Clinical Pharmacology is the study of pharmacokinetic processes including absorption, distribution, metabolism and excretion, and the response to drugs in the human body. Individual variability in both the pharmacokinetics and effects of drugs is common. The effects/side effects of many drugs are concentration-dependent, highlighting the usefulness of total drug concentration measurement in serum/plasma, so called therapeutic drug monitoring (TDM). Gene variants encoding proteins responsible for drug metabolism and transport, as well as drug actions, may explain some of the concentration/response variability. Our research group is involved in the optimization of drug therapy using TDM, pharmacogenetic analyses, biomarkers and other outcome measures. For drugs and toxic substances, we investigate the relationships between serum concentrations and effects/side effects.
Projects
At Clinical Pharmacology Ullevål:
- Use of antihypertensive drugs, measurements of serum concentrations, cytochrome genes, biomarkers, blood pressure and heart rate in patients treated for hypertension, in collaboration with the IDA-study
- Tailored intervention for identification of harmful use of alcohol and psychoactive drugs among hospitalized patients, AlcoTail - Oslo universitetssykehus HF (in Norwegian)
At the National Centre for Epilepsy, SSE, led by Cecilie Johannessen Landmark, Professor, MSc. Pharm, PhD:
- TDM of antiseizure medications in various patient groups (SSE)
- Pharmacokinetic variability of new antiseizure medications (SSE)
PhD-candidate in the projects: Katrine Heger, MScPharm (OsloMet)
Collaboration with
- Cathrine Brunborg, M.Sc.
- Arne Helland, Ass. Professor, MD, PhD
- The IDA-study: Camilla Lund Søraas, MD, PhD, Clin. Coordinator, and Anne Cecilie Larstorp, Ass. Professor, MD, PhD.
- SSE has national and international collaborators
