Olav Røise

• Eiding, Helge; Røise, Olav & Kongsgaard, Ulf (2022). Potentially Severe Incidents During Interhospital Transport of Critically Ill Patients, Frequently Occurring But Rarely Reported: A Prospective Study. Journal of patient safety. ISSN 1549-8417. 18(1), p. E315–E319. doi: 10.1097/PTS.0000000000000769. Full text in Research Archive
• Yuh, Esther; Jain, Sonia; Sun, Xiaoying; Pisică, Dana; Harris, Mark H. & Taylor, Sabrina R. [Show all 56 contributors for this article] (2021). Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. JAMA Neurology. ISSN 2168-6149. 78(9), p. 1137–1148. doi: 10.1001/jamaneurol.2021.2120. Full text in Research Archive
• Mikolic, Ana; Groeniger, Joost Oude; Zeldovich, Marina; Wilson, Lindsay; van Lennep, Jeanine Roeters & van Klaveren, David [Show all 51 contributors for this article] (2021). Explaining Outcome Differences between Men and Women following Mild Traumatic Brain Injury. Journal of Neurotrauma. ISSN 0897-7151. 38(23). doi: 10.1089/neu.2021.0116. Full text in Research Archive
• Riemann, Lennart; Voormolen, Daphne; Rauen, Katrin; Zweckberger, Klaus; Unterberg, Andreas & Younsi, Alexander [Show all 50 contributors for this article] (2021). Persistent postconcussive symptoms in children and adolescents with mild traumatic brain injury receiving initial head computed tomography. Journal of Neurosurgery: Pediatrics. ISSN 1933-0707. 27(5), p. 538–547. doi: 10.3171/2020.9.PEDS20421.
• Ceyisakar, Iris; Huijben, Jilske A.; Maas, Andrew I. R.; Lingsma, Hester F.; van Leeuwen, Nikki & Andelic, Nada [Show all 49 contributors for this article] (2021). Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences? Neurocritical Care. ISSN 1541-6933. doi: 10.1007/s12028-021-01386-y. Full text in Research Archive
• Huijben, Jilske A.; Dixit, Abhishek; Stocchetti, Nino; Maas, Andrew I. R.; Lingsma, Hester F. & van der Jagt, Mathieu [Show all 55 contributors for this article] (2021). Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis. Critical Care. ISSN 1364-8535. 25(78). doi: 10.1186/s13054-020-03370-y. Full text in Research Archive
• Citerio, Giuseppe; Robba, Chiara; Rebora, Paola; Petrosino, Matteo; Rossi, elenora & Malgeri, L [Show all 53 contributors for this article] (2021). Management of arterial partial pressure of carbon dioxide in the frst week after traumatic brain injury: results from the CENTER-TBI study. Intensive Care Medicine. ISSN 0342-4642. 47, p. 961–973. doi: 10.1007/s00134-021-06470-7. Full text in Research Archive
• Horton, lindsay; Rhodes, Jonathan; Menon, David K.; Maas, Andrew I. R.; Wilson, Lindsay & Andelic, Nada [Show all 48 contributors for this article] (2021). Questionnaires vs Interviews for the Assessment of Global Functional Outcomes After Traumatic Brain Injury. JAMA Network Open. ISSN 2574-3805. 4(11). Full text in Research Archive
• Wiegers, E; Lingsma, Hester F.; Huijben, Jilske A.; Cooper, David James; Citerio, Giuseppe & Frisvold, Shirin [Show all 53 contributors for this article] (2021). Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study. Lancet Neurology. ISSN 1474-4422. 20(8), p. 627–638. doi: 10.1016/S1474-4422%2821%2900162-9.
• van Veen, Ernest; Van Der Jagt, Mathieu; Citerio, Giuseppe; Stocchetti, Nino; Gommers, Diederik & Burdorf, Alex [Show all 51 contributors for this article] (2021). Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study. Intensive Care Medicine. ISSN 0342-4642. 47, p. 1115–1129. doi: 10.1007/s00134-021-06484-1. Full text in Research Archive
• Gravesteijn, Benjamin; Sewalt, Charlie; Venema, Esmee; Nieboer, Daan; Steyerberg, Ewout W. & Andelic, Nada [Show all 49 contributors for this article] (2021). Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study. Journal of Neurotrauma. ISSN 0897-7151. 13(38), p. 1842–1857. doi: 10.1089/neu.2020.7218.
