Søren Erik Pischke

Image of Søren Erik Pischke
Norwegian version of this page
Username
Visiting address Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postal address Postboks 4950 Nydalen OUS HF Rikshospitalet 0424 Oslo

S. Pischke is a researcher at the Complement Research Group and senior consultant in critical care medicine at Department of Anaesthesiology, Oslo University Hospital, Rikshospitalet.

Overall research aim is (1) to describe innate immunity mechanisms in ischemia/reperfusion injury and (2) to attenuate the reperfusion injury both in vitro and in vivo with high potential for transfer to clinical studies.

Disease focus is on preventing detrimental effects of ischemia/reperfusion in transplantation (kidney and liver) and myocardial infarction. The group has developed unique models of hypoxia/reoxygenation of cultured endothelial cells in combination with a full blood model and the use of ex vivo machine perfusion to simulate reperfusion in porcine kidneys.

S. Pischke is a scholar of the "Young Research Talent" program of the Norwegian Research Council and holds a Department Research Grant. He is main supervisor of 2 PhD students and 1 PostDoc in addition to co-supervior of 3 PhD students.

Tags: innate immunity, complement system, C5, TLR, critical care, intensive care, anaesthesiology

Publications

  • Chaban, Viktoriia; Nakstad, Espen R.; Stær-Jensen, Henrik; Schjalm, Camilla; Seljeflot, Ingebjørg & Vaage, Ingvar Jarle [Show all 12 contributors for this article] (2021). Complement activation is associated with poor outcome after out-of-hospital cardiac arrest. Resuscitation. ISSN 0300-9572. p. 1–8. doi: 10.1016/j.resuscitation.2021.05.038. Full text in Research Archive
  • Witczak, B.J.; Pischke, Soeren; Reisæter, Anna Varberg; Midtvedt, Karsten; Ludvigsen, Judith K. & Heldal, Kristian [Show all 10 contributors for this article] (2021). Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.738927.
  • Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver & Pischke, Soeren [Show all 15 contributors for this article] (2021). A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity. Journal of Immunology. ISSN 0022-1767. 207(6), p. 1641–1651. doi: 10.4049/jimmunol.2001471. Full text in Research Archive
  • Rognes, Ingrid Nygren; Pischke, Søren Erik; Ottestad, William; Røislien, Jo; Berg, Jens Petter & Johnson, Christina [Show all 8 contributors for this article] (2021). Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study. Molecular medicine (Cambridge, Mass. Print). ISSN 1076-1551. 27, p. 1–13. doi: 10.1186/s10020-021-00286-3. Full text in Research Archive
  • Pischke, Soeren; Hødnebø, Stina; Wester, Torjus; Haugaa, Håkon; Kvernebo, Knut & Barratt-Due, Andreas [Show all 7 contributors for this article] (2020). Intraperitoneal microdialysis detects intestinal leakage earlier than hemodynamic surveillance and systemic inflammation in a pig model. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(2), p. 219–227. doi: 10.1080/00365521.2020.1863459. Full text in Research Archive
  • Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne & Holten, Aleksander Rygh [Show all 32 contributors for this article] (2020). Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients . Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(40), p. 25018–25025. doi: 10.1073/pnas.2010540117. Full text in Research Archive
  • Ueland, Thor; Heggelund, Lars; Lind, Andreas; Holten, Aleksander Rygh; Tonby, Kristian & Michelsen, Annika [Show all 26 contributors for this article] (2020). Elevated plasma sTIM-3 levels in patients with severe COVID-19. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 147(1), p. 92–98. doi: 10.1016/j.jaci.2020.09.007. Full text in Research Archive
  • Lipcsey, Miklos; Tenhunen, Jyrki; Pischke, Soeren; Kuitunen, Anne; Flaatten, Hans & De Geer, Lina [Show all 15 contributors for this article] (2020). Endotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Study. Shock. ISSN 1073-2322. 54(2), p. 224–231. doi: 10.1097/SHK.0000000000001503. Full text in Research Archive
  • Chaban, Viktoriia; Clarke, Gerard; Skandsen, Toril; Islam, Rakibul; Einarsen, Cathrine Elisabeth & Vik, Anne [Show all 10 contributors for this article] (2020). Systemic inflammation persists the first year after mild traumatic brain injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study. Journal of Neurotrauma. ISSN 0897-7151. 37(19), p. 2120–2130. doi: 10.1089/neu.2019.6963. Full text in Research Archive
  • Nieuwenhuijs-Moeke, Gertrude J.; Pischke, Soeren E.; Berger, Stefan; Sanders, Jan Stephan F; Pol, Robert A & Struys, Michel M. R. F. [Show all 8 contributors for this article] (2020). Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. Journal of Clinical Medicine. ISSN 2077-0383. 9:253(1), p. 1–33. doi: 10.3390/jcm9010253.
  • Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian & Pischke, Soeren [Show all 22 contributors for this article] (2020). Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19. Scientific Reports. ISSN 2045-2322. 10. doi: 10.1038/s41598-020-78710-7. Full text in Research Archive
  • Thorgersen, Ebbe Billmann; Barratt-Due, Andreas; Haugaa, Håkon; Harboe, Morten; Pischke, Søren & Nilsson, Per [Show all 7 contributors for this article] (2019). The role of complement in liver injury, regeneration, and transplantation. Hepatology. ISSN 0270-9139. 70(2), p. 725–736. doi: 10.1002/hep.30508. Full text in Research Archive
  • Ottestad, William Arne; Rognes, Ingrid Nygren; Pischke, Søren; Mollnes, Tom Eirik; Andersson, Ulf & Eken, Torsten (2019). Biphasic release of the alarmin high mobility group box 1 protein early after trauma predicts poor clinical outcome. Critical Care Medicine. ISSN 0090-3493. 47(8), p. e614–e622. doi: 10.1097/CCM.0000000000003800. Full text in Research Archive
  • Pischke, Søren; Hestenes, Siv Merete; Johansen, Harald Thidemann; Fure, Hilde; Bugge, Jan F & Espinoza, Andreas Westenvik [Show all 12 contributors for this article] (2019). Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model. PLOS ONE. ISSN 1932-6203. 14:e0218624(6). doi: 10.1371/journal.pone.0218624. Full text in Research Archive
  • Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne & Ekholt, Karin [Show all 18 contributors for this article] (2018). IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Frontiers in Immunology. ISSN 1664-3224. 9. doi: 10.3389/fimmu.2018.02035. Full text in Research Archive
  • Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter & Seljeflot, Ingebjørg [Show all 12 contributors for this article] (2018). Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock. ESC Heart Failure. ISSN 2055-5822. 5(3), p. 292–301. doi: 10.1002/ehf2.12266. Full text in Research Archive
  • Yang, Runkuan; Zhu, Shengtao; Pischke, Søren Erik; Haugaa, Håkon; Zou, Xiaoping & Tønnessen, Tor Inge (2018). Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice. Journal of Surgical Research. ISSN 0022-4804. 228, p. 14–19. doi: 10.1016/j.jss.2018.02.049.
  • Hellerud, Bernt C; Orrem, Hilde Lang; Dybwik, Knut Gustav; Pischke, Søren Erik; Barratt-Due, Andreas & Castellheim, Albert [Show all 15 contributors for this article] (2017). Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis. Journal of Intensive Care. ISSN 2052-0492. 5:21, p. 1–9. doi: 10.1186/s40560-017-0217-0. Full text in Research Archive
  • Barratt-Due, Andreas; Pischke, Søren Erik; Nilsson, Per; Espevik, Terje & Mollnes, Tom Eirik (2017). Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets. Journal of Leukocyte Biology. ISSN 0741-5400. 101(1), p. 193–204. doi: 10.1189/jlb.3VMR0316-132R. Full text in Research Archive
  • Pischke, Søren Erik; Gustavsen, Alice; Orrem, Hilde Lang; Egge, Kjetil Hagene; Courivaud, Fredric A A & Fontenelle, Hugues [Show all 15 contributors for this article] (2017). Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function. Basic Research in Cardiology. ISSN 0300-8428. 112:20(3). doi: 10.1007/s00395-017-0610-9. Full text in Research Archive
  • Gustavsen, Alice; Nymo, Stig Haugset; Landsem, Anne; Christiansen, Dorte; Ryan, Liv & Husebye, Harald [Show all 11 contributors for this article] (2016). Combined inhibition of complement and CD14 attenuates bacteria-induced inflammation in human whole blood more efficiently than antagonizing the toll-like receptor 4-MD2 complex. Journal of Infectious Diseases. ISSN 0022-1899. 214(1), p. 140–150. doi: 10.1093/infdis/jiw100. Full text in Research Archive
  • Khan, Faraz Hameed; Pharo, Anne Margrethe; Lindstad, Julie Katrine; Mollnes, Tom Eirik; Tønnessen, Tor Inge & Pischke, Søren Erik (2015). Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis. Scandinavian Journal of Immunology. ISSN 0300-9475. 82(5), p. 467–475. doi: 10.1111/sji.12332.
  • Pischke, Søren Erik; Hyler, Stefan; Tronstad, Christian; Bergsland, Jacob; Fosse, Erik & Halvorsen, Per Steinar [Show all 8 contributors for this article] (2015). Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time. British Journal of Anaesthesia. ISSN 0007-0912. 114(3), p. 414–422. doi: 10.1093/bja/aeu381.
  • Fretland, Åsmund Avdem; Sokolov, Andrey; Postriganova, Nadezda; Kazaryan, Airazat M.; Pischke, Søren Erik & Nilsson, Per [Show all 11 contributors for this article] (2015). Inflammatory response after laparoscopic versus open resection of colorectal liver metastases: Data from the oslo-comet trial. Medicine. ISSN 0025-7974. 94:e1786(42). doi: 10.1097/MD.0000000000001786. Full text in Research Archive
