Halvor Rollag

• Blom, Kjersti Benedicte; Kro, Grete Anette Birkeland; Midtvedt, Karsten; Jenssen, Trond; Reisæter, Anna Varberg & Rollag, Halvor [Show all 14 contributors for this article] (2024). Cellular immunity against cytomegalovirus and risk of infection after kidney transplantation. Frontiers in Immunology. 15, p. 1–11. doi: 10.3389/fimmu.2024.1414830. Full text in Research Archive Show summary

  Introduction Cytomegalovirus (CMV) infection remains a challenge following kidney transplantation (KTx). Currently, CMV-IgG serostatus at transplantation is used to individualize CMV preventive strategies. We assessed the clinical utility of CMV-IGRA for predicting CMV infection following KTx. Methods We performed a nationwide prospective cohort study from August 2016 until December 2022. Data from all adult KTx recipients in Norway, n=1,546 (R+; n=1,157, D+/R-; n=260, D-/R-; 129), were included with a total of 3,556 CMV-IGRA analyses (1,375 at KTx, 1,188 at eight weeks, 993 one-year after KTx) and 35,782 CMV DNAemia analyses. Results In R+ recipients CMV-IGRA status, measured at any of the time-points, could not identify any differential risk of later CMV infection. D+/R- recipients remaining CMV-IGRA negative 1-year after transplantation (regardless of positive CMV DNAemia and/or CMV IgG status at that time) had increased risk of developing later CMV infection compared to D+/R- recipients who had become CMV-IGRA positive (14% vs. 2%, p=0.01). Conclusion Knowledge of pre-transplant CMV-IGRA status did not provide additional information to CMV-IgG serostatus that could improve current post-transplant CMV treatment algorithms. However, D+/R- recipients with a persisting negative CMV-IGRA one-year after transplantation remained at increased risk of experiencing later CMV infection. Therefore we advocate post-transplant CMV-IGRA monitoring in these patients.

• Blom, Kjersti Benedicte; Kro, Grete Anette Birkeland; Midtvedt, Karsten; Jenssen, Trond; Reisæter, Anna Varberg & Rollag, Halvor [Show all 15 contributors for this article] (2023). Cytomegalovirus High-risk Kidney Transplant Recipients Show No Difference in Long-term Outcomes Following Preemptive Versus Prophylactic Management. Transplantation. ISSN 0041-1337. 107(8), p. 1846–1853. doi: 10.1097/TP.0000000000004615. Full text in Research Archive Show summary

  Background. Following kidney transplantation (KT), cytomegalovirus (CMV) infection remains an important challenge. Both prophylactic and preemptive antiviral protocols are used for CMV high-risk kidney recipients (donor seropositive/recipient seronegative; D+/R–). We performed a nationwide comparison of the 2 strategies in de novo D+/R– KT recipients accessing long-term outcomes. Methods. A nationwide retrospective study was conducted from 2007 to 2018, with follow-up until February 1, 2022. All adult D+/R– and R+ KT recipients were included. During the first 4 y, D+/R– recipients were managed preemptively, changing to 6 mo of valganciclovir prophylaxis from 2011. To adjust for the 2 time eras, de novo intermediate-risk (R+) recipients, who received preemptive CMV therapy throughout the study period, served as longitudinal controls for possible confounders. Results. A total of 2198 KT recipients (D+/R–, n = 428; R+, n = 1770) were included with a median follow-up of 9.4 (range, 3.1–15.1) y. As expected, a greater proportion experienced a CMV infection in the preemptive era compared with the prophylactic era and with a shorter time from KT to CMV infection (P < 0.001). However, there were no differences in long-term outcomes such as patient death (47/146 [32%] versus 57/282 [20%]; P = 0.3), graft loss (64/146 [44%] versus 71/282 [25%]; P = 0.5), or death censored graft loss (26/146 [18%] versus 26/282 [9%]; P = 0.9) in the preemptive versus prophylactic era. Long-term outcomes in R+ recipients showed no signs of sequential era–related bias. Conclusions. There were no significant differences in relevant long-term outcomes between preemptive and prophylactic CMV-preventive strategies in D+/R– kidney transplant recipients.

• Barlinn, Regine; Dudman, Susanne Gjeruldsen; Rollag, Halvor; Trogstad, Lill; Lindstrøm, Jonas Christoffer & Magnus, Per Minor (2022). Maternal cytomegalovirus infection and delayed language development in children at 3 years of age-a nested case-control study in a large population-based pregnancy cohort. PLOS ONE. 17(12). doi: 10.1371/journal.pone.0278623. Full text in Research Archive Show summary

  Introduction Maternal cytomegalovirus (CMV) infection in pregnancy may result in vertical transmission of CMV to the child. Long-term effects of congenital CMV infection include visual, cognitive as well as neurological impairment. The aim of this study was to estimate the odds ratios for CMV seropositivity and seroconversion in mothers, with and without delayed language development in 3 year old children, nested within a large cohort. Material and methods The Norwegian Mother, Father and Child Cohort Study (MoBa) is a prospective population-based pregnancy cohort that includes 95 200 mothers and 114 500 children. Blood samples were obtained from mothers during pregnancy weeks 17 or 18 in pregnancy and after birth. We included 300 women from MoBa with children suffering from delayed language development at three years of age, based on validated questionnaires. Within the cohort, 1350 randomly selected women were included as controls to perform a nested case-control study. The cases and controls were tested for CMV IgG antibodies by an enzyme-linked immunosorbent assay. Results Among mothers of cases, 63.2% were CMV-IgG positive in the sample at birth, as compared to 55.9% among controls; OR 1.36, (95% CI; 1.05 to 1.76). Also, among case mothers, 8/118 (6.8%) initially seronegative cases, seroconverted. Among initially seronegative controls, seroconversion occurred in 23/618 (3.7%) mothers. The OR for seroconversion in cases as compared to control mothers was 1.88 (CI; 0.82 to 4.31), thus not statistically significant different. Conclusion This study shows a higher risk of delayed language development at three years of age in children born by mothers seropositive for CMV, compared to children born from seronegative mothers.