• Sewalt, Charlie; Gravesteijn, Benjamin; Menon, David; Lingsma, Hester F.; Maas, Andrew I. R. & Stocchetti, Nino [Show all 51 contributors for this article] (2021). Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. ISSN 1757-7241. 29(1), p. 1–11. doi: 10.1186/s13049-021-00930-1. Full text in Research Archive
• Böhm, Julia K.; Schaeben, Victoria; Schäfer, Nadine; Güting, Helge; Lefering, Rolf & Thorn, Sophie [Show all 52 contributors for this article] (2021). Extended Coagulation Profling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis. Neurocritical Care. ISSN 1541-6933. doi: 10.1007/s12028-021-01400-3. Full text in Research Archive
• Wang, Biyao; Zeldovich, Marina; Rauen, Katrin; Wu, Yi-Jhen; Covic, Amra & Muller, Isabelle [Show all 50 contributors for this article] (2021). Longitudinal analyses of the reciprocity of depression and anxiety after traumatic brain injury and its clinical implications. Journal of Clinical Medicine. ISSN 2077-0383. 10(23). doi: 10.3390/jcm10235597. Full text in Research Archive
• Stenehjem, Jo Steinson; Røise, Olav; Nordseth, Trond; Clausen, Thomas; Natvig, Bård & Skurtveit, Svetlana Ondrasova [Show all 10 contributors for this article] (2021). Injury Prevention and long-term Outcomes following Trauma - The IPOT project: a protocol for prospective nationwide registry-based studies in Norway. BMJ Open. ISSN 2044-6055. 11(5). doi: 10.1136/bmjopen-2020-046954. Full text in Research Archive
• Finstad, Jeanette; Røise, Olav; Rosseland, Leiv Arne; Clausen, Thomas & Havnes, Ingrid Amalia (2021). Discharge from the trauma centre: exposure to opioids, unmet information needs and lack of follow up—a qualitative study among physical trauma survivors. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. ISSN 1757-7241. 29(1), p. 1–12. doi: 10.1186/s13049-021-00938-7. Full text in Research Archive
• Andelic, Nada; Røe, Cecilie; Tenovuo, Olli; Azouvi, Philippe; Dawes, Helen & Majdan, Marek [Show all 56 contributors for this article] (2021). Unmet Rehabilitation Needs after Traumatic Brain Injury across Europe: Results from the CENTER-TBI Study. Journal of Clinical Medicine. ISSN 2077-0383. 10(5). doi: 10.3390/jcm10051035. Full text in Research Archive
• Horn, Joachim; Rasmussen, Hanne; Bukholm, Ida Rashida Khan; Røise, Olav & Terjesen, Terje (2021). Compensation claims in pediatric orthopedics in Norway between 2012 and 2018: a nationwide study of 487 patients. Acta Orthopaedica. ISSN 1745-3674. 92(5), p. 615–620. doi: 10.1080/17453674.2021.1932922. Full text in Research Archive
• Søberg, Helene Lundgaard; Moksnes, Håkon Øgreid; Anke, Audny; Røise, Olav; Røe, Ellen-Cecilie Treu & Aas, Eline [Show all 20 contributors for this article] (2021). Rehabilitation Needs, Service Provision, and Costs in the First Year Following Traumatic Injuries: Protocol for a Prospective Cohort Study. JMIR Research Protocols. ISSN 1929-0748. 10(4), p. 1–10. doi: 10.2196/25980. Full text in Research Archive
• Borgen, Ida Maria Henriksen; Røe, Cecilie; Brunborg, Cathrine; Tenovuo, Olli; Azouvi, Philippe & Dawes, Helen [Show all 50 contributors for this article] (2021). Care transitions in the first 6 months following traumatic brain injury: Lessons from the CENTER-TBI study. Annals of Physical and Rehabilitation Medicine. ISSN 1877-0657. 64(6). doi: 10.1016/j.rehab.2020.10.009. Full text in Research Archive
• van Veen, Ernest; van der Jagt, Mathieu; Citerio, Guiseppe; Stocchetti, Nino; Epker, Jelle & Gommers, Diederik [Show all 50 contributors for this article] (2020). End-of-life practices in traumatic brain injury patients: Report of a questionnaire from the CENTER-TBI study. Journal of critical care. ISSN 0883-9441. 58, p. 78–88. doi: 10.1016/j.jcrc.2020.04.001. Full text in Research Archive
• Timmers, Marjolein; van Dijck, Jeroen T. J. M.; van Wijk, Roel P J; Legrand, Valerie; van Veen, Ernest & Maas, Andrew I.R. [Show all 50 contributors for this article] (2020). How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study. BMC Medical Ethics. ISSN 1472-6939. 21:36(1). doi: 10.1186/s12910-020-00480-8. Full text in Research Archive
• Mikolic, Ana; van Klaveren, David; Oude Groeniger, Joost; Wiegers, E; Lingsma, Hester F & Zeldovich, Marina [Show all 50 contributors for this article] (2020). Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury. Journal of Neurotrauma. ISSN 0897-7151. 38(2), p. 235–251. doi: 10.1089/neu.2020.7228. Full text in Research Archive
• Mikolic, Ana; Polinder, Suzanne; Steyerberg, Ewout W; Retel Helmrich, Isabel; Giacino, Joseph T. & Maas, Andrew I.R. [Show all 51 contributors for this article] (2020). Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study. Journal of Neurotrauma. ISSN 0897-7151. 38(2), p. 196–209. doi: 10.1089/neu.2020.7074. Full text in Research Archive
• Mathieu, Francois; Güting, Helge; Gravesteijn, Benjamin; Monteiro, Miguel; Glocker, Ben & Kornaropoulos, Evgenios [Show all 51 contributors for this article] (2020). Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury: A CENTER-TBI Propensity-Matched Cohort Analysis. Journal of Neurotrauma. ISSN 0897-7151. 37(19), p. 2069–2080. doi: 10.1089/neu.2019.6911.
• Gravesteijn, BY; Sewalt, Charlie; Stocchetti, Nino; Citerio, Giuseppe; Ercole, Ari & Lingsma, Hester F [Show all 54 contributors for this article] (2020). Prehospital Management of Traumatic Brain Injury across Europe: A CENTER-TBI Study. Prehospital Emergency Care. ISSN 1090-3127. doi: 10.1080/10903127.2020.1817210. Full text in Research Archive
• Dijkland, Simone; Retel Helmrich, Isabel; Nieboer, Daan; van der Jagt, Mathieu; Dippel, Diederik W.J. & Menon, David K [Show all 50 contributors for this article] (2020). Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients. Journal of Neurotrauma. ISSN 0897-7151. doi: 10.1089/neu.2020.7300.
