Nils Eiel Steen

• Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila & Djurovic, Srdjan (2020). Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, behavior, and immunity.  ISSN 0889-1591.  87, s 634- 644 . doi: 10.1016/j.bbi.2020.02.008 Full text in Research Archive.
• Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey A.; O`Connell, Kevin; Frei, Oleksandr; Bettella, Francesco; Wirgenes, Katrine Verena; Krull, Florian; Fan, Chun C.; Dale, Anders; Smeland, Olav Bjerkehagen; Djurovic, Srdjan & Andreassen, Ole Andreas (2020). Shared genetic loci between body mass index and major psychiatric disorders: A genome-wide association study. JAMA psychiatry.  ISSN 2168-6238.  77(5), s 503- 512 . doi: 10.1001/jamapsychiatry.2019.4188
• Benjamin, Silje Beatrice Rognås; Valstad, Mathias; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Moberget, Torgeir; Winterton, Adriano; Haram, Marit; Høegh, Margrethe Collier; Lagerberg, Trine Vik; Steen, Nils Eiel; Larsen, Lars; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2020). Heart rate variability is associated with disease severity in psychosis spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  00:110108, s 1- 8 . doi: 10.1016/j.pnpbp.2020.110108 Full text in Research Archive.
• Hjell, Gabriela; Mørch-Johnsen, Lynn; Holst, René; Tesli, Natalia; Bell, Christina; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Werner, Maren Caroline Frogner; Melle, Ingrid; Andreassen, Ole Andreas; Lagerberg, Trine Vik; Steen, Nils Eiel & Haukvik, Unn Kristin H. (2020). Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior.  ISSN 2162-3279. . doi: 10.1002/brb3.1751 Full text in Research Archive.
• Hjelseng, Ingrid Varvin; Vaskinn, Anja; Ueland, Torill; Lunding, Synve Hoffart; Reponen, Elina Johanna; Steen, Nils Eiel; Andreassen, Ole Andreas & Aas, Monica (2020). Childhood Trauma Is Associated With Poorer Social Functioning in Severe Mental Disorders Both During an Active Illness Phase and in Remission. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2020.03.015
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva; Abrahamsen, Tore G; Nerhus, Mari; Wedervang-Resell, Kirsten; Lonning, Vera Louise Hiorth; Johannessen, Jarle; Steen, Nils Eiel; Agartz, Ingrid; Stenberg, Nina; Hundhausen, Thomas Eckhard; Mørkrid, Lars & Andreassen, Ole Andreas (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal.  ISSN 0892-6638.  34(6), s 8114- 8124 . doi: 10.1096/fj.201900855RRR
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas & Ueland, Thor (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry.  ISSN 1664-0640.  11 . doi: 10.3389/fpsyt.2020.00672 Full text in Research Archive. Show summary

  Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interplay with dyslipidemia is a central driver in the pathogenesis of CVD. We hypothesize that evaluation of atherogenic lipid ratios together with inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis, could give novel information on immune-related mechanisms involved in early CVD risk in patients with psychotic disorders. Methods: As a measure for CVD risk we calculated atherogenic lipid ratios using established sex-specific cut-offs: Total cholesterol/high-density lipoprotein; HDL-c (TC/HDL) and triglyceride/HDL-c (TG/HDL) were evaluated in 571 schizophrenia (SCZ) and 247 bipolar disorder (BD) patients, and in 99 healthy controls (HC). In addition, as a measure of low-grade inflammation, we measured fasting plasma levels of nine stable atherogenic inflammatory markers in patients (SCZ, BD) and in HC. The elevated inflammatory markers and CVD risk in patients, as reflected by TC/HDL and TG/HDL, were further assessed in multivariable analyses adjusting for comorbid cardio-metabolic risk factors. Results: A markedly higher proportion (26%-31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses. Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies. Keywords: CVD risk; bipolar disorder; dyslipidemia; inflammatory biomarkers; schizophrenia.

• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders. Schizophrenia Research.  ISSN 0920-9964.  218, s 55- 62 . doi: 10.1016/j.schres.2020.03.006 Full text in Research Archive.
• Winterton, Adriano; Rødevand, Linn; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Associations of loneliness and social isolation with cardiovascular and metabolic health: A systematic review and meta-analysis protocol. Systematic Reviews.  ISSN 2046-4053.  9(1) . doi: 10.1186/s13643-020-01369-8 Full text in Research Archive.
