia spectrum and bipolar disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10:649, p. 1–8. doi: 10.3389/fpsyt.2019.00649. Full text in Research Archive
• Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu & Etain, Bruno [Show all 61 contributors for this article] (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. ISSN 2194-7511. 7(1), p. 1–10. doi: 10.1186/s40345-019-0156-x. Full text in Research Archive
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr & Reponen, Elina Johanna [Show all 9 contributors for this article] (2019). Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(5), p. 464–471. doi: 10.1111/acps.13019. Full text in Research Archive
• Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2019). Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. p. 1–10. doi: 10.1007/s00406-019-01017-w. Full text in Research Archive
• Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia & Djurovic, Srdjan [Show all 12 contributors for this article] (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry. ISSN 2158-3188. 9. doi: 10.1038/s41398-019-0432-7. Full text in Research Archive
• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen & Matson, Wayne [Show all 13 contributors for this article] (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine. ISSN 0033-2917. 17(2). doi: 10.1017/S0033291719000400. Full text in Research Archive
• Aas, Monica; Pizzagalli, Diego A.; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Ueland, Torill & Melle, Ingrid [Show all 9 contributors for this article] (2019). Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2019.01.011. Full text in Research Archive
• Rødevand, Linn ; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna & Mørch, Ragni Helene [Show all 12 contributors for this article] (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(4), p. 348–360. doi: 10.1111/acps.13008.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin & Savage, Jeanne E. [Show all 15 contributors for this article] (2019). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Molecular Psychiatry. ISSN 1359-4184. p. 1–10. doi: 10.1038/s41380-018-0332-x. Full text in Research Archive
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Show all 11 contributors for this article] (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, p. 87–95. doi: 10.1016/j.psyneuen.2019.01.001. Full text in Research Archive
• Aas, Monica; Djurovic, Srdjan; Ueland, Torill; Mørch, Ragni Helene; Anderssen, Jannicke Fjæra & Reponen, Elina Johanna [Show all 11 contributors for this article] (2018). The relationship between physical activity, clinical and cognitive characteristics and BDNF mRNA levels in patients with severe mental disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. doi: 10.1080/15622975.2018.1557345.
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr & Steen, Vidar Martin [Show all 8 contributors for this article] (2018). Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(7), p. 795–802. doi: 10.1007/s00406-018-0897-z. Full text in Research Archive
• Gjerde, Priyanthi Borgen; Jørgensen, Kjetil Nordbø; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Vidar Martin [Show all 7 contributors for this article] (2018). Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 282, p. 55–63. doi: 10.1016/j.pscychresns.2018.10.001.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Show all 11 contributors for this article] (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, p. 74–81. doi: 10.1016/j.jpsychires.2018.09.014.
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun & Reponen, Elina Johanna [Show all 12 contributors for this article] (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2018.08.007. Full text in Research Archive
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun & Gardsjord, Erlend Strand [Show all 14 contributors for this article] (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports. ISSN 2045-2322. 8:5349, p. 1–8. doi: 10.1038/s41598-018-23703-w. Full text in Research Archive
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun & Gardsjord, Erlend Strand [Show all 14 contributors for this article] (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational Psychiatry. ISSN 2158-3188. 8:55, p. 1–10. doi: 10.1038/s41398-018-0102-1. Full text in Research Archive
• Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2018). Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics. European psychiatry. ISSN 0924-9338. 48, p. 71–78. doi: 10.1016/j.eurpsy.2017.04.001.
• Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene & Gardsjord, Erlend Strand [Show all 11 contributors for this article] (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 82, p. 263–271. doi: 10.1016/j.pnpbp.2017.11.004.
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene & Reponen, Elina Johanna [Show all 13 contributors for this article] (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, Behavior, and Immunity. ISSN 0889-1591. 65, p. 342–349. doi: 10.1016/j.bbi.2017.06.005. Full text in Research Archive
• Aas, Monica; Kauppi, Karolina; Brandt, Christine Lycke; Tesli, Martin Steen; Kaufmann, Tobias & Steen, Nils Eiel [Show all 10 contributors for this article] (2017). Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. Psychological Medicine. ISSN 0033-2917. 47(4), p. 669–679. doi: 10.1017/S0033291716002762.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2016). Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. 18(6), p. 471–482. doi: 10.1080/15622975.2016.1245441.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2016). Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting. International journal of bipolar disorders. ISSN 2194-7511. 4(24). doi: 10.1186/s40345-016-0067-z. Full text in Research Archive
• Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2016). Metabolic abnormalities related to treatment with selective serotonin reuptake inhibitors in patients with schizophrenia or bipolar disorder. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 36(6), p. 615–620. doi: 10.1097/JCP.0000000000000582.
• Tesli, Martin Steen; Wirgenes, Katrine Verena; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia & Hoseth, Eva Zsuzsanna [Show all 14 contributors for this article] (2016). VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls. British Journal of Psychiatry. ISSN 0007-1250. 209(2), p. 114–120. doi: 10.1192/bjp.bp.115.161950.