  • Hyler, Stefan; Pischke, Søren Erik; Halvorsen, Per Steinar; Espinoza, Andreas Westenvik; Bergsland, Jacob & Tønnessen, Tor Inge [Show all 8 contributors for this article] (2015). Continuous monitoring of regional function by a miniaturized ultrasound transducer allows early quantification of low-grade myocardial ischemia. Journal of the American Society of Echocardiography. ISSN 0894-7317. 28(4), p. 486–494. doi: 10.1016/j.echo.2014.12.014.
  • Egge, Kjetil Hagene; Thorgersen, Ebbe Billmann; Pischke, Søren Erik; Lindstad, Julie Katrine; Pharo, Anne Margrethe & Bongoni, Anjan K. [Show all 10 contributors for this article] (2015). Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14. Immunobiology. ISSN 0171-2985. 220(8), p. 999–1005. doi: 10.1016/j.imbio.2015.04.002.
  • Huber-Lang, Markus; Barratt-Due, Andreas; Pischke, Søren Erik; Sandanger, Øystein; Nilsson, Per & Nunn, Miles A. [Show all 10 contributors for this article] (2014). Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice. Journal of Immunology. ISSN 0022-1767. 192(11), p. 5324–5331. doi: 10.4049/jimmunol.1400341.
  • Barratt-Due, Andreas; Thorgersen, Ebbe Billmann; Egge, Kjetil Hagene; Pischke, Søren Erik; Sokolov, Andrey & Hellerud, Bernt C [Show all 13 contributors for this article] (2013). Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis. Journal of Immunology. ISSN 0022-1767. 191(2), p. 819–827. doi: 10.4049/jimmunol.1201909.
  • Barratt-Due, Andreas; Sokolov, Andrey; Gustavsen, Alice; Hellerud, Bernt C; Egge, Kjetil Hagene & Pischke, Søren Erik [Show all 11 contributors for this article] (2013). Polyvalent immunoglobulin significantly attenuated the formation of IL-1 beta in Escherichia coli-induced sepsis in pigs. Immunobiology. ISSN 0171-2985. 218(5), p. 683–689. doi: 10.1016/j.imbio.2012.08.268.
  • Thorgersen, Ebbe Billmann; Pischke, Søren Erik; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine & Pharo, Anne Margrethe [Show all 8 contributors for this article] (2013). Systemic CD14 inhibition attenuates organ inflammation in porcine escherichia coli sepsis. Infection and Immunity. ISSN 0019-9567. 81(9), p. 3173–3181. doi: 10.1128/IAI.00390-13.
  • Haugaa, Håkon; Almaas, Runar; Thorgersen, Ebbe Billmann; Foss, Aksel; Line, Pål Dag & Sanengen, Truls [Show all 13 contributors for this article] (2013). Clinical experience with microdialysis catheters in pediatric liver transplants. Liver transplantation. ISSN 1527-6465. 19(3), p. 305–314. doi: 10.1002/lt.23578.
  • Barratt-Due, Andreas; Pischke, Søren Erik; Brekke, Ole Lars; Thorgersen, Ebbe Billmann; Nielsen, Erik Waage & Espevik, Terje [Show all 8 contributors for this article] (2012). Bride and groom in systemic inflammation - The bells ring for complement and Toll in cooperation. Immunobiology. ISSN 0171-2985. 217(11), p. 1047–1056. doi: 10.1016/j.imbio.2012.07.019.
  • Haugaa, Håkon; Thorgersen, Ebbe Billmann; Pharo, Anne Margrethe; Boberg, Kirsten Muri; Foss, Aksel & Line, Pål Dag [Show all 12 contributors for this article] (2012). Early bedside detection of ischemia and rejection in liver transplants by microdialysis. Liver transplantation. ISSN 1527-6465. 18(7), p. 839–849. doi: 10.1002/lt.23425.
  • Pischke, Søren Erik; Tronstad, Christian; Holhjem, Lars; Halvorsen, Per Steinar & Tønnessen, Tor Inge (2012). Perioperative detection of myocardial ischaemia/reperfusion with a novel tissue CO2 monitoring technology. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 42(1), p. 157–163. doi: 10.1093/ejcts/ezr278.
  • Haugaa, Håkon; Thorgersen, Ebbe Billmann; Pharo, Anne Margrethe; Boberg, Kirsten Muri; Foss, Aksel & Line, Pål Dag [Show all 13 contributors for this article] (2012). Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts. Liver transplantation. ISSN 1527-6465. 18(12), p. 1421–1429. doi: 10.1002/lt.23503.
  • Pischke, Søren Erik; Tronstad, Christian; Holhjem, Lars; Line, Pål Dag; Haugaa, Håkon & Tønnessen, Tor Inge (2012). Hepatic and Abdominal Carbon Dioxide Measurements Detect and Distinguish Hepatic Artery Occlusion and Portal Vein Occlusion in Pigs. Liver transplantation. ISSN 1527-6465. 18(12), p. 1485–1494. doi: 10.1002/lt.23544.
  • Tronstad, Christian; Pischke, Søren Erik; Holhjem, L; Tønnessen, Tor Inge; Martinsen, Ørjan Grøttem & Grimnes, Sverre (2010). Early detection of cardiac ischemia using a conductometric pCO(2) sensor: real-time drift correction and parameterization. Physiological Measurement. ISSN 0967-3334. 31(9), p. 1241–1255. doi: 10.1088/0967-3334/31/9/013.

