Natural Killer cell biology and cell therapy
The group studies the molecular and cellular basis for NK cell differentiation and NK repertoire development in healthy and sick people.
The main focus of our group's research is to gain insight into how killer cell (NK cell) immunoglobulin-like receptors (KIR) affect the function of human NK cells. KIR are HLA class I-binding receptors with important roles in reproduction and immunity against infections. KIR also have important function in the treatment of leukemia with stem cells transplantation from a donor (allogeneic haematopoietic stem cell transplantation - HSCT).
We examine the factors that stimulate the development of KIR repertoires in allogeneic stem cell transplantation and implications for control of viral reactivation and leukemia relapse.
The group engages in translational research and has established a platform for NK cell-based immunotherapy for patients with cancer recurrence or lack of treatment response.
The research group is mainly based at the Norwegian Radium Hospital and Oslo University Hospital/University of Oslo. However, the group has a node at the Karolinska Institutet and maintain strong interactions with three research networks at the Karolinska Institutet: Immunomodulatory Therapies for Autoimmunity and Cancer (IMTAC), Theme Center for Regenerative Medicine and Center for Infectious Medicine (CIM)
The PI and some group members have double affiliation to CIM.
We always want to get in touch with highly motivated students and potential post-docs. If you are interested in doing research within our group please contact the group leader Kalle Malmberg.