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen & Nerhus, Mari [Show all 13 contributors for this article] (2015). Serum level of venlafaxine is associated with better memory in psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 169(1-3), p. 386–392. doi: 10.1016/j.schres.2015.10.021.
• Quintana, Daniel; Westlye, Lars Tjelta; Kaufmann, Tobias; Rustan, Øyvind; Brandt, Christine Lycke & Haatveit, Beathe Christin [Show all 8 contributors for this article] (2015). Reduced heart rate variability in schizophrenia and bipolar disorder compared to healthy controls. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 133(1), p. 44–52. doi: 10.1111/acps.12498.
• Haram, Marit; Tesli, Martin Steen; Dieset, Ingrid; Steen, Nils Eiel; Røssberg, Jan Ivar & Djurovic, Srdjan [Show all 8 contributors for this article] (2014). An attempt to identify single nucleotide polymorphisms contributing to possible relationships between personality traits and oxytocin-related genes. Neuropsychobiology. ISSN 0302-282X. 69(1), p. 25–30. doi: 10.1159/000356965.
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Dieset, Ingrid; Aas, Monica & Nerhus, Mari [Show all 11 contributors for this article] (2014). Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders. Journal of Psychiatric Research. ISSN 0022-3956. 52(1), p. 57–62. doi: 10.1016/j.jpsychires.2014.01.017.
• Mork, Erlend; Walby, Fredrik A; Harkavy-Friedman, Jill M.; Barrett, Elizabeth Ann; Steen, Nils Eiel & Lorentzen, Steinar [Show all 9 contributors for this article] (2013). Clinical characteristics in schizophrenia patients with or without suicide attempts and non-suicidal self-harm - a cross-sectional study. BMC Psychiatry. ISSN 1471-244X. 13. doi: 10.1186/1471-244X-13-255. Full text in Research Archive
• Aas, Monica; Haukvik, Unn Kristin H.; Djurovic, Srdjan; Bergmann, Ørjan; Athanasiu, Lavinia & Tesli, Martin Steen [Show all 13 contributors for this article] (2013). BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 46, p. 181–188. doi: 10.1016/j.pnpbp.2013.07.008.
• Larsson, Sara; Aas, Monica; Klungsøyr, Ole; Agartz, Ingrid; Mork, Erlend & Steen, Nils Eiel [Show all 12 contributors for this article] (2013). Patterns of childhood adverse events are associated with clinical characteristics of bipolar disorder. BMC Psychiatry. ISSN 1471-244X. 13. doi: 10.1186/1471-244X-13-97.
• Hope, Sigrun; Ueland, Thor; Steen, Nils Eiel; Dieset, Ingrid; Lorentzen, Steinar & Berg, Akiah Ottesen [Show all 9 contributors for this article] (2013). Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophrenia Research. ISSN 0920-9964. 145(1-3), p. 36–42. doi: 10.1016/j.schres.2012.12.023.
• Larsson, Sara; Andreassen, Ole Andreas; Aas, Monica; Røssberg, Jan Ivar; Mork, Erlend & Steen, Nils Eiel [Show all 12 contributors for this article] (2013). High prevalence of childhood trauma in patients with schizophrenia spectrum and affective disorder. Comprehensive Psychiatry. ISSN 0010-440X. 54(2), p. 123–127. doi: 10.1016/j.comppsych.2012.06.009.
• Aas, Monica; Steen, Nils Eiel; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Lorentzen, Steinar & Sundet, Kjetil Søren [Show all 8 contributors for this article] (2012). Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning? Psychiatry Research. ISSN 0165-1781. 198(3), p. 495–500. doi: 10.1016/j.psychres.2011.12.045.
• Aas, Monica; Djurovic, Srdjan; Athanasiu, Lavinia; Steen, Nils Eiel; Agartz, Ingrid & Lorentzen, Steinar [Show all 9 contributors for this article] (2012). Serotonin Transporter Gene Polymorphism, Childhood Trauma, and Cognition in Patients With Psychotic Disorders. Schizophrenia Bulletin. ISSN 0586-7614. 38(1), p. 15–22. doi: 10.1093/schbul/sbr113.
• Hope, Sigrun; Dieset, Ingrid; Agartz, Ingrid; Steen, Nils Eiel; Ueland, Thor & Melle, Ingrid [Show all 8 contributors for this article] (2011). Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. Journal of Psychiatric Research. ISSN 0022-3956. 45(12), p. 1608–1616. doi: 10.1016/j.jpsychires.2011.08.003.
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Hope, Sigrun; Barrett, Elisabeth Ann & Larsson, Sara [Show all 13 contributors for this article] (2011). Increased systemic cortisol metabolism in patients with schizophrenia and bipolar disorder: a mechanism for increased stress vulnerability? Journal of Clinical Psychiatry. ISSN 0160-6689. 72(11), p. 1515–1521. doi: 10.4088/JCP.10m06068yel.
• Steen, Nils Eiel; Lorentzen, Steinar; Barrett, Elisabeth Ann; Lagerberg, Trine Vik; Hope, Sigrun & Larsson, Sara [Show all 11 contributors for this article] (2011). Sex-specific cortisol levels in bipolar disorder and schizophrenia during mental challenge - Relationship to clinical characteristics and medication. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 35(4), p. 1100–1107. doi: 10.1016/j.pnpbp.2011.03.008.
