Thomas Sæther

Associate Professor - Nuclear Receptor Group
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Phone +47-22851510
Room 4120
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Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1046 Blindern 0317 OSLO
Other affiliations Department of Nutrition

Academic Interests

I am an Associate Professor in the Molecular Nutrition research group, where we study energy balance and lifestyle diseases. In a collaborative effort with the University of Tromsø and MabCent - SFI we try to identify novel nuclear receptor ligands from marine invertebrates and evaluate them as drug candidates to treat type 2 diabetes and metabolic syndrome.

Teaching responsibilities

Social media

Higher education and employment history

  • Postdoc in the MYB group at IMBV, UiO, from 2008 to 2012, focusing on the transcription factor c-Myb, eukaryotic gene regulation, transcription, chromatin, epigenetics, and post-translational modification, especially SUMOylation.
  • PhD in molecular biosciences, UiO, 2008: Positive and negative modulation of the transactivation potential of the transcription factor c-Myb - novel regulatory mechanisms for a classical proto-oncoprotein. Read more
  • MSc in biochemistry, UiO, 2003:  Metabolism of polyunsaturated fatty acids in rat testis. Read more

Honoraria

  • Throne Holst Foundation of Nutrition Research, Best poster 2016: Anti-diabetic activity from marine lipids: new anti-diabetic drug.
  • Nordic Association for Andrology’s Young Scientist Award, 2001: Effect of dietary fats, insulin and dexamethasone on delta-6-desaturase expression in rat testis.

Collaboration

  • Prof. Trond Vidar Hansen, Dept. of Pharmaceutical Chemistry , UiO: Chemical synthesis of PPAR-activating compounds.
  • Prof. Ingebrigt Sylte, Dept. of Medical Biology, UiT The Arctic University of Norway: 3D in silico docking of PPAR-agonists.
  • Senior Scientist Steinar Paulsen, MabCent - SFI, UiT The Arctic University of Norway: HTS for novel nuclear receptor ligands from marine invertebrates.
  • Prof. Dan Voytas, University of Minnesota: Design of zincfinger nucleases for targeted gene editing.
  • Prof. Tom Gonda, University of Queensland: Studies of the transforming potential of the transcription factor c-Myb.

Publications

Moldes-Anaya, A, Sæther T, Uhlig S, Nebb HI, Larsen T, Eilertsen HC, Paulsen SM (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Mar Drugs 15(6):148.

Lorenzo PI, Brendeford EM, Gilfillan S, Gavrilov AA, Leedsak M, Razin SV, Eskeland R, Sæther T, Gabrielsen OS (2011) Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes Cancer 2(8):805-17.

Haugen TB, Tefre T, Malm G, Jönsson BA, Rylander L, Hagmar L, Bjørsvik C, Henrichsen T, Sæther T, Figenschau Y, Giwercman A (2011) Differences in serum levels of CB-153 and p,p'-DDE, and reproductive parameters between men living south and north in Norway. Reprod Toxicol 32(3):261-7.

Alm-Kristiansen AH, Lorenzo PI, Molværsmyr AK, Matre V, Ledsaak M, Sæther T, Gabrielsen OS (2011) PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Mol Cancer 10:21.

Sæther T, Pattabiraman DR, Alm-Kristiansen AH, Vogt-Kielland LT, Gonda TJ, Gabrielsen OS (2011) A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene 30(2):212-22.

Molværsmyr AK, Sæther T, Gilfillan S, Lorenzo PI, Kvaløy H, Matre V, Gabrielsen OS (2010) A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Res 38(15):4970-84.

Rylander L, Wetterstrand B, Haugen TB, Malm G, Malm J, Bjørsvik C, Henrichsen T, Sæther T, Giwercman A (2009) Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian J Androl 11(6):723-30.

Alm-Kristiansen AH, Sæther T, Matre V, Gilfillan S, Dahle O, Gabrielsen OS (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene 27(34):4644-56.

Berge T, Matre V, Brendeford EM, Sæther T, Lüscher B, Gabrielsen OS (2007) Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown. Blood Cells Mol Dis 39(3):278-86.

Ruhayel Y, Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Rylander L, Levine RJ, Giwercman A (2007) Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clin Endocrinol (Oxf). 67(1):85-92.

Sæther T, Berge T, Ledsaak M, Matre V, Alm-Kristiansen AH, Dahle O, Aubry F, Gabrielsen OS (2007) The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. J Biol Chem 282(19):13994-4005.

Sæther T, Tran TN, Rootwelt H, Grav HJ, Christophersen BO, Haugen TB (2007) Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction 133(2):467-77.

Aschim EL, Sæther T, Wiger R, Grotmol T, Haugen TB (2004). Differential distribution of splice variants of estrogen receptor beta in human testicular cells suggests specific functions in spermatogenesis. J Steroid Biochem Mol Biol 92(1-2):97-106.

Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Hagmar L, Rylander L, Levine RJ, Giwercman A (2004) Reproductive function during summer and winter in Norwegian men living north and south of the Arctic circle. J Clin Endocrinol Metab 89(9):4397-402.

