Biochemical endocrinology and metabolism
The aim of this research group is to explore metabolic aberrations in endocrine diseases for the identification and validation of new biomarkers.
Endocrine and metabolic diseases such as diabetes, thyroid diseases, adrenal diseases and osteoporosis are major causes of morbidity and mortality. The challenges are to identify persons at risk, implement therapeutic and preventive measures and monitor effects of these actions. Adequate diagnostics and follow-up of treatment depend heavily on biomarkers in blood, urine, tears and saliva.
We use transcriptomic, proteomic and metabolomic approaches in close collaboration with the Dept of Endocrinology, Oslo University Hospital(OUS).
Finding new biomarkers
Proteomic / metabolomic profiling of human insulin producing cells aiming at discovering biomarkers for cell mas / function
Posttranslational modification of albumin in diabetes and late complications of diabetes
Prospective evaluation of biomarkers of tear fluid in Graves ophtalmopathy
Metabolomic profiling of tear fluid in Graves ophtalmopathy
- Functional studies of genetic modifications in thyroid hormone resistance
- Proteomic / metabolomic profiling of human fat tissue
- Gene expression of vitamin D stimulated insulin producing cells
- Metabolomic profiling of hyperglycemic clamp in humans
- Proteomic profiling of CSF in narcolepsy
- Influence of estrogen supplementations on cortisol measurements in humans
- Steroid profiling in congenital adrenal hyperplasia