• Barlinn, Regine; Trogstad, Lill; Rollag, Halvor; Frøen, Jahn Frederik; Magnus, Per & Dudman, Susanne Gjeruldsen (2020). Parvovirus B19 DNAemia in pregnant women in relation to perinatal death: A nested case‐control study within a large population‐based pregnancy cohort. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 99(7), p. 856–864. doi: 10.1111/aogs.13801. Full text in Research Archive Show summary

  Introduction: Parvovirus B19 (B19V) is the infectious cause of exanthema infectiosum. In Europe around 40% of pregnant women are susceptible to infection. Having small children at home is the main risk factor for contracting an infection during pregnancy. The association between B19V‐infection and perinatal death is not yet settled. The aims of the study were to estimate the association between maternal parvovirus B19 infection in pregnancy and perinatal death, and to assess the significance of a positive B19V PCR in pregnancy. Material and methods: The study population consists of women included in the Norwegian Mother and Child Cohort Study, a prospective population‐based pregnancy cohort of nearly 100 000 women. Blood samples were obtained during weeks 17‐18 in pregnancy (M1), at birth, and in umbilical cord blood. Within participants in the pregnancy cohort, 138 cases of perinatal death and 1350 controls with live‐born children were included in a nested case‐control study. Samples were analyzed with B19V serology and B19V PCR according to a predefined test algorithm. For cases, medical records and laboratory results from hospitals were combined with the results of B19V serology and PCR. The reported causes of perinatal death were categorized using the classification system: Causes Of Death and Associated Conditions (CODAC). Results: The B19V seroconversion rates were 9.8% for cases and 6.8% for control mothers. The odds ratio for maternal B19V infection in cases compared with controls was 1.28 (95% CI 0.35‐4.70), adjusted for age, parity, body mass index and tobacco use. B19V‐PCR‐positive samples were detected at weeks 17‐18 of gestation in both cases and controls. The proportion of positive samples was similar in cases and controls, 24% and 28.2%, respectively. Mothers with PCR‐positive M1 samples transmitted B19V vertically in 9.1% of cases and in 11.9% of the controls. Of all perinatal deaths, 53% were attributed to placental pathology or unknown causes. Conclusions: B19V PCR positivity was high and similar in both cases and controls. In our study B19V DNAemia was not seen to be associated with fatal outcome of pregnancy. The clinical significance of B19V DNA detection during pregnancy is uncertain. Caution is needed when diagnosing a B19V infection based only on B19V DNAemia.

• Richardson, Ann K; Walker, Logan; Cox, Brian; Rollag, Halvor; Robinson, Bridget Anne & Morrin, Helen [Show all 12 contributors for this article] (2019). Breast cancer and cytomegalovirus. Clinical and Translational Oncology. ISSN 1699-048X. doi: 10.1007/s12094-019-02164-1. Full text in Research Archive Show summary

  Purpose To determine whether cytomegalovirus is causally associated with breast cancer and whether cytomegalovirus should be categorised as an oncogenic virus. Methods We undertook a review of published epidemiological and laboratory studies, using established causal criteria: Bradford Hill criteria to determine whether cytomegalovirus is associated with breast cancer; and Evans/Mueller criteria to determine whether cytomegalovirus should be categorised as an oncogenic virus. Results Although there are inconsistencies in the findings of published epidemiological and laboratory studies, these may be explained by factors such as: differences in timing of blood samples, differences in selection of cases and controls, or high cytomegalovirus seroprevalence among participants in the epidemiological studies; and, in the laboratory studies, differences in sample preparations, age of sample, whether or not paired breast cancer and normal breast tissue samples were used, differences in the tests, primers and/or antibodies used, differences in histological types of breast cancer studied, and/or features of the virus. Conclusions Overall, the results of published studies of cytomegalovirus and breast cancer suggest cytomegalovirus is a causal factor for at least some types of breast cancer. If the evidence for a link between cytomegalovirus and breast cancer continues to strengthen, further research could lead to: targeted screening; therapy using antiviral drugs; and, perhaps, primary prevention of a significant proportion of breast cancer. Vaccination against viruses has already been shown to be effective in preventing cervix and liver cancer; cytomegalovirus vaccines are already under development.

• Barlinn, Regine; Dudman, Susanne Gjeruldsen; Trogstad, Lill; Gibory, Moustafa; Müller, Fredrik & Magnus, Per [Show all 7 contributors for this article] (2018). Maternal and congenital cytomegalovirus infections in a population-based pregnancy cohort study. APMIS - Journal of Pathologiy, Microbiology and Immunology. ISSN 0903-4641. 126(12), p. 899–906. doi: 10.1111/apm.12899. Full text in Research Archive
• Barlinn, Regine; Rollag, Halvor; Trogstad, Lill; Vainio, Kirsti; Basset, Coraline & Magnus, Per [Show all 7 contributors for this article] (2017). High incidence of maternal parvovirus B19 infection in a large unselected population-based pregnancy cohort in Norway. Journal of Clinical Virology. ISSN 1386-6532. 94, p. 57–62. doi: 10.1016/j.jcv.2017.07.010. Full text in Research Archive
• Smedbråten, Julia; Sagedal, Solbjørg; Åsberg, Anders; Hartmann, Anders; Rollag, Halvor & Mjøen, Geir [Show all 10 contributors for this article] (2017). Collectin liver 1 and collectin kidney 1 of the lectin complement pathway are associated with mortality after kidney transplantation. American Journal of Transplantation. ISSN 1600-6135. 17(1), p. 265–271. doi: 10.1111/ajt.13933. Full text in Research Archive
• Åsberg, Anders; Humar, Atul; Rollag, Halvor; Jardine, Alan G.; Kumar, Deepali & Aukrust, Pål [Show all 9 contributors for this article] (2016). Lessons Learned from a Randomized Study of Oral Valganciclovir Versus Parenteral Ganciclovir Treatment of Cytomegalovirus Disease in Solid Organ Transplant Recipients: The VICTOR Trial. Clinical Infectious Diseases. ISSN 1058-4838. 62(9), p. 1154–1160. doi: 10.1093/cid/ciw084. Full text in Research Archive
• SMEDBRÅTEN, Julia; Mjøen, Geir; Hartmann, Anders; Åsberg, Anders; Rollag, Halvor & Mollnes, Tom Eirik [Show all 10 contributors for this article] (2016). Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients. BMC Nephrology. 17(1). doi: 10.1186/s12882-016-0373-9. Full text in Research Archive Show summary

