Thomas Bøhmer

• Bøhmer, Thomas; Bachtyari, Zivar; Sommer, Christine & Hammerstad, Sara Salehi (2020). Auto regulatory capacity of the thyroid gland after numerous iodinated contrast media investigations. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 80(3), p. 191–195. doi: 10.1080/00365513.2019.1709658. Full text in Research Archive
• Schrader, Harald; Bøhmer, Thomas & Aasly, Jan (2019). The incidence of diagnosis of Munchausen syndrome, other factitious disorders, and malingering. Behavioural Neurology. ISSN 0953-4180. 2019, p. 1–7. doi: 10.1155/2019/3891809. Full text in Research Archive Show summary

  Background. Systematic studies on factitious disorders and malingering in large populations are rare. To address this issue, we performed a nationwide epidemiological study in Norway on the incidence of these diagnoses in an unselected patient population. In particular, we tried to confirm the diagnoses and to estimate the contribution of Munchausen syndrome to the spectrum of factitious disorders. Methods. We analyzed data obtained from the Norwegian Patient Registry (NPR), which provided a deidentified list of all patients from 2008 to 2016 who had received the ICD-10 diagnosis of F68.1 or the diagnosis code Z76.5. Results. Altogether, 237 patients (99 females; 138 males) received a diagnosis of F68.1. Code Z76.5 was applied to 52 patients (12 females; 40 males), all diagnosed within health institutions. Three of 1700 specialists (somatic specialist, psychologist, or psychiatrist) in private practice had diagnosed a factitious disorder in altogether 87 patients. After contacting these specialists, we could identify no true case of F68.1. For 24 of 146 patients who were equally distributed by gender within health institutions, we managed to identify the diagnosing healthcare providers. Of these 24 patients, only 11 correctly qualified for code F68.1. Only two female patients qualified for a Munchausen syndrome diagnosis. Conclusions. There is a male predominance for the diagnosis of malingering. An earlier suspicion of a female predominance for Munchausen syndrome is upheld. There is significant underdiagnosing and misdiagnosing for both conditions and for factitious disorders in general. To separate the most serious form of factitious disorders from milder forms and to facilitate more systematic research, we recommend a specific ICD diagnosis for Munchausen syndrome.

• Jensen, Helge Leander B.; Lillenes, Meryl Sønderby; Rabano, Alberto; Günther, Clara-Cecilie; Riaz, Tahira & Kalayou, Shewit [Show all 9 contributors for this article] (2018). Expression of nucleotide excision repair in Alzheimer's disease is higher in brain tissue than in blood. Neuroscience Letters. ISSN 0304-3940. 672, p. 53–58. doi: 10.1016/j.neulet.2018.02.043. Full text in Research Archive Show summary

  Age-related changes are increased in patients with Alzheimer's disease (AD), including oxidative stress and DNA damage. We propose that genotoxic stress and DNA repair responses influence neurodegeneration in the pathogenesis of AD. Here, we focus on nucleotide excision repair (NER). Real-time qPCR and mass spectrometry were employed to determine the expression levels of selected NER components. The mRNA levels of the genes encoding the NER proteins RAD23B, RPA1, ERCC1, PCNA and LIG3 as well as the NER-interacting base excision repair protein MPG in blood and brain tissue from four brain regions in patients with AD or mild cognitive impairment and healthy controls (HC), were assessed. NER mRNA levels were significantly higher in brain tissue than in blood. Further, LIG3 mRNA levels in the frontal cortex was higher in AD versus HC, while mRNA levels of MPG and LIG3 in entorhinal cortex and RPA1 in the cerebellum were lower in AD versus HC. In blood, RPA1 and ERCC1 mRNA levels were lower in AD patients than in HC. Alterations in gene expression of NER components between brain regions were associated with AD, connecting DNA repair to AD pathogenesis and suggesting a distinct role for NER in the brain.

