Publications
-
Søyseth, Vidar; Henneberger, Paul K.; Lindstrøm, Jonas Christoffer; Virji, Mohammed Abbas; Einvik, Gunnar & Bakke, Berit
[Show all 7 contributors for this article]
(2026).
Exposure to Polycyclic Aromatic Hydrocarbons, but Not to Dust or Fluorides, in the Norwegian Aluminum Industry Is Associated With Accelerated Annual Decline in Lung Function.
American Journal of Industrial Medicine.
ISSN 0271-3586.
69(8),
p. 674–682.
doi:
10.1002/ajim.70102.
-
Hardang, Ingrid Marie; Benth, Jurate Saltyte; Moe, Morten Kaare; Kononova, Natalia; Søyseth, Vidar & Einvik, Gunnar
(2025).
Hepcidin Isoforms in Chronic Obstructive Pulmonary Disease Compared with the General Population.
The Journal of Applied Laboratory Medicine (JALM).
ISSN 2576-9456.
10(5),
p. 1265–1278.
doi:
10.1093/jalm/jfaf095.
Full text in Research Archive
Show summary
Introduction
Hepcidin (Hep), a major regulator of iron metabolism, has several isoforms whose biological functions remain unknown. In chronic obstructive pulmonary disease (COPD) several factors, such as inflammation and hypoxemia, stimulate or inhibit Hep production. Our aims were to assess the isoform concentrations in COPD, explore the associations between the isoforms and pathophysiological variables, and assess the effect of initiation of long-term oxygen treatment (LTOT) on Hep concentrations.
Methods
The study population constituted 84 patients with COPD and 59 non-COPD participants. Hep isoforms, parameters of inflammation and iron status, and partial pressures of arterial oxygen (pO2) were measured at baseline and at 6-months follow-up in COPD patients. Associations between isoforms and clinical and biochemical characteristics were examined by multivariable tobit regression, while tobit regression with random effects was used to assess whether initiation of LTOT influenced the isoforms.
Results
At least one isoform was detected in 96% of the participants, of which Hep25 was the most and Hep22 the least common. All isoforms were associated with C-reactive protein and ferritin. Hep25 and Hep24 were also associated with transferrin saturation, and Hep24 was associated with urine albumin-creatinine ratio. None of the isoforms were associated with hemoglobin, pO2, smoking, or COPD. There was a significant reduction of Hep25 and Hep24 from baseline to follow-up.
Conclusions
All isoforms were associated with inflammation, while Hep25 and Hep24 were associated with circulating iron and Hep24 with kidney disease. The concentrations of Hep isoforms were not associated with COPD, nor did initiation of LTOT result in significant changes of isoform concentrations.
-
Hardang, Ingrid Marie; Søyseth, Vidar; Kononova, Natalia; Hagve, Tor Arne & Einvik, Gunnar
(2024).
COPD: Iron Deficiency and Clinical Characteristics in Patients With and Without Chronic Respiratory Failure.
Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation.
11(3),
p. 261–269.
doi:
10.15326/jcopdf.2023.0477.
Full text in Research Archive
-
-
Ruud, Espen Asak; Heck, Sigurd; Stavem, Knut; Søyseth, Vidar; Geitung, Jonn Terje & Ashraf, Haseem
(2022).
Low diffusion capacity of the lung predicts pneumothorax and chest drainage after CT-guided lung biopsy.
BMC Research Notes.
15(1).
doi:
10.1186/s13104-022-06234-6.
Full text in Research Archive
Show summary
Objectives Complications after CT-guided lung biopsy is a burden both for the individual patient and for the overall healthcare. Pneumothorax is the most common complication. This study determined the association between lung function tests and pneumothorax and chest drainage following CT-guided lung biopsy in consecutive patients in a large university hospital. Results We prospectively registered 875 biopsy procedures from 786 patients in one institution from January 27th 2012 to March 1st 2017 and recorded complications including pneumothorax with or without chest drainage. Lung function data from 637 patients undergoing 710 of the procedures were available. The association of lung function measures with pneumothorax with or without chest drainage was assessed using multivariable logistic regression analyses. Diffusion capacity for carbon monoxide (DLCO) below 4.70 mmol/min/kPa was associated with increased occurrence of pneumothorax and chest drainage after CT guided lung biopsy. We found no association between FEV1, RV and occurrence of pneumothorax and chest drainage. We found low DLCO to be a risk factor of pneumothorax and chest drainage after CT-guided lung biopsy. This should be taken into account in planning and performing the procedure.
-
Kononova, Natalia; Einvik, Gunnar; Holmedahl, Nils Henrik; Hagve, Tor-Arne; Omland, Torbjørn & Søyseth, Vidar
(2022).
It is unlikely that oxygen supplementation in COPD patients with chronic respiratory failure reduce cardiac troponin level.
BMC Pulmonary Medicine.
22,
p. 1–8.
doi:
10.1186/s12890-022-02169-7.
Full text in Research Archive
Show summary
Background Cardiac troponin T (cTnT) is a biomarker of myocardial injury frequently elevated in COPD patients, potentially because of hypoxemia. This non-randomised observational study investigates whether long-term oxygen treatment (LTOT) reduces the cTnT level. Methods We compared cTnT between COPD patients who were candidates for LTOT (n = 20) with two reference groups. Patients from both reference groups were matched with the index group using propensity score.Reference groups consists of institutional pulmonary rehabilitation patients (short-term group) (n = 105 after matching n = 11) and outpatients at a pulmonary rehabilitation clinic (long-term group)(n = 62 after matching n = 10). Comparison was done within 24 h after LTOT initiation in first reference group and within 6 months after inclusion in the second group. Results The geometric mean of (standard deviation in parentheses) cTnT decreased from 17.8 (2.3) ng/L (between 8 and 9 a.m.) to 15.4 (2.5) ng/L between 1 and 2 p.m. in the LTOT group, and from 18.4 (4.8) ng/L to15.4 (2.5) ng/L in group (1) The corresponding long-term results were 17.0 (2.9) ng/L at inclusion (between 10 and 12 a.m.) to 18.4 (2.4) ng/L after 3 months in the LTOT-group, and from 14.0 (2.4) ng/L to 15.4 (2.5) ng/L after 6 months in group (2) None of the differences in cTnT during the follow-up between the LTOT-group and their matched references were significant. Conclusion Initiation of LTOT was not associated with an early or sustained reduction in cTnT after treatment with oxygen supplementation.
-
Ruud, Espen Asak; Stavem, Knut; Geitung, Jonn Terje; Borthne, Arne Sigmund; Søyseth, Vidar & Ashraf, Haseem
(2021).
Predictors of pneumothorax and chest drainage after percutaneous CT-guided lung biopsy: A prospective study.
European Radiology.
ISSN 0938-7994.
doi:
10.1007/s00330-020-07449-6.
Full text in Research Archive
-
Søyseth, Vidar; Kononova, Natalia; Neukamm, Anke; Holmedahl, Nils Henrik; Hagve, Tor-Arne & Omland, Torbjørn
[Show all 7 contributors for this article]
(2021).
Systemic inflammation induced by exacerbation of COPD or pneumonia in patients with COPD induces cardiac troponin elevation.
BMJ Open Respiratory Research.
8(1),
p. 1–8.
doi:
10.1136/bmjresp-2021-000997.