  Background Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement system is an essential component of the innate immunity. The aim of the present study was to investigate the association of effector molecules of the lectin complement pathway with graft and patient survival after kidney transplantation. Methods Two mannan-binding lectin (MBL) associated proteases, MASP-2 and MASP-3 (activators of the lectin pathway) and two MBL-associated proteins, MAp44 and MAp19 (inhibitors of the lectin pathway) were measured at the time of transplantation in 382 patients (≥17 years old) transplanted in 2000–2001. The cohort was followed until December 31, 2014. Data on patient and graft survival were obtained from the Norwegian Renal Registry. Cox proportional hazard regression models were performed for survival analyses. Results Low MAp44 level (1st versus 2–4 quartile) was significantly associated with overall mortality; HR 1.52, 95 % CI 1.08–2.14, p = 0.017. In the sub analyses in groups below and above median age (51.7 years), low MAp44 as a predictor of overall mortality was statistically significant only in recipients of ≤51.7 years; HR 2.57, 95 % CI 1.42–4.66, p = 0.002. Furthermore, low MAp44 was associated with mortality due to infectious diseases; HR 2.22, 95 % CI 1.11–4.41, p = 0.023. There was no association between MASP-2, MASP-3 or MAp19 levels and patient mortality. No association between any measured biomarkers and death censored graft loss was found. Conclusions Low MAp44 level at the time of transplantation was associated with increased overall mortality in kidney recipients of median age of 51.7 years or below and with mortality due to infectious diseases in the whole patient cohort after nearly 14-years of follow up after transplantation. No associations between other effector molecules; MASP-2, MASP-3 or MAp19 and recipient mortality were found, as well as no association of any biomarker with death censored graft loss. Keywords Kidney transplantation – Complement – Recipient survival

