Søren Erik Pischke

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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 4950 Nydalen 0424 OSLO

S. Pischke is a researcher at the Complement Research Group and senior consultant in critical care medicine at Department of Anaesthesiology, Oslo University Hospital, Rikshospitalet.

Overall research aim is (1) to describe innate immunity mechanisms in ischemia/reperfusion injury and (2) to attenuate the reperfusion injury both in vitro and in vivo with high potential for transfer to clinical studies.

Disease focus is on preventing detrimental effects of ischemia/reperfusion in transplantation (kidney and liver) and myocardial infarction. The group has developed unique models of hypoxia/reoxygenation of cultured endothelial cells in combination with a full blood model and the use of ex vivo machine perfusion to simulate reperfusion in porcine kidneys.

S. Pischke is a scholar of the "Young Research Talent" program of the Norwegian Research Council and holds a Department Research Grant. He is main supervisor of 2 PhD students and 1 PostDoc in addition to co-supervior of 3 PhD students.

Tags: innate immunity, complement system, C5, TLR, critical care, intensive care, anaesthesiology

Publications

  • Ottestad, William Arne; Rognes, Ingrid Nygren; Pischke, Søren; Mollnes, Tom Eirik; Andersson, Ulf & Eken, Torsten (2019). Biphasic release of the alarmin high mobility group box 1 protein early after trauma predicts poor clinical outcome. Critical Care Medicine.  ISSN 0090-3493.  47(8), s e614- e622 . doi: 10.1097/CCM.0000000000003800
  • Pischke, Søren; Hestenes, Siv Merete; Johansen, Harald Thidemann; Fure, Hilde; Bugge, Jan F; Espinoza, Andreas Westenvik; Skulstad, Helge; Edvardsen, Thor; Fosse, Erik; Mollnes, Tom Eirik; Halvorsen, Per Steinar & Nielsen, Erik Waage (2019). Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model. PLOS ONE.  ISSN 1932-6203.  14:e0218624(6) . doi: 10.1371/journal.pone.0218624 Full text in Research Archive.
  • Thorgersen, Ebbe Billmann; Barratt-Due, Andreas; Haugaa, Håkon; Harboe, Morten; Pischke, Søren; Nilsson, Per & Mollnes, Tom Eirik (2019). The role of complement in liver injury, regeneration, and transplantation.. Hepatology.  ISSN 0270-9139.  70(2), s 725- 736 . doi: 10.1002/hep.30508
  • Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter; Seljeflot, Ingebjørg; Husebye, Trygve Guttorm; Aukrust, Pål; Yndestad, Arne; Andersen, Geir Øystein; Barratt-Due, Andreas & Mollnes, Tom Eirik (2018). Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock. ESC Heart Failure.  ISSN 2055-5822.  5(3), s 292- 301 . doi: 10.1002/ehf2.12266 Full text in Research Archive.
  • Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas & Mollnes, Tom Eirik (2018). IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Frontiers in Immunology.  ISSN 1664-3224.  9 . doi: 10.3389/fimmu.2018.02035 Full text in Research Archive.
  • Yang, Runkuan; Zhu, Shengtao; Pischke, Søren Erik; Haugaa, Håkon; Zou, Xiaoping & Tønnessen, Tor Inge (2018). Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice. Journal of Surgical Research.  ISSN 0022-4804.  228, s 14- 19 . doi: 10.1016/j.jss.2018.02.049
  • Barratt-Due, Andreas; Pischke, Søren Erik; Nilsson, Per; Espevik, Terje & Mollnes, Tom Eirik (2017). Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.. Journal of Leukocyte Biology.  ISSN 0741-5400.  101(1), s 193- 204 . doi: 10.1189/jlb.3VMR0316-132R Full text in Research Archive.