Full text in Research Archive
Show summary
Background Troponin is a biomarker of myocardial injury. In chronic obstructive pulmonary disease (COPD), troponin is an important determinant of mortality after acute exacerbation. Whether acute exacerbation of COPD (AECOPD) causes troponin elevation is not known. Here, we investigated whether troponin is increased in AECOPD compared to stable COPD. Methods We included 320 patients with COPD in the stable state and 63 random individuals from Akershus University hospital’s catchment area. All participants were ≥40 years old (mean 65·1 years, SD 7·6) and 176 (46%) were females. The geometric mean of high-sensitivity cardiac troponin T (hs-cTnT) was 6·9 ng/L (geometric-SD 2·6). They were followed regarding hospital admission for the subsequent 5 years. Results During the 5-year follow-up, we noted 474 hospitalisations: Totally, 150 and 80 admissions were due to AECOPD or pneumonia, respectively. The geometric mean ratio with geometric SE ( GSE) between cTnT at admission and stable state in AECOPD and pneumonia was 1·27 (GSE=1.11, p=0·023) and 1·28 (GSE=1.14, p=0·054), respectively. After inclusion of blood leucocyte count and C reactive protein at hospitalisation, these ratios attenuated to zero. However, we estimated an indirect of AECOPD and pneumonia on the ratio between hs-cTnT at admission and the stable state to 1·16 (p=0·022) and 1·22 (p=0·008), representing 91% (95% CI 82% to 100%) and 95% (95% CI 83% to 100%) of the total effects, respectively. Conclusion AECOPD and pneumonia in patients with COPD is associated with higher cTnT levels. This association appears to be mediated by systemic inflammation.
-
Søyseth, Torunn Stavnes; Dew, Mary Amanda; Samersaw-Lund, May Brit; Haugstad, Gro Killi; Søyseth, Vidar & Malt, Ulrik Fredrik
(2020).
Coping Patterns and Emotional Distress in
Patients With Chronic Obstructive Lung
Disease Who Are Undergoing Lung
Transplant Evaluation.
Progress in transplantation.
ISSN 1526-9248.
30(3),
p. 228–234.
doi:
10.1177/1526924820933817.
Full text in Research Archive
Show summary
Objectives: Living with severe lung disease like chronic obstructive pulmonary disease (COPD) is a very stressful situation. The way patients cope may impact their symptoms of anxiety and depression and physical function as well. We studied how ways of coping are associated with levels of emotional distress and lung function in patients with COPD being evaluated for lung transplantation. Methods: Sixty-five (mean age 57 years, 46% females) patients completed the General Health Questionnaire-30 (GHQ-30) assessing emotional distress and the Ways of Coping Questionnaire. Measurements of lung function and 6-minute walk test were included. Results: Seventeen (26%) patients had elevated emotional distress. Logistic regression of chronic GHQ score with gender, age, body mass index, lung function, and coping scales as covariates showed that escape avoidance and selfcontrolling coping and forced vital lung capacity were significantly associated with high emotional distress. Odds ratio of emotional distress increased with 5.2 per tertile (P ¼ .011) in escape avoidance coping score. Moreover, we revealed that emotionally distressed patients cope with their current situation by refusing to believe the current situation and taking their distress out on other people. Conclusion: Among patients with COPD, a high level of emotional distress was uniquely associated with escapeavoidance coping and lung function. Future work should ascertain whether coping style predicts distress or whether distress increases the use of escape-avoidance coping. Nevertheless, our findings indicate that if either element is present, health care professionals should be attentive to the need for interventions to improve patients’ well-being.
-
Kononova, Natalia; Sikkeland, Liv Ingunn Bjoner; Mahmood, Faiza; Vistnes, Maria; Kongerud, Johny & Einvik, Gunnar
[Show all 7 contributors for this article]
(2019).
Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.
BMC Pulmonary Medicine.
19.
doi:
10.1186/s12890-018-0765-7.
Full text in Research Archive
Show summary
Background Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV1). This study investigated whether indices of airway inflammation are predictors of dFEV1 in a general population-based sample. Methods The study, conducted from 2003 to 2005, included 120 healthy Norwegian subjects aged 40 to 70 years old. At baseline, the participants completed a self-administered respiratory questionnaire and underwent a clinical examination that included spirometry, venous blood sampling, and induced sputum examination. From 2015 to 2016, 62 (52%) participants agreed to a follow-up examination that did not include induced sputum examination. Those with a FEV1/forced vital capacity (FVC) ratio < 0.70 underwent a bronchial reversibility test. The levels of cytokines, pro-inflammatory M1 macrophage phenotypes were measured in induced sputum using bead-based multiplex analysis. The associations between cytokine levels and dFEV1 were then analysed. Results The mean dFEV1 was 32.9 ml/year (standard deviation 26.3). We found no associations between dFEV1 and the baseline indices of sputum inflammation. Seven participants had irreversible airflow limitation at follow-up. They had lower FEV1 and gas diffusion at baseline compared with the remaining subjects. Moreover, two of these individuals had a positive reversibility test and sputum eosinophilia at baseline. Conclusions In this cohort of presumably healthy subjects, we found no associations between sputum inflammatory cells or mediators and dFEV1 during 10 years of follow-up.
-
Einvik, Gunnar; Bhatnagar, Rahul; Holmedahl, Nils Henrik; Neukamm, Anke; Omland, Torbjørn & Søyseth, Vidar
(2017).
Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T.
COPD: Journal of Chronic Obstructive Pulmonary Disease.
ISSN 1541-2555.
14(3),
p. 318–323.
doi:
10.1080/15412555.2017.1298085.
Full text in Research Archive
Show summary
During acute exacerbation of chronic obstructive pulmonary disease (AECOPD), myocardial stress may be aggravated. Sparse data exist concerning the prevalence and correlates of cardiac arrhythmias in the stable and exacerbated states of COPD. We hypothesized that AECOPD is associated with increased prevalence of cardiac arrhythmias independent of COPD-severity and co-morbidity, and explored possible mechanisms. A 24-hour Holter recording was obtained in 74 patients with stable COPD and 45 patients with AECOPD (mean age 54 years, 56% women). Any incidence of supraventricular tachycardia (SVT), frequent premature ventricular complex (PVC, >30/hour) and complex ventricular ectopy (bigeminy, trigeminy or non-sustained ventricular tachycardia) was recorded and compared between the two groups. Adjustments were made for by stable disease-related co-variates (demography, co-morbidity, COPD-severity) and by acute disease-related co-variates (heart rate, cardiac troponin T (cTnT), PO2, PCO2 and C-reactive protein (CRP)) in explorative analyses. The prevalence of SVT, frequent PVCs or complex ventricular ectopy was 40%, 27% and 33% in AECOPD, and 31%, 31% and 12% in stable COPD, respectively. Frequent PVC, but not SVT or complex ventricular ectopy, was significantly increased in AECOPD compared to stable COPD, odds ratio 3.03 (1.03–10.5, p = 0.039) when adjusted for stable disease-related co-variates. Higher heart rate, cTnT and CRP attenuated the association between AECOPD and frequent PVC to non-significant, while heart rate remained associated with frequent PVC. In conclusion, frequent PVC is more prevalent in exacerbated than in the stable states of COPD. Attenuation effects of cTnT, tachycardia and CRP suggest that cardiac stress or inflammation may be involved in mechanisms causing frequent PVC i AECOPD. © 2017 Taylor & Francis
-
Søyseth, Vidar; Henneberger, Paul K; Einvik, Gunnar; Virji, Mohammed Abbas; Bakke, Berit & Kongerud, Johny
(2016).