• Ueland, Thor; Rollag, Halvor; Hartmann, Anders; Jardine, Alan G.; Humar, Atul & Bignamini, Angelo A [Show all 8 contributors for this article] (2015). Increased osteoprotegerin predicts poor virological outcome during anticytomegalovirus theapy in solid organ transplant recipients. Transplantation. ISSN 0041-1337. 99(1), p. 100–105. doi: 10.1097/TP.0000000000000227. Full text in Research Archive
• Smedbråten, Yuliya V.; Sagedal, Solbjørg; Mjøen, Geir; Hartmann, Anders; Fagerland, Morten & Rollag, Halvor [Show all 8 contributors for this article] (2015). High Ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients. Transplantation. ISSN 0041-1337. 99(4), p. 791–796. doi: 10.1097/TP.0000000000000422. Full text in Research Archive
• Béziat, Vivien; Sleiman, Marwan; Goodridge, Jodie; Kaarbø, Mari; Liu, Lisa L. & Rollag, Halvor [Show all 9 contributors for this article] (2015). Polyclonal expansion of NKG2C+ NK cells in TAP-deficient patients. Frontiers in Immunology. 6. doi: 10.3389/fimmu.2015.00507. Full text in Research Archive
• Garrido, Rafael San-Juan; Manuel, Oriol; Hirsch, Hans Hans; Fernández-Ruiz, Mario; López-Medrano, Francisco & Comoli, Patrizia [Show all 10 contributors for this article] (2015). Current preventive strategies and management of Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in Europe. Results of the ESGICH Questionnaire-based Cross-sectional Survey. Clinical Microbiology and Infection (CMI). ISSN 1198-743X. 21(6), p. 604.e1–604.e9. doi: 10.1016/j.cmi.2015.02.002. Full text in Research Archive
• Lisboa, Luiz Filipe; Egli, Adrian; O'Shea, Daire; Åsberg, Anders; Hartmann, Anders & Rollag, Halvor [Show all 10 contributors for this article] (2015). Hcmv-miR-UL22A-5p: A biomarker in transplantation with broad impact on host gene expression and potential immunological implications. American Journal of Transplantation. ISSN 1600-6135. 15(7), p. 1893–1902. doi: 10.1111/ajt.13222. Full text in Research Archive
• Turowski, Gitta Erika; Rollag, Halvor & Roald, Borghild (2015). Viral infection in placenta relevant cells – a morphological and immunohistochemical cell culture study. APMIS - Journal of Pathologiy, Microbiology and Immunology. ISSN 0903-4641. 123(1), p. 60–64. doi: 10.1111/apm.12307. Full text in Research Archive
• Ueland, Thor; Rollag, Halvor; Hartmann, Anders; Jardine, Alan George; Humar, Atul & Michelsen, Annika [Show all 9 contributors for this article] (2014). Secreted Wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients. American Journal of Transplantation. ISSN 1600-6135. 14(1), p. 210–215. doi: 10.1111/ajt.12506. Full text in Research Archive
• Husøy, Magnus Andreas Rognlien; Brinch, Lorentz; Tjønnfjord, Geir Erland; Gedde-Dahl, Tobias Jr.; Heldal, Dag & Holme, Pål Andre [Show all 16 contributors for this article] (2014). Allogen stamcelletransplantasjon hos voksne 1985-2012. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 134(16), p. 1569–1575. doi: 10.4045/tidsskr.13.1415. Full text in Research Archive
• Smedbråten, Yuliya V.; Sagedal, Solbjørg; Leivestad, Torbjørn; Mjøen, Geir; Osnes, Kåre & Rollag, Halvor [Show all 10 contributors for this article] (2014). The impact of early cytomegalovirus infection after kidney transplantation on long-term graft and patient survival. Clinical Transplantation. ISSN 0902-0063. 28(1), p. 120–126. doi: 10.1111/ctr.12288. Full text in Research Archive
• Taraldsrud, Eli; Fevang, Børre; Aukrust, Pål; Beiske, Klaus; Fløisand, Yngvar & Frøland, Stig Sophus [Show all 8 contributors for this article] (2014). Common variable immunodeficiency revisited: Normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9. Clinical and Experimental Immunology. ISSN 0009-9104. 175(3), p. 439–448. doi: 10.1111/cei.12239. Full text in Research Archive
• Razonable, Raymund R; Åsberg, Anders; Rollag, Halvor; Duncan, John; Boisvert, Denis & Yao, Joseph D [Show all 9 contributors for this article] (2013). Virologic Suppression Measured by a Cytomegalovirus (CMV) DNA Test Calibrated to the World Health Organization International Standard Is Predictive of CMV Disease Resolution in Transplant Recipients. Clinical Infectious Diseases. ISSN 1058-4838. 56(11), p. 1546–1553. doi: 10.1093/cid/cit096. Full text in Research Archive
• Rollag, Halvor; Ueland, Thor; Åsberg, Anders; Hartmann, Anders; Jardine, Alan G. & Humar, Atul [Show all 9 contributors for this article] (2013). Characterization of Cytomegalovirus Disease in Solid Organ Transplant Recipients by Markers of Inflammation in Plasma. PLOS ONE. 8(4). doi: 10.1371/journal.pone.0060767. Full text in Research Archive
• Brantsæter, Arne; Johannessen, Asgeir; Holberg-Petersen, Mona; Sandvik, Leiv; Naman, Ezra & Kivuyo, Sokoine [Show all 9 contributors for this article] (2012). Cytomegalovirus viremia in dried blood spots is associated with an increased risk of death in HIV-infected patients: a cohort study from rural Tanzania. International Journal of Infectious Diseases. ISSN 1201-9712. 16(12), p. E879–E885. doi: 10.1016/j.ijid.2012.08.003. Full text in Research Archive