  • Hellerud, Bernt C; Orrem, Hilde Lang; Dybwik, Knut Gustav; Pischke, Søren Erik; Barratt-Due, Andreas; Castellheim, Albert; Fure, Hilde; Bergseth, Grete; Christiansen, Dorte; Nunn, Miles A.; Espevik, Terje; Lau, Corinna; Brandtzæg, Petter; Nielsen, Erik Waage & Mollnes, Tom Eirik (2017). Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis. Journal of Intensive Care.  ISSN 2052-0492.  5:21, s 1- 9 . doi: 10.1186/s40560-017-0217-0 Full text in Research Archive.
  • Pischke, Søren Erik; Gustavsen, Alice; Orrem, Hilde Lang; Egge, Kjetil Hagene; Courivaud, Fredric A A; Fontenelle, Hugues; Despont, Alain; Bongoni, Anjan K.; Rieben, Robert; Tønnessen, Tor Inge; Nunn, Miles A.; Scott, Helge; Skulstad, Helge; Barratt-Due, Andreas & Mollnes, Tom Eirik (2017). Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function. Basic Research in Cardiology.  ISSN 0300-8428.  112:20(3) . doi: 10.1007/s00395-017-0610-9 Full text in Research Archive.
  • Gustavsen, Alice; Nymo, Stig Haugset; Landsem, Anne; Christiansen, Dorte; Ryan, Liv; Husebye, Harald; Lau, Corinna; Pischke, Søren Erik; Lambris, John D.; Espevik, Terje & Mollnes, Tom Eirik (2016). Combined inhibition of complement and CD14 attenuates bacteria-induced inflammation in human whole blood more efficiently than antagonizing the toll-like receptor 4-MD2 complex. Journal of Infectious Diseases.  ISSN 0022-1899.  214(1), s 140- 150 . doi: 10.1093/infdis/jiw100 Full text in Research Archive. Show summary
  • Egge, Kjetil Hagene; Thorgersen, Ebbe Billmann; Pischke, Søren Erik; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Bongoni, Anjan K.; Rieben, Robert; Nunn, Miles A.; Barratt-Due, Andreas & Mollnes, Tom Eirik (2015). Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14. Immunobiology.  ISSN 0171-2985.  220(8), s 999- 1005 . doi: 10.1016/j.imbio.2015.04.002
  • Fretland, Åsmund Avdem; Sokolov, Andrey; Postriganova, Nadezda; Kazaryan, Airazat M.; Pischke, Søren Erik; Nilsson, Per; Rognes, Ingrid Nygren; Bjørnbeth, Bjørn Atle; Fagerland, Morten; Mollnes, Tom Eirik & Edwin, Bjørn (2015). Inflammatory response after laparoscopic versus open resection of colorectal liver metastases: Data from the oslo-comet trial. Medicine (Baltimore, Md.).  ISSN 0025-7974.  94:e1786(42) . doi: 10.1097/MD.0000000000001786 Full text in Research Archive.
  • Hyler, Stefan; Pischke, Søren Erik; Halvorsen, Per Steinar; Espinoza, Andreas Westenvik; Bergsland, Jacob; Tønnessen, Tor Inge; Fosse, Erik & Skulstad, Helge (2015). Continuous monitoring of regional function by a miniaturized ultrasound transducer allows early quantification of low-grade myocardial ischemia. Journal of the American Society of Echocardiography.  ISSN 0894-7317.  28(4), s 486- 494 . doi: 10.1016/j.echo.2014.12.014
  • Khan, Faraz Hameed; Pharo, Anne Margrethe; Lindstad, Julie Katrine; Mollnes, Tom Eirik; Tønnessen, Tor Inge & Pischke, Søren Erik (2015). Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis. Scandinavian Journal of Immunology.  ISSN 0300-9475.  82(5), s 467- 475 . doi: 10.1111/sji.12332
  • Pischke, Søren Erik; Hyler, Stefan; Tronstad, Christian; Bergsland, Jacob; Fosse, Erik; Halvorsen, Per Steinar; Skulstad, Helge & Tønnessen, Tor Inge (2015). Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time. British Journal of Anaesthesia.  ISSN 0007-0912.  114(3), s 414- 422 . doi: 10.1093/bja/aeu381
  • Huber-Lang, Markus; Barratt-Due, Andreas; Pischke, Søren Erik; Sandanger, Øystein; Nilsson, Per; Nunn, Miles A.; Denk, Stephanie; Gaus, Wilhelm; Espevik, Terje & Mollnes, Tom Eirik (2014). Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice. Journal of Immunology.  ISSN 0022-1767.  192(11), s 5324- 5331 . doi: 10.4049/jimmunol.1400341 Show summary