Annual decline in forced expiratory volume is steeper in aluminum potroom workers than in workers without exposure to potroom fumes.
American Journal of Industrial Medicine.
ISSN 0271-3586.
59(4),
p. 322–329.
doi:
10.1002/ajim.22570.
Full text in Research Archive
Show summary
Background:
Aluminum potroom exposure is associated with increased mortality of COPD but the association between potroom exposure and annual decline in lung function is unknown. We have measured lung volumes annually using spirometry from 1986 to 1996. The objective was to compare annual decline in forced expiratory volume in 1 s (dFEV1) and forced vital capacity (dFVC).
Methods:
The number of aluminum potroom workers was 4,546 (81% males) and the number of workers in the reference group was 651 (76% males). The number of spirometries in the index group and the references were 24,060 and 2,243, respectively.
Results:
After adjustment for confounders, the difference in dFEV1 and dFVC between the index and reference groups were 13.5 (P < 0.001) and −8.0 (P = 0.060) ml/year.
Conclusion:
Aluminum potroom operators have increased annual decline in FEV1 relative to a comparable group with non‐exposure to potroom fumes and gases.
-
-
-
Neukamm, Anke; Einvik, Gunnar; Høiseth, Arne Didrik; Søyseth, Vidar; Holmedahl, Nils Henrik & Kononova, Natalia
[Show all 7 contributors for this article]
(2016).
The prognostic value of measurement of high-sensitive cardiac troponin T for mortality in a cohort of stable chronic obstructive pulmonary disease patients.
BMC Pulmonary Medicine.
16(1).
doi:
10.1186/s12890-016-0319-9.
Full text in Research Archive
Show summary
Background Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD). Cardiac troponin (cTn) elevation, indicating myocardial injury, is frequent during acute COPD exacerbations and associated with increased mortality. The prognostic value of circulating cTnT among COPD patients in the stable state of the disease is still unknown. The purpose of the present study was to assess the association between circulating cTnT measured by a high sensitive assay (hs-cTnT) and all-cause mortality among patients with stable COPD without overt CVD. Methods In a prospective cohort study we included 275 patients from the Akershus University Hospital’s outpatient clinic and from Glittre, a pulmonary rehabilitation clinic. COPD-severity and cardiovascular risk factors were assessed, and time to all-cause death was recorded during a mean follow-up time of 2.8 years. Results One hundred-eighty patients (65%) had hs-cTnT concentrations ≥ the level of detection (5.0 ng/L) and 66 patients (24%) had hs-cTnT above the normal range (≥14.0 ng/L). In total, 47 patients (17%) died. hs-cTnT concentrations in the ranges <5.0, 5.0–13.9 and ≥14 ng/L were associated with crude mortality rates of 2.8, 4.4 and 11.0 per 100 patient-years, respectively. In adjusted analyses the hazard ratios (95% confidence intervals) for death were 1.7 (0.8–3.9) and 2.9 (1.2–7.2) among patients with hs-cTnT concentrations 5.0–13.9 and ≥14 ng/L, respectively, compared to patients with hs-cTnT <5.0 ng/L. Conclusions hs-cTnT elevation is frequently present in patients with stable COPD without overt CVD, and associated with increased mortality, independently of COPD-severity and other cardiovascular risk factors.
-
Sikkeland, Liv Ingunn Bjoner; Johnsen, Helle Laier; Riste, Tonje Bøyum; Alexis, Neil E.; Halvorsen, Bente & Søyseth, Vidar
[Show all 7 contributors for this article]
(2016).
Sputum neutrophils are elevated in smelter workers, and systemic neutrophils are associated with rapid decline in FEV1.
Occupational and Environmental Medicine.
ISSN 1351-0711.
73(7),
p. 459–466.
doi:
10.1136/oemed-2015-103083.
Full text in Research Archive
Show summary
Abstract:
Objectives In a previous study on smelter workers we, found significant relationship between exposure to dust and accelerated annual decline in forced expiratory volume in 1 s (FEV1). In this cross-sectional study at the end of a follow-up, we aimed to investigate the possible association between annual decline in FEV1 and markers of airways, and systemic inflammation in smelter workers.
Methods: Employees (n=76 (27 current smokers)) who had been part of a longitudinal study (9–13 years) that included spirometry (>6 measurements) and respiratory questionnaires, performed induced sputum, exhaled NO and had blood drawn. Participants with annual decline in FEV1≥45 mL were compared with participants with annual decline <45 mL; also 26 non-exposed controls were included.
Results: Compared with non-exposed controls, smelter workers demonstrated a significantly increased percentage of neutrophils (mean (SD)) (57% (17) vs 31% (15)) and matrix metalloproteinases 8 (MMP-8) levels in sputum, and MMP-9, surfactant protein D (SpD) and transforming growth factor β (TGFb) levels in blood. A significant association in FEV1≥45 mL was found for blood neutrophils when controlling for smoking habits (OR=1.7 (95% CI 1.0 to 2.8), p=0.045). Airway and blood protein markers were not associated with annual decline in FEV1.
Conclusions: All workers displayed airway and systemic inflammation characterised by increased levels of neutrophils and MMP-8 in sputum, and MMP-9, SpD and TGFβ in blood compared with non-exposed controls. Blood neutrophils in particular were significantly elevated in those workers with the most rapid decline in lung function. A similar observation was not seen with airway neutrophils. In the present study, we were able to identify systemic but not airway inflammatory markers that can predict increased decline in FEV1 in smelter workers.
-
Søyseth, Vidar; Henneberger, Paul; Virji, Mohammed Abbas; Bakke, Berit & Kongerud, Johny
(2015).
Construction of a job exposure matrix to dust, fluoride, and polycyclic aromatic hydrocarbons in the Norwegian aluminum industry using prediction models.
Annals of Occupational Hygiene.
ISSN 0003-4878.
59(9),
p. 1106–1121.
doi:
10.1093/annhyg/mev069.
Full text in Research Archive
Show summary
Background:
The Norwegian aluminum industry developed and implemented a protocol for prospective monitoring of employees’ exposure using personal samplers. We analyzed these data to develop prediction lines to construct a job exposure matrix (JEM) for the period 1986–1995.
Methods:
The protocol for personal monitoring of exposure was implemented in all seven Norwegian aluminum plants in 1986 and continued until 1995. Personal samplers were used to collect total dust, fluorides, and total polycyclic aromatic hydrocarbons (PAH). In addition, exposure could be categorized according to process, i.e. prebake, Søderberg, and ‘other’. We constructed four-dimensional JEMs characterized by: Plant, Job descriptor, Process, and Year. Totally 8074, 6734, and 3524 measurements were available for dust, fluorides, and PAH, respectively. The data were analyzed using linear mixed models with two-way interactions. The models were assessed using the Akaike criterion (AIC) and unadjusted R2. The significance level was set to 10% (two-sided) for retaining variables in the model.
