Academic interests
- General Practice
- Neurology
- Headache incl. migraine
- Medication overuse, addiction, dependency-related behaviour
- Screening and Brief Intervention
- Medical out-of-hour services
- Mountain medicine, wilderness medicine, rescue medicine
Education/background
- 2017 to present: Associate professor, Department of General Practice, University of Oslo
- 2014-2017: Postdoctoral fellow, Department of General Practice, University of Oslo
- 2014: Ph.d with the thesis “Brief Intervention for Medication-overuse headache in primary care”
- 2013-to present: resident, Department of Neurology, Akershus University Hospital
- 2008-2014: PhD student - Department of General Practice, University of Oslo
- 2011: part-time at the central primary care emergency ward in Oslo
- 2010: General practitioner (part-time) in the municipality of Høyanger
- 2007-08: General practitioner and chief medical officer in the municipality of Høyanger
- 2005-07: Intern at Department of Medicine, Orthopedics and Surgery at Helse Førde hospital (Nordfjord/Førde) and the municipality of Balestrand
- 2004-05: Six months as resident doctor with students licentia practicandi at the Acute psychiatric ward, the University Hospital of Northern Norway (UNN)
- 2004 Medical students mandatory practice period at Longyearbyen Hospital, Svalbard 3 months
- 2003 Medical students mandatory practice period at Internal Medicine and Surgery, Hammerfest Hospital 2+2 months
- 2005: Medical degree (MD) University of Tromsø
- 1999-2005: Medical school, University Of Tromsø
Positions held
- 2018-to present: Norwegian representative International Headache Society and European Headache Federation
- 2017-to present: Board member and vice-chair of the Norwegian Headache Society
- 2016-to present: European Academy of Neurology (EAN) Scientific Panel Headache
- 2014-to present: Board member of the International Headache Society (IHS) Trainees and Residents Special Interest Group
- 2013-2014: Member of the group “AG4 – kommunesektoren” in the national strategy process ”HelseOmsorg21”.
- 2012-13: Member of the project group within the Norwegian Medical Association (representing the College of General Practice), working with the plan for further
development of the Norwegian list patient system (“Opptrappingsplan for fastlegeordningen 2015-2020”).
- 2012-2013: Board member of Oslo Legeforening
- 2012-2015: Member of Project Group within the LVS (Doctors in Scientific Positions) and YLF (Junior Hospital Doctors Association), working with recruitment schemes for younger doctors into research
- 2011-2015: Board member of LVS (Doctors in Scientific Positions) at the Norwegian Medial Association
- 2011-2015: Founding member of the Project Group (ALIS-utvalget) within the Norwegian College of General Practice, working with recruitment schemes for younger doctors into primary care
- 2010-12: Board member of the PhD forum at HELSAM (The institute of general practice and public health) , University of Oslo
- 2009-to present: Member of the Network Group for Out-Of-Hours Services at Norwegian College of General Practice (part of the Norwegian Medical Association)
- 2005-2006 Union Representative (Nordfjord Sjukehus), Norwegian Junior Hospital Doctors' Association (YLF), the Norwegian Medical Association
Awards
- European Academy of Neurology (EAN) Investigator Award for the subspecialty Headache - 1st EAN Congress Berlin, Germany June 2015
- Norwegian Neurological Federation - National Headache fellowship 2018
- Best poster presentation at the Norwegian Neurology Congress 2018
- Forsberg og Aulies legat 2018
Collaboration
- Research unit for Neuroscience at Oslo University Hospital
- Health Service Research, Research Centre, Akershus University Hospital
- Head and Neck Research Group, Akershus University Hospital
- Danish Headache Center, Rigshospitalet, Copenhagen, Denmark
- Department of Neuroradiology, Instituto Besta, Milano, Italy
Courses taught
- 2008-to present: Teaching and censorship in various terms (including final exams) in Medical School at the University of Oslo
- 2010-12: Various lectures held twice a year at the Oslo Emergency ward for the doctors there as a part of their educational activity
- 2010-12: Teaching CME groups about headache
- 2010-12: Project and course leader for a CME course called Management of chronic headache in primary care – course held 11 times (15 hours each course)
Publications
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Kristoffersen, Espen Saxhaug; Waage, Siri; Pallesen, Staale & Bjorvatn, Bjørn
(2024).
Changes in work schedule affect headache frequency among Norwegian nurses: A 3-year-follow-up study.
Occupational and Environmental Medicine.
ISSN 1351-0711.
doi:
10.1136/oemed-2023-109164.
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Siepen, Bernhard M.; Forfang, Elisabeth; Branca, Mattia; Drop, Boudewijn; Mueller, Madlaine & Goeldlin, Martina B.
[Show all 36 contributors for this article]
(2024).
Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries.
Stroke and Vascular Neurology.