• Winterton, Adriano; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Improving the precision of intranasal oxytocin research. Nature Human Behaviour.  ISSN 2397-3374.  s 1- 10 . doi: 10.1038/s41562-020-00996-4
• Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry.  ISSN 2158-3188.  9 . doi: 10.1038/s41398-019-0432-7 Full text in Research Archive.
• Aas, Monica; Pizzagalli, Diego A.; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Ueland, Torill; Melle, Ingrid; Agartz, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas (2019). Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2019.01.011 Full text in Research Archive.
• Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill; Andreassen, Ole Andreas; Steen, Vidar Martin & Melle, Ingrid (2019). Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334.  s 1- 10 . doi: 10.1007/s00406-019-01017-w Full text in Research Archive.
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Reponen, Elina Johanna; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2019). Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139(5), s 464- 471 . doi: 10.1111/acps.13019 Full text in Research Archive.
• O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Frei, Oleksandr; Krull, Florian; Askeland, Ragna Bugge; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyða; Guðmundsson, Ólafur; Stefánsson, Hreinn; Fan, Chun C.; Steen, Nils Eiel; Reichborn-Kjennerud, Ted; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan & Andreassen, Ole Andreas (2019). Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 11 . doi: 10.1038/s41380-019-0613-z Full text in Research Archive. Show summary

  Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, genetic correlation reported for these disorders is low and non-significant. Here we aimed to better characterize the genetic architecture of these disorders utilizing recent large genome-wide association studies (GWAS). We analyzed independent GWAS summary statistics for ADHD (19,099 cases and 34,194 controls) and BD (20,352 cases and 31,358 controls) applying the conditional/conjunctional false discovery rate (condFDR/conjFDR) statistical framework that increases the power to detect novel phenotype-specific and shared loci by leveraging the combined power of two GWAS. We observed cross-trait polygenic enrichment for ADHD conditioned on associations with BD, and vice versa. Leveraging this enrichment, we identified 19 novel ADHD risk loci and 40 novel BD risk loci at condFDR <0.05. Further, we identified five loci jointly associated with ADHD and BD (conjFDR < 0.05). Interestingly, these five loci show concordant directions of effect for ADHD and BD. These results highlight a shared underlying genetic risk for ADHD and BD which may help to explain the high comorbidity rates and difficulties in differentiating between ADHD and BD in the clinic. Improving our understanding of the underlying genetic architecture of these disorders may aid in the development of novel stratification tools to help reduce these diagnostic difficulties.

• O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, G. Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan & Andreassen, Ole Andreas (2019). Identification of genetic loci shared between ADHD, intelligence and educational attainment. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2019.11.015 Full text in Research Archive.
• Ringen, Petter Andreas; Reponen, Elina Johanna; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Steen, Nils Eiel & Melle, Ingrid (2019). Predictors for antipsychotic dosage change in the first year of treatment in schizophrenia spectrum and bipolar disorders. Frontiers in Psychiatry.  ISSN 1664-0640.  10:649, s 1- 8 . doi: 10.3389/fpsyt.2019.00649 Full text in Research Archive.
• Rødevand, Linn; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna; Mørch, Ragni Helene; Lunding, Synve Hoffart; Vedal, Trude Seselie Jahr; Dieset, Ingrid; Melle, Ingrid; Lagerberg, Trine Vik & Andreassen, Ole Andreas (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139(4), s 348- 360 . doi: 10.1111/acps.13008 Show summary

  Objective: While CVD risk has decreased in the general population during the last decade, the situation in patients with schizophrenia (SCZ) and bipolar disorder (BD) is unknown. Methods: We compared CVD risk factors in patients with SCZ and BD recruited from 2002‐2005 (2005 sample, N = 270) with patients recruited from 2006‐2017 (2017 sample, N = 1011) from the same catchment area in Norway. The 2017 sample was also compared with healthy controls (N = 922) and the general population (N range = 1285‐4587, Statistics Norway) from the same area and period. Results: Patients with SCZ and BD in the 2017 sample had significantly higher level of most CVD risk factors compared to healthy controls and the general population. There was no significant difference in the prevalence of CVD risk factors in SCZ between the 2005 and 2017 samples except a small increase in glucose in the 2017 sample. There were small‐to‐moderate reductions in hypertension, obesity, total cholesterol, low‐density lipoprotein, systolic and diastolic blood pressure in the BD 2017 sample compared to the 2005 sample. Conclusion: Despite major advances in health promotion during the past decade, there has been no reduction in the level of CVD risk factors in patients with SCZ and modest improvement in BD.

• Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta & Bellivier, Frank (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders.  ISSN 2194-7511.  7(1), s 1- 10 . doi: 10.1186/s40345-019-0156-x Full text in Research Archive.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2019). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 10 . doi: 10.1038/s41380-018-0332-x Full text in Research Archive.
• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail & Andreassen, Ole Andreas (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine.  ISSN 0033-2917.  17(2) . doi: 10.1017/S0033291719000400 Full text in Research Archive.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology.  ISSN 0306-4530.  103, s 87- 95 . doi: 10.1016/j.psyneuen.2019.01.001 Full text in Research Archive.
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid & Andreassen, Ole Andreas (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2018.08.007 Full text in Research Archive.
• Aas, Monica; Djurovic, Srdjan; Ueland, Torill; Mørch, Ragni Helene; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Cattaneo, Annamaria; Steen, Nils Eiel; Agartz, Ingrid; Melle, Ingrid & Andreassen, Ole Andreas (2018). The relationship between physical activity, clinical and cognitive characteristics and BDNF mRNA levels in patients with severe mental disorders. World Journal of Biological Psychiatry.  ISSN 1562-2975. . doi: 10.1080/15622975.2018.1557345
• Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel; Andreassen, Ole Andreas & Spigset, Olav (2018). Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics. European psychiatry.  ISSN 0924-9338.  48, s 71- 78 . doi: 10.1016/j.eurpsy.2017.04.001
• Gjerde, Priyanthi Borgen; Jørgensen, Kjetil Nordbø; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole Andreas; Steen, Vidar Martin & Agartz, Ingrid (2018). Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders. Psychiatry Research : Neuroimaging.  ISSN 0925-4927.  282, s 55- 63 . doi: 10.1016/j.pscychresns.2018.10.001
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2018). Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334.  269(7), s 795- 802 . doi: 10.1007/s00406-018-0897-z Full text in Research Archive.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports.  ISSN 2045-2322.  8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w Full text in Research Archive.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational Psychiatry.  ISSN 2158-3188.  8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1 Full text in Research Archive.
• Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene; Gardsjord, Erlend Strand; Jørgensen, Kjetil Nordbø; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  82, s 263- 271 . doi: 10.1016/j.pnpbp.2017.11.004
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research.  ISSN 0022-3956.  106, s 74- 81 . doi: 10.1016/j.jpsychires.2018.09.014
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Full text in Research Archive.
• Aas, Monica; Kauppi, Karolina; Brandt, Christine Lycke; Tesli, Martin Steen; Kaufmann, Tobias; Steen, Nils Eiel; Agartz, Ingrid; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. Psychological Medicine.  ISSN 0033-2917.  47(4), s 669- 679 . doi: 10.1017/S0033291716002762
• Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel; Andreassen, Ole Andreas & Spigset, Olav (2016). Metabolic abnormalities related to treatment with selective serotonin reuptake inhibitors in patients with schizophrenia or bipolar disorder.. Journal of Clinical Psychopharmacology.  ISSN 0271-0749.  36(6), s 615- 620 . doi: 10.1097/JCP.0000000000000582
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Ueland, Torill; Spigset, Olav & Andreassen, Ole Andreas (2016). Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders. World Journal of Biological Psychiatry.  ISSN 1562-2975.  18(6), s 471- 482 . doi: 10.1080/15622975.2016.1245441
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Vaskinn, Anja; Spigset, Olav & Andreassen, Ole Andreas (2016). Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting. International journal of bipolar disorders.  ISSN 2194-7511.  4(24) . doi: 10.1186/s40345-016-0067-z Full text in Research Archive.