Results:
In 1986, the geometric mean (95% confidence interval in parentheses) for total dust, total fluorides, and PAH were 3.18 (0.46–22.2) mg m−3, 0.58 (0.085–4.00) mg m−3, and 33.9 (2.3–504) µg m−3, respectively. During 10 years of follow-up, the exposure to total dust, fluorides, and PAH decreased by 9.2, 11.7, and 14.9% per year, respectively. Each model encompassed from 49 to 72 significant components of the interaction terms. The interaction components were at least as important as the main effects, and 65 to 91% of the significant components of the interaction terms were time-dependent.
Conclusion:
Our prediction models indicated that exposures were highly time-dependent. We expect that the time-dependent changes in exposure are of major importance for longitudinal studies of health effects in the aluminum industry.
-
Søyseth, Vidar; Johnsen, Helle Laier; Henneberger, Paul K. & Kongerud, Johny
(2015).
Increased decline in pulmonary function among employees
in Norwegian smelters reporting work-related
asthma-like symptoms.
Journal of Occupational and Environmental Medicine.
ISSN 1076-2752.
57(9),
p. 1004–1008.
doi:
10.1097/JOM.0000000000000518.
Full text in Research Archive
Show summary
Objective: To investigate associations between work-related asthma-like symptoms (WASTH) and annual pulmonary function decline among employees of 18 Norwegian smelters.
Methods: A 5-year longitudinal study in which WASTH was defined as a combination of dyspnea and wheezing that improved on rest days and vacation.
Results: A total of 12,966 spirometry examinations were performed in 3084 employees. Crude annual decline in forced expiratory volume in 1 second (FEV1) (dFEV1) was 32.9 mL/yr (95% confidence interval, 30.5 to 35.3), and crude annual decline in forced vital capacity (FVC) (dFVC) was 40.9 mL/yr (37.8 to 43.9). After adjustment for relevant covariates, employees reporting WASTH showed higher dFEV1 by 16.0 m:/yr (3.4 to 28.6) and higher dFVC by 20.5 mL/yr (6.0 to 35.0) compared with employees not reporting WASTH.
Conclusion: Work-related asthma-like symptom was associated with greater annual declines in FEV1 and FVC, indicating a restrictive pattern.
-
-
Søyseth, Vidar; Aaløkken, Trond Mogens; Mynarek, Georg; Naalsund, Anne; Strøm, Erik Heyerdahl & Scott, Helge
[Show all 7 contributors for this article]
(2015).
Diagnosis of biopsy verified usual interstitial pneumonia by computed tomography.
Respiratory Medicine.
ISSN 0954-6111.
109(7),
p. 897–903.
doi:
10.1016/j.rmed.2015.05.008.
Full text in Research Archive
Show summary
Objective
To identify the combination of clinical data and high resolution computed tomography (HRCT) features that best identified biopsy verified usual interstitial pneumonia (UIP).
Methods
The study included 91 patients with a tentative diagnosis of interstitial lung disease. All underwent clinical investigation, surgical lung biopsy and HRCT. Two independent readers assessed the HRCT images for the extent and pattern of abnormality. On the basis of the biopsy result the patients were categorized in three groups: 1) Usual interstitial pneumonia, 2) Other idiopathic interstitial pneumonias (IIPs) and hypersensitivity pneumonitis and 3) Other interstitial lung diseases. The diagnostic value of HRCT was investigated using likelihood ratio to estimate the post-test probability of UIP.
Results
We found that UIP was associated with significantly higher scores for reticular pattern and for bronchiectasis than the remaining patients (p < 0.001). Moreover, these scores showed a steeper cranial-caudal increase in patients with histologically verified UIP than in the remaining patients (p < 0.001). UIP was associated with lower scores for ground glass opacities (p < 0.001). Using Bayes theorem and likelihood ratio estimation we found that UIP could be diagnosed with 90% certainty in patients 60 years or older and restrictive pattern in spirometry provided that HRCT demonstrated at least 15% reticular pattern and no ground glass opacities.
Conclusion
In older patients with a restrictive spirometry in whom HRCT demonstrates a reticular pattern without ground glass opacities surgical lung biopsy is not warranted for the diagnosis of UIP.
-
Høiseth, Arne Didrik; Neukamm, Anke; Hagve, Tor-Arne; Omland, Torbjørn; Brekke, Pål Haugar & Søyseth, Vidar
(2014).
The clinical value of serial measurement of high-sensitivity cardiac troponin T in acute exacerbations ofchronic obstructive pulmonary disease.
Open heart.
1.
doi:
10.1136/openhrt-2013-000001.
Full text in Research Archive
-
Neukamm, Anke; Høiseth, Arne Didrik; Søyseth, Vidar & Omland, Torbjørn
(2014).
The authors’ reply.
Heart.
ISSN 1355-6037.
Full text in Research Archive
-
-
-
Neukamm, Anke; Høiseth, Arne Didrik; Hagve, Tor-Arne; Søyseth, Vidar & Omland, Torbjørn
(2013).
High-sensitivity cardiac troponin T levels are increased in stable COPD.
Heart.
ISSN 1355-6037.
99(6),
p. 382–387.
doi:
10.1136/heartjnl-2012-303429.
Full text in Research Archive
Show summary
Objective To assess the distribution of high-sensitivity cardiac troponin T (hs-cTnT) concentrations in stable chronic obstructive pulmonary disease (COPD), and whether hs-cTnT is associated with pulmonary function. Design Prospectively designed, cross-sectional study. Setting Outpatient clinic of Norwegian teaching hospital and community-based setting. Participants Sample of 101 stable COPD patients from the hospital's outpatient clinic and 120 individuals derived from a random general population sample. Main outcomes Ratio of hs-cTnT in stable COPD patients compared with references from the general population. Change in ratio of hs-cTnT per unit increase of relevant covariables. Results The crude geometric means of circulating hs-cTnT in the cases and the references were 7.75 and 3.01 ng/l, respectively (p <0.001); that is, a relative ratio of 2.57 (95% CI 2.05 to 3.23). After adjustment for relevant confounders, this ratio was moderately attenuated to 1.65 (1.31–2.08). In the total study cohort, as well as among stable COPD patients, we found a significant positive association between hs-cTnT and interleukin-6 concentrations (p <0.001) and the presence of pathologic Q waves (p=0.023). Among stable COPD patients, one quartile increase in forced expiratory volume 1 was associated with a 39% decrease in hs-cTnT and patient category (Global Initiative of Obstructive Lung Disease classification 2011) was positively associated with hs-cTnT (p trend <0.001) after multivariate adjustment. Conclusions Stable COPD is independently associated with higher hs-cTnT compared with randomly drawn subjects from the general population. In patients with stable COPD, higher hs-cTnT seems to be associated with immune activation and the severity of the disease.
-
Høiseth, Arne Didrik; Omland, Torbjørn; Karlsson, Bo Daniel; Brekke, Pål Haugar & Søyseth, Vidar
(2013).
Standardized evaluation of lung congestion during COPD exacerbation better identifies patients at risk of dying.
The International Journal of Chronic Obstructive Pulmonary Disease.
ISSN 1176-9106.
8,
p. 621–629.
doi:
10.2147/COPD.S52854.
Full text in Research Archive
-
Søyseth, Vidar; Johnsen, Helle Laier & Kongerud, Johny
(2013).
Respiratory hazards of metal smelting.
Current opinion in pulmonary medicine.
ISSN 1070-5287.
19(2),
p. 158–162.
doi:
10.1097/MCP.0b013e32835ceeae.
