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Biochemical endocrinology and metabolism

The aim of this research group is to explore metabolic aberrations in endocrine diseases for the identification and validation of new biomarkers.

Endocrine and metabolic diseases such as diabetes, thyroid diseases, adrenal diseases and osteoporosis are major causes of morbidity and mortality. The challenges are to identify persons at risk, implement therapeutic and preventive measures and monitor effects of these actions. Adequate diagnostics and follow-up of treatment depend heavily on biomarkers in blood, urine, tears and saliva.

We use transcriptomic, proteomic and metabolomic approaches in close collaboration with the Dept of Endocrinology, Oslo University Hospital(OUS).

Projects

Finding new biomarkers

 Diabetes

  • Proteomic / metabolomic profiling of  human insulin producing cells aiming at discovering biomarkers for cell mas / function

  • Posttranslational modification of albumin in diabetes and late complications of diabetes

 Thyroid disease

  • Prospective evaluation of biomarkers of tear fluid in Graves ophtalmopathy

  • Metabolomic profiling of tear fluid in Graves ophtalmopathy

Basal studies

  • Functional studies of genetic modifications in thyroid hormone resistance
  • Proteomic / metabolomic profiling of human fat tissue
  • Gene expression of  vitamin D stimulated insulin producing cells
  • Metabolomic profiling of hyperglycemic clamp in humans
  • Proteomic profiling of CSF in narcolepsy

Other Projects

  • Influence of estrogen supplementations on cortisol measurements in humans
  • Steroid profiling in congenital adrenal hyperplasia
Published Mar. 15, 2017 12:12 PM - Last modified July 23, 2020 11:39 AM

Contact

Group leader

Participants

  • Jens Petter Berg
  • Milaim Pepaj
  • May L. Bredahl
  • Vigdis Enge
  • Anne Nærby
  • Nina Gjerlaugsen
  • Sandra Rinne Dahl
  • Finn Erik Aas
  • Mette E. Bornstedt
  • Ellen Marie Haave
  • Louise Koren Dahll
  • Svetlana N. Zykova
Detailed list of participants