  • Barratt-Due, Andreas; Sokolov, Andrey; Gustavsen, Alice; Hellerud, Bernt C; Egge, Kjetil Hagene; Pischke, Søren Erik; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Castellheim, Albert; Thorgersen, Ebbe Billmann & Mollnes, Tom Eirik (2013). Polyvalent immunoglobulin significantly attenuated the formation of IL-1 beta in Escherichia coli-induced sepsis in pigs. Immunobiology.  ISSN 0171-2985.  218(5), s 683- 689 . doi: 10.1016/j.imbio.2012.08.268
  • Barratt-Due, Andreas; Thorgersen, Ebbe Billmann; Egge, Kjetil Hagene; Pischke, Søren Erik; Sokolov, Andrey; Hellerud, Bernt C; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Bongoni, Anjan K.; Rieben, Robert; Nunn, Miles; Scott, Helge & Mollnes, Tom Eirik (2013). Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis. Journal of Immunology.  ISSN 0022-1767.  191(2), s 819- 827 . doi: 10.4049/jimmunol.1201909
  • Haugaa, Håkon; Almaas, Runar; Thorgersen, Ebbe Billmann; Foss, Aksel; Line, Pål Dag; Sanengen, Truls; Bergmann, Gisli Bjørn; Olin, Per Bertil Mårten; Wælgaard, Lars Torbjørn; Grindheim, Guro; Pischke, Søren Erik; Mollnes, Tom Eirik & Tønnessen, Tor Inge (2013). Clinical experience with microdialysis catheters in pediatric liver transplants. Liver transplantation.  ISSN 1527-6465.  19(3), s 305- 314 . doi: 10.1002/lt.23578
  • Thorgersen, Ebbe Billmann; Pischke, Søren Erik; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Hellerud, Bernt C & Mollnes, Tom Eirik (2013). Systemic CD14 inhibition attenuates organ inflammation in porcine escherichia coli sepsis. Infection and Immunity.  ISSN 0019-9567.  81(9), s 3173- 3181 . doi: 10.1128/IAI.00390-13
  • Barratt-Due, Andreas; Pischke, Søren Erik; Brekke, Ole Lars; Thorgersen, Ebbe Billmann; Nielsen, Erik Waage; Espevik, Terje; Huber-Lang, Markus & Mollnes, Tom Eirik (2012). Bride and groom in systemic inflammation - The bells ring for complement and Toll in cooperation. Immunobiology.  ISSN 0171-2985.  217(11), s 1047- 1056 . doi: 10.1016/j.imbio.2012.07.019
  • Haugaa, Håkon; Thorgersen, Ebbe Billmann; Pharo, Anne Margrethe; Boberg, Kirsten Muri; Foss, Aksel; Line, Pål Dag; Sanengen, Truls; Almaas, Runar; Grindheim, Guro; Wælgaard, Lars Torbjørn; Pischke, Søren Erik; Mollnes, Tom Eirik & Tønnessen, Tor Inge (2012). Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts. Liver transplantation.  ISSN 1527-6465.  18(12), s 1421- 1429 . doi: 10.1002/lt.23503
  • Haugaa, Håkon; Thorgersen, Ebbe Billmann; Pharo, Anne Margrethe; Boberg, Kirsten Muri; Foss, Aksel; Line, Pål Dag; Sanengen, Truls; Almaas, Runar; Grindheim, Guro; Pischke, Søren Erik; Mollnes, Tom Eirik & Tønnessen, Tor Inge (2012). Early bedside detection of ischemia and rejection in liver transplants by microdialysis. Liver transplantation.  ISSN 1527-6465.  18(7), s 839- 849 . doi: 10.1002/lt.23425
  • Pischke, Søren Erik; Tronstad, Christian; Holhjem, Lars; Halvorsen, Per Steinar & Tønnessen, Tor Inge (2012). Perioperative detection of myocardial ischaemia/reperfusion with a novel tissue CO2 monitoring technology. European Journal of Cardio-Thoracic Surgery.  ISSN 1010-7940.  42(1), s 157- 163 . doi: 10.1093/ejcts/ezr278
  • Pischke, Søren Erik; Tronstad, Christian; Holhjem, Lars; Line, Pål Dag; Haugaa, Håkon & Tønnessen, Tor Inge (2012). Hepatic and Abdominal Carbon Dioxide Measurements Detect and Distinguish Hepatic Artery Occlusion and Portal Vein Occlusion in Pigs. Liver transplantation.  ISSN 1527-6465.  18(12), s 1485- 1494 . doi: 10.1002/lt.23544
  • Tronstad, Christian; Pischke, Søren Erik; Holhjem, L; Tønnessen, Tor Inge; Martinsen, Ørjan Grøttem & Grimnes, Sverre (2010). Early detection of cardiac ischemia using a conductometric pCO(2) sensor: real-time drift correction and parameterization. Physiological Measurement.  ISSN 0967-3334.  31(9), s 1241- 1255 . doi: 10.1088/0967-3334/31/9/013