Sæther T, Tran TN, Rootwelt H, Christophersen BO, Haugen TB (2003) Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Biol Reprod 69(1):117-24.

  • Moldes-Anaya, Angel; Sæther, Thomas; Uhlig, Silvio; Nebb, Hilde Irene; Larsen, Terje; Eilertsen, Hans Christian & Paulsen, Steinar Martin (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ . Marine Drugs.  ISSN 1660-3397.  15(148) . doi: 10.3390/md15060148
  • Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Molværsmyr, Ann-Kristin; Matre, Vilborg; Ledsaak, Marit; Sæther, Thomas & Gabrielsen, Odd Stokke (2011). PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Molecular Cancer.  ISSN 1476-4598.  10 . doi: 10.1186/1476-4598-10-21
  • Haugen, Trine B.; Tefre, Toril; Malm, Gunilla; Jønsson, Bo AG; Rylander, Lars; Hagmar, Lars; Bjørsvik, Cathrine; Henrichsen, Trine; Sæther, Thomas; Figenschau, Yngve & Giwercman, Aleksander (2011). Differences in serum levels of CB-153 and p,p '-DDE, and reproductive parameters between men living south and north in Norway. Reproductive Toxicology.  ISSN 0890-6238.  32(3), s 261- 267 . doi: 10.1016/j.reprotox.2011.06.072
  • Lorenzo, Petra Isabel O.; Brendeford, Elen Margrethe; Gilfillan, Siv; Gavrilov, Alexey A; Ledsaak, Marit; Razin, Sergey V; Eskeland, Ragnhild; Sæther, Thomas & Gabrielsen, Odd Stokke (2011). Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes & cancer.  ISSN 1947-6019.  2(8), s 805- 817 . doi: 10.1177/1947601911428224
  • Sæther, Thomas; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege; Vogt- Kielland, Linn Troye; Gonda, T.J. & Gabrielsen, Odd Stokke (2011). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene.  ISSN 0950-9232.  30(2), s 212- 222 . doi: 10.1038/onc.2010.397
  • Molværsmyr, Ann-Kristin; Sæther, Thomas; Gilfillan, Siv; Lorenzo, Petra Isabel O.; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2010). A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Research.  ISSN 0305-1048.  38(15), s 4970- 4984 . doi: 10.1093/nar/gkq245
  • Rylander, Lars; Wetterstrand, Boel; Haugen, Trine B.; Malm, Gunilla; Malm, Johan; Bjørsvik, Cathrine; Henrichsen, Trine; Sæther, Thomas & Giwercman, Aleksander (2009). Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian Journal of Andrology.  ISSN 1008-682X.  11(6), s 723- 730 . doi: 10.1038/aja.2009.64
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Matre, Vilborg; Otnæss, Siv Kolstø; Dahle, Øyvind & Gabrielsen, Odd Stokke (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene.  ISSN 0950-9232.  27, s 4644- 4656 . doi: 10.1038/onc.2008.105
  • Berge, Tone; Matre, Vilborg; Brendeford, Elen Margrethe; Sæther, Thomas; Lüscher, Bernhard & Gabrielsen, Odd Stokke (2007). Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitaion and c-Myb knockdown. Blood Cells, Molecules & Diseases.  ISSN 1079-9796.  39(3), s 278- 286 . doi: 10.1016/j.bcmd.2007.05.007
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Yngve; Rylander, Lars; Levine, Richard J. & Giwercman, Aleksander (2007). Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clinical Endocrinology.  ISSN 0300-0664.  67 . doi: 10.1111/j.1365-2265.2007.02843.x
  • Sæther, Thomas; Berge, T; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege; Dahle, O; Aubry, F & Gabrielsen, Odd Stokke (2007). The chromatin remodeling factor Mi-2 alpha acts as a novel co-activator for human c-Myb. Journal of Biological Chemistry.  ISSN 0021-9258.  282 . doi: 10.1074/jbc.M700755200
  • Sæther, Thomas; Tran, TN; Rootwelt, H; Grav, HJ; Christophersen, BO & Haugen, Trine B. (2007). Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction.  ISSN 1470-1626.  133(2), s 467- 477 . doi: 10.1530/REP-06-00294
  • Aschim, Elin L.; Sæther, Thomas; Wiger, Richard; Grotmol, Tom & Haugen, Trine B. (2004). Differential distribution of splice variants of estrogen receptor β in human testicular cells suggests specific functions in spermatogenesis. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  92(1-2), s 97- 106
  • Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Yngve; Hagmar, Lars; Rylander, Lars; Levine, Richard J. & Giwercman, Aleksander (2004). Reproductive function during summer and winter in Norwegian men living north and south of the Arctic Circle. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  89(9), s 4397- 4402
  • Sæther, Thomas; Tran, Thien Ngoc; Rootwelt, Helge; Christophersen, Bjørn & Haugen, Trine Berit (2003). Expression and Regulation of delta 5-Desaturase, delta 6-Desaturase, Stearoyl-Coenzyme A (CoA) Desaturase 1, and Stearoyl-CoA Desaturase 2 in Rat Testis. Biology of Reproduction.  ISSN 0006-3363.  69, s 117- 124