ISSN 2059-8688.
doi:
10.1136/svn-2023-002813.
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Bjelkarøy, Maria Torheim; Simonsen, Tone Breines; Siddiqui, Tahreem Ghazal; Halset, Sigrid; Cheng, Socheat & Grambaite, Ramune
[Show all 10 contributors for this article]
(2024).
Brief Intervention as a Method to Reduce Z-Hypnotic Use by Older Adults: Feasibility Case Series.
JMIR Formative Research.
ISSN 2561-326X.
8(1).
doi:
10.2196/51862.
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Kristoffersen, Espen Saxhaug; Pallesen, Ståle; Waage, Siri & Bjorvatn, Bjørn
(2024).
The long-term effect of work schedule, shift work disorder, insomnia and restless legs syndrome on headache among nurses: A prospective longitudinal cohort study.
Cephalalgia.
ISSN 0333-1024.
44(1).
doi:
10.1177/03331024231226323.
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Van De Munckhof, Anita; Borhani-Haghighi, Afshin; Aaron, Sanjith; Krzywicka, Katarzyna; Sánchez van Kammen, Mayte & Cordonnier, Charlotte
[Show all 48 contributors for this article]
(2023).
Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries.
International Journal of Stroke.
ISSN 1747-4930.
18(9),
p. 1112–1120.
doi:
10.1177/17474930231182901.
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Ken-Dror, Gie; Sharma, Pankaj; Kristoffersen, Espen Saxhaug & Study Group, CVT VITT
(2023).
ABO blood group associated with cerebral venous thrombosis after Oxford-AstraZeneca COVID-19 vaccination: a case-control study.
Journal of the Royal Society of Medicine.
ISSN 0141-0768.
doi:
10.1177/01410768231214341.
Full text in Research Archive
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Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette & Martinsen, Amy
[Show all 30 contributors for this article]
(2023).
COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study.
Osteoarthritis and Cartilage Open.
ISSN 2665-9131.
6(1),
p. 1–7.
doi:
10.1016/j.ocarto.2023.100424.
Full text in Research Archive
Show summary
Objective:
Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults <40 years of age and can result in loss of life quality. Our aim was to explore the genetic background of DDH in order to improve diagnosis, management and longterm outcome.
Design:
We used the large, ongoing, longitudinal Trøndelag Health Study (HUNT) database. Case definition was based on ICD-9/-10 diagnoses of DDH, or osteoarthritis secondary to DDH. Analyses were performed using SAIGE software, with covariates including sex, batch, birth year and principal components. We included only single nucleotide polymorphisms (SNPs) with minor allele frequency (MAF)
0.01, R2
0.8 and Hardy-Weinberg equilibrium (HWE) P-value
0.0001. Significance level was set at p < 5x10-8. Meta-analysis using data from DDH and primary osteoarthritis genome-wide association studies (GWASs) was done using METAL software. The study was approved by the regional ethical committee.
Results:
Analysis included 69,500 individuals, of which 408 cases, and 8,531,386 SNPs. Two SNPs near COL11A1 were significantly associated with DDH; rs713162 (
= -0.43, SE = 0.07, p = 8.4x10-9) and rs6577334 (
= -0.43, SE = 0.08, p = 8.9x10-9). COL11A1 has previously been associated with acetabular dysplasia and osteoarthritis. Meta-analysis supported previous GWAS findings of both DDH and primary osteoarthritis.
Conclusions:
This large, genome-wide case-control study indicates an association between COL11A1 and DDH and is an important contribution to investigating the etiology of DDH, with further research needed.
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Larsen, Kristin Tveitan; Selseth, Maiken Nordahl; Jahr, Silje Holt; Hillestad, Vigdis; Koubaa, Nojoud & Sandset, Else Charlotte
[Show all 8 contributors for this article]
(2022).
Prehospital Blood Pressure and Clinical and Radiological Outcomes in Acute Spontaneous Intracerebral Hemorrhage.
Stroke.
ISSN 0039-2499.
53(12),
p. 3633–3641.
doi:
10.1161/STROKEAHA.121.038524.
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Nguyen, Thanh N; Qureshi, Muhammad M; Klein, Piers; Yamagami, Hiroshi; Mikulik, Robert & Etminan, Nima
[Show all 275 contributors for this article]
(2022).
Global impact of the COVID-19 pandemic on subarachnoid haemorrhage hospitalisations, aneurysm treatment and in-hospital mortality: 1-year follow-up.
Journal of Neurology, Neurosurgery and Psychiatry.
ISSN 0022-3050.
93(10),
p. 1028–1038.
doi:
10.1136/jnnp-2022-329200.
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Clausen, Tobias Christian; Greve, Nikolaos Kalogeropoulos; Müller, Kai Ivar; Kristoffersen, Espen Saxhaug & Schytz, Henrik Winther
(2022).