• Lisboa, L; Tong, Y; Kumar, Deepali; Pang, Xiaoli; Åsberg, Anders & Hartmann, Anders [Show all 10 contributors for this article] (2012). Analysis and clinical correlation of genetic variation in cytomegalovirus. Transplant Infectious Disease. ISSN 1398-2273. 14(2), p. 132–140. doi: 10.1111/j.1399-3062.2011.00685.x. Full text in Research Archive
• Emery, Vincent C; Manuel, Oriol; Åsberg, Anders; Pang, Xiaoli; Kumar, Deepali & Hartmann, Anders [Show all 12 contributors for this article] (2012). Differential decay kinetics of human cytomegalovirus glycoprotein B genotypes following antiviral chemotherapy. Journal of Clinical Virology. ISSN 1386-6532. 54(1), p. 56–60. doi: 10.1016/j.jcv.2012.01.015. Full text in Research Archive
• Ranneberg-Nilsen, Toril; Rollag, Halvor; Slettebakk, Ragnhild; Backe, Paul Hoff; Olsen, Øyvind & Luna, Luisa [Show all 7 contributors for this article] (2012). The Chromatin Remodeling Factor SMARCB1 Forms a Complex with Human Cytomegalovirus Proteins UL114 and UL44. PLOS ONE. 7(3). doi: 10.1371/journal.pone.0034119. Full text in Research Archive
• Rollag, Halvor; Åsberg, Anders; Ueland, Thor; Hartmann, Anders; Jardine, Alan & Humar, Atul [Show all 9 contributors for this article] (2012). Treatment of Cytomegalovirus Disease in Solid Organ Transplant Recipients: Markers of Inflammation as Predictors of Outcome. Transplantation. ISSN 0041-1337. 94(10), p. 1060–1065. doi: 10.1097/TP.0b013e31826c39de. Full text in Research Archive
• Myhre, Hans-Arne; Dorenberg, Dagny Haug; Kristiansen, Knut Ivan; Rollag, Halvor; Leivestad, Torbjørn & Åsberg, Anders [Show all 7 contributors for this article] (2011). Incidence and outcomes of ganciclovir-resistant cytomegalovirus infections in 1244 kidney transplant recipients. Transplantation. ISSN 0041-1337. 92(2), p. 217–223. doi: 10.1097/TP.0b013e31821fad25. Full text in Research Archive
• Lisboa, L; Åsberg, Anders; Kumar, Deepali; Pang, Xiaoli; Hartmann, Anders & Preiksaitis, Jutta K [Show all 10 contributors for this article] (2011). The Clinical Utility of Whole Blood Versus Plasma Cytomegalovirus Viral Load Assays for Monitoring Therapeutic Response. Transplantation. ISSN 0041-1337. 91(2), p. 231–236. doi: 10.1097/TP.0b013e3181ff8719. Full text in Research Archive
• Åsberg, Anders; Jardine, AG; Bignamini, Angelo A; Rollag, Halvor; Pescovitz, Mark D & Gahlemann, Christoph C [Show all 8 contributors for this article] (2010). Effects of the Intensity of Immunosuppressive Therapy on Outcome of Treatment for CMV Disease in Organ Transplant Recipients. American Journal of Transplantation. ISSN 1600-6135. 10(8), p. 1881–1888. doi: 10.1111/j.1600-6143.2010.03114.x. Full text in Research Archive
• Cox, B; Richardson, A; Graham, P; Gislefoss, Randi Elin; Jellum, Egil & Rollag, Halvor (2010). Breast cancer, cytomegalovirus and Epstein-Barr virus: a nested case-control study. British Journal of Cancer. ISSN 0007-0920. 102(11), p. 1665–1669. doi: 10.1038/sj.bjc.6605675. Full text in Research Archive
• Boivin, Guy; Goyette, N; Rollag, Halvor; Jardine, Alan; Pescovitz, Mark D & Åsberg, Anders [Show all 9 contributors for this article] (2009). Cytomegalovirus resistance in solid organ transplant recipients treated with intravenous ganciclovir or oral valganciclovir. Antiviral Therapy. ISSN 1359-6535. 14(5), p. 697–704. Full text in Research Archive
• Manuel, Oriol; Åsberg, Anders; Pang, Xiaoli; Rollag, Halvor; Emery, Vincent C & Preiksaitis, Jutta K [Show all 12 contributors for this article] (2009). Impact of genetic polymorphisms in cytomegalovirus glycoprotein B on outcomes in solid-organ transplant recipients with cytomegalovirus disease. Clinical Infectious Diseases. ISSN 1058-4838. 49(8), p. 1160–1166. doi: 10.1086/605633. Full text in Research Archive
• Åsberg, Anders; Humar, Atul; Jardine, Alan; Rollag, Halvor; Pescovitz, Mark D & Mouas, Houria [Show all 11 contributors for this article] (2009). Long-Term Outcomes of CMV Disease Treatment with Valganciclovir Versus IV Ganciclovir in Solid Organ Transplant Recipients. American Journal of Transplantation. ISSN 1600-6135. 9(5), p. 1205–1213. doi: 10.1111/j.1600-6143.2009.02617.x. Full text in Research Archive
• Humar, Atul; Åsberg, Anders; Kumar, Deepali; Hartmann, Anders; Moussa, George & Jardine, Alan [Show all 10 contributors for this article] (2009). An assessment of herpesvirus co-infections in patients with CMV disease: Correlation with clinical and virological outcomes. American Journal of Transplantation. ISSN 1600-6135. 9(2), p. 374–381. doi: 10.1111/j.1600-6143.2008.02501.x. Full text in Research Archive
• Sagedal, Solbjørg; Thiel, Steffen; Hansen, Troels Krarup; Mollnes, Tom Eirik; Rollag, Halvor & Hartmann, Anders (2008). Impact of the complement lectin pathway on cytomegalovirus disease early after kidney transplantation. Nephrology, Dialysis and Transplantation. ISSN 0931-0509. 23(12), p. 4054–4060. doi: 10.1093/ndt/gfn355. Full text in Research Archive
• Ranneberg-Nilsen, T; Dale, HA; Luna, L; Slettebakk, R; Sundheim, Ottar & Rollag, H [Show all 7 contributors for this article] (2008). Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44). Journal of Molecular Biology (JMB). ISSN 0022-2836. 381, p. 276–288. doi: 10.1016/j.jmb.2008.05.028. Full text in Research Archive