View all works in Cristin

  • Laake, Jon Henrik; Aasmundstad, Tor Aksel; Kåsine, Trine; Pischke, Soeren & Barratt-Due, Andreas (2020). Covid-19: Evidens-, eminens-, eller erfaringsbasert behandling? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(12), p. 1–2. doi: 10.4045/tidsskr.20.0649.
  • Sokolova, Marina; Ekholt, Karin; Mollnes, Tom Eirik & Pischke, Søren (2019). HYPOXIA FOLLOWED BY WHOLE BLOOD REOXYGENATIONINDUCED ENDOTHELIAL CELL ACTIVATION IN A COMPLEMENTC5 AND TOLL-LIKE RECEPTOR CD14 DEPENDENT MANNER.
  • Pischke, Søren Erik; Haugaa, Håkon & Haney, Michael (2017). A neglected organ in multiple organ failure - 'skin in the game'? Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 61(1), p. 5–7. doi: 10.1111/aas.12823.
  • Mollnes, Tom Eirik; Barratt-Due, Andreas; Pischke, Søren Erik; Sandanger, Inger; Nilsson, Per & Lambris, J [Show all 10 contributors for this article] (2013). Double-blockade of CD14 and complement component C5 abolish the inflammatory storm and improve survival in mouse polymicrobial sepsis. Molecular Immunology. ISSN 0161-5890. 56(3), p. 294–294. doi: 10.1016/j.molimm.2013.05.153.
  • Thorgersen, Ebbe Billmann; Pischke, Søren Erik; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine & Pharo, Anne Margrethe [Show all 8 contributors for this article] (2012). Systemic CD14-inhibition attenuates local inflammatory responses organ-dependently in porcine Escherichia coli-sepsis. Immunobiology. ISSN 0171-2985. 217(11), p. 1206–1206. doi: 10.1016/j.imbio.2012.08.222.
  • Barratt-Duel, Andreas; Thorgersen, Ebbe Billmann; Egge, Kjetil Hagene; Pischke, Søren Erik; Sokolov, Andrey & Hellerud, Bernt C [Show all 11 contributors for this article] (2012). Combined inhibition of complement (C5) and CD14 markedly attenuates blood thrombogenicity, inflammation and hemodynamic changes in porcine sepsis. Immunobiology. ISSN 0171-2985. 217(11), p. 1152–1152. doi: 10.1016/j.imbio.2012.08.067.
  • Mollnes, Tom Eirik; Barratt-Due, Andreas; Pischke, Søren Erik; Sandanger, Øystein; Nunn, Miles A. & Espevik, Terje [Show all 8 contributors for this article] (2012). The systemic inflammatory reaction in polymicrobial sepsis induced by murine cecal ligation and puncture is equally dependent on C5 and CD14. Immunobiology. ISSN 0171-2985. 217(11), p. 1129–1129. doi: 10.1016/j.imbio.2012.08.002.
  • Hyler, Stefan; Pischke, Søren Erik; Halvorsen, Per Steinar; Espinoza, Andreas Westenvik; Hestenes, Siv Merete & Bergsland, Jacob [Show all 8 contributors for this article] (2010). Systolic and postsystolic velocities quantify low grade myocardial ischaemia by a miniaturized epicardial ultrasonic sensor. European Heart Journal. ISSN 0195-668X. 31, p. 45–45.

View all works in Cristin

Published Aug. 29, 2016 10:49 AM - Last modified July 15, 2019 5:37 PM

Research groups