Telemedicine in headache care: A systematic review.
Cephalalgia.
ISSN 0333-1024.
42(13),
p. 1397–1408.
doi:
10.1177/03331024221111554.
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Kristoffersen, Espen Saxhaug; Bjorvatn, Bjørn; Halvorsen, Peder Andreas; Nilsen, Stein; Fossum, Guro Haugen & Fors, Egil Andreas
[Show all 12 contributors for this article]
(2022).
The Norwegian PraksisNett: a nationwide practice-based research network with a novel IT infrastructure.
Scandinavian Journal of Primary Health Care.
ISSN 0281-3432.
40(2),
p. 217–226.
doi:
10.1080/02813432.2022.2073966.
Full text in Research Archive
Show summary
Clinical research in primary care is relatively scarce. Practice-based research networks (PBRNs) are research infrastructures to overcome hurdles associated with conducting studies in primary care. In Norway, almost all 5.4 million inhabitants have access to a general practitioner (GP) through a patient-list system. This gives opportunity for a PBRN with reliable information about the general population. The aim of the current paper is to describe the establishment, organization and function of PraksisNett (the Norwegian Primary Care Research Network).
Materials and Methods
We describe the development, funding and logistics of PraksisNett as a nationwide PBRN.
Results
PraksisNett received funding from the Research Council of Norway for an establishment period of five years (2018–2022). It is comprised of two parts; a human infrastructure (employees, including academic GPs) organized as four regional nodes and a coordinating node and an IT infrastructure comprised by the Snow system in conjunction with the Medrave M4 system. The core of the infrastructure is the 92 general practices that are contractually linked to PraksisNett. These include 492 GPs, serving almost 520,000 patients. Practices were recruited during 2019–2020 and comprise a representative mix of rural and urban settings spread throughout all regions of Norway.
Conclusion
Norway has established a nationwide PBRN to reduce hurdles for conducting clinical studies in primary care. Improved infrastructure for clinical studies in primary care is expected to increase the attractiveness for studies on the management of disorders and diseases in primary care and facilitate international research collaboration. This will benefit both patients, GPs and society in terms of improved quality of care.
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Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin Sean; Frei, Oleksandr & Shadrin, Alexey
[Show all 39 contributors for this article]
(2022).
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools.
Brain.
ISSN 0006-8950.
145(1),
p. 142–153.
doi:
10.1093/brain/awab267.
Full text in Research Archive
Show summary
Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five shared risk loci. Using the largest samples to date and novel statistical tools, we aimed to determine the extent to which migraine’s polygenic architecture overlaps with bipolar disorder, depression and schizophrenia beyond genetic correlation, and to identify shared genetic loci. Summary statistics from genome-wide association studies were acquired from large-scale consortia for migraine (n cases = 59 674; n controls = 316 078), bipolar disorder (n cases = 20 352; n controls = 31 358), depression (n cases = 170 756; n controls = 328 443) and schizophrenia (n cases = 40 675, n controls = 64 643). We applied the bivariate causal mixture model to estimate the number of disorder-influencing variants shared between migraine and each mental disorder, and the conditional/conjunctional false discovery rate method to identify shared loci. Loci were functionally characterized to provide biological insights. Univariate MiXeR analysis revealed that migraine was substantially less polygenic (2.8 K disorder-influencing variants) compared to mental disorders (8100–12 300 disorder-influencing variants). Bivariate analysis estimated that 800 (SD = 300), 2100 (SD = 100) and 2300 (SD = 300) variants were shared between bipolar disorder, depression and schizophrenia, respectively. There was also extensive overlap with intelligence (1800, SD = 300) and educational attainment (2100, SD = 300) but not height (1000, SD = 100). We next identified 14 loci jointly associated with migraine and depression and 36 loci jointly associated with migraine and schizophrenia, with evidence of consistent genetic effects in independent samples. No loci were associated with migraine and bipolar disorder. Functional annotation mapped 37 and 298 genes to migraine and each of depression and schizophrenia, respectively, including several novel putative migraine genes such as L3MBTL2, CACNB2 and SLC9B1. Gene-set analysis identified several putative gene sets enriched with mapped genes including transmembrane transport in migraine and schizophrenia. Most migraine-influencing variants were predicted to influence depression and schizophrenia, although a minority of mental disorder-influencing variants were shared with migraine due to the difference in polygenicity. Similar overlap with other brain-related phenotypes suggests this represents a pool of ‘pleiotropic’ variants that influence vulnerability to diverse brain-related disorders and traits. We also identified specific loci shared between migraine and each of depression and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for experimental validation.
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Bergh, Elin; Jahr, Silje Holt; Rønning, Ole Morten; Askim, Torunn; Thommessen, Bente & Kristoffersen, Espen Saxhaug
(2022).
