Victor Greiff

• Amoriello, Roberta; Greiff, Victor; Aldinucci, Alessandra; Bonechi, Elena; Carnasciali, Alberto; Peruzzi, Benedetta; Repice, Anna Maria; Mariottini, Alice; Saccardi, Riccardo; Mazzanti, Benedetta; Massacesi, Luca & Ballerini, Clara (2020). The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies. Frontiers in Immunology.  ISSN 1664-3224.  11:559, s 1- 19 . doi: 10.3389/fimmu.2020.00559
• Greiff, Victor; Yaari, Gur & Cowell, Lindsay G. (2020). Mining adaptive immune receptor repertoires for biological and clinical information using machine learning. Current Opinion in Systems Biology.  ISSN 2452-3100.  24, s 109- 119 . doi: 10.1016/j.coisb.2020.10.010
• Kräutler, Nike Julia; Yermanos, Alexander; Pedrioli, Alessandro; Welten, Suzanne P.M.; Lorgé, Dominique; Greczmiel, Ute; Bartsch, Ilka; Scheuermann, Jörg; Kiefer, Jonathan D.; Eyer, Klaus; Menzel, Ulrike; Greiff, Victor; Neri, Dario; Stadler, Tanja; Reddy, Sai T. & Oxenius, Annette (2020). Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection. Cell reports.  ISSN 2211-1247.  30(4), s 997- 1012 . doi: 10.1016/j.celrep.2019.12.088
• Li, Hai; Limenitakis, Julien P.; Greiff, Victor; Yilmaz, Bahtiyar; Schären, Olivier; Urbaniak, Camilla; Zünd, Mirjam; Lawson, Melissa A. E.; Young, Ian D.; Rupp, Sandra; Heikenwalder, Mathias; McCoy, Kathy D.; Hapfelmeier, Siegfried; Ganal-Vonarburg, Stephanie C. & Macpherson, Andrew J. (2020). Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature.  ISSN 0028-0836.  584(7820), s 274- 278 . doi: 10.1038/s41586-020-2564-6 Full text in Research Archive.
• Smakaj, Erand; Babrak, Lmar; Ohlin, Mats; Shugay, Mikhail; Briney, Bryan; Tosoni, Deniz; Galli, Christopher; Grobelsek, Vendi; D'Angelo, Igor; Olson, Branden; Reddy, Sai T.; Greiff, Victor; Truck, Johannes; Marquez, Susanna; Lees, William D. & Miho, Enkelejda (2020). Benchmarking immunoinformatic tools for the analysis of antibody repertoire sequences. Bioinformatics.  ISSN 1367-4803.  36(6), s 1731- 1739 . doi: 10.1093/bioinformatics/btz845 Full text in Research Archive.
• Weber, Cédric R.; Akbar, Rahmad; Yermanos, Alexander; Pavlovic, Milena; Snapkov, Igor; Sandve, Geir Kjetil; Reddy, Sai T. & Greiff, Victor (2020). immuneSIM: tunable multi-feature simulation of B- and T-cell receptor repertoires for immunoinformatics benchmarking. Bioinformatics.  ISSN 1367-4803.  36(11), s 3594- 3596 . doi: 10.1093/bioinformatics/btaa158 Full text in Research Archive.
• Yermanos, Alexander; Dounas, Andreas; Greiff, Victor; Stadler, Tanja; Oxenius, Annette & Reddy, Sai T. (2020). Inter- and intraspecies comparison of phylogenetic fingerprints and sequence diversity of immunoglobulin variable genes. Immunogenetics.  ISSN 0093-7711.  72(5), s 279- 294 . doi: 10.1007/s00251-020-01164-8
• Yermanos, Alexander; Kräutler, Nike Julia; Pedrioli, Alessandro; Menzel, Ulrike; Greiff, Victor; Stadler, Tanja; Oxenius, Annette & Reddy, Sai T. (2020). IgM Antibody Repertoire Fingerprints in Mice Are Personalized but Robust to Viral Infection Status. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  10:254, s 1- 13 . doi: 10.3389/fcimb.2020.00254
• Bartolomé Casado, Raquel; Landsverk, Ole J. B.; Chauhan, Sudhir Kumar; Richter, Lisa Maria; Phung, Danh; Greiff, Victor; Risnes, Louise Fremgaard; Yao, Ying; Neumann, Ralf Stefan; Yaqub, Sheraz; Øyen, Ole; Horneland, Rune; Aandahl, Einar Martin; Paulsen, Vemund; Sollid, Ludvig Magne; Qiao, Shuo Wang; Bækkevold, Espen Sønderaal & Jahnsen, Frode Lars (2019). Resident memory CD8 T cells persist for years in human small intestine. Journal of Experimental Medicine (JEM).  ISSN 0022-1007.  216(10), s 2412- 2426 . doi: 10.1084/jem.20190414 Full text in Research Archive.
• Brown, Alex; Snapkov, Igor; Akbar, Rahmad; Pavlovic, Milena; Miho, Enkelejda; Sandve, Geir Kjetil & Greiff, Victor (2019). Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires. Molecular Systems Design & Engineering.  ISSN 2058-9689.  4(4), s 701- 736 . doi: 10.1039/c9me00071b
• Miho, Enkelejda; Roskar, Rok; Greiff, Victor & Reddy, Sai T. (2019). Large-scale network analysis reveals the sequence space architecture of antibody repertoires. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-09278-8 Full text in Research Archive.
• Ohlin, Mats; Scheepers, Cathrine; Corcoran, Martin; Lees, William D.; Busse, Christian E.; Bagnara, Davide; Thörnqvist, Linnea; Bürckert, Jean-Philippe; Jackson, Katherine J.L.; Ralph, Duncan; Schramm, Chaim A.; Marthandan, Nishanth; Breden, Felix; Scott, Jamie; Matsen, Frederick A.; Greiff, Victor; Yaari, Gur; Kleinstein, Steven H.; Christley, Scott; Sherkow, Jacob S.; Kossida, Sofia; Lefranc, Marie-Paule; van Zelm, Menno C.; Watson, Corey T. & Collins, Andrew M. (2019). Inferred allelic variants of immunoglobulin receptor genes: A system for their evaluation, documentation, and naming. Frontiers in Immunology.  ISSN 1664-3224.  10:435, s 1- 13 . doi: 10.3389/fimmu.2019.00435 Full text in Research Archive.
• Tomescu-Baciu, Alina; Johansen, Jorunn; Holmøy, Trygve; Greiff, Victor; Stensland, Maria; De Souza, Gustavo Antonio; Vartdal, Frode & Lossius, Peter Andreas Vold (2019). Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  333:576966, s 1- 7 . doi: 10.1016/j.jneuroim.2019.576966 Full text in Research Archive. Show summary

