The projects main research is the gut microbiota and its impact on chronic inflammatory diseases and autoimmunity.
About the project
In the ERC-funded project StopAutoimmunity we study primary sclerosing cholangitis, a disease of the liver and biliary tree, looking specifically at patients who get recurrent disease after liver transplantation.
The hypothesis is that byproducts of gut bacterial activity contributes to the disease process and that treatment targeting the gut may stop or reverse disease development.
This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 802544.
- Kummen M, Thingholm LB, Rühlemann MC, Holm K, Hansen SH, Moitinho-Silva L, Liwinski T, Zenouzi R, Storm-Larsen C, Midttun Ø, McCann A, Ueland PM, Høivik ML, Vesterhus M, Trøseid M, Laudes M, Lieb W, Karlsen TH, Bang C, Schramm C, Franke A, Hov JR. Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. 2021 Apr;160(5):1784-1798.e0. doi: 10.1053/j.gastro.2020.12.058. Epub 2020 Dec 31. PMID: 33387530; PMCID: PMC7611822.