Reasons and predictors of non-thrombolysis in patients with acute ischemic stroke admitted within 4.5 h.
Acta Neurologica Scandinavica.
ISSN 0001-6314.
146(1),
p. 61–69.
doi:
10.1111/ane.13622.
Full text in Research Archive
Show summary
Abstract
Objectives
Thrombolytic treatment in acute ischemic stroke (AIS) reduces stroke-related disability. Nearly 40% of all patients with AIS (<4.5 h) receive thrombolysis, but there is a large variation in the use between hospitals. Little is known about reasons and predictors for not giving thrombolytic treatment. Therefore, we aimed to investigate reasons for non-thrombolysis in patients admitted within 4.5 h.
Methods
All patients with AIS (<4.5 h) admitted to Akershus University Hospital, Norway, between January 2015 and December 2017 were examined. Patient characteristics and reasons for not giving thrombolysis were registered. Descriptive statistics and logistic regression analyses were performed.
Results
Of 535 patients admitted with AIS (<4.5 h), 250 (47%) did not receive thrombolysis and of these only 26% had an absolute contraindication to treatment. Among the 74% with relative contraindications, the most common reasons given were mild and improving symptoms. Previous stroke (OR 3.32, 95%CI 1.99–5.52), arriving between 3 h and 4.5 h after onset (OR 7.76, 95%CI 3.73–16.11) or having mild symptoms (OR 2.33, 95%CI 1.56–3.49) were all significant predictors of not receiving thrombolytic treatment in the multivariable logistic regression model.
Conclusion
A large proportion of patients with AIS do not receive thrombolysis. This study highlights up-to-date findings that arriving late in the time window, mild symptoms, and previous stroke are strong predictors of non-treatment. It is uncertain whether there is an underuse of thrombolysis in AIS. Increasing the utility of thrombolysis in the 4.5 h time window must be weighed against possible harms.
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Do, Thien Phu; Dømgaard, Mikala; Stefansen, Simon; Kristoffersen, Espen Saxhaug; Ashina, Messoud & Hansen, Jakob Møller
(2022).
Barriers and gaps in headache education: a national cross-sectional survey of neurology residents in Denmark.
BMC Medical Education.
ISSN 1472-6920.
22.
doi:
10.1186/s12909-022-03299-6.
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Siddiqui, Tahreem Ghazal; Bjelkarøy, Maria Torheim; Cheng, Socheat; Kristoffersen, Espen Saxhaug; Grambaite, Ramune & Lundqvist, Christofer
(2022).
The effect of cognitive function and central nervous system depressant use on mortality—A prospective observational study of previously hospitalised older patients.
PLOS ONE.
ISSN 1932-6203.
17(3).
doi:
10.1371/journal.pone.0263024.
Full text in Research Archive
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Romoli, Michele; Eusebi, Paolo; Forlivesi, Stefano; Gentile, Mauro; Giammello, Fabrizio & Piccolo, Laura
[Show all 20 contributors for this article]
(2021).
Stroke network performance during the first COVID-19 pandemic stage: A meta-analysis based on stroke network models.
International Journal of Stroke.
ISSN 1747-4930.
16(7),
p. 771–783.
doi:
10.1177/17474930211041202.
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Stubberud, Anker; Buse, Dawn C.; Kristoffersen, Espen Saxhaug; Linde, Mattias & Tronvik, Erling Andreas
(2021).
Is there a causal relationship between stress and migraine? Current evidence and implications for management.
The Journal of Headache and Pain.
ISSN 1129-2369.
22,
p. 1–11.
doi:
10.1186/s10194-021-01369-6.
Full text in Research Archive
Show summary
Background
The purpose of this narrative review is to examine the literature investigating a causal relationship between stress and migraine and evaluate its implications for managing migraine.
Methods
PubMed, PsycINFO and CINAHL were searched from 1988 to August 2021, identifying 2223 records evaluating the relationship between stress and migraine. Records were systematically screened. All potentially relevant records were thematically categorized into six mechanistic groups. Within each group the most recent reports providing new insights were cited.
Results
First, studies have demonstrated an association of uncertain causality between high stress loads from stressful life events, daily hassles or other sources, and the incidence of new-onset migraine. Second, major stressful life events seem to precede the transformation from episodic to chronic migraine. Third, there is some evidence for changes in levels of stress as a risk factor for migraine attacks. Research also suggests there may be a reversed causality or that stress-trigger patterns are too individually heterogeneous for any generalized causality. Fourth, migraine symptom burden seems to increase in a setting of stress, partially driven by psychiatric comorbidity. Fifth, stress may induce sensitization and altered cortical excitability, partially explaining attack triggering, development of chronic migraine, and increased symptom burden including interictal symptom burden such as allodynia, photophobia or anxiety. Finally, behavioral interventions and forecasting models including stress variables seem to be useful in managing migraine.