• Vande Vyvere, Thijs; De La Rosa, Ezequiel; Wilms, Guido; Nieboer, Daan; Steyerberg, Ewout & Maas, Andrew I.R. [Show all 51 contributors for this article] (2020). Prognostic Validation of the NINDS Common Data Elements for the Radiologic Reporting of Acute Traumatic Brain Injuries: A CENTER-TBI Study. Journal of Neurotrauma. ISSN 0897-7151. 37(11), p. 1269–1282. doi: 10.1089/neu.2019.6710.
• Huijbers, Jilske; Wiegers, E; Lingsma, Hester F; Citerio, Giuseppe; Maas, Andrew I.R. & Menon, David K [Show all 51 contributors for this article] (2020). Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe: a CENTER-TBI analysis. Intensive Care Medicine. ISSN 0342-4642. 46(5), p. 995–1004. doi: 10.1007/s00134-020-05965-z. Full text in Research Archive
• Czeiter, Endre; Amrein, Krisztina; Gravesteijn, BY; Lecky, Fiona; Menon, David K & Mondello, Stefania [Show all 50 contributors for this article] (2020). Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study. EBioMedicine. ISSN 2352-3964. 56. doi: 10.1016/j.ebiom.2020.102785. Full text in Research Archive
• van Wijk, Roel P J; van Dijck, Jeroen T. J. M.; Timmers, Marjolein; van Veen, Ernest; Citerio, Giuseppe & Lingsma, Hester F [Show all 50 contributors for this article] (2020). Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study. Journal of critical care. ISSN 0883-9441. 59(15), p. 6–15. doi: 10.1016/j.jcrc.2020.05.004.
• Riemann, Lennart; Zweckberger, Klaus; Unterberg, Andreas; El Damaty,, Ahmed; Younsi, Alexander & Andelic, Nada [Show all 50 contributors for this article] (2020). Injury Causes and Severity in Pediatric Traumatic Brain Injury Patients Admitted to the Ward or Intensive Care Unit: A Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study. Frontiers in Neurology. ISSN 1664-2295. 11. doi: 10.3389/fneur.2020.00345. Full text in Research Archive Show summary

  Background: Traumatic brain injury (TBI) is the leading cause of death and disability in children. It includes a range of different pathologies that differ considerably from adult TBI. Analyzing and understanding injury patterns of pediatric TBI is essential to establishing new preventive efforts as well as to improve clinical management. Methods: The multi-center, prospectively collected CENTER-TBI core and registry databases were screened and patients were included when younger than 18 years at enrollment and admitted to the regular ward (admission stratum) or intensive care unit (ICU stratum) following TBI. Patient demographics, injury causes, clinical findings, brain CT imaging details, and outcome (GOSE at 6 months follow-up) were retrieved and analyzed. Injury characteristics were compared between patients admitted to the regular ward and ICU and multivariate analysis of factors predicting an unfavorable outcome (GOSE 1-4) was performed. Results from the core study were compared to the registry dataset which includes larger patient numbers but no follow-up data. Results: Two hundred and twenty seven patients in the core dataset and 687 patients in the registry dataset were included in this study. In the core dataset, road-traffic incidents were the most common cause of injury overall and in the ICU stratum, while incidental falls were most common in the admission stratum. Brain injury was considered serious to severe in the majority of patients and concurrent injuries in other body parts were very common. Intracranial abnormalities were detected in 60% of initial brain CTs. Intra- and extracranial surgical interventions were performed in one-fifth of patients. The overall mortality rate was 3% and the rate of unfavorable outcome 10%, with those numbers being considerably higher among ICU patients. GCS and the occurrence of secondary insults could be identified as independent predictors for an unfavorable outcome. Injury characteristics from the core study could be confirmed in the registry dataset. Conclusion: Our study displays the most common injury causes and characteristics of pediatric TBI patients that are treated in the regular ward or ICU in Europe. Road-traffic incidents were especially common in ICU patients, indicating that preventive efforts could be effective in decreasing the incidence of severe TBI in children.