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  • Sokolova, Marina; Ekholt, Karin; Mollnes, Tom Eirik & Pischke, Søren (2019). HYPOXIA FOLLOWED BY WHOLE BLOOD REOXYGENATIONINDUCED ENDOTHELIAL CELL ACTIVATION IN A COMPLEMENTC5 AND TOLL-LIKE RECEPTOR CD14 DEPENDENT MANNER.
  • Pischke, Søren Erik; Haugaa, Håkon & Haney, Michael (2017). A neglected organ in multiple organ failure - 'skin in the game'?. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  61(1), s 5- 7 . doi: 10.1111/aas.12823
  • Mollnes, Tom Eirik; Barratt-Due, Andreas; Pischke, Søren Erik; Sandanger, Inger; Nilsson, Per; Lambris, J; Nunn, Miles A.; Denk, Stephanie; Espevik, Terje & Huber-Lang, Markus (2013). Double-blockade of CD14 and complement component C5 abolish the inflammatory storm and improve survival in mouse polymicrobial sepsis. Molecular Immunology.  ISSN 0161-5890.  56(3), s 294- 294 . doi: 10.1016/j.molimm.2013.05.153
  • Barratt-Duel, Andreas; Thorgersen, Ebbe Billmann; Egge, Kjetil Hagene; Pischke, Søren Erik; Sokolov, Andrey; Hellerud, Bernt C; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Nunn, Miles A.; Scott, Helge & Mollnes, Tom Eirik (2012). Combined inhibition of complement (C5) and CD14 markedly attenuates blood thrombogenicity, inflammation and hemodynamic changes in porcine sepsis. Immunobiology.  ISSN 0171-2985.  217(11), s 1152- 1152 . doi: 10.1016/j.imbio.2012.08.067
  • Mollnes, Tom Eirik; Barratt-Due, Andreas; Pischke, Søren Erik; Sandanger, Øystein; Nunn, Miles A.; Espevik, Terje; Denk, Stephanie & Huber-Lang, Markus (2012). The systemic inflammatory reaction in polymicrobial sepsis induced by murine cecal ligation and puncture is equally dependent on C5 and CD14. Immunobiology.  ISSN 0171-2985.  217(11), s 1129- 1129 . doi: 10.1016/j.imbio.2012.08.002
  • Thorgersen, Ebbe Billmann; Pischke, Søren Erik; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Hellerud, Bernt C & Mollnes, Tom Eirik (2012). Systemic CD14-inhibition attenuates local inflammatory responses organ-dependently in porcine Escherichia coli-sepsis. Immunobiology.  ISSN 0171-2985.  217(11), s 1206- 1206 . doi: 10.1016/j.imbio.2012.08.222
  • Hyler, Stefan; Pischke, Søren Erik; Halvorsen, Per Steinar; Espinoza, Andreas Westenvik; Hestenes, Siv Merete; Bergsland, Jacob; Fosse, Erik & Skulstad, Helge (2010). Systolic and postsystolic velocities quantify low grade myocardial ischaemia by a miniaturized epicardial ultrasonic sensor. European Heart Journal.  ISSN 0195-668X.  31, s 45- 45

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Published Aug. 29, 2016 10:49 AM - Last modified July 15, 2019 5:37 PM

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