Full text in Research Archive
Show summary
Purpose of review:
The metal smelting industry is an important industry in the majority of countries in the world and employs
millions of workers. In most of the production types, a variety of pollutants are emitted into the workplace
atmosphere. Some of these pollutants have sensitizing properties, whereas other act as irritants in the
respiratory tract. This review will explore the recent studies (2010–2012) which address the impact of
exposure to pollutants in the smelting industry on nonmalignant respiratory disorders.
Recent findings:
The association between different respiratory symptoms as well as pulmonary function and the level of
exposure to different agents has been investigated. Likewise, the effect of primary prevention (exposure
reduction) and secondary prevention (relocation) has been studied. Finally, the association between the
incidence of community-acquired pneumonia and exposure to pollutants encountered at work in the
smelting industry and the results from mortality studies are reported.
Summary:
It appears that exposure to emissions of pollutants in the smelting industry is associated with respiratory
symptoms, including asthma, lung function decline and chronic obstructive pulmonary disease, depending
on the type of production. Moreover, it is possible that these exposures may enhance the risk of infectious
pneumonia.
-
-
Johnsen, Helle Laier; Bugge, Merete Drevvatne; Føreland, Solveig; Kjuus, Helge; Kongerud, Johny & Søyseth, Vidar
(2013).
Dust exposure is associated with increased lung function loss among workers in the Norwegian silicon carbide industry.
Occupational and Environmental Medicine.
ISSN 1351-0711.
70(11),
p. 803–809.
doi:
10.1136/oemed-2012-101068.
Full text in Research Archive
Show summary
Objectives: To investigate the relationship between dust exposure and annual change in lung function among employees in Norwegian silicon carbide (SiC) plants using a quantitative job exposure matrix (JEM) regarding total dust.
Methods: All employees, 20–55 years of age by inclusion (n=456), were examined annually for up to 5 years (1499 examinations). Spirometry was performed at each examination, and a questionnaire encompassing questions of respiratory symptoms, smoking status, job and smoking history, and present job held was completed. A JEM was constructed based on 1970 personal total dust exposure measurements collected during the study period. The association between lung function and total dust exposure was investigated using linear mixed models.
Results: The annual change in forced expiratory volume (FEV) in one second per squared height, FEV1/height2, per mg/m3 increase in dust exposure was −2.3 (95% CI −3.8 to −0.79) (mL/m2)×year−1. In an employee of average height (1.79 m) and exposure (1.4 mg/m3) the estimated contribution to the annual change in FEV1 associated with dust was 10.4 mL/year. The annual change in FEV1/height2 in current, compared with non-smokers was −1.9 (−7.2 to 3.4) (mL/m2)×year−1. The estimated overall annual decline in FEV1 among current and non-smokers in the highest exposed group was −91.2 (−124.3 to −58.1) (mL/m2)×year−1 and −49.0 (−80.2 to −17.8) (mL/m2)×year−1, respectively.
Conclusions: Dust exposure, expressed by a quantitative JEM, was found to be associated with an increased yearly decline in FEV1 in employees of Norwegian SiC plants.
-
Høiseth, Arne Didrik; Omland, Torbjørn; Hagve, Tor-Arne; Brekke, Pål Haugar & Søyseth, Vidar
(2012).
Determinants of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort study.
BMC Pulmonary Medicine.
12(22).
doi:
10.1186/1471-2466-12-22.
Full text in Research Archive
Show summary
Background A high-sensitivity cardiac troponin T (hs-cTnT) concentration above the 99th percentile (i.e. 14 ng/L) is common during Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and associated with increased mortality. The objective of the study was to identify factors associated with hs-cTnT levels during AECOPD. Methods We included 99 patients with AECOPD on admission. As 41 patients had one or more repeat admissions, there were 202 observations in the final analysis. We recorded clinical and biochemical data, medication, spirometry, chest radiographs, and ECGs. The data were analysed for cross-sectional and longitudinal associations using ordinary least square as well as linear mixed models with the natural logarithm of hs-cTnT as the dependent variable. Results Mean age at inclusion was 71.5 years, mean FEV1/FVC was 45%, and median hs-cTnT was 27.0 ng/L. In a multivariable model there was a 24% increase in hs-cTnT per 10 years increase in age (p < 0.0001), a 6% increase per 10 μmol/L increase in creatinine (p = 0.037), and a 2% increase per month after enrollment (p = 0.046). Similarly, the ratios of hs-cTnT between patients with and without tachycardia (heart rate ≥100/min) and with and without history of arterial hypertension were 1.25 (p = 0.042) and 1.44 (p = 0.034), respectively. We found no significant association between arterial hypoxemia and elevated hs-cTnT. Conclusion Age, arterial hypertension, tachycardia, and serum creatinine are independently associated with the level of hs-cTnT on admission for AECOPD.
-
Søyseth, Vidar; Johnsen, Helle Laier; Bugge, Merete Drevvatne & Kongerud, Johny
(2012).
The association between symptoms and exposure is stronger in dropouts than in non-dropouts among employees in Norwegian smelters: a five-year follow-up study.
International Archives of Occupational and Environmental Health.
ISSN 0340-0131.
85(1),
p. 27–33.
doi:
10.1007/s00420-011-0631-x.
Full text in Research Archive
Show summary
Purpose:
We have investigated the association between respiratory symptoms and dust exposure among employees in 18 Norwegian smelters using a longitudinal design.
Methods:
All employees (N = 3,084) were examined annually for 5 years (12,996 health examinations). At each examination, the subjects reported if they had respiratory symptoms, coded as 1 (yes) or 0 (no), on a respiratory questionnaire. Symptom score was constructed as the sum of symptoms (0–5). Full-time workers in the production line were classified as line operators; subjects never exposed in the production line were regarded as non-exposed. The remaining individuals were classified as non-line operators. A job-exposure matrix regarding dust exposure was also available. Analyses of repeated measurements were performed using generalised linear mixed model with log-link (Poisson regression). Adjustments were made for overdispersion.
Results:
The mean age at inclusion was 39.0 years, and 89% were men. The median dust exposure in tertiles 1–3 was 0.19, 1.76 and 3.47 mg/m3. The longitudinal analyses showed that the association between symptoms-score ratio (SSR) and job category was significantly stronger in dropouts compared with non-dropouts (p = 0.01). Among the dropouts, SSR was 1.61 (95% confidence interval: 1.27–2.05) and 1.39 (1.09–1.77) in line operators and non-line operators compared with non-exposed employees, respectively. The corresponding SSR for subjects who completed the study was 1.13 (1.01–1.27) and 1.12 (1.00–1.26), respectively. Similarly, among the dropouts, the SSR between the second and the first tertile was 1.28 (1.05–1.55) and 1.37 (1.13–1.66) between the third tertile and the first tertile.
Conclusions:
Line operators had more respiratory symptoms than non-exposed employees. This effect was significantly stronger in dropouts than in those who continued their jobs, indicating that there is a selection of subjects without respiratory symptoms in this industry.
-
-
Søyseth, Vidar; Johnsen, Helle Laier; Henneberger, Paul K. & Kongerud, Johny
(2012).
The incidence of work-related asthma-like symptoms and dust exposure in Norwegian smelters.
American Journal of Respiratory and Critical Care Medicine.
ISSN 1073-449X.
185(12),
p. 1280–1285.
doi:
10.1164/rccm.201110-1809OC.