• Tesli, Martin Steen; Wirgenes, Katrine Verena; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Hoseth, Eva Zsuzsanna; Nerhus, Mari; Lagerberg, Trine Vik; Steen, Nils Eiel; Agartz, Ingrid; Melle, Ingrid; Dieset, Ingrid; Djurovic, Srdjan & Andreassen, Ole Andreas (2016). VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls. British Journal of Psychiatry.  ISSN 0007-1250.  209(2), s 114- 120 . doi: 10.1192/bjp.bp.115.161950
• Quintana, Daniel; Westlye, Lars Tjelta; Kaufmann, Tobias; Rustan, Øyvind; Brandt, Christine Lycke; Haatveit, Beathe Christin; Steen, Nils Eiel & Andreassen, Ole Andreas (2015). Reduced heart rate variability in schizophrenia and bipolar disorder compared to healthy controls. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  133(1), s 44- 52 . doi: 10.1111/acps.12498
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Vaskinn, Anja; Spigset, Olav & Andreassen, Ole Andreas (2015). Serum level of venlafaxine is associated with better memory in psychotic disorders. Schizophrenia Research.  ISSN 0920-9964.  169(1-3), s 386- 392 . doi: 10.1016/j.schres.2015.10.021
• Haram, Marit; Tesli, Martin Steen; Dieset, Ingrid; Steen, Nils Eiel; Røssberg, Jan Ivar; Djurovic, Srdjan; Andreassen, Ole Andreas & Melle, Ingrid (2014). An attempt to identify single nucleotide polymorphisms contributing to possible relationships between personality traits and oxytocin-related genes. Neuropsychobiology.  ISSN 0302-282X.  69(1), s 25- 30 . doi: 10.1159/000356965
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Dieset, Ingrid; Aas, Monica; Nerhus, Mari; Haram, Marit; Agartz, Ingrid; Melle, Ingrid; Berg, Jens Petter & Andreassen, Ole Andreas (2014). Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders. Journal of Psychiatric Research.  ISSN 0022-3956.  52(1), s 57- 62 . doi: 10.1016/j.jpsychires.2014.01.017
• Aas, Monica; Haukvik, Unn Kristin H.; Djurovic, Srdjan; Bergmann, Ørjan; Athanasiu, Lavinia; Tesli, Martin Steen; Hellvin, Tone; Steen, Nils Eiel; Agartz, Ingrid; Lorentzen, Steinar; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Melle, Ingrid (2013). BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  46, s 181- 188 . doi: 10.1016/j.pnpbp.2013.07.008
• Hope, Sigrun; Ueland, Thor; Steen, Nils Eiel; Dieset, Ingrid; Lorentzen, Steinar; Berg, Akiah Ottesen; Agartz, Ingrid; Aukrust, Pål & Andreassen, Ole Andreas (2013). Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophrenia Research.  ISSN 0920-9964.  145(1-3), s 36- 42 . doi: 10.1016/j.schres.2012.12.023
• Larsson, Sara; Aas, Monica; Klungsøyr, Ole; Agartz, Ingrid; Mork, Erlend; Steen, Nils Eiel; Barrett, Elizabeth Ann; Lagerberg, Trine Vik; Røssberg, Jan Ivar; Melle, Ingrid; Andreassen, Ole Andreas & Lorentzen, Steinar (2013). Patterns of childhood adverse events are associated with clinical characteristics of bipolar disorder. BMC Psychiatry.  ISSN 1471-244X.  13 . doi: 10.1186/1471-244X-13-97
• Larsson, Sara; Andreassen, Ole Andreas; Aas, Monica; Røssberg, Jan Ivar; Mork, Erlend; Steen, Nils Eiel; Barrett, Elisabeth Ann; Lagerberg, Trine Vik; Peleikis, Dawn Elisabeth; Agartz, Ingrid; Melle, Ingrid & Lorentzen, Steinar (2013). High prevalence of childhood trauma in patients with schizophrenia spectrum and affective disorder. Comprehensive Psychiatry.  ISSN 0010-440X.  54(2), s 123- 127 . doi: 10.1016/j.comppsych.2012.06.009
• Mork, Erlend; Walby, Fredrik A; Harkavy-Friedman, Jill M.; Barrett, Elizabeth Ann; Steen, Nils Eiel; Lorentzen, Steinar; Andreassen, Ole Andreas; Melle, Ingrid & Mehlum, Lars (2013). Clinical characteristics in schizophrenia patients with or without suicide attempts and non-suicidal self-harm - a cross-sectional study. BMC Psychiatry.  ISSN 1471-244X.  13 . doi: 10.1186/1471-244X-13-255 Full text in Research Archive.