• Wilson, Lindsay; Horton, Lindsay; Kunzmann, Kevin; Sahakian, Barbara J.; Newcombe, Virginia & Stamatakis, E [Show all 50 contributors for this article] (2020). Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury . Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. doi: 10.1136/jnnp-2020-324492. Full text in Research Archive
• Böhm, JK; Güting, Helge; Thorn, S; Schäfer, Nadine; Rambach, V & Schöchl, Herbert [Show all 50 contributors for this article] (2020). Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis. Neurocritical Care. ISSN 1541-6933. doi: 10.1007/s12028-020-01151-7. Full text in Research Archive
• Glette, Malin Knutsen; Kringeland, Tone Åslaug; Røise, Olav & Wiig, Siri (2020). Would you be interested in participating in a study about hospital readmissions…? Experiences with methodological strategies and techniques for recruiting GPs to participate in qualitative research. Tidsskrift for omsorgsforskning. ISSN 2387-5976. 6(2), p. 178–183. doi: 10.18261/issn.2387-5984-2020-02-14. Full text in Research Archive
• Cuevas-Østrem, Mathias; Røise, Olav; Wisborg, Torben & Jeppesen, Elisabeth (2020). Epidemiology of geriatric trauma patients in Norway: A nationwide analysis of Norwegian Trauma Registry data, 2015-2018. A retrospective cohort study. Injury. ISSN 0020-1383. doi: 10.1016/j.injury.2020.11.007. Full text in Research Archive
• Skansaar, Ola Fougner; Tverdal, Cathrine Buaas; Rønning, Pål André; Skogen, Karoline; Brommeland, Tor & Røise, Olav [Show all 9 contributors for this article] (2020). Traumatic brain injury—the effects of patient age on treatment intensity and mortality. BMC Neurology. ISSN 1471-2377. 20:376, p. 1–10. doi: 10.1186/s12883-020-01943-6. Full text in Research Archive
• Aase, Karina; Guise, Veslemøy; Billett, Stephen; Sollid, Stephen J. M.; Njå, Ove & Røise, Olav [Show all 9 contributors for this article] (2020). Resilience in healthcare (RiH): a longitudinal research programme protocol. BMJ Open. ISSN 2044-6055. 10(10). doi: 10.1136/bmjopen-2020-038779. Full text in Research Archive
• Robba, Chiara; Rebora, Paola; Banzato, Erika; Wiegers, E; Stocchetti, Nino & Menon, David [Show all 50 contributors for this article] (2020). Incidence, Risk Factors, and Effects on Outcome of Ventilator-Associated Pneumonia in Patients With Traumatic Brain Injury: Analysis of a Large, Multicenter, Prospective, Observational Longitudinal Study . Chest. ISSN 0012-3692. 158(6), p. 2292–2303. doi: 10.1016/j.chest.2020.06.064.
• Huie, Russel J; Mondello, Stefania; Lindsell, Christopher J.; Antiga, L; Yuh, Esther & Zanier, Elisa [Show all 50 contributors for this article] (2020). Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations . Journal of Neurotrauma. ISSN 0897-7151. doi: 10.1089/neu.2019.6762.
• Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David & Van Calster, Ben [Show all 50 contributors for this article] (2020). Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury . Journal of Clinical Epidemiology. ISSN 0895-4356. 122, p. 95–107. doi: 10.1016/j.jclinepi.2020.03.005. Full text in Research Archive
• Feng, Junfeng; van Veen, Ernest; Chun, Yang; Huijben, Jilske A.; Lingsma, Hester F & Gao, Guoyi [Show all 50 contributors for this article] (2020). Comparison of Care System and Treatment Approaches for Patients with Traumatic Brain Injury in China versus Europe: A CENTER-TBI Survey Study . Journal of Neurotrauma. ISSN 0897-7151. 37, p. 1806–1817. doi: 10.1089/neu.2019.6900.
• Huijben, Jilske A.; Wiegers, E; Ercole, Ari; de Keizer, Nicolette; Maas, Andrew I. R. & Steyerberg, Ewout W. [Show all 50 contributors for this article] (2020). Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study . Critical Care. ISSN 1364-8535. doi: 10.1186/s13054-020-2791-0. Full text in Research Archive
• Robba, Chiara; Galimberti, Stefania; Graziano, Francesca; Wiegers, E; Lingsma, Hester F & Iaquaniello, Carolina [Show all 50 contributors for this article] (2020). Tracheostomy practice and timing in traumatic brain-injured patients: a CENTER-TBI study . Intensive Care Medicine. ISSN 0342-4642. 46, p. 983–994. doi: 10.1007/s00134-020-05935-5.
• Gravesteijn, BY; Sewalt, Charlie; Ercole, Ari; Akerlund, Cecilia; Nelson, David & Maas, Andrew IR [Show all 50 contributors for this article] (2020). Toward a New Multi-Dimensional Classification of Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Study . Journal of Neurotrauma. ISSN 0897-7151. 37(7). doi: 10.1089/neu.2019.6764.
• Gravesteijn, BY; Sewalt, Charlie; Nieboer, D.; Menon, David K.; Maas, Andrew I. R. & Lecky, Fiona E. [Show all 50 contributors for this article] (2020). Tracheal intubation in traumatic brain injury: a multicentre prospective observational study . British Journal of Anaesthesia. ISSN 0007-0912. 125(4), p. 505–517. doi: 10.1016/j.bja.2020.05.067. Full text in Research Archive
• Voormolen, Daphne; Zeldovich, Marina; Haagsma, Juanita; Polinder, Suzanne; Friedrich, Sarah & Maas, Andrew I. R. [Show all 49 contributors for this article] (2020). Outcomes after Complicated and Uncomplicated Mild Traumatic Brain Injury at Three-and Six-Months Post-Injury: Results from the CENTER-TBI Study . Journal of Clinical Medicine. ISSN 2077-0383. 9. doi: 10.3390/jcm9051525. Full text in Research Archive
• Zeldovich, Marina; Wu, Yi-Jhen; Gorbunova, Anastasia; Mikolic, Ana; Polinder, Suzanne & Plass, Anne Marie [Show all 51 contributors for this article] (2020). Influence of Sociodemographic, Premorbid, and Injury-Related Factors on Post-Concussion Symptoms after Traumatic Brain Injury . Journal of Clinical Medicine. ISSN 2077-0383. 9. doi: 10.3390/jcm9061931. Full text in Research Archive
• Voormolen, Daphne; Polinder, Suzanne; von Steinbuechel, Nicole; Feng, Yan; Wilson, Lindsay & Oppe, Mark [Show all 51 contributors for this article] (2020). Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom . Quality of Life Research. ISSN 0962-9343. 29. doi: 10.1007/s11136-020-02583-6. Full text in Research Archive
• Jacob, Louis; Cogne, Melanie; Tenovuo, Olli; Røe, Cecilie; Andelic, Nada & Majdan, Marek [Show all 50 contributors for this article] (2020). Predictors of access to rehabilitation in the year following traumatic brain injury: A European prospective and multicenter study . Neurorehabilitation and Neural Repair. ISSN 1545-9683. 34(9), p. 814–830. doi: 10.1177/1545968320946038.