Full text in Research Archive
Show summary
Rationale: The prevalence of respiratory symptoms amongemployees
in smelters is positively associated with dust exposure.
Objectives: To investigate the association between the incidence of
work-related asthma-like symptoms (WASTH) and dust exposure.
Methods: All the employees were invited to participate in a 5-year
longitudinal study. The outcome of WASTH was defined as the combination
of dyspnea and wheezing improving on rest days or vacation
in an individual who had no asthma previously. Information
about smoking and occupational status was obtained from a questionnaire.
A job exposure matrix of total dust was developed. Multivariate
data analyses were performed using Cox regression.
Measurements and Main Results: The total follow-up time of the employees
(n ¼ 2,476) was 8,469 years, and the median follow-up time
for participantswas 4.0 years.During the follow-up, 91employees developed
WASTH, and the corresponding incidence rate for WASTH
per 1,000 person-years was 8.9 (7.3–10.9) (95% confidence interval
in parentheses). The risk ratio ofWASTH increased significantly (P ¼
0.0001)with dust exposure in the middle andhighcategories (1.0–2.9
and>3.0mg/m3). Stratifiedanalyses showedthat theeffect ofcurrent
dust exposure varied with both previous exposure (PE) to dust and
fumes (P ¼ 0.006) and airflow limitation (AFL) (P ¼ 0.033). The final
analyses showedthat the risk ratios forWASTHper 1mg/m3 increase in
current dust exposure were 1.1 (0.93–1.2), 1.4 (1.1–1.8), 1.6 (1.1–2.3),
and 1.9 (1.2–3.0) for the categories (PE1/AFL2), (PE2/AFL2), (PE1/
AFL1, and (PE2/AFL1).
Conclusions: In conclusion, dust exposure was associated with an increased
incidence of WASTH.
Keywords: work-related asthma-like symptoms; incidence; dust exposure
-
Høiseth, Arne Didrik; Omland, Torbjørn; Hagve, Tor-Arne; Brekke, Pål Haugar & Søyseth, Vidar
(2012).
NT-proBNP independently predicts long term mortality after acute exacerbation of COPD - a prospective cohort study.
Respiratory Research.
ISSN 1465-9921.
13(97).
doi:
10.1186/1465-9921-13-97.
Full text in Research Archive
Show summary
Background Cardiovascular disease is prevalent and frequently unrecognized in patients with chronic obstructive pulmonary disease (COPD). NT-proBNP is an established risk factor in patients with heart failure. NT-proBNP may also be released from the right ventricle. Thus serum NT-proBNP may be elevated during acute exacerbations of COPD (AECOPD). The prognostic value of NT-proBNP in patients hospitalized with AECOPD is sparsely studied. Our objective was to test the hypothesis that NT-proBNP independently predicts long term mortality following AECOPD. Methods A prospective cohort study of 99 patients with 217 admissions with AECOPD. Clinical, electrocardiographic, radiological and biochemical data were collected at index and repeat admissions and analyzed in an extended survival analysis with time-dependent covariables. Results Median follow-up time was 1.9 years, and 57 patients died during follow-up. NT-proBNP tertile limits were 264.4 and 909 pg/mL, and NT-proBNP in tertiles 1 through 3 was associated with mortality rates of 8.6, 35 and 62 per 100 patient-years, respectively (age-adjusted log-rank p<0.0001). After adjustment for age, gender, peripheral edema, cephalization and cTnT in a multivariable survival model, the corresponding hazard ratios for dying were 2.4 (0.95-6.0) and 3.2 (1.3-8.1) (with 95% confidence intervals in parentheses, p-value for trend 0.013). Conclusions NT-proBNP is a strong and independent determinant of mortality after AECOPD.
-
Høiseth, Arne Didrik; Neukamm, Anke; Karlsson, Bo Daniel; Omland, Torbjørn; Brekke, Pål Haugar & Søyseth, Vidar
(2011).
Elevated high-sensitivity cardiac troponin T is associated with increased mortality after acute exacerbation of chronic obstructive pulmonary disease.
Thorax.
ISSN 0040-6376.
66(9),
p. 775–781.
doi:
10.1136/thx.2010.153122.
Full text in Research Archive
-
Søyseth, Vidar; Johnsen, Helle Laier; Bugge, Merete Drevvatne; Hetland, Siri & Kongerud, Johny
(2011).
Incidence of Airflow Limitation Among Employees in Norwegian Smelters.
American Journal of Industrial Medicine.
ISSN 0271-3586.
54(9),
p. 707–713.
doi:
10.1002/ajim.20946.
Full text in Research Archive
Show summary
We have investigated the association between the incidence of airflow limitation and occupational exposure.
The employees (n = 3,924) were investigated annually during five years (n = 16,570) using spirometry. Exposure was classified using job category and a job exposure matrix. Airflow limitation was expressed using two indices: (i) as forced expiratory volume in one second/force vital capacity (FEV1/FVC) <0.7 and (ii) lower limit of normal (LLN).
The incidence of airflow limitation was 21.2/1000 years−1 and 15.1/1000 years−1 using the fixed limit (0.7) and the LLN criterion, respectively. We found a dose–response relationship between the incidence of airflow limitation and tobacco consumption and with job‐category in non‐smokers. The associations between airflow limitation and covariates were independent of how airflow limitation was defined.
The incidence of airflow limitation defined as FEVl/FVC <0.7 yielded higher incidence rates of airflow limitation than LLN. We found a significant association between the incidence of airflow limitation and occupational exposure in non‐smokers.
-
Søyseth, Torunn Stavnes; Søyseth, Vidar & Mengshoel, Anne Marit
(2011).
Pain reduction after a multidisiplinary education programme for elderly women with osteoporosis - a pilot study.
Fysioterapeuten.
ISSN 0016-3384.
p. 16–21.
Full text in Research Archive
-
Søyseth, Vidar; Johnsen, Helle Laier; Bugge, Merete Drevvatne; Hetland, Siri & Kongerud, Johny
(2011).
Prevalence of airflow limitation among employees in Norwegian smelters: a longitudinal study.
Occupational and Environmental Medicine.
ISSN 1351-0711.
68(1),
p. 24–29.
doi:
10.1136/oem.2009.049452.
Full text in Research Archive
Show summary
Aims To investigate the association between airflow limitation and occupational exposure and to compare a fixed limit with an age adjusted limit for airflow limitation.
Methods 3924 employees in 24 Norwegian smelters and related workplaces were investigated annually over 5 years (n=16 570) using spirometry and a respiratory questionnaire on smoking habits and job category. Employees working full time on the production line were classified as line operators; subjects who never worked on the production line were regarded as non-exposed. A job exposure matrix (JEM) was available in most smelters. Airflow limitation was expressed as (i) forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC ratio) <0.7 and (ii) FEV1/FVC ratio less than the lower limit of normal (LLN). Longitudinal analyses on the prevalence of airflow limitation were performed using a generalised linear mixed model.
Results The prevalence of airflow limitation was stable during follow-up. The OR of airflow limitation during follow-up was 1.24 (95% CI 1.03 to 1.50) in line operators compared with unexposed subjects for FEV1/FVC ratio <0.7 and 1.44 (1.14 to 1.81) for FEV1/FVC ratio <LLN. A dose–response relationship was also found between prevalence of airflow limitation and dust exposure. The annual decline in FEV1 was −77.5 (SD 99.9) ml/year in subjects with FEV1/FVC ratio <0.7 and −83.8 (114.2) ml/year in subjects with FEV1/FVC ratio <LLN.