Conclusion
The exact causal relationships in which stress causes incidence, chronification, migraine attacks, or increased burden of migraine remains unclear. Several individuals benefit from stress-oriented therapies, and such therapies should be offered as an adjuvant to conventional treatment and to those with a preference. Further understanding the relationship between stress, migraine and effective therapeutic options is likely to be improved by characterizing individual patterns of stress and migraine, and may in turn improve therapeutics.
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Kristoffersen, Espen Saxhaug; Faiz, Kashif Waqar; Hansen, Jakob Møller; Tronvik, Erling Andreas; Frich, Jan C & Lundqvist, Christofer
[Show all 7 contributors for this article]
(2021).
The management and clinical knowledge of headache disorders among general practitioners in Norway: a questionnaire survey.
The Journal of Headache and Pain.
ISSN 1129-2369.
22(1),
p. 1–11.
doi:
10.1186/s10194-021-01350-3.
Full text in Research Archive
Show summary
Background
General practitioners (GPs) diagnose and manage a majority of headache patients seeking health care. With the aim to understand the potential for clinical improvement and educational needs, we performed a study to investigate Norwegian GPs knowledge about headache and its clinical management.
Methods
We invited GPs from a random sample of 130 Norwegian continuous medical education (CME) groups to respond to an anonymous questionnaire survey.
Results
367 GPs responded to the survey (73% of invited CME groups, 7.6% of all GPs in Norway). Mean age was 46 (SD 11) years, with an average of 18 (SD 10) years of clinical experience. In general the national treatment recommendations were followed, while the International Classification of Headache Disorders and other international guidelines were rarely used. Overall, 80% (n = 292) of the GPs suggested adequate prophylactic medication for frequent episodic migraine, while 28% (n = 101) suggested adequate prophylactic medication for chronic tension-type headache (CTTH). Half (52%, n = 191)) of the respondents were aware that different types of acute headache medication can lead to medication-overuse headache (MOH), and 59% (n = 217) knew that prophylactic headache medication does not lead to MOH. GPs often used MRI in the diagnostic work-up. GPs reported that lack of good treatment options was a main barrier to more optimized treatment of headache patients.
Conclusion
The knowledge of management of CTTH and MOH was moderate compared to migraine among Norwegian GPs.
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Harder, Aster V.E.; Winsvold, Bendik K S; Noordam, Raymond; Vijfhuizen, Lisanne S.; Børte, Sigrid & Kogelman, Lisette J.A.
[Show all 22 contributors for this article]
(2021).
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache.
Annals of Neurology.
ISSN 0364-5134.
90(2),
p. 203–216.
doi:
10.1002/ana.26146.
Full text in Research Archive
Show summary
Objective
Identifying common genetic variants that confer genetic risk for cluster headache.
Methods
We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord-Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell-derived RNA-sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses.
Results
An association was found with cluster headache for 4 independent loci (r2 < 0.1) with genomewide significance (p < 5 × 10−8), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33–1.72 near RP11-815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37–1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26–1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54–0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene-based mapping yielded ASZ1 as possible fifth locus. RNA-sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients.
Interpretation
This genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders.
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Bjørk, Marte-Helene; Kristoffersen, Espen Saxhaug; Tronvik, Erling Andreas & Nordeng, Hedvig Marie Egeland
(2021).
Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding.
European Journal of Neurology.
ISSN 1351-5101.
28(7),
p. 2443–2455.
doi:
10.1111/ene.14864.
Full text in Research Archive
Show summary
Many clinicians lack experience in managing trigeminal autonomic cephalalgias (TACs) in pregnancy and lactation. In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing/autonomic symptoms (SUNCT/SUNA). Treating these rare, severe headache conditions often requires off-label drugs that have uncertain teratogenic potential. In the last few years, several new treatment options and safety documentation have emerged, but clinical guidelines are lacking. This narrative review aimed to provide an updated clinical guide and good clinical practice recommendations for the management of these debilitating headache disorders in pregnancy and lactation.
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Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S; Sandset, Else Charlotte; Storstein, Anette & Faiz, Kashif Waqar
(2021).
Experiences, distress and burden among neurologists in Norway during the COVID-19 pandemic.
PLOS ONE.
ISSN 1932-6203.
16:e0246567(2),
p. 1–14.
doi:
10.1371/journal.pone.0246567.
Full text in Research Archive
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Kristoffersen, Espen Saxhaug; Jahr, Silje Holt; Faiz, Kashif Waqar; Thommessen, Bente & Rønning, Ole M.
(2021).
Stroke admission rates before, during and after the first phase of the COVID-19 pandemic.
Neurological Sciences.
ISSN 1590-1874.