• Andelic, Nada; Røe, Cecilie; Brunborg, Cathrine; Zeldovich, Marina; Løvstad, Marianne & Løke, Daniel [Show all 49 contributors for this article] (2020). Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study . Journal of Neurology. ISSN 0340-5354. 268. doi: 10.1007/s00415-020-10022-2. Full text in Research Archive Show summary

  Background: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods: Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported. Results: Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue. Conclusion: A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study.

• Arango-Lasprilla, Juan Carlos L; Zedovich, Marina; Olabarrieta-Landa, Laiene; Forslund, Marit Vindal; Núñez-Fernández, Silvia & von Steinbuechel, Nicole [Show all 51 contributors for this article] (2020). Early Predictors of Employment Status One Year Post Injury in Individuals with Traumatic Brain Injury in Europe . Journal of Clinical Medicine. ISSN 2077-0383. 9(6), p. 1–16. doi: 10.3390/jcm9062007. Full text in Research Archive
• Wiig, Siri; Aase, Karina; Billett, Stephen; Canfield, Carolyn; Røise, Olav & Njå, Ove [Show all 11 contributors for this article] (2020). Defining the boundaries and operational concepts of resilience in the resilience in healthcare research program. BMC Health Services Research. ISSN 1472-6963. 330. doi: 10.1186/s12913-020-05224-3. Full text in Research Archive
• Gravesteijn, BY; Sewalt, C.; Ercole, Ari; Lecky, Fiona; Menon, David & Steyerberg, Ewout W [Show all 50 contributors for this article] (2020). Variation in the practice of tracheal intubation in Europe after traumatic brain injury: a prospective cohort study. Anaesthesia. ISSN 0003-2409. 75(1), p. 45–53. doi: 10.1111/anae.14838. Full text in Research Archive
• Bjøro, Benedikte; Mykkeltveit, Ida Helene; Rustøen, Tone; Altinbas, Bahar Candas; Røise, Olav & Bentsen, Signe Berit (2019). Intraoperative peripheral nerve injury related to lithotomy positioning with steep Trendelenburg in patients undergoing robotic-assisted laparoscopic surgery - A systematic review. Journal of Advanced Nursing. ISSN 0309-2402. 76(2), p. 490–503. doi: 10.1111/jan.14271.
• Steyerberg, Ewout W; Wiegers, E; Sewalt, C.; Buki, Andras; Citerio, Giuseppe & De Keyser, Veronique [Show all 50 contributors for this article] (2019). Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. Lancet Neurology. ISSN 1474-4422. 8(10), p. 923–934. doi: 10.1016/S1474-4422%2819%2930232-7. Show summary

  BACKGROUND: The burden of traumatic brain injury (TBI) poses a large public health and societal problem, but the characteristics of patients and their care pathways in Europe are poorly understood. We aimed to characterise patient case-mix, care pathways, and outcomes of TBI. METHODS: CENTER-TBI is a Europe-based, observational cohort study, consisting of a core study and a registry. Inclusion criteria for the core study were a clinical diagnosis of TBI, presentation fewer than 24 h after injury, and an indication for CT. Patients were differentiated by care pathway and assigned to the emergency room (ER) stratum (patients who were discharged from an emergency room), admission stratum (patients who were admitted to a hospital ward), or intensive care unit (ICU) stratum (patients who were admitted to the ICU). Neuroimages and biospecimens were stored in repositories and outcome was assessed at 6 months after injury. We used the IMPACT core model for estimating the expected mortality and proportion with unfavourable Glasgow Outcome Scale Extended (GOSE) outcomes in patients with moderate or severe TBI (Glasgow Coma Scale [GCS] score ≤12). The core study was registered with ClinicalTrials.gov, number NCT02210221, and with Resource Identification Portal (RRID: SCR_015582). FINDINGS: Data from 4509 patients from 18 countries, collected between Dec 9, 2014, and Dec 17, 2017, were analysed in the core study and from 22 782 patients in the registry. In the core study, 848 (19%) patients were in the ER stratum, 1523 (34%) in the admission stratum, and 2138 (47%) in the ICU stratum. In the ICU stratum, 720 (36%) patients had mild TBI (GCS score 13-15). Compared with the core cohort, the registry had a higher proportion of patients in the ER (9839 [43%]) and admission (8571 [38%]) strata, with more than 95% of patients classified as having mild TBI. Patients in the core study were older than those in previous studies (median age 50 years [IQR 30-66], 1254 [28%] aged >65 years), 462 (11%) had serious comorbidities, 772 (18%) were taking anticoagulant or antiplatelet medication, and alcohol was contributory in 1054 (25%) TBIs. MRI and blood biomarker measurement enhanced characterisation of injury severity and type. Substantial inter-country differences existed in care pathways and practice. Incomplete recovery at 6 months (GOSE <8) was found in 207 (30%) patients in the ER stratum, 665 (53%) in the admission stratum, and 1547 (84%) in the ICU stratum. Among patients with moderate-to-severe TBI in the ICU stratum, 623 (55%) patients had unfavourable outcome at 6 months (GOSE <5), similar to the proportion predicted by the IMPACT prognostic model (observed to expected ratio 1·06 [95% CI 0·97-1·14]), but mortality was lower than expected (0·70 [0·62-0·76]). INTERPRETATION: Patients with TBI who presented to European centres in the core study were older than were those in previous observational studies and often had comorbidities. Overall, most patients presented with mild TBI. The incomplete recovery of many patients should motivate precision medicine research and the identification of best practices to improve these outcomes. FUNDING: European Union 7th Framework Programme, the Hannelore Kohl Stiftung, OneMind, and Integra LifeSciences Corporation.