• Torbergsen, Anne Cathrine; Watne, Leiv Otto; Wyller, Torgeir Bruun; Frihagen, Frede Jon; Strømsøe, Knut & Bøhmer, Thomas [Show all 7 contributors for this article] (2017). Micronutrients and the risk of hip fracture: Case–control study. Clinical Nutrition. ISSN 0261-5614. 36(2), p. 438–443. doi: 10.1016/j.clnu.2015.12.014. Full text in Research Archive Show summary

  Background: Vitamin D, and possibly vitamin K, has an established association to fracture risk. Other vitamins are, however, less studied. Aim: To determine whether specific micronutrients other than 25(OH)D and vitamin K play a role in risk of hip fracture and bone turnover. Methods: In this caseecontrol study, blood was drawn for measurements of vitamins A, B6, B12, C, E, and folic acid as well as the bone turnover markers osteocalcin and bone-specific alkaline phosphatase upon admission for hip fracture in 116 patients and in 73 home-dwelling non fractured controls. Results for vitamin K1 and 25(OH)D from the same populations have been reported previously. Results: Low vitamin A, C, and E concentrations were independently associated with a risk of hip fracture. The adjusted odds ratio (95% confidence interval) per 10 mmol/L increase in vitamin A concentration was 0.74 (0.65e0.84); for 1 mmol/L vitamin C and E: 0.94 (0.92e0.97) and 0.81 (0.74e0.89) respectively. The results were principally unchanged when 25(OH)D, vitamin K1, Body Mass Index, and other potential confounders were adjusted for. All vitamins except B12 and folic acid correlated positively with total osteocalcin and negatively with bone-specific alkaline phosphatase. Conclusions: Low vitamin A, C, and E concentrations are associated with an increased risk of hip fracture, possibly mediated through bone turnover mechanisms. This caseecontrol study is registered at: ClinicalTrials.gov. NCT01738776. The patient related outcome is also registered at: ClinicalTrials.gov. NCT01009268.

• Ulstein, Ingun & Bøhmer, Thomas (2017). Normal vitamin levels and nutritional indices in Alzheimer's disease patients with mild cognitive impairment or dementia with normal body mass indexes. Journal of Alzheimer's Disease. ISSN 1387-2877. 55(2), p. 717–725. doi: 10.3233/JAD-160393. Full text in Research Archive
• Aaseth, Eirik; Fagerland, Morten; Aas, Anne-Marie; Hewitt, Stephen I; Risstad, Hanne & Kristinsson, Jon Adalsteinn [Show all 9 contributors for this article] (2015). Vitamin concentrations 5 years after gastric bypass. European Journal of Clinical Nutrition. ISSN 0954-3007. 69, p. 1249–1255. doi: 10.1038/ejcn.2015.82. Full text in Research Archive Show summary

  Background/Objectives: Few studies have investigated the effects of bariatric surgery on vitamin status in the long term. We examined changes in vitamin status up to 5 years after Roux-en-Y gastric bypass surgery. Subjects/Methods: Using a retrospectively maintained database of patients undergoing weight loss surgery, we identified all patients operated with Roux-en-Y gastric bypass at our tertiary care hospital during July 2004–May 2008. Data on vitamin concentrations and patient-reported intake of dietary supplements were collected up to July 2012. Linear mixed models were used to estimate changes in vitamin concentrations during follow-up, adjusting for age and sex. All patients were recommended daily oral multivitamin, calcium/vitamin D and iron supplements and 3-monthly intramuscular B-12 after surgery. Results: Out of the 443 patients operated with gastric bypass, we included 441 (99.5%) patients with one or more measurements of vitamin concentrations (75.1% women; mean age 41.5 years, mean body mass index 46.1 kg/m2 at baseline). At 5 years after surgery, the patients' estimated mean vitamin concentrations were either significantly higher (vitamin B-6, folic acid, vitamin B-12, vitamin C and vitamin A) or not significantly different (thiamine, 25-hydroxyvitamin D and lipid-adjusted vitamin E) compared with before surgery. Use of multivitamin, calcium/vitamin D and vitamin B-12 supplements was reported by 1–9% of patients before surgery, 79–84% of patients at 1 year and 52–83% of patients 5 years after surgery. Conclusions: In patients who underwent gastric bypass surgery, estimated vitamin concentrations were either significantly increased or unchanged up to 5 years after surgery.