• Steen, Nils Eiel; Tesli, Martin Steen; Kähler, Anna Katarina; Methlie, Paal; Hope, Sigrun & Barrett, Elisabeth Ann [Show all 16 contributors for this article] (2010). SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 34(8), p. 1500–1506. doi: 10.1016/j.pnpbp.2010.08.013.
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Agartz, Ingrid; Lorentzen, Steinar & Djurovic, Srdjan [Show all 9 contributors for this article] (2010). Osteoprotegerin levels in patients with severe mental disorders. Journal of Psychiatry & Neuroscience. ISSN 1180-4882. 35(5), p. 304–310. doi: 10.1503/jpn.090088.
• Larsson, Sara; Lorentzen, Steinar; Mork, Erlend; Barrett, Elisabeth Ann; Steen, Nils Eiel & Lagerberg, Trine Vik [Show all 11 contributors for this article] (2010). Age at onset of bipolar disorder in a Norwegian catchment area sample. Journal of Affective Disorders. ISSN 0165-0327. 124(1-2), p. 174–177. doi: 10.1016/j.jad.2009.10.031.
• Barrett, Elizabeth Ann; Sundet, Kjetil Søren; Færden, Ann; Nesvåg, Ragnar; Agartz, Ingrid & Fosse, Roar [Show all 10 contributors for this article] (2010). Suicidality before and in the early phases of first episode psychosis. Schizophrenia Research. ISSN 0920-9964. 119(1-3), p. 11–17. doi: 10.1016/j.schres.2010.03.022.
• Barrett, Elisabeth Ann; Sundet, Kjetil Søren; Færden, Ann; Agartz, Ingrid; Bratlien, Unni & Romm, Kristin Lie [Show all 11 contributors for this article] (2010). Suicidality in first episode psychosis is associated with insight and negative beliefs about psychosis. Schizophrenia Research. ISSN 0920-9964. 123(2-3), p. 257–262. doi: 10.1016/j.schres.2010.07.018.
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Steen, Nils Eiel; Birkenæs, Astrid Brate & Lorentzen, Steinar [Show all 9 contributors for this article] (2009). Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor. Bipolar Disorders. ISSN 1398-5647. 11(7), p. 726–734.

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• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin & Savage, Jeanne [Show all 15 contributors for this article] (2019). Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence (Molecular Psychiatry, (2020), 25, 4, (844-853), 10.1038/s41380-018-0332-x). Molecular Psychiatry. ISSN 1359-4184. 25(4), p. 914–914. doi: 10.1038/s41380-019-0456-7.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Show all 11 contributors for this article] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; Savage, Jeanne E. & Watanabe, Kyoko [Show all 14 contributors for this article] (2018). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and intelligence .
• Quintana, Daniel; Steen, Nils Eiel & Andreassen, Ole Andreas (2017). The Promise of Intranasal Esketamine as a Novel and Effective Antidepressant. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2017.3738.
• Aas, Monica; Djurovic, Srdjan; Athanasiu, Lavinia; Tesli, Martin Steen; Hellvin, Tone & Steen, Nils Eiel [Show all 11 contributors for this article] (2012). Interaction between (BDNF) VAL66Met, childhood adverse events and impaired cognition in patients with schizophrenia spectrum and bipolar disorder. Early Intervention in Psychiatry. ISSN 1751-7885. 6, p. 45–45.
• Aas, Monica; Djurovic, Srdjan; Athanasiu, Lavinia; Steen, Nils Eiel; Agartz, Ingrid & Lorentzen, Steinar [Show all 9 contributors for this article] (2011). SEROTONIN TRANSPORTER GENE POLYMORPHISMS, CHILDHOOD TRAUMA AND COGNITION IN PATIENTS WITH PSYCHOTIC DISORDERS. Schizophrenia Bulletin. ISSN 0586-7614. 37, p. 80–80.
• Hope, Sigrun; Melle, Ingrid; Ueland, Thor; Lorentzen, Steinar; Steen, Nils Eiel & Berg, Akiah Ottesen [Show all 10 contributors for this article] (2011). INTERLEUKIN 1 RECEPTOR ANTAGONIST AND TUMOR NECROSIS FACTOR RECEPTOR 1 ARE ASSOCIATED WITH GENERAL SEVERITY AND PSYCHOTIC SYMPTOMS IN SCHIZOPHRENIA AND BIPOLAR DISORDER. Schizophrenia Bulletin. ISSN 0586-7614. 37, p. 115–116.
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Steen, Nils Eiel; Birkenæs, Astrid Brate & Lorentzen, Steinar [Show all 9 contributors for this article] (2009). SIMILAR INFLAMMATORY PROFILE IN BIPOLAR DISORDER AND SCHIZOPHRENIA: SELECTIVE INCREASE IN SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR I AND VON WILLEBRAND FACTOR. Schizophrenia Bulletin. ISSN 0586-7614. 35, p. 235–235.

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