• Voomolen, DC; Haagsma, JA; Polinder, Suzanne; Maas, AIR; Steyerberg, Ewout W & Vulekovic, Peter [Show all 50 contributors for this article] (2019). Post-concussion symptoms in complicated vs. Uncomplicated mild traumatic brain injury patients at three and six months post-injury: Results from the CENTER-TBI study. Journal of Clinical Medicine. ISSN 2077-0383. 8(11). doi: 10.3390/jcm8111921. Full text in Research Archive
• Glette, Malin Knutsen; Kringeland, Tone Åslaug; Røise, Olav & Wiig, Siri (2019). Hospital physicians’ views on discharge and readmission processes: a qualitative study from Norway. BMJ Open. ISSN 2044-6055. 9, p. 1–15. doi: 10.1136/bmjopen-2019-031297. Full text in Research Archive
• Van Essen, Thomas; den Boogert, HF; Cnossen, MC; De Ruiter, Godard CW; Haitsma, Ian & Polinder, S [Show all 21 contributors for this article] (2018). Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study. Acta Neurochirurgica. ISSN 0001-6268. 161(3), p. 435–449. doi: 10.1007/s00701-018-3761-z. Full text in Research Archive
• Vande Vyvere, Thijs; Wilms, Guido; Claes, Lene; Leon, Francisco Martin; Nieboer, Daan & Verheyden, Jan [Show all 20 contributors for this article] (2018). Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research. Journal of Neurotrauma. ISSN 0897-7151. 35, p. 1–13. doi: 10.1089/neu.2018.6061.
• Huijben, Jilske A.; Volovici, Victor; Cnossen, Maryse C.; Haitsma, Iain K.; Stocchetti, Nino & Maas, Andrew I. R. [Show all 24 contributors for this article] (2018). Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Critical Care. ISSN 1364-8535. 22(1), p. 1–9. doi: 10.1186/s13054-018-2000-6. Full text in Research Archive
• van Veen, Ernest; Van Der Jagt, Mathieu; Cnossen, Maryse C.; Maas, Andrew I. R.; De Beaufort, Inez D. & Menon, David K. [Show all 21 contributors for this article] (2018). Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study. Critical Care. ISSN 1364-8535. 22(306), p. 1–11. doi: 10.1186/s13054-018-2241-4. Full text in Research Archive
• Glette, Malin Knutsen; Røise, Olav; Kringeland, Tone Åslaug; Churruca, Kate; Braithwaite, Jeffrey & Wiig, Siri (2018). Nursing home leaders’and nurses’experiences of resources,staffing and competence levels and the relation to hospital readmissions –a case study. BMC Health Services Research. ISSN 1472-6963. 18(955), p. 1–15. doi: 10.1186/s12913-018-3769-3. Full text in Research Archive
• Glette, Malin Knutsen; Kringeland, Tone Åslaug; Røise, Olav & Wiig, Siri (2018). Exploring physicians' decision-making in hospital readmission processes - a comparative case study. BMC Health Services Research. ISSN 1472-6963. 18(725). doi: 10.1186/s12913-018-3538-3. Full text in Research Archive
• Wiig, Siri; Bourrier, Mathilde; Aase, Karina & Røise, Olav (2018). Transparency in Health Care: Disclosing Adverse Events to the Public, Risk Communication for the Future,. Springer. ISSN 978-3-319-74098-0. p. 111–127. doi: 10.1007/978-3-319-74098-0. Full text in Research Archive
• Maas, Andrew IR; Menon, David K; Adelson, P. D.; Andelic, Nada; Bell, MJ & InTBIR, Participants and Investigators [Show all 14 contributors for this article] (2017). Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurology. ISSN 1474-4422. 16(12), p. 987–1048. doi: 10.1016/S1474-4422%2817%2930371-X.
• Clarke-Jenssen, John; Westberg, Marianne; Røise, Olav; Storeggen, Stein Arne Øvre; Bere, Tone Tufte & Silberg, Inger Elisabeth [Show all 7 contributors for this article] (2017). Reduced survival for uncemented compared to cemented total hip arthroplasty after operatively treated acetabular fractures. Injury. ISSN 0020-1383. 48(11), p. 2534–2539. doi: 10.1016/j.injury.2017.08.071. Full text in Research Archive
• Cnossen, Maryse C.; Huijben, Jilske A.; Van Der Jagt, Mathieu; Volovici, Victor; Van Essen, Thomas & Polinder, Suzanne [Show all 26 contributors for this article] (2017). Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: A survey in 66 neurotrauma centers participating in the CENTER-TBI study. Critical Care. ISSN 1364-8535. 21:233, p. 1–12. doi: 10.1186/s13054-017-1816-9.