• Risstad, Hilde; Søvik, Torgeir Thorson; Engström, My; AASHEIM, ERLEND T.; Fagerland, Morten & Olsén, Monika Fagervik [Show all 12 contributors for this article] (2015). Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: A randomized clinical trial. JAMA Surgery. ISSN 2168-6254. 150(4), p. 352–361. doi: 10.1001/jamasurg.2014.3579. Full text in Research Archive
• Torbergsen, Anne Cathrine; Watne, Leiv Otto; Wyller, Torgeir Bruun; Frihagen, Frede Jon; Strømsøe, Knut & Bøhmer, Thomas [Show all 7 contributors for this article] (2015). Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study. Clinical Nutrition. ISSN 0261-5614. 34(1), p. 101–106. doi: 10.1016/j.clnu.2014.01.016. Full text in Research Archive
• Sæland, Mone Eli; Wandel, Margareta; Bøhmer, Thomas & Haugen, Margaretha (2014). Abscess infections and malnutrition - a cross-sectional study of polydrug addicts in Oslo, Norway. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 74(4), p. 322–328. doi: 10.3109/00365513.2014.891256. Full text in Research Archive Show summary

  Injection drug use and malnutrition are widespread among polydrug addicts in Oslo, Norway, but little is known about the frequency of abscess infections and possible relations to malnutrition. Objectives. To assess the prevalence of abscess infections, and differences in nutritional status between drug addicts with or without abscess infections. Design. A cross-sectional study of 195 polydrug addicts encompassing interview of demographics, dietary recall, anthropometric measurements and biochemical analyses. All respondents were under the influence of illicit drugs and were not participating in any drug treatment or rehabilitation program at the time of investigation. Results. Abscess infections were reported by 25% of the respondents, 19% of the men and 33% of the women (p = 0.025). Underweight (BMI < 18.5 kg/m2) was significantly more prevalent in the abscess infected than in the non-abscess-infected group (p = 0.001). The abscess-infected addicts reported fewer meals, lower intakes of fruits and vegetables, lower energy percentage (E%) from protein and higher E% from sugar. They also had lower total intakes of vitamins D, B1, B6, B12, folic acid and vitamin C than the non-abscess-infected group. The two groups differed significantly with respect to S-C-peptide (p = 0.042) and B-HbA1c (p = 0.012), and the prevalence of hyperhomocysteinemia (P-tHCY > 15 μmol/L) was 73% in the abscess-infected group and 41% in the non-abscess-infected group (p = 0.001). The concentrations of S-25-hydroxy-vitamin D3 was very low. Conclusion. The prevalence of abscess infections was 25% among the examined polydrug addicts. Dietary, anthropometric and biochemical assessment indicated a relation between abscess infections and malnutrition.

• Bentsen, Håvard; Osnes, Kåre; Refsum, Helge; Solberg, Dag & Bøhmer, Thomas (2013). A randomized placebo-controlled trial of an omega-3 fatty acid and vitamins E+C in schizophrenia. Translational Psychiatry. 3. doi: 10.1038/tp.2013.110. Full text in Research Archive Show summary