42(3),
p. 791–798.
doi:
10.1007/s10072-021-05039-y.
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Kristoffersen, Espen Saxhaug; Jahr, Silje Holt; Faiz, Kashif Waqar; Storstein, Anette; Winsvold, Bendik K S & Sandset, Else Charlotte
(2021).
Acute stroke care during the first phase of COVID-19 pandemic in Norway.
Acta Neurologica Scandinavica.
ISSN 0001-6314.
143(4),
p. 349–354.
doi:
10.1111/ane.13392.
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Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker & Winsvold, Bendik K S
(2020).
Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study.
BMJ Open.
ISSN 2044-6055.
10.
doi:
10.1136/bmjopen-2020-040685.
Full text in Research Archive
Show summary
Objectives: To evaluate the association between caesarean section and migraine in a population-based register-linked cohort study.
Setting: Data from the population-based Nord-Trøndelag Health Studies (HUNT2 and HUNT3) were linked to information from the Norwegian Medical Birth Registry.
Participants: 65 343 participants responded to the headache questions in any of the two HUNT studies. Only those answering the headache questions in HUNT2 or 3 and had information about mode of delivery in the Norwegian Medical Birth Registry (born after 1967) were included. Our final sample consisted of 6592 women and 4602 men, aged 19–41 years.
Outcomes: ORs for migraine given caesarean section. Analyses were performed in multivariate logistic regression models.
Results: After adjusting for sex, age and fetal growth restriction, delivery by caesarean section was not associated with migraine later in life (OR 0.86, 95% CI 0.64 to 1.15). Delivery by caesarean section was associated with a reduced OR of non-migrainous headache (OR 0.77, 95% CI 0.60 to 0.99).
Conclusion: No association was found between caesarean section and migraine in this population-based register-linked study.
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Kristoffersen, Espen Saxhaug; Harper, Charlotte Elena; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller & Faiz, Kashif Waqar
(2020).
Incidence and mortality of cerebral venous thrombosis in a Norwegian population.
Stroke.
ISSN 0039-2499.
51(10),
p. 3023–3029.
doi:
10.1161/STROKEAHA.120.030800.
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Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Stavem, Knut; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer
(2020).
Health-related quality of life in hospitalized older patients with versus without prolonged use of opioid analgesics, benzodiazepines, and z-hypnotics: a cross-sectional study.
BMC Geriatrics.
ISSN 1471-2318.
20(425),
p. 1–9.
doi:
10.1186/s12877-020-01838-8.
Full text in Research Archive
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Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker & Winsvold, Bendik K S
(2020).
Migraine, obesity and body fat distribution - a population-based study.
The Journal of Headache and Pain.
ISSN 1129-2369.
21,
p. 1–8.
doi:
10.1186/s10194-020-01163-w.
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Background:
Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between obesity and headache in a large, population-based study where we could take into account body fat distribution, migraine subtypes and tension-type headache.
Methods:
The third population-based Nord-Trøndelag Health Study (HUNT3) included validated headache questionnaires and objective anthropometric measurements. Using a cross-sectional design, our sample consisted of 18,191 women and 14,985 men, aged 19 to 96 years. Of these 4290 (12.9%) had migraine, 4447 (13.4%) had frequent tension-type headache (TTH), and 24,439 were headache-free controls. A total of 5049 individuals with unclassified headache were excluded from the analyses. Using logistic regression, we modeled the association between obesity and headache prevalence, adjusting for relevant confounders.
Results:
Both total body obesity (TBO) and abdominal obesity (AO) were associated with a higher prevalence of migraine when compared to headache-free controls (OR 1.45 95% CI 1.32–1.59 and OR 1.29 95% CI 1.18–1.41, respectively), in particular for individuals < 50 years of age (OR 1.74 95% CI 1.54–1.98 and OR 1.89 95% CI 1.69–2.11). Similar results were seen for migraine with and without aura. Similar Overall, a weaker associations were as observed between obesity and TTH. There was a dose-response relationship between obesity categories and increased headache frequency in subjects with migraine. TBO was associated with migraine prevalence and attack frequency independent of AO.
Conclusion:
Both TBO and AO were associated with migraine prevalence and attack frequency. This association was largely limited to individuals < 50 years of age. TBO, rather than AO, may be a better measure of obesity in relation to migraine.
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Siddiqui, Tahreem Ghazal; Cheng, Socheat; Gossop, Michael; Kristoffersen, Espen Saxhaug; Grambaite, Ramune & Lundqvist, Christofer
(2020).
Association between prescribed central nervous system depressant drugs, comorbidity and cognition among hospitalised older patients: a cross-sectional study.
BMJ Open.
ISSN 2044-6055.
10(7).
doi:
10.1136/bmjopen-2020-038432.
Full text in Research Archive
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Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi & Posner, Daniel C.