• Kibsgård, Thomas; Röhrl, Stephan Maximillian; Røise, Olav; Sturesson, Bengt & Stuge, Britt (2017). Movement of the sacroiliac joint during the Active Straight Leg Raise test in patients with long-lasting severe sacroiliac joint pain. Clinical Biomechanics. ISSN 0268-0033. 47, p. 40–45. doi: 10.1016/j.clinbiomech.2017.05.014.
• Clarke-Jenssen, John; Røise, Olav; Øvre, Stein A. & Madsen, Jan Erik (2017). Long-term survival and risk factors for failure of the native hip joint after operatively treated displaced acetabular fractures. The Bone & Joint Journal. ISSN 2049-4394. 99B(6), p. 834–840. doi: 10.1302/0301-620X.99B6.BJJ-2016-1013.R1. Full text in Research Archive
• Cnossen, Maryse C.; Polinder, Suzanne; Lingsma, Hester F.; Maas, Andrew I.R.; Menon, David & Steyerberg, Ewout W. [Show all 17 contributors for this article] (2016). Variation in structure and process of care in traumatic brain injury: Provider profiles of European Neurotrauma Centers participating in the CENTER-TBI study. PLOS ONE. ISSN 1932-6203. 11:e0161367(8). doi: 10.1371/journal.pone.0161367.
• Clarke-Jenssen, John; Wikerøy, Annette Konstanse Bordewich; Røise, Olav; Øvre, Stein A. & Madsen, Jan Erik (2016). Long-term survival of the native hip after a minimally displaced, nonoperatively treated acetabular fracture. Journal of Bone and Joint Surgery. American volume. ISSN 0021-9355. 98(16), p. 1392–1399. doi: 10.2106/JBJS.15.01154.
• Adelved, Aron; Töttermann, Anna; Glott, Thomas; Hellund, Johan Castberg; Madsen, Jan Erik & Røise, Olav (2016). Long-term functional outcome after traumatic lumbosacral dissociation. A retrospective case series of 13 patients. Injury. ISSN 0020-1383. 47(7), p. 1562–1568. doi: 10.1016/j.injury.2016.04.006.
• Søberg, Helene L.; Bautz-Holter, Erik; Finset, Arnstein; Røise, Olav & Andelic, Nada (2015). Physical and mental health 10 years after multiple trauma: A prospective cohort study. Journal of Trauma and Acute Care Surgery. ISSN 2163-0755. 78(3), p. 628–633. doi: 10.1097/TA.0000000000000541.
• Clarke-Jenssen, John; Øvre, Stein A.; Røise, Olav & Madsen, Jan Erik (2015). Acetabular fracture assessment in four different pelvic trauma centers: have the Judet views become superfluous? Archives of Orthopaedic and Trauma Surgery. ISSN 0936-8051. 135(7), p. 913–918. doi: 10.1007/s00402-015-2223-9.
• Utheim, Nils Christian; Josefsen, Roger; Nakstad, Per Hjalmar; Solgaard, Torfinn & Røise, Olav (2015). Occipital condyle fracture and lower cranial nerve palsy after blunt head trauma - a literature review and case report. Journal of Trauma Management & Outcomes. ISSN 1752-2897. 9(2). doi: 10.1186/s13032-015-0024-3.
• Adelved, Aron; Tötterman, Anna; Glott, Thomas; Søberg, Helene L.; Madsen, Jan Erik & Røise, Olav (2014). Patient-reported health minimum 8 years after operatively treated displaced sacral fractures: A prospective cohort study. Journal of Orthopaedic Trauma. ISSN 0890-5339. 28(12), p. 686–693. doi: 10.1097/BOT.0000000000000242.
• Kibsgård, Thomas Johan; Røise, Olav & Stuge, Britt (2014). Pelvic joint fusion in patients with severe pelvic girdle pain - A prospective single-subject research design study. BMC Musculoskeletal Disorders. ISSN 1471-2474. 15(1). doi: 10.1186/1471-2474-15-85.
• Kibsgård, Thomas Johan; Røise, Olav; Sturesson, Bengt; Röhrl, Stephan Maximillian & Stuge, Britt (2014). Radiosteriometric analysis of movement in the sacroiliac joint during a single-leg stance in patients with long-lasting pelvic girdle pain. Clinical Biomechanics. ISSN 0268-0033. 29(4), p. 406–411. doi: 10.1016/j.clinbiomech.2014.02.002.
• Adelved, Aron; Tötterman, Anna; Hellund, Johan Castberg; Glott, Thomas; Madsen, Jan Erik & Røise, Olav (2014). Radiological findings correlate with neurological deficits but not with pain after operatively treated sacral fractures. An 11-year follow-up study of 28 patients. Acta Orthopaedica. ISSN 1745-3674. 85(4), p. 408–414. doi: 10.3109/17453674.2014.908344.

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• Søberg, Helene L.; Moksnes, Håkon Øgreid; Anke, Audny Gabriele Wagner; Røise, Olav; Røe, Cecilie & Aas, Eline [Show all 20 contributors for this article] (2022). Erratum: Rehabilitation Needs, Service Provision, and Costs in the First Year following Traumatic Injuries: Protocol for a Prospective Cohort Study ((JMIR Res Protoc (2021) 10: 4 (e25980) DOI: 10.2196/25980). JMIR Research Protocols. ISSN 1929-0748. 11(3). doi: 10.2196/37723.