• Kvale, Espen Østhagen; Fløisand, Yngvar; Lund-Johansen, Fridtjof; Rollag, Halvor; Farkas, Lorant & Ghanekar, Smita [Show all 9 contributors for this article] (2007). Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells. Blood. ISSN 0006-4971. 109. doi: 10.1182/blood-2006-06-031484. Full text in Research Archive
• Sagedal, Solbjørg; Rollag, Halvor & Hartmann, Anders (2007). Cytomegalovirus infection in renal transplant recipients is associated with impaired survival irrespective of expected mortality risk. Clinical Transplantation. ISSN 0902-0063. 21, p. 309–313. Full text in Research Archive
• Åsberg, Anders; Humar, Atul; Rollag, Halvor; Jardine, A.G.; Mouas, Houria & Pescovitz, Mark D [Show all 10 contributors for this article] (2007). Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. American Journal of Transplantation. ISSN 1600-6135. 7(9), p. 2106–2113. doi: 10.1111/j.1600-6143.2007.01910.x. Full text in Research Archive
• Valderhaug, Tone Gretland; Valderhaug, tone Gretland; Hjelmesæth, Jøran; Rollag, Halvor; Leivestad, Torbjørn & Røislien, Jo [Show all 8 contributors for this article] (2007). Reduced incidence of new-onset posttransplantation diabetes mellitus during the last decade. Transplantation. ISSN 0041-1337. 84(9), p. 1125–1130. doi: 10.1097/01.tp.0000287191.45032.38. Full text in Research Archive
• Arora, S; Jenum, Pål Arne; Aukrust, P; Rollag, Halvor; Andreassen, AK & Simonsen, S [Show all 10 contributors for this article] (2007). Pre-transplant Toxoplasma gondii seropositivity among heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality. Journal of the American College of Cardiology. ISSN 0735-1097. 50, p. 1967–1972. doi: 10.1016/j.jacc.2007.07.068. Full text in Research Archive
• Ranneberg-Nilsen, Toril; Bjørås, Magnar; Luna, Gomez Luisa; Slettebakk, Ragnhild; Dale, Hege Avsnes & Seeberg, Erling Christen [Show all 7 contributors for this article] (2006). Human cytomegalovirus infection modulates DNA base excision repair in fibroblast cells. Virology. ISSN 0042-6822. 348, p. 389–397. Full text in Research Archive
• Kvale, Espen Østhagen; Dalgaard, Jakob; Lund-Johansen, Fridtjof; Rollag, Halvor; Farkas, Lorant & Midtvedt, Karsten [Show all 9 contributors for this article] (2006). CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell–stimulatory capability upon infection. Blood. ISSN 0006-4971. 107(5), p. 2022–2029. doi: 10.1182/blood-2005-05-2016. Full text in Research Archive
• Degre, Miklos; Sagedal, Solbjørg & Rollag, Halvor (2005). Viral infections in immunocompromised patients. A review. Acta Microbiologica et Immunologica Hungarica. ISSN 1217-8950. 52, p. 351–362. Full text in Research Archive
• Sagedal, Solbjørg; Hartmann, Anders & Rollag, Halvor (2005). The impact of early cytomegalovirus infection and disease in renal transplant recipients. Clinical Microbiology and Infection (CMI). ISSN 1198-743X. 11(7), p. 518–530. Full text in Research Archive
• Hjelmesæth, Jøran; Muller, Fredrik; Jenssen, Trond; Rollag, Halvor; Sagedal, Solbjørg & Hartmann, Anders (2005). Is there a link between cytomegalovirus infection and new-onset posttransplantation diabetes mellitus? Potential mechanisms of virus induced beta-cell damage. Nephrology, Dialysis and Transplantation. ISSN 0931-0509. 20, p. 2311–2315. Full text in Research Archive
• Hjelmesæth, Jøran; Sagedal, Solbjørg; Hartmann, Anders; Rollag, Halvor; Egeland, Thore & Hagen, M [Show all 8 contributors for this article] (2004). Cytomegalovirus infection is associated with increased risk for new-onset diabetes and impaired insulin release after renal transplantation. Diabetologia. ISSN 0012-186X. 47, p. 1550–1556. Full text in Research Archive
• Sagedal, Solbjørg; Hartmann, Anders; Nordal, KP; Osnes, K; Leivestad, Torbjørn & Foss, Aksel [Show all 9 contributors for this article] (2004). Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival. Kidney International. ISSN 0085-2538. 66, p. 329–337. Full text in Research Archive
• Sagedal, Solbjørg; Nordal, KP; Hartmann, Anders; Midtvedt, Karsten; Foss, A & Asberg, A [Show all 9 contributors for this article] (2003). Pre-emptive therapy of CMVpp65 antigen positive renal transplant recipients with oral ganciclovir: a randimized, comparative study. Nephrology, Dialysis and Transplantation. ISSN 0931-0509. 18, p. 1899–1908. Full text in Research Archive
• Nordøy, Ingvild; Rollag, Halvor; Lien, Egil; Sindre, Hilde; Degre, Miklos & Aukrust, Pål [Show all 8 contributors for this article] (2003). Cytomegalovirus infection induces production of human interleukin-10 in macrophages. European Journal of Clinical Microbiology and Infectious Diseases. ISSN 0934-9723. 22, p. 737–741. Full text in Research Archive
• Rollag, Halvor; Sagedal, Solbjørg; Kristiansen, K. I.; Kvale, Dag; Holter, Ellen & Degre, Miklos [Show all 7 contributors for this article] (2002). Cytomegalovirus DNA concentration in plasma predicts development of cytomegalovirus disease in kidney transplant recipients. Clinical Microbiology and Infection (CMI). ISSN 1198-743X. 8, p. 431–434. Full text in Research Archive