• Aas, Monica; Djurovic, Srdjan; Athanasiu, Lavinia; Steen, Nils Eiel; Agartz, Ingrid; Lorentzen, Steinar; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Melle, Ingrid (2012). Serotonin Transporter Gene Polymorphism, Childhood Trauma, and Cognition in Patients With Psychotic Disorders. Schizophrenia Bulletin.  ISSN 0586-7614.  38(1), s 15- 22 . doi: 10.1093/schbul/sbr113
• Aas, Monica; Steen, Nils Eiel; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Lorentzen, Steinar; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Melle, Ingrid (2012). Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning?. Psychiatry Research.  ISSN 0165-1781.  198(3), s 495- 500 . doi: 10.1016/j.psychres.2011.12.045
• Hope, Sigrun; Dieset, Ingrid; Agartz, Ingrid; Steen, Nils Eiel; Ueland, Thor; Melle, Ingrid; Aukrust, Pål & Andreassen, Ole Andreas (2011). Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. Journal of Psychiatric Research.  ISSN 0022-3956.  45(12), s 1608- 1616 . doi: 10.1016/j.jpsychires.2011.08.003
• Steen, Nils Eiel; Lorentzen, Steinar; Barrett, Elisabeth Ann; Lagerberg, Trine Vik; Hope, Sigrun; Larsson, Sara; Berg, Akiah Ottesen; Agartz, Ingrid; Melle, Ingrid; Berg, Jens Petter & Andreassen, Ole Andreas (2011). Sex-specific cortisol levels in bipolar disorder and schizophrenia during mental challenge - Relationship to clinical characteristics and medication. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  35(4), s 1100- 1107 . doi: 10.1016/j.pnpbp.2011.03.008
• Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Hope, Sigrun; Barrett, Elisabeth Ann; Larsson, Sara; Mork, Erlend; Almås, Bjørg; Løvås, Kristian; Agartz, Ingrid; Melle, Ingrid; Berg, Jens Petter & Andreassen, Ole Andreas (2011). Increased systemic cortisol metabolism in patients with schizophrenia and bipolar disorder: a mechanism for increased stress vulnerability?. Journal of Clinical Psychiatry.  ISSN 0160-6689.  72(11), s 1515- 1521 . doi: 10.4088/JCP.10m06068yel
• Barrett, Elisabeth Ann; Sundet, Kjetil Søren; Færden, Ann; Agartz, Ingrid; Bratlien, Unni; Romm, Kristin Lie; Mork, Erlend; Røssberg, Jan Ivar; Steen, Nils Eiel; Andreassen, Ole Andreas & Melle, Ingrid (2010). Suicidality in first episode psychosis is associated with insight and negative beliefs about psychosis. Schizophrenia Research.  ISSN 0920-9964.  123(2-3), s 257- 262 . doi: 10.1016/j.schres.2010.07.018
• Barrett, Elizabeth Ann; Sundet, Kjetil Søren; Færden, Ann; Nesvåg, Ragnar; Agartz, Ingrid; Fosse, Roar; Mork, Erlend; Steen, Nils Eiel; Andreassen, Ole Andreas & Melle, Ingrid (2010). Suicidality before and in the early phases of first episode psychosis. Schizophrenia Research.  ISSN 0920-9964.  119(1-3), s 11- 17 . doi: 10.1016/j.schres.2010.03.022
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Agartz, Ingrid; Lorentzen, Steinar; Djurovic, Srdjan; Steen, Nils Eiel; Ueland, Thor & Andreassen, Ole Andreas (2010). Osteoprotegerin levels in patients with severe mental disorders. Journal of Psychiatry & Neuroscience.  ISSN 1180-4882.  35(5), s 304- 310 . doi: 10.1503/jpn.090088
• Larsson, Sara; Lorentzen, Steinar; Mork, Erlend; Barrett, Elisabeth Ann; Steen, Nils Eiel; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Aminoff, Sofie Ragnhild; Agartz, Ingrid; Melle, Ingrid & Andreassen, Ole Andreas (2010). Age at onset of bipolar disorder in a Norwegian catchment area sample. Journal of Affective Disorders.  ISSN 0165-0327.  124(1-2), s 174- 177 . doi: 10.1016/j.jad.2009.10.031