[Show all 57 contributors for this article]
(2022).
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.
Nature.
ISSN 0028-0836.
doi:
10.1038/s41586-022-05492-5.
Show summary
In the version of this article initially published, the name of the
PRECISE4Q Consortium was misspelled as “PRECISEQ” and has now
been amended in the HTML and PDF versions of the article. Further,
data in the first column of Supplementary Table 55 were mistakenly
shifted and have been corrected in the file accompanying the HTML
version of the article
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Jahr, Silje Holt; Sandset, Else Charlotte; Faiz, Kashif Waqar; Larsen, Kristin Tveitan; Hillestad, Vigdis & Selseth, Maiken Nordahl
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(2022).
PRE-HOSPITAL SYSTOLIC BLOOD PRESSURE AND DIAGNOSIS IN SUSPECTED STROKE: THE AKERSHUS STUDY OF ISCHEMIC STROKE AND THROMBOLYSIS-1.
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Bjerkreim, Anna Therese; Jahr, Silje Holt; Faiz, Kashif Waqar; Larsen, Kristin Tveitan; Hillestad, Vigdis & Selseth, Maiken Nordahl
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(2022).
TIME ON SCENE BEFORE ADMISSION OF ACUTE STROKE AND STROKE MIMICS: THE AKERSHUS STUDY OF ISCHEMIC STROKE AND THROMBOLYSIS-1.
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Larsen, Kristin Tveitan; Selseth, Maiken Nordahl; Jahr, Silje Holt; Hillestad, Vigdis; Koubaa, Nojoud & Sandset, Else Charlotte
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(2022).
IMPACT OF ANTITHROMBOTIC TREATMENT ON ASSOCIATIONS BETWEEN PREHOSPITAL SYSTOLIC BLOOD PRESSURE AND OUTCOMES IN ACUTE, SPONTANEOUS INTRACEREBRAL HAEMORRHAGE.
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Koubaa, Nojoud; Larsen, Kristin Tveitan; Hillestad, Vigdis; Selseth, Maiken Nordahl; Jahr, Silje Holt & Faiz, Kashif Waqar
[Show all 13 contributors for this article]
(2022).
EPIDEMIOLOGY AND CLINICAL PRESENTATION OF SPONTANEOUS CEREBELLAR HEMORRHAGE IN A NORWEGIAN POPULATION.
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Krzywicka, Katarzyna; Sánchez Van Kammen, Mayte; Sousa, Diana Aguiar de; Heldner, Mirjam R; Aron, S & Jiang, D.
[Show all 31 contributors for this article]
(2022).
DIRECT ORAL ANTICOAGULANTS FOR THE TREATMENT OF CEREBRAL VENOUS THROMBOSIS (DOAC-CVT).
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Dharmi, Sanpreet Grewal; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller; Faiz, Kashif Waqar & Kristoffersen, Espen Saxhaug
(2022).
CLINICAL PRESENTATION AND LONG-TERM OUTCOMES OF CEREBRAL VENOUS THROMBOSIS IN A NORWEGIAN POPULATION.
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Altmann, Marianne; Rønning, Ole Morten; Fure, Brynjar; Selnes, Per; Reichenbach, Antje & Kristoffersen, Espen Saxhaug
[Show all 7 contributors for this article]
(2022).
SHORT- AND LONG-TERM MORTALITY AFTER LACUNAR INFARCT.
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Do, Thien Phu; Dømgaard, Mikala; Stefansen, Simon; Kristoffersen, Espen Saxhaug; Ashina, Messoud & Møller Hansen, Jakob
(2022).
Barriers and gaps in headache education: a national cross-sectional survey of neurology residents in Denmark.
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Bjelkarøy, Maria Torheim; Simonsen, Tone Breines; Siddiqui, Tahreem Ghazal; Halset, Sigrid; Cheng, Socheat & Grambaite, Ramune
[Show all 10 contributors for this article]
(2022).
Brief intervention as a method for reducing use of z-hypnotics in older adult – a feasibility study
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Bjelkarøy, Maria Torheim; Simonsen, Tone Breines; Siddiqui, Tahreem Ghazal; Halset, Sigrid; Cheng, Socheat & Grambaite, Ramune
[Show all 10 contributors for this article]
(2022).
Brief intervention as a method for reducing use of z-hypnotics in older adult – a feasibility study
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Nilsen, Stein; Bjorvatn, Bjørn & Kristoffersen, Espen Saxhaug
(2021).
PraksisNett- status etter tre år.
Utposten.
ISSN 0800-5680.
2-2021.
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Bjelkarøy, Maria Torheim; Siddiqui, Tahreem Ghazal; Cheng, Socheat; Benth, Jurate Saltythè; Simonsen, Tone Breines & Halset, Sigrid
[Show all 9 contributors for this article]
(2021).