  Membrane lipid metabolism and redox regulation may be disturbed in schizophrenia. We examined the clinical effect of adding an omega-3 fatty acid and/or vitamins E+C to antipsychotics. It was hypothesized that lower baseline levels of polyunsaturated fatty acids (PUFAs) would predict more benefit from the add-on treatment. The trial had a multicenter, randomized, double-blind, placebo-controlled 2 × 2 factorial design. Patients aged 18–39 years with schizophrenia or related psychoses were consecutively included at admission to psychiatric departments in Norway. They received active or placebo ethyl-eicosapentaenoate (EPA) 2 g day−1 and active or placebo vitamin E 364 mg day−1+vitamin C 1000 mg day−1 (vitamins) for 16 weeks. The main outcome measures were Positive and Negative Syndrome Scale (PANSS) total and subscales scores, analyzed by linear mixed models. Ninety-nine patients were included. At baseline, erythrocyte PUFA were measured in 97 subjects. Given separately, EPA and vitamins increased drop-out rates, whereas when combined they did not differ from placebo. In low PUFA patients, EPA alone impaired the course of total PANSS (Cohen’s d=0.29; P=0.03) and psychotic symptoms (d=0.40; P=0.003), especially persecutory delusions (d=0.48; P=0.0004). Vitamins alone impaired the course of psychotic symptoms (d= 0.37; P=0.005), especially persecutory delusions (d=0.47; P=0.0005). Adding vitamins to EPA neutralized the detrimental effect on psychosis (interaction d=0.31; P=0.02). In high PUFA patients, there were no significant effects of trial drugs on PANSS scales. In conclusion, given separately during an acute episode, EPA and vitamins E+C induce psychotic symptoms in patients with low levels of PUFA. Combined, these agents seem safe.

• Hewitt, Stephen; Søvik, Torgeir Thorson; AASHEIM, ERLEND T.; Kristinsson, Jon Adalsteinn; Jahnsen, Jørgen & Birketvedt, Grethe [Show all 9 contributors for this article] (2013). Secondary Hyperparathyroidism, Vitamin D Sufficiency, and Serum Calcium 5 Years After Gastric Bypass and Duodenal Switch. Obesity Surgery. ISSN 0960-8923. 23(3), p. 384–390. doi: 10.1007/s11695-012-0772-3. Full text in Research Archive
• Bentsen, Håvard; Solberg, Dag Kristen; Refsum, Helge & Bøhmer, Thomas (2012). Clinical and biochemical validation of two endophenotypes of schizophrenia defined by levels of polyunsaturated fatty acids in red blood cells. Prostaglandins, Leukotrienes and Essential Fatty Acids. ISSN 0952-3278. 87(1), p. 35–41. doi: 10.1016/j.plefa.2012.05.005. Full text in Research Archive
• AASHEIM, ERLEND T.; Johnson, Line Kristin; Hofsø, Dag; Bøhmer, Thomas & Hjelmesæth, Jøran (2012). Vitamin status after gastric bypass and lifestyle intervention: a comparative prospective study. Surgery for Obesity and Related Diseases. ISSN 1550-7289. 8(2), p. 169–175. doi: 10.1016/j.soard.2011.01.038. Full text in Research Archive
• Sæland, Mone; Haugen, Margaretha; Eriksen, Frank-Leo; Wandel, M; Smehaugen, Anne & Bøhmer, Thomas [Show all 7 contributors for this article] (2011). High sugar consumption and poor nutrient intake among drug addicts in Oslo, Norway. British Journal of Nutrition. ISSN 0007-1145. 105(4), p. 618–624. doi: 10.1017/S0007114510003971. Full text in Research Archive
• Bentsen, Håvard; Solberg, Dag Kristen; Refsum, Helge; Gran, Jon Michael; Bøhmer, Thomas & Torjesen, Peter A [Show all 8 contributors for this article] (2011). Bimodal Distribution of Polyunsaturated Fatty Acids in Schizophrenia Suggests Two Endophenotypes of the Disorder. Biological Psychiatry. ISSN 0006-3223. 70(1), p. 97–105. doi: 10.1016/j.biopsych.2011.02.011. Full text in Research Archive
• Aasheim, Erlend T; Elshorbagy, Amany K; Diep, Lien My; Søvik, Torgeir Thorson; Mala, Tom & Valdivia-Garcia, Maria [Show all 10 contributors for this article] (2011). Effect of bariatric surgery on sulphur amino acids and glutamate. British Journal of Nutrition. ISSN 0007-1145. 106(3), p. 432–440. doi: 10.1017/S0007114511000201. Full text in Research Archive Show summary