• Steen, Nils Eiel; Tesli, Martin Steen; Kähler, Anna Katarina; Methlie, Paal; Hope, Sigrun; Barrett, Elisabeth Ann; Larsson, Sara; Mork, Erlend; Løvås, Kristian; Røssberg, Jan Ivar; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Lorentzen, Steinar; Berg, Jens Petter & Andreassen, Ole Andreas (2010). SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  34(8), s 1500- 1506 . doi: 10.1016/j.pnpbp.2010.08.013
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Steen, Nils Eiel; Birkenæs, Astrid Brate; Lorentzen, Steinar; Agartz, Ingrid; Ueland, T & Andreassen, Ole Andreas (2009). Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor. Bipolar Disorders.  ISSN 1398-5647.  11(7), s 726- 734

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• Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen; Frei, Oleksandr; Wirgenes, Katrine Verena; O`Connell, Kevin; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Sugrue, Leo P.; Wang, Yunpeng; Svenningsson, Per; Sharma, Manu; Pihlstrøm, Lasse; Toft, H. Mathias S.; O’Donovan, Michael; Djurovic, Srdjan; Desikan, Rahul S; Dale, Anders M. & Andreassen, Ole Andreas (2020). Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2020.01.026
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2018). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and intelligence.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?. Journal of Psychiatric Research.  ISSN 0022-3956. . doi: 10.1016/j.jpsychires.2018.11.012
• Quintana, Daniel; Steen, Nils Eiel & Andreassen, Ole Andreas (2017). The Promise of Intranasal Esketamine as a Novel and Effective Antidepressant. JAMA psychiatry.  ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2017.3738
• Aas, Monica; Djurovic, Srdjan; Athanasiu, Lavinia; Tesli, Martin Steen; Hellvin, Tone; Steen, Nils Eiel; Agartz, Ingrid; Lorentzen, Steinar; Sundet, Kjetil Søren; Andreassen, Ole A & Melle, Ingrid (2012). Interaction between (BDNF) VAL66Met, childhood adverse events and impaired cognition in patients with schizophrenia spectrum and bipolar disorder. Early Intervention in Psychiatry.  ISSN 1751-7885.  6, s 45- 45
• Aas, Monica; Djurovic, Srdjan; Athanasiu, Lavinia; Steen, Nils Eiel; Agartz, Ingrid; Lorentzen, Steinar; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Melle, Ingrid (2011). SEROTONIN TRANSPORTER GENE POLYMORPHISMS, CHILDHOOD TRAUMA AND COGNITION IN PATIENTS WITH PSYCHOTIC DISORDERS. Schizophrenia Bulletin.  ISSN 0586-7614.  37, s 80- 80
• Hope, Sigrun; Melle, Ingrid; Ueland, Thor; Lorentzen, Steinar; Steen, Nils Eiel; Berg, Akiah Ottesen; Dieset, Ingrid; Agartz, Ingrid; Aukrust, Pål & Andreassen, Ole Andreas (2011). INTERLEUKIN 1 RECEPTOR ANTAGONIST AND TUMOR NECROSIS FACTOR RECEPTOR 1 ARE ASSOCIATED WITH GENERAL SEVERITY AND PSYCHOTIC SYMPTOMS IN SCHIZOPHRENIA AND BIPOLAR DISORDER. Schizophrenia Bulletin.  ISSN 0586-7614.  37, s 115- 116
• Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Steen, Nils Eiel; Birkenæs, Astrid Brate; Lorentzen, Steinar; Agartz, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2009). SIMILAR INFLAMMATORY PROFILE IN BIPOLAR DISORDER AND SCHIZOPHRENIA: SELECTIVE INCREASE IN SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR I AND VON WILLEBRAND FACTOR. Schizophrenia Bulletin.  ISSN 0586-7614.  35, s 235- 235
• Steen, Nils Eiel; Lorentzen, Steinar; Melle, Ingrid; Agartz, Ingrid; Berg, Jens Petter & Andreassen, Ole Andreas (2008). Variation in cortisol levels and relationship to stress in bipolar disorder. Biological Psychiatry.  ISSN 0006-3223.  63, s 142S- 142S

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