Brief intervention as a method for reducing z
hypnotics in the older adult a feasibility study.
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Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Benth, Jurate Saltythè; Grambaite, Ramune & Kristoffersen, Espen Saxhaug
[Show all 7 contributors for this article]
(2021).
Pain and central nervous system depressing medication in hospitalised Norwegian older adults.
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Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Benth, Jurate Saltythè; Grambaite, Ramune & Kristoffersen, Espen Saxhaug
[Show all 7 contributors for this article]
(2021).
Pain and central nervous system depressing medication in hospitalised Norwegian older adults.
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Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Benth, Jūratė Šaltytė; Grambaite, Ramune & Kristoffersen, Espen Saxhaug
[Show all 7 contributors for this article]
(2021).
The association between pain and central nervous system depressing medication among hospitalised Norwegian older adults ( - and onwards from there; a pilot RCT).
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Kristoffersen, Espen Saxhaug; Faiz, Kashif Waqar; Sandset, Else Charlotte; Storstein, Anette; Stefansen, Simon & Winsvold, Bendik K S
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(2020).
Correction to: Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway (The Journal of Headache and Pain, (2020), 21, 1, (128), 10.1186/s10194-020-01195-2).
The Journal of Headache and Pain.
ISSN 1129-2369.
21(1).
doi:
10.1186/s10194-020-01199-y.
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Kristoffersen, Espen Saxhaug
(2019).
Cerebral venetrombose.
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Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer
(2019).
Characteristics of at-risk patients and a reliable screening tool for detecting medication dependence among elderly patients.
European Journal of Neurology.
ISSN 1351-5101.
26.
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Siddiqui, Tahreem Ghazal; Cheng, Socheat; Grambaite, Ramune; Michele, Gossop; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer
(2019).
Long-term use of central nervous system depressant medications is associated with reduced cognitive function in hospitalised older patients: a cross sectional study.
European Journal of Neurology.
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26.
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Harper, Charlotte Elena; Faiz, Kashif Waqar; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller & Kristoffersen, Espen Saxhaug
(2019).
Incidence and mortality of cerebral
venous thrombosis in a Norwegian
population.
European Journal of Neurology.
ISSN 1351-5101.
26,
p. 382–382.
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Harper, Charlotte Elena; Faiz, Kashif Waqar; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller & Kristoffersen, Espen Saxhaug
(2019).
INCIDENCE AND MORTALITY OF CEREBRAL VENOUS THROMBOSIS IN A NORWEGIAN POPULATION.
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4,
p. 321–322.
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Kristoffersen, Espen Saxhaug; REICHENBACH, ANTJE; Faiz, Kashif Waqar; Bergh, Elin; Baar, Anette & Altmann, Marianne
[Show all 9 contributors for this article]
(2019).
Prehospital tidsbruk ved hjerneslag. Tid brukt på hentested.
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Harper, Charlotte Elena; Faiz, Kashif Waqar; Aaseth, Kjersti; Vetvik, Kjersti & Kristoffersen, Espen Saxhaug
(2019).
Reinnleggelse i nevrologisk avdeling grunnet postpunksjonshodepine etter utredning av akutt hodepine.
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Aaseth, Kjersti; Harper, Charlotte Elena; Vetvik, Kjersti; Faiz, Kashif Waqar & Kristoffersen, Espen Saxhaug
(2019).
Utredning av subaraknoidalblødning – fortsatt behov for spinalpunksjon?
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Carlsen, Louise N; Høst, Christel; Dømgaard, Mikala; Kristoffersen, Espen Saxhaug & Jensen, Rigmor Højland
(2019).
Brief Intervention – treatment of medication
overuse headache in primary and secondary
care, a study protocol.
Cephalalgia.
ISSN 0333-1024.
39.
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Snoer, A. H.; Lund, Nunu; Jensen, Rigmor Højland; Kristoffersen, Espen Saxhaug; Barloese, Mads & Hansen, Jakob Møller
(2019).
More precise phenotyping of cluster headache
using prospective attack reports.
Cephalalgia.
ISSN 0333-1024.
39.
doi:
10.1177/0333102419859835.
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Carlsen, Louise N; Høst, Christel; Dømgaard, Mikala; Kristoffersen, Espen Saxhaug; Jensen, Rigmor Højland & Hansen, Jakob Møller
(2019).
Brief Intervention – treatment of medication overuse headache in primary and secondary care, a study
protocol.
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Snoer, A. H.; Lund, Nunu; Jensen, Rigmor Højland; Kristoffersen, Espen Saxhaug; Barloese, Mads & Hansen, Jakob Møller
(2019).
More precise phenotyping of cluster headache using prospective attack reports.
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Published
Apr. 13, 2011 2:45 PM
- Last modified
Dec. 3, 2018 11:17 AM