Conclusion Prevalence of airflow limitation was higher in exposed than non-exposed employees. Both the FEV1/FVC ratio <0.7 and FEV1/FVC ratio <LLN identify subjects with accelerated annual decline in FEV1.
-
Johnsen, Helle Laier; Hetland, Siri M.; Saltyte-Benth, Jurate; Kongerud, Johny & Søyseth, Vidar
(2010).
Dust Exposure Assessed by a Job Exposure Matrix Is Associated with Increased Annual Decline in FEV1 A 5-year Prospective Study of Employees in Norwegian Smelters.
American Journal of Respiratory and Critical Care Medicine.
ISSN 1073-449X.
181(11),
p. 1234–1240.
doi:
10.1164/rccm.200809-1381OC.
Full text in Research Archive
Show summary
Rationale: The relationship between dust exposure and annual decline in lung function among employees in the smelting industry is unknown.
Objectives: The aim of the study was to investigate the relationship between annual change in lung function and occupational dust exposure among workers in 15 Norwegian smelters.
Methods: All employees (n = 2,620) were examined annually for 5 years (11,335 health examinations). At each examination spirometry was performed and a respiratory questionnaire was completed. The smelters were grouped as follows: (1) ferrosilicon alloys (FeSi) and silicon metal (Si-metal); and (2) silicon manganese (SiMn), ferromanganese (FeMn), and ferrochromium (FeCr). A job exposure matrix was available on the basis of 2,619 personal dust exposure measurements. The association between lung function expressed as FEV1 and FVC per squared height (height2) and dust exposure was investigated using multivariate linear mixed model analyses.
Measurements and Main Results: The annual change in FEV1/height2 (δFEV1) related to dust exposure in the FeSi/Si-metal and SiMn/FeMn/FeCr smelters was –0.42 (95% confidence interval, −0.95 to 0.11) and −1.1 (−2.1 to −0.12) (ml/m2) × (mg/m3)−1 × year−1, respectively. The annual decline in FEV1/height2 was 1.6 ml/m2 (0.15 to 3.1) steeper in smokers than in nonsmokers. The median geometric mean of the time-weighted dust exposure concentration levels of the employees was 2.3 mg/m3 in the FeSi/Si-metal smelters and 1.6 mg/m3 in the SiMn/FeMn/FeCr smelters. Among nonsmokers, δFEV1 was −0.86 (−1.6 to −0.10) and –1.1 (−2.5 to 0.25) (ml/m2) × (mg/m3)−1 × year−1 in the FeSi/Si-metal and SiMn/FeMn/FeCr smelters, respectively. Thus, for a 1.80 m tall employee the annual decline in FEV1 associated with average dust exposure was 5.7 ml/year in the SiMn/FeMn/FeCr smelters, and 6.4 ml/year for a nonsmoker in the FeSi/Si-metal smelters.
Conclusions: In all smelters combined, the annual change in FEV1 was negatively associated with increasing dust exposure. This association was also significant among workers in SiMn/FeMn/FeCr smelters and among nonsmokers in the FeSi/Si-metal smelters.
-
-
Søyseth, Vidar; Johnsen, Helle Laier; Bugge, M; Hetland, SM & Kongerud, Johny
(2009).
The association between symptoms and dust exposure among employees in the Norwegian smelting industry.
American Journal of Respiratory and Critical Care Medicine.
ISSN 1073-449X.
34,
p. 1845–1845.
Full text in Research Archive
-
Brekke, Pål Haugar; Omland, Torbjørn; Holmedal, S.H.; Smith, Pål & Søyseth, Vidar
(2009).
Determinants of cardiac troponin T elevation in COPD exacerbation - a cross-sectional study.
BMC Pulmonary Medicine.
9(35).
doi:
10.1186/1471-2466-9-35.
Full text in Research Archive
Show summary
Background Cardiac Troponin T (cTnT) elevation during exacerbations of chronic obstructive pulmonary disease (COPD) is associated with increased mortality the first year after hospital discharge. The factors associated with cTnT elevation in COPD are not known. Methods From our hospital's database, all patients admitted with COPD exacerbation in 2000–03 were identified. 441 had measurement of cTnT performed. Levels of cTnT ≥ 0.04 μg/l were considered elevated. Clinical and historical data were retrieved from patient records, hospital and laboratory databases. Odds ratios for cTnT elevation were calculated using logistic regression. Results 120 patients (27%) had elevated cTnT levels. The covariates independently associated with elevated cTnT were increasing neutrophil count, creatinine concentration, heart rate and Cardiac Infarction Injury Score (CIIS), and decreasing hemoglobin concentration. The adjusted odds ratios (95% confidence intervals in parentheses) for cTnT elevation were 1.52 (1.20–1.94) for a 5 × 106/ml increase in neutrophils, 1.21 (1.12–1.32) for a 10 μmol/l increase in creatinine, 0.80 (0.69–0.92) for a 1 mg/dl increase in hemoglobin, 1.24 (1.09–1.42) for a 10 beats/minute increase in heart rate and 1.44 (1.15–1.82) for a 10 point increase in CIIS. Conclusion Multiple factors are associated with cTnT elevation, probably reflecting the wide panorama of comorbid conditions typically seen in COPD. The positive association between neutrophils and cTnT elevation is compatible with the concept that an exaggerated inflammatory response in COPD exacerbation may predispose for myocardial injury.
-
Johnsen, Helle Laier; Søyseth, Vidar; Hetland, SM; Saltyte-Benth, Jurate & Kongerud, Johny
(2008).
Production of silicon alloys is associated with respiratory symptoms among employees in Norwegian smelters.
International Archives of Occupational and Environmental Health.
ISSN 0340-0131.
81,
p. 451–459.
doi:
10.1007/s00420-007-0237-5.
Full text in Research Archive
Show summary
Objectives:
To develop a qualitative exposure classification of employees in Norwegian smelters and to investigate the relationship between respiratory symptoms and occupational exposure using this classification.
Methods:
The 3,924 participants completed a standardised questionnaire including questions of respiratory symptoms, familial asthma, allergy, doctor-diagnosed asthma, smoking habits, previous exposure and occupation. The employees were classified according to their current job function: (1) line operators were employed full time on the production line, (2) non-exposed employees did not work in production, (3) the remaining employees were classified as non-line operators. The association between the prevalence of respiratory symptoms and job category was examined using multivariate logistic regression.
Results:
The mean age of the participants was 38.6 years (standard deviation 9.2 years), 88.5% were males. The odds ratios (OR) (95% confidence intervals in parenthesis) for dyspnoea, cough and phlegm regarding previous exposure compared with no previous exposure were 1.4 (1.1–1.7), 1.4 (1.2–1.8) and 1.3 (1.0–1.7), respectively. The OR in line operators compared with non-exposed employees was 1.2 (0.9–1.7) for dyspnoea, 1.3 (1.0–1.8) for cough and 1.9 (1.4–2.7) for phlegm. The OR for respiratory symptoms was higher in relation to previous exposure than current job function except for phlegm.
Conclusion:
In Norwegian smelters respiratory symptoms appear to be positively related to both current job function and previous exposure. Previous exposure appears to be more important than current job function.