• Glette, Malin Knutsen; Kringeland, Tone Åslaug; Røise, Olav & Wiig, Siri (2022). Helsepersonells erfaringer med reinnleggelser fra primærhelsetjenesten – en oppsummering av en casestudie. Tidsskrift for omsorgsforskning. ISSN 2387-5976. p. 1–10. doi: 10.18261/tfo.8.1.4.
• Uleberg, Oddvar; Stenehjem, Jo S.; Nordseth, Trond; Clausen, Thomas; Natvig, Bård & Skurtveit, Svetlana Ondrasova [Show all 12 contributors for this article] (2022). The injury prevention and outcomes following trauma (IPOT) project: is a nationwide registry-based study in Norway feasible?
• Cuevas-Østrem, Mathias; Røise, Olav; Wisborg, Torben & Jeppesen, Elisabeth (2021). Røntgenundersøkelser av bekkenet hos eldre traumepasienter. En studie fra Nasjonalt Traumeregister.
• Cuevas-Østrem, Mathias; Wisborg, Torben; Røise, Olav & Jeppesen, Elisabeth (2021). Geriatric trauma patients are less likely to receive advanced prehospital care. A study from the Norwegian Trauma Registry.
• Stenehjem, Jo S.; Røise, Olav; Nordseth, Trond; Clausen, Thomas; Natvig, Bård & Skurtveit, Svetlana Ondrasova [Show all 12 contributors for this article] (2021). Injury Prevention and long-term Outcomes following Trauma - the IPOT project: a protocol for prospective nationwide registry-based studies in Norway.
• Rosseland, Leiv Arne; Stenehjem, Jo S.; Nordseth, Trond; Clausen, Thomas; Natvig, Bård & Skurtveit, Svetlana Ondrasova [Show all 12 contributors for this article] (2021). The Injury Prevention and Outcomes following Trauma project: a prospective nationwide registry-based study in Norway.
• Nordseth, Trond; Stenehjem, Jo S.; Uleberg, Oddvar; Røise, Olav & Rosseland, Leiv Arne (2021). The Injury Prevention and Outcomes after Trauma project: differences in survival between health trusts.
• Andelic, Nada; Røe, Cecilie; Brunborg, Cathrine; Zeldovich, Marina; Løvstad, Marianne & Løke, Daniel [Show all 19 contributors for this article] (2020). Correction to: Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study (Journal of Neurology, (2020), 10.1007/s00415-020-10022-2). Journal of Neurology. ISSN 0340-5354. 268, p. 74–76. doi: 10.1007/s00415-020-10174-1.
• Cuevas-Østrem, Mathias; Røise, Olav; Wisborg, Torben & Jeppesen, Elisabeth (2020). Geriatric Trauma – a rising tide. Assessing Patient Safety challenges in a vulnerable population using Norwegian Trauma Registry data and focus group interviews: A mixed-methods research protocol. JMIR Research Protocols. ISSN 1929-0748. 9(4). doi: 10.2196/15722. Full text in Research Archive
• Glette, Malin Knutsen; Kringeland, Tone Åslaug; Røise, Olav & Wiig, Siri (2019). Exploring hospital readmissions from the primary healthcare service – A multiple case study .
• Glette, Malin Knutsen; Kringeland, Tone Åslaug; Røise, Olav & Wiig, Siri (2019). Bedre samhandling i kampen mot reinnleggelser? Sydvesten. 4(25), p. 10–11.
• Røise, Olav (2019). Sykling er sunt, men kan også være farlig. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(12). doi: 10.4045/tidsskr.19.0530.
• Aaberg, Oddveig Reiersdal; Ballangrud, Randi; Karlsen, Tore; Røise, Olav; MOGER, THOMAS A WAKSVIK & Bergestuen, Linda [Show all 7 contributors for this article] (2019). Utdannet til pasientsikkehet og forbedring-pasientsikkerhet et teamansvar!
• Glette, Malin Knutsen; Røise, Olav; Kringeland, Tone Åslaug & Wiig, Siri (2018). The influence of nursing home Resources on hospital readmissions - A Qualitative study of nurses' and nursing home leaders' perspective.
• Wiig, Siri & Røise, Olav (2017). Innspill fra UiS til stortingets Helse og omsorgskommitee om lov om uavhengig undersøkelseskommisjon i helse og omsorgstjenesten.
• Wiig, Siri; Aase, Karina; Bourrier, Mathilde & Røise, Olav (2016). Transparency in healthcare: Displaying adverse events to the public.
• Søberg, Helene L.; Bautz-Holter, Erik; Finset, Arnstein; Røise, Olav & Andelic, Nada (2015). Physical and mental health 10 years after multiple trauma - a prospective cohort study.
• Søberg, Helene L.; Bautz-Holter, Erik; Finset, Arnstein; Røise, Olav & Andelic, Nada (2015). Physical and mental health 10 years after multiple trauma - a prospective cohort study.
• Glette, Malin Knutsen; Wiig, Siri; Røise, Olav & Kringeland, Tone Åslaug (2020). Exploring hospital readmissions from the primary healthcare service - A multiple Case Study. Universitetet i Stavanger. ISSN 978-82-7644-932-7.

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