  In multiple sclerosis (MS), B cells are trafficking across the blood-brain barrier, but it is not known how this relates to the synthesis of oligoclonal IgG. We used quantitative mass spectrometry of oligoclonal bands and high-throughput sequencing of immunoglobulin heavy-chain variable transcripts to study the longitudinal B cell response in the cerebrospinal fluid (CSF) and blood of two MS patients. Twenty of 22 (91%) and 25 of 28 (89%) of oligoclonal band peptides persisted in samples collected 18 months apart, in spite of a dynamic exchange across the blood-CSF barrier of B lineage cells connecting to oligoclonal IgG.

• Mason, Derek M; Weber, Cédric R.; Parola, Cristina; Meng, Simon M; Greiff, Victor; Kelton, William & Reddy, Sai T. (2018). High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis. Nucleic Acids Research (NAR).  ISSN 0305-1048.  46(14), s 7436- 7449 . doi: 10.1093/nar/gky550
• Miho, Enkelejda; Yermanos, Alexander; Weber, Cédric R.; Berger, Christoph T; Reddy, Sai T. & Greiff, Victor (2018). Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires. Frontiers in Immunology.  ISSN 1664-3224.  9: 224, s 1- 15 . doi: 10.3389/fimmu.2018.00224 Full text in Research Archive.
• Yermanos, Alexander; Greiff, Victor; Krautler, Nike Julia; Menzel, Ulrike; Dounas, Andreas; Miho, Enkelejda; Oxenius, Annette; Stadler, Tanja & Reddy, Sai T. (2017). Comparison of methods for phylogenetic B-cell lineage inference using time-resolved antibody repertoire simulations (AbSim). Bioinformatics.  ISSN 1367-4803. . doi: https://doi.org/10.1093/bioinformatics/btx533

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