  Plasma total cysteine (tCys) concentrations are associated with BMI. To study the relationship between tCys and BMI, we monitored the changes in serum concentrations of tCys and metabolically related compounds in sixty obese patients (BMI 50–60 kg/m2) from before to 1 year after either gastric bypass surgery (mean 30 % weight loss) or duodenal switch surgery (mean 41 % weight loss). A total of fifty-eight healthy persons (BMI 17–31 kg/m2) served as controls. Before surgery, obese patients had modestly (approximately 17 %) higher mean serum tCys, and markedly (>2-fold) higher glutamate concentrations, than controls (P ≤ 0·001 for both). Serial examinations after surgery revealed that gastric bypass patients had no change in tCys concentrations (P = 0·22), while duodenal switch patients showed a modest (approximately 12 %) but significant decrease in tCys (P < 0·001). Total homocysteine concentrations increased in duodenal switch patients but not in gastric bypass patients. Independent of surgery type, serum concentrations of methionine and cystathionine decreased (P < 0·05 for both), while serum glutathione and taurine remained stable. Glutamate concentrations declined, as did γ-glutamyltransferase activity (P < 0·001 for both). These results show that despite 30 % weight loss, and decreases in methionine, cystathionine and glutamate, there was no significant change in serum tCys in patients after gastric bypass surgery. The decrease in tCys in patients undergoing duodenal switch could be related to malabsorption. The present findings do not suggest that BMI is a causal determinant of plasma tCys. © 2011 Cambridge University Press

• AASHEIM, ERLEND T.; Bjorkman, Sofia; Søvik, Torgeir Thorson; Engstrom, My; Hanvold, Susanna & Mala, Tom [Show all 8 contributors for this article] (2009). Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch. American Journal of Clinical Nutrition. ISSN 0002-9165. 90(1), p. 15–22. doi: 10.3945/ajcn.2009.27583. Full text in Research Archive
• Sæland, M; Haugen, Margaretha; Eriksen, FL; Smehaugen, Anne; Wandel, M & Bøhmer, Thomas [Show all 7 contributors for this article] (2009). Living as a drug addict in Oslo, Norway - a study focusing on nutrition and health. Public Health Nutrition (PHN). ISSN 1368-9800. 12(5), p. 630–636. doi: 10.1017/S1368980008002553. Full text in Research Archive
• Mowe, Morten; Diep, L. & Bøhmer, Thomas (2008). Greater seven-year survival in very aged patients with body mass index between 24 and 26 kg/m2. Journal of The American Geriatrics Society. ISSN 0002-8614. 56(2), p. 359–360. Full text in Research Archive
• Nygaard, Ingerid H; Valbø, Annlill; Pethick, SV & Bøhmer, Thomas (2008). Does oral magnesium relieve pregancy-induced leg cramps ? European Journal of Obstetrics, Gynecology, and Reproductive Biology. ISSN 0301-2115. 141(1), p. 23–26. Full text in Research Archive
• AASHEIM, ERLEND T.; Hofso, D; Hjelmesaeth, J; Birkeland, Kåre I. & Bøhmer, Thomas (2008). Vitamin status in morbidly obese patients: a cross-sectional study. American Journal of Clinical Nutrition. ISSN 0002-9165. 87(2), p. 362–369. Full text in Research Archive
• AASHEIM, ERLEND T.; Mala, Tom; Søvik, Torgeir Thorson; Kristinsson, Jon Adalsteinn & Bøhmer, Thomas (2007). Kirurgisk behandling av sykelig fedme. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 127, p. 38–42. Full text in Research Archive
• Glaso, M.; Nordbo, G.; Diep, L. & Bøhmer, Thomas (2004). Reduced Concentrations of Several Vitamins in Normal Weight Patients with Late-Onset Dementia of the Alzheimer Type without Vascular Disease. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 8(5), p. 407–13. Full text in Research Archive
• Bøhmer, Thomas (2004). Kosttilskudd eller ikke? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 124(21), p. 2798–9. Full text in Research Archive
• Bøhmer, Thomas (2002). Vitamin A. In Stakkestad, Jacob A. & Åsberg, Arne (Ed.), Brukerhåndbok i Klinisk Kjemi. Akademisk Forlag. ISSN 9788278680322. p. 582–83. Full text in Research Archive
• Bøhmer, Thomas (2002). Vitamin E. In Stakkestad, Jacob A. & Åsberg, Arne (Ed.), Brukerbok i Klinisk Kjemi. Akademisk Forlag. ISSN 9788278680322. p. 584–85. Full text in Research Archive
• Bøhmer, Thomas (2002). Karnitin. In Stakkestad, Jacob A. & Åsberg, Arne (Ed.), Brukerbok i Klinisk Kjemi. Akademisk Forlag. ISSN 9788278680322. p. 308–10. Full text in Research Archive
• Bøhmer, Thomas (2002). Tiamin. In Stakkestad, Jacob A. & Åsberg, Arne (Ed.), Brukerbok i Klinisk Kjemi. Akademisk Forlag. ISSN 9788278680322. p. 532–33. Full text in Research Archive
• Bøhmer, Thomas (2002). Askorbinsyre. In Stakkestad, Jacob A. & Åsberg, Arne (Ed.), Brukerbok i Klinisk Kjemi. Akademisk Forlag. ISSN 9788278680322. p. 125–26. Full text in Research Archive
• Lundgren, Bo; Mowé, Morten; Norseth, J & Bøhmer, Thomas (2002). Zinc deficiency is of limited clinical importance in the elderly (>69 y) of Oslo. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 6, p. 243–244. Full text in Research Archive
• Selvaag, Edgar; Bøhmer, Thomas & Benkestock, K. (2002). Reduced serum concentrations of riboflavine and ascorbic acid, and blood thiamine pyrophosphate and pyridoxal-5-phosphate in geriatric patients with and without pressure sores. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 6, p. 75–77. Full text in Research Archive
• Mowé, Morten & Bøhmer, Thomas (2002). Reduced appetite. A predictor for undernutrition in aged people. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 6, p. 81–83. Full text in Research Archive
• Bøhmer, Thomas (1997). Endocrinological disturbances in germ cell tumour patients. Comparison of hormone levels and kinetics in peripheral and testicular vein blood. Advances in Experimental Medicine and Biology. ISSN 0065-2598. 424, p. 75–76. Full text in Research Archive
• Bøhmer, Thomas & Yngve, T (1996). Midler med uklar terapeutisk berettigelse. Biologisk aktive substanser. In Vennerød, Anne Marie (Eds.), Norsk legemiddelhåndbok for helsepersonell. Full text in Research Archive
• Mowé, Morten; Bøhmer, Thomas & Haug, Egil (1996). Serum calcidiol and calcitriol concentrations in elderly people: variations with age, sex, season and disease. Clinical Nutrition. ISSN 0261-5614. 15, p. 201–206. Full text in Research Archive
• Mowé, Morten & Bøhmer, Thomas (1996). Increased levels of alcohol markers (_gGT, MCV, ASAT, ALAT) in elderly patients are not related to high alcohol intake. Journal of The American Geriatrics Society. ISSN 0002-8614. 44, p. 1136–1137. Full text in Research Archive
• Mowé, Morten & Bøhmer, Thomas (1996). Eating problems among home living elderly people may lead to disease and hospitalization. Nutrition reviews. ISSN 0029-6643. 52, p. 22–24. Full text in Research Archive
• Bøhmer, Thomas & Pedersen, Terje Rolf (1996). Avbrudd i legenes arbeid i sykehus. En trussel mot kvalitet? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 116, p. 1226–1228. Full text in Research Archive
• Bøhmer, Thomas (1996). Drug-induced carnitine deficiency. In Seim, H & Løster, H (Ed.), Carnitine Pathobiochemical basis and clinical applications. Verlag Ponte Press, Bochum. Full text in Research Archive
• Mowé, Morten; Bøhmer, Thomas & Haug, Egil (1996). Serum calcidiol and calcitriol concentrations in elderly people: variations with age, sex, season and disease. Clinical Nutrition. ISSN 0261-5614. 15, p. 201–201. Full text in Research Archive
• Diep, Quy N.; Bøhmer, Thomas & Skrede, Steinar (1995). Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. Biochimica et Biophysica Acta. ISSN 0006-3002. doi: 10.1016/0304-4165(94)00129-l. Full text in Research Archive