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• Rollag, Halvor; Müller, Fredrik & Tonjum, Tone (2019). Medisinsk mikrobiologi. Gyldendal Akademisk. ISBN 9788205500983. 516 p. Full text in Research Archive
• Degre, Miklos; Hovig, Berit & Rollag, Halvor (2009). Medisinsk Mikrobiologi, 3.utg. Gyldendal Akademisk. ISBN 9788205315907. 803 p. Full text in Research Archive
• Degre, Miklos; Hovig, Berit & Rollag, Halvor (2008). Medisinsk mikrobiologi 3.utgave. Gyldendal Akademisk. ISBN 9788205315907. 803 p. Full text in Research Archive
• Degre, M; Hovig, B; Bukholm, Geir & Rollag, Halvor (2005). Medisinsk mikrobiologi, 3. utg. Gyldendal Akademisk. 600 p. Full text in Research Archive

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• Rollag, Halvor; Holter, Ellen & Müller, Fredrik (2015). Re: Hørselstap hos barn i Østfold 2000 - 09. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 135(6), p. 513–513. doi: 10.4045/tidsskr.15.0262. Full text in Research Archive
• SMEDBRÅTEN, YULIYA V.; Hartmann, Anders; Rollag, Halvor; Foss, Aksel; Leivestad, Torbjørn & Sagedal, S (2012). The Long-Term Impact of Early Cytomegalovirus Infection after Kidney Transplantaion. American Journal of Transplantation. ISSN 1600-6135. 12, p. 170–171. Full text in Research Archive
• Taraldsrud, Eli; Floisand, Y; Aukrust, Pål; Rollag, Halvor; Fevang, Børre & Olweus, Johanna (2012). PLASMACYTOID DENDRITIC CELLS HAVE NORMAL FUNCTION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. Journal of Clinical Immunology. ISSN 0271-9142. 32, p. 50–50. Full text in Research Archive
• Hausken, Jon; Klingenberg, Olav; Mørkrid, Lars; Rollag, Halvor; Foss, Aksel & Midtvedt, Karsten (2012). Elevated Troponin I and NT-proBNP at the Time of Transplantation May Predict a Major Adverse Cardiac Event in the Early Postoperative Period After Renal Transplantation. Transplantation. ISSN 0041-1337. 94(2), p. E15–E16. doi: 10.1097/TP.0b013e31825b7633. Full text in Research Archive
• Smedbraaten, Yuliya V.; Hartmann, Anders; Rollag, Halvor; Leivestad, Torbjørn; Foss, Aksel & Viko, Håvard [Show all 8 contributors for this article] (2012). LONG-TERM IMPACT OF EARLY CYTOMEGALOVIRUS INFECTION AFTER KIDNEY TRANSPLANTATION. Nephrology, Dialysis and Transplantation. ISSN 0931-0509. 27, p. 68–69. Full text in Research Archive
• Razonable, Raymund R; Yao, Joseph; Caliendo, Angela M; Do, Tri; Duncan, John & Humar, Atul [Show all 8 contributors for this article] (2012). Virological Suppression as Measured by the WHO International Standard Is Predictive of CMV Disease Resolution in Transplant Recipients. American Journal of Transplantation. ISSN 1600-6135. 12, p. 70–70. Full text in Research Archive
• Åsberg, Anders; Jardine, AG; Bignamini, AA; Rollag, Halvor; Gahlemann, Christoph C & Humar, A [Show all 7 contributors for this article] (2011). Response to Letter About Intensity of Immunosuppressive Therapy on Outcome of Treatment for CMV Disease. American Journal of Transplantation. ISSN 1600-6135. 11(5), p. 1103–1104. doi: 10.1111/j.1600-6143.2011.03500.x. Full text in Research Archive
• Åsberg, Anders; Rollag, Halvor & Hartmann, Anders (2010). Valganciclovir for the prevention and treatment of CMV in solid organ transplant recipients. Expert Opinion on Pharmacotherapy. ISSN 1465-6566. 11(7), p. 1159–1166. doi: 10.1517/14656561003742954. Full text in Research Archive
• Lisboa, L; Asberg, A; Hartmann, Anders; Kumar, Deepali; Pescovitz, M & Rollag, Halvor [Show all 10 contributors for this article] (2009). Comparison of Highly Sensitive vs. Standard CMV Viral Load Assays for Monitoring Therapeutic Response. American Journal of Transplantation. ISSN 1600-6135. 9, p. 249–249. Full text in Research Archive
• Lisboa, L; Åsberg, Anders; Hartmann, Anders; Kumar, Deepali; Pescovitz, Mark D & Rollag, Halvor [Show all 10 contributors for this article] (2009). Comparison of Highly Sensitive vs. Standard CMV Viral Load Assays for Monitoring Therapeutic Response. Full text in Research Archive
• Humar, Atul; Åsberg, Anders; Hartmann, Anders; Pescovitz, Mark D; Rollag, Halvor & Jardine, AG [Show all 7 contributors for this article] (2009). Natural Polymorphisms in CMV Genes and Their Effect on Viral Fitness. Full text in Research Archive
• Humar, A; Asberg, A; Hartmann, Anders; Pescovitz, Mark D; Rollag, Halvor & Jardine, A [Show all 7 contributors for this article] (2009). Natural Polymorphisms in CMV Genes and Their Effect on Viral Fitness. American Journal of Transplantation. ISSN 1600-6135. 9, p. 302–303. Full text in Research Archive
• Arora, Satish; Jenum, PA; Aukrust, Pål; Rollag, Halvor; Andreassen, Arne K. & Simonsen, Svein [Show all 10 contributors for this article] (2008). Pretransplant toxoplasma gondii seropositivity amongst heart transplant recipients is associated with an increase risk of all-cause and cardiac mortality. Full text in Research Archive
• Manuel, Oriol; Emery, Vincent C; Åsberg, Anders; Hartmann, Anders; Pescovitz, Mark D & Pang, Xiaoli [Show all 9 contributors for this article] (2008). A Prospective Study of Viral Genetic Polymorphisms in CMV Glycoprotein B and their Association with Clinical and Virologic Outcomes in Patients with CMV Disease: Results from the VICTOR Study. Full text in Research Archive
• Åsberg, Anders; Pescovitz, Mark D; Humar, Atul; Rollag, Halvor; Mouas, Houria & Hartmann, Anders (2008). Oral valganciclovir and intravenous ganciclovir results in comparable long-term outcomes in transplant recipients with CMV disease: The VICTOR study. Full text in Research Archive
• Arora, Satish; Jenum, Pål Arne; Aukrust, Pål; Rollag, Halvor; Andreassen, Arne K. & Simonsen, Svein [Show all 10 contributors for this article] (2008). Pre-transplant Toxoplasma gondii seropositivlty among heart transplant recipients and mortality - Reply. Journal of the American College of Cardiology. ISSN 0735-1097. 51, p. 1827–1828. doi: 10.1016/j.jacc.2008.02.028. Full text in Research Archive
• Emery, Vincent C; Manuel, Oriol; Åsberg, Anders; Hartmann, Anders; Pang, Xiaoli & Pescovitz, Mark D [Show all 10 contributors for this article] (2008). Differential decay kinetics of CMV DNAemia after antiviral therapy in patients with simultaneous co-infection with different viral strains. Full text in Research Archive
• Manuel, Oriol; Pang, Xiaoli; Preiksaitis, Jutta K; Emery, Vincent C; Kumar, Deepali & Åsberg, Anders [Show all 12 contributors for this article] (2008). A prospective study of viral genetic polymorphisms in CMV glycoprotein B and their association with clinical and virological outcomes in patients with CMV disease. Full text in Research Archive
• Pescovitz, Mark D; Hartmann, Anders; Humar, Atul; Rollag, Halvor; Jardine, Alan & Bignamini, Angelo A [Show all 7 contributors for this article] (2008). Management of posttransplant CMV disease: Lessons learned from the VICTOR trial. Full text in Research Archive
• Hartmann, Anders; Humar, Atul; Rollag, Halvor; Jardine, Alan; Pescovitz, Mark D & Bignamini, Angelo A [Show all 7 contributors for this article] (2008). Oral valganciclovir and intravenous ganciclovir in the treatment of CMV disease have comparable long-term outcomes in organ transplant recipients: The VICTOR study. Full text in Research Archive
• Manuel, O; Asberg, A; Hartmann, Anders; Pang, XL; Pescovitz, M & Bignamini, A [Show all 9 contributors for this article] (2008). Differential decay kinetics of CMV DNAemia after antiviral therapy in patients with simultaneous co-infections with different viral strains. American Journal of Transplantation. ISSN 1600-6135. 8, p. 230–230. Full text in Research Archive