-
Johnsen, Helle Laier; Hetland, SM; Saltyte-Benth, Jurate; Kongerud, Johny & Søyseth, Vidar
(2008).
Quantitative and Qualitative Assessment of Exposure among Employees in Norwegian Smelters.
Annals of Occupational Hygiene.
ISSN 0003-4878.
52(7),
p. 623–633.
doi:
10.1093/annhyg/men046.
Full text in Research Archive
-
Johnsen, Helle Laier; Kongerud, Johny; Hetland, SM; Saltyte-Benth, Jurate & Søyseth, Vidar
(2008).
Decreased lung function among employees at Norwegian smelters.
American Journal of Industrial Medicine.
ISSN 0271-3586.
51(4),
p. 296–306.
doi:
10.1002/ajim.20557.
Full text in Research Archive
-
Søyseth, Vidar; Johnsen, Helle Laier & Kongerud, Johny
(2008).
Prediction of dropout from respiratory symptoms and airflow limitation in a longitudinal respiratory study.
Scandinavian Journal of Work, Environment and Health.
ISSN 0355-3140.
34,
p. 224–229.
Full text in Research Archive
-
Brekke, Pål Haugar; Omland, Torbjørn; Holmedal, S.H.; Smith, Pål & Søyseth, Vidar
(2008).
Troponin T elevation and long-term mortality after chronic obstructive pulmonary disease exacerbation.
European Respiratory Journal.
ISSN 0903-1936.
31,
p. 563–570.
doi:
10.1183/09031936.00015807.
Full text in Research Archive
-
Brekke, Pål Haugar; Omland, Torbjørn; Smith, Pål & Søyseth, Vidar
(2008).
Underdiagnosis of myocardial infartion in COPD - cardiac infarction injury score (CIIS) in patients hospitalised for COPD exacerbation.
Respiratory Medicine.
ISSN 0954-6111.
102,
p. 1243–1247.
doi:
10.1016/j.rmed.2008.04.010.
Full text in Research Archive
-
-
-
-
-
Søyseth, Vidar; Johnsen, Helle Laier; Saltyte-Benth, Jurate; Hetland, SM & Kongerud, Johny
(2007).
Production of silicon metal and alloys is associated with accelerated decline in lung function - A 5-year prospective study among 3924 employees in Norwegian smelters.
Journal of Occupational and Environmental Medicine.
ISSN 1076-2752.
49.
doi:
10.1097/JOM.0b013e3181452830.
Full text in Research Archive
-
Frostad, Anne; Søyseth, Vidar; Andersen, Aage & Gulsvik, Amund
(2006).
Respiratory symptoms as predictors of all-cause mortality in an urban community: a 30-year follow-up.
Journal of Internal Medicine.
ISSN 0954-6820.
259(5),
p. 520–529.
doi:
10.1111/j.1365-2796.2006.01631.x.
Full text in Research Archive
-
Frostad, Anne; Søyseth, Vidar; Haldorsen, Tor; Andersen, Aage & Gulsvik, Amund
(2006).
Respiratory symptoms and 30 year mortality from obstructive lung disease and pneumonia.
Thorax.
ISSN 0040-6376.
61(11),
p. 951–956.
doi:
10.1136/thx.2006.059436.
Full text in Research Archive
-
-
Nystad, Wenche; Søyseth, Vidar & Magnus, Per
(1997).
Forekomsten av astma blant skolebarn i Norge i perioden 1985-94.
Tidsskrift for Den norske legeforening (Tidsskriftet).
ISSN 0029-2001.
117,
p. 644–647.
Full text in Research Archive
-
Søyseth, Vidar; Boe, Jacob & Kongerud, Johny
(1997).
Relation between decline in FEV1 and exposure to dust and tobacco smoke in aluminium potroom workers.
Occupational and Environmental Medicine.
ISSN 1351-0711.
54(1),
p. 27–31.
Full text in Research Archive
-
Søyseth, Vidar; Kongerud, Johny & Boe, Jacob
(1996).
Increased variability in bronchial responsiveness in aluminium potroom workers with work-related asthma-like symptoms.
Journal of Occupational and Environmental Medicine.
ISSN 1076-2752.
38,
p. 66–69.
Full text in Research Archive
-
Søyseth, Vidar; Kongerud, Johny & Boe, Jacob
(1996).
Allergen sensitization and exposure to irritants in infancy.
Allergy. European Journal of Allergy and Clinical Immunology.
ISSN 0105-4538.
51,
p. 719–723.
Full text in Research Archive
View all works in NVA
-
-
Søyseth, Torunn Stavnes; Lund, MB; Haugstad, Gro Killi; Bjørtuft, Øystein; Søyseth, Vidar & Malt, Ulrik Fredrik
(2016).
Significant Associations between emotional coping strategies and psychological distress- a national cohort study of potential lung transplant candidates.
Full text in Research Archive
-
Søyseth, Torunn Stavnes; Haugstad, Gro Killi; Bjørtuft, Øystein; Lund, May Brit; Søyseth, Vidar & Malt, Ulrik Fredrik
(2015).
Psychological distress in Potential Lung Tranplant Candidates: A National Cohort Study.
Full text in Research Archive
-
-
-
-
-
-
-
Søyseth, Torunn Stavnes; Lund, May Britt; Heldal, Aasta; Bjortuft, Øystein; Søyseth, Vidar & Haugstad, Gro Killi
(2012).
Mental Health and bodily pain in patients awaiting lung transplantation. Conclusion: The strong associations between MH and VT and BP may be of clinical relevance. The highly significant differences in PF between COPD and fibrosis may be of clinical importance in patients awaiting lung transplantation.
Full text in Research Archive
-
Søyseth, Torunn Stavnes; Heldal, Aasta; Haugstad, Gro Killi; Søyseth, Vidar; Bjørtuft, Øystein & Lund, May Brit
(2011).
Anxiety, depression and coping in patients awaiting lung transplantation.
Full text in Research Archive
-
Neukamm, Anke; Høiseth, Arne Didrik; Hagve, Tor-Arne; Søyseth, Vidar & Omland, Torbjørn
(2011).
High sensitivity cardiac troponin T levels
are increased in stable COPD (Poster).
Full text in Research Archive
-
Søyseth, Vidar; Johnsen, Helle Laier; Bugge, M & Kongerud, Johny
(2009).
Prevalence and incidence of airflow limitation among employees in Norwegian smelters.
Full text in Research Archive
-
Sjaaheim, T.; Kongerud, Johny & Søyseth, Vidar
(2003).
Work-related asthmatic symptoms in aluminium potroom workers are associated with increased blood eosinophils.
American Journal of Respiratory and Critical Care Medicine.
ISSN 1073-449X.
p. A717–A717.
Full text in Research Archive
-
Søyseth, Vidar; Boe, Jacob & Kongerud, Johny
(1996).
Fall i FEV1 og eksponering for støv og tobakk hos elektrolyseoperatører i aluminiumsindustrien.
Full text in Research Archive
-
-
Høiseth, Arne Didrik; Søyseth, Vidar; Omland, Torbjørn & Brekke, Pål Haugar
(2013).
Myocardial injury and stress during acute exacerbation of chronic obstructive pulmonary disease. A prospective cohort study.
Akademika forlag.
ISSN 9788282647526.
Full text in Research Archive
-
View all works in NVA
Published
Apr. 13, 2011 2:55 PM
- Last modified
May 27, 2011 4:13 PM