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• Tallaksen, Chantal M E.; Bøhmer, Thomas; Karlsen, Jan & Bell, Helge (1997). Determination of thiamin and its phosphate esters in human blood, plasma and urine. Academic Press, New York. -1 p. Full text in Research Archive

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• Bøhmer, Thomas (2023). Kokker på sykehus. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 143(9). doi: 10.4045/tidsskr.23.0187. Full text in Research Archive
• Aasly, Jan; Bøhmer, Thomas & Schrader, Harald (2017). Utfordringer ved Münchhausens syndrom. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 137(10), p. 696–697. doi: 10.4045/tidsskr.17.0268. Full text in Research Archive
• Schrader, Harald; Aasly, Jan & Bøhmer, Thomas (2017). H. Schrader og medarbeider svarer:. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 137(14/15), p. 976–977. doi: 10.4045/tidsskr.17.0581. Full text in Research Archive
• Jensen, Helge Leander B.; Lillenes, Meryl Sønderby; Günther, Clara-Cecilie; Rabano, Alberto; Ulstein, Ingun & Bøhmer, Thomas [Show all 7 contributors for this article] (2016). The DNA Nucleotide Excision Repair Profile in Blood and Brain Tissue from Patients with Alzheimer's Disease. Full text in Research Archive Show summary

  Alzheimer’s disease (AD) is a progressive, multifactorial neurodegenerative disorder that is the main cause of dementia globally. AD is clinically well characterized, however, little is known about the early etiology. Aging is the greatest risk factor for the development of dementia including AD, and age-related changes are augmented in patients with AD. Increased oxidative stress, resulting from imbalance in production and clearance of reactive oxygen species (ROS), can damage DNA and other macromolecules, leading to genome instability and disrupted cellular functions. Oxidative DNA damage is primarily repaired by the base excision repair (BER) pathway, however, the nucleotide excision repair (NER) pathway repairing helix distorting damages also seems to be involved. NER is known to be associated with neurodegenerative disorders like Cockayne syndrome and some subtypes of Xeroderma pigmentosum, and may play a role in the early stages of AD. To this end, we addressed the role of the NER pathway in the development of AD by comparing the expression of the DNA repair components RAD23B, RPA1, ERCC1, LIG3, PCNA and MPG in blood and post-mortem brain tissue from patients with AD, mild cognitive impairment (MCI) and healthy controls (HC). mRNA levels of the DNA repair components selected were significantly higher in the brain compared to blood. Notably, the expression of LIG3 (frontal cortex) and RPA1 (cerebellum) was higher in the AD brain than in healthy controls. This suggests an important role of NER in the brain relevant for the etiology of AD.