• Hartmann, Anders; Humar, A; Rollag, Halvor; Jardine, AG; Pescovitz, MD & Bignamini, AA [Show all 7 contributors for this article] (2008). Oral valganciclovir and intravenous ganciclovir in the treatment of CMV disease have comparable long term outcomes in organ transplant recipients: The VICTOR study. American Journal of Transplantation. ISSN 1600-6135. 8, p. 567–567. Full text in Research Archive
• Arora, Satish; Jenum, P; Aukrust, Pål; Rollag, Halvor; Andreassen, Arne K. & Simonsen, Svein [Show all 10 contributors for this article] (2008). Pretransplant toxoplasma gondii seropositivity amongst heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 27, p. S187–S187. Full text in Research Archive
• Pescovitz, MD; Hartmann, Anders; Humar, A; Rollag, Halvor; Jardine, AG & Bignamini, AA [Show all 7 contributors for this article] (2008). Management of post transplant CMV disease: Lessons learned from the VICTOR trial. American Journal of Transplantation. ISSN 1600-6135. 8, p. 183–183. Full text in Research Archive
• Arora, Satish; Jenum, Pål Arne; Aukrust, Pål; Rollag, Halvor; Andreassen, Arne K. & Simonsen, Svein [Show all 10 contributors for this article] (2007). Pretransplant Toxoplasma gondii seropositivity amongst heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality. Full text in Research Archive
• Hartmann, Anders; Humar, Atul; Rollag, Halvor; Jardine, A.G.; Pescovitz, Mark D & Sgarabotto, Dino [Show all 7 contributors for this article] (2007). Oral valganciclovir is as effective and safe as iv ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Full text in Research Archive
• Humar, Atul; Åsberg, Anders; Rollag, Halvor; Jardine, A.G.; Pescovitz, Mark D & Tuncer, Murat [Show all 8 contributors for this article] (2007). Oral valganciclovir and intravenous ganciclovir have comparable cytomegalovirus (CMV) viral clearance kinetics in the treatment of CMV disease. Full text in Research Archive
• Humar, A; Åsberg, Anders; Rollag, Halvor; Jardine, A.G.; Pescovitz, Mark D & Tuncer, Murat [Show all 8 contributors for this article] (2007). Oral valganciclovir and intravenous ganciclovir have comparable cytomegalovirus (CMV) viral clearance kinetics in the treatment of CMV disease. American Journal of Transplantation. ISSN 1600-6135. 7. Full text in Research Archive
• Åsberg, Anders; Humar, Atul; Rollag, Halvor; Jardine, AG; Mouas, Houria & Pescovitz, Mark D [Show all 10 contributors for this article] (2007). Oral valganciclovir is non-inferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Full text in Research Archive
• Valderhaug, Tone Gretland; Hjelmesæth, Jøran; Rollag, Halvor; Leivestad, Torbjørn; Røislien, Jo & Jenssen, Trond Geir [Show all 7 contributors for this article] (2006). Reduced incidence of PTDM during the last decade. Full text in Research Archive
• Kvale, Espen Østhagen; Fløisand, Yngvar; Lund-Johansen, Fridtjof; Rollag, Halvor; Brandtzæg, Per & Jahnsen, Frode Lars [Show all 7 contributors for this article] (2006). Plasmacytoid dendritic cells regulate recall responses by rapid induction of IL-10 in CD4+ memory T cells. Tissue Antigens. ISSN 0001-2815. 67, p. 443–444. Full text in Research Archive
• Ranneberg-Nilsen, Torill; Bjørås, Magnar; Luna, Luisa; Slettebakk, Ragnhild; Seeberg, Erling Christen & Rollag, Halvor (2003). Human cytomegalovirus infection regulates the base excision DNA-repair activity in fibroblast cells. Full text in Research Archive
• Hartmann, Anders; Sagedal, Solbjørg; Foss, Aksel; Leivestad, Torbjørn; Osnes, Kåre & Fauchald, Per [Show all 7 contributors for this article] (2003). Effects of CMV infection and CMV disease on long-term patient and graft survival after renal transplantation. Full text in Research Archive
• Sagedal, Solbjørg; Nordal, Knut P.; Hartmann, Anders; Midtvedt, Karsten; Foss, Aksel & Åsberg, Anders [Show all 8 contributors for this article] (2003). Preemptive therapy of CMV pp65 antigen positive renal transplant recipients with oral ganciclovir- a randomised, comparative study. Full text in Research Archive
• Ranneberg-Nilsen, Torill; Rasouli, P.; Bjørås, Magnar; Luna, Luisa; Slettebakk, Ragnhild & Seeberg, Erling Christen [Show all 7 contributors for this article] (2002). Base excision repair in human cytomegalovirus infected cells. Full text in Research Archive
• Sagedal, Solbjørg; Nordal, Knut P.; Hartmann, Anders; Sund, Ståle; Scott, Helge & Degre, Miklos [Show all 10 contributors for this article] (2002). The impact of cytomegalovirus infection and disease on rejection episodes in renal allograft recipients. Full text in Research Archive
• Solheim, Bjarte G.; Tølløfsrud, Stein; Noddeland, Harald; Rollag, Halvor; Svennevig, Jan Ludvig & Brosstad, Frank Roger [Show all 8 contributors for this article] (2002). Universal Solvent/detergent plasma. Full text in Research Archive
• Dale, H.A.; Rollag, Halvor; Seeberg, Erling Christen & Bjørås, Magnar (2002). Molecular characterization of recombinant Uracil DNA-glycosylase from human cytomegalovirus. Full text in Research Archive
• Solheim, Bjarte G.; Tølløfsrud, Stein; Noddeland, Harald; Rollag, Halvor; Svennevig, Jan Ludvig & Brosstad, Frank Roger [Show all 8 contributors for this article] (2002). Universal Solvent/detergent plasma. Full text in Research Archive
• Løland, B. Fossum; Kvale, Dag; Holter, Ellen; Rollag, Halvor; Clausen, Ole Petter Fraas & Farstad, Inger Nina [Show all 11 contributors for this article] (2002). CMV infections and disease in patients treated with allogeneic stem cell transplantation 1985-2001. Single centre experience. Full text in Research Archive
• Kanestrøm, Anita; Litleskare, Irene; Bragstad, Karoline; Dudman, Susanne Gjeruldsen; Bergersen, Bente Magny & Kran, Anne-Marte Bakken [Show all 10 contributors for this article] (2016). Usage of Antivirals and the Occurrence of Antiviral Resistance. RAVN in Norway 2015. Folkehelseinstituttet. ISSN 9788280827692. Full text in Research Archive
• Rollag, Halvor; Nordbø, Svein Arne; Tylden, Garth Daryl & Hoddevik, Gunnar Martin (2014). Laboratoriediagnostikk ved cytomegalovirusinfeksjoner. Strategimøte 31. oktober 2013. Folkehelseinstituttet. ISSN 9788280826299. Full text in Research Archive Show summary

  I regi av ”Referansegruppe for ekstern kvalitetssikring i virologi og serologi” ble det holdt strategimøte om laboratoriediagnostikk ved cytomegalovirus infeksjon den 31. oktober 2013 i Oslo. Rapporten inneholder oppsummering og anbefalinger for diagnostikk slik det kom fram på møtet, samt sammendrag av foredragene (manuskriptene) som er gjengitt i sin helhet.

• Kilander, Anette; Dudman, Susanne Gjeruldsen; Stene-Johansen, Kathrine; Vik, Inger Sofie Samdal; Hungnes, Olav & Waalen, Kristian [Show all 9 contributors for this article] (2013). Usage of antivirals and the occurrence of antiviral resistance in Norway 2011-2012. RAVN 2011–12. Folkehelseinstituttet. ISSN 9788280825681. Full text in Research Archive
• Rollag, Halvor; Størvold, Gunnar; Myrmel, Helge; Nordbø, Svein Arne; Aaberge, Ingeborg Sundsvalen & Hoddevik, Gunnar Martin (2006). Virusinfeksjoner ved immunsvikt. Strategimøte 2006. Folkehelseinstituttet. ISSN 9788280822130. Full text in Research Archive

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