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  • Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin; Sylte, Ingebrigt; Hansen, Trond Vidar & Nebb, Hilde Irene (2015). Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Sæther, Thomas (2014). Anti-diabetic activity from marine lipids (ADAM): New anti-diabetic drugs.
  • Bindesbøll, Christian; Fan, Qiong; Sæther, Thomas; Dalen, Knut Tomas; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2013). Nuclear receptors as targets for treatment and prevention of metabolic diseases.
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2013). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets.
  • Moldes-Anaya, Angel; Sæther, Thomas; Larsen, Laila Norrheim; Larsen, Terje; Nebb, Hilde Irene & Paulsen, Steinar (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Moldes-Anaya, Angel; Sæther, Thomas; Norrheim-Larsen, Laila; Nebb, Hilde Irene; Larsen, Terje & Paulsen, Steinar (2013). Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae.
  • Sæther, Thomas; Moldes-Anaya, Angel; Larsen, Laila Norrheim; Larsen, Terje; Paulsen, Steinar & Nebb, Hilde Irene (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2012). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets.
  • Molværsmyr, Ann-Kristin; Ledsaak, Marit; Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Matre, Vilborg; Sæther, Thomas & Gabrielsen, Odd Stokke (2012). The SUMO E3 ligase PIAS1 interacts with c-Myb and enhances its transcriptional activity.
  • Sæther, Thomas; Bengtsen, Mads; Molværsmyr, Ann-Kristin; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege; Ledsaak, Marit; Gonda, T.J. & Gabrielsen, Odd Stokke (2012). Regulating the regulator: SUMO functions as a master switch for the transcription factor c-Myb.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Gilfillan, Siv; Alm-Kristiansen, Anne Hege; Aabel, Linn Ingeborg; Matre, Vilborg & Gabrielsen, Odd Stokke (2011). The hematopoietic transcription factor c-Myb functions as an epigenetic organizer.
  • Rangberg, Anbjørg; Sæther, Thomas & Gabrielsen, Odd Stokke (2010). Design of a system for inducible SUMOylation of the transcription factor c-Myb.
  • Sæther, Thomas & Erling, Hobøl (2010). Hekkefugltaksering på Fautøya og Rossholmens vesttange, Sesongrapport 2010 .
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Gilfillan, Siv; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2010). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch.
  • Sæther, Thomas; Pattabiraman, D.R.; Aabel, Linn Ingeborg; Matre, Vilborg; Gonda, T.J. & Gabrielsen, Odd Stokke (2010). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability.
  • Kvebæk, Yngve; Sæther, Thomas; Aspelund, Trond & Hobøl, Erling (2009). NORDRE ØYEREN - Trend, trekkprofil og preferanseområde for viktige vannfuglarter - Komplett statusliste og øvrige artsvurderinger .
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2009). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch.
  • Vollsund, Pernille; Bergholtz, Stine Louise; Sæther, Thomas; Aasland, Rein & Gabrielsen, Odd Stokke (2009). Understanding the phosphorylation-sumoylation cross talk in the transcription factor c-Myb.
  • Sæther, Thomas (2008). Positive and negative modulation of the transactivation potential of the transcription factor c-Myb - novel regulatory mechanisms for a classical proto-oncoprotein .
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Matre, Vilborg; Lorenzo, Petra Isabel O. & Gabrielsen, Odd Stokke (2008). SUMO-conjugation of the transcription factor c-Myb controls cooperative behaviour and induces an activator-to-repressor switch in the negative regulatory domain.
  • Molværsmyr, Ann-Kristin; Kvaløy, Heidi; Sæther, Thomas; Matre, Vilborg & Gabrielsen, Odd Stokke (2007). Controlling gene expression through SUMO-conjugation - the importance of synergy.
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege; Dahle, Øyvind; Aubry, Florence & Gabrielsen, Odd Stokke (2007). The chromatin remodelling factor Mi-2alpha acts as a novel co-activator for human c-Myb.
  • Sæther, Thomas; Tran, Thien N.; Rootwelt, Helge; Grav, Hans J.; Christophersen, Bjørn O. & Haugen, Trine B. (2006). Desaturase expression, lipid profile, and sperm morphology are differently affected by fat free diet in cauda and caput epididymis in the rat.
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Ledsaak, Marit; Matre, Vilborg & Gabrielsen, Odd Stokke (2006). FLASH is a coregulator of the transcription factor c-Myb.
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Yngve; Hagmar, Lars; Rylander, Lars; Levine, Richard J. & Giwercman, Aleksander (2004). Seasonal Variation in Melatonin, Reproductive Hormones and Semen Parameters in Men living North and South of the Arctic Circle.
  • Sæther, Thomas; Christophersen, Bjørn O. & Haugen, Trine B. (2004). Essential fatty acid deficiency