• AASHEIM, ERLEND T.; Birkeland, Kåre I. & Bøhmer, Thomas (2010). Erratum. American Journal of Clinical Nutrition. ISSN 0002-9165. 91(1), p. 239–240. Full text in Research Archive
• Bøhmer, Thomas; BØEN, ANNE & Høymork, Siv Cathrine (2010). Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. carnitine and glucose/thiamine. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 45(6), p. 762–763. doi: 10.3109/00365521003624169. Full text in Research Archive
• AASHEIM, ERLEND T.; Hove, Anne Birgitte & Bøhmer, Thomas (2009). Thiamine assay values: influence of anticoagulants and haemoglobin. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 69(4), p. 460–461. doi: 10.1080/00365510902783676. Full text in Research Archive
• AASHEIM, ERLEND T.; Bjorkman, Sofia; Søvik, Torgeir Thorson; Engstrom, My; Hanvold, Susanna & Mala, Tom [Show all 8 contributors for this article] (2009). Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch. Full text in Research Archive
• AASHEIM, ERLEND T. & Bøhmer, Thomas (2008). Low urinary magnesium excretion in morbidly obese women. Clinical Nutrition. ISSN 0261-5614. Full text in Research Archive
• AASHEIM, ERLEND T. & Bøhmer, Thomas (2008). Low preoperative vitamin levels in morbidly obese patients: a role of systemic inflammation? Surgery for Obesity and Related Diseases. ISSN 1550-7289. 4, p. 779–780. doi: 10.1016/j.soard.2008.09.002. Full text in Research Archive
• Aasheim, ET & Bøhmer, Thomas (2008). Low preoperative vitamin levels in morbidly obese patients: a role of systemic inflammation? Surgery for Obesity and Related Diseases. ISSN 1550-7289. 4(6), p. 779–780. doi: 10.1016/j.soard.2008.09.002. Full text in Research Archive
• Solemdal, Kirsten; Bøhmer, Thomas & Willumsen, Tiril (2006). Dental status in elderly patients with hip fracture. Full text in Research Archive
• Welle, Ida & Bøhmer, Thomas (2004). Vitamin C serum levels in adults living in Oslo: variation by gender, age and residence area. European Journal of Public Health. ISSN 1101-1262. 14(4), p. 104–5. Full text in Research Archive
• Bøhmer, Thomas; Diep, L. & Mowé, Morten (2004). Reduced ascorbic acid concentrations in the hospitalized and homeliving elderly. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 8, p. 451–2. Full text in Research Archive
• Glasø, M.; Nordbø, Gunhild; Diep, Lien & Bøhmer, Thomas (2003). Reduced concentrations of ascorbic acid, thiaminedisphosphate, retinol and a-tocopherol in patients with mild to moderate DAT without vascular disease. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 7(4), p. 205–205. Full text in Research Archive
• Bøhmer, Thomas; Mowé, Morten; Selvaag, Edgar & Glasø, M. (2003). Multidemensional approach to undernutrition is necessary for optimal diagnosis and adequate therapy. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 7(4), p. 201–201. Full text in Research Archive
• Berg, Jens Petter; Torjesen, Peter A.; Haug, Egil & Bøhmer, Thomas (2002). Kortisolresistens forårsaket av mutasjoner i glukokortikoidreseptor. Full text in Research Archive
• Bøhmer, Thomas (2002). Malnutrition in the elderly in an affluent society. Full text in Research Archive
• Bøhmer, Thomas (2002). Underernæring. Eutrophia. ISSN 0803-5946. 1. Full text in Research Archive
• Bøhmer, Thomas (1997). [Where does geriatric care go]? Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 117(11), p. 1646–1647. Full text in Research Archive
• Bøhmer, Thomas & Røseth, Arne G. (1997). Prolonged digitoxin half-time causing intoxication on low dose (0.05 mg/day) in the elderly with reduced S-albumin concentration. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 1(2). Full text in Research Archive
• Mowé, Morten; Bøhmer, Thomas & Haug, Egil (1997). Serum calcidiol concentrations in elderly people. Variation with age, sex, season and supplement. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 1(2). Full text in Research Archive
• AASHEIM, ERLEND T. & Bøhmer, Thomas (2010). Vitamin concentrations in Scandinavian obese subjects undergoing surgical and non-surgical weight loss. Universitetet i Oslo. ISSN 9788280725936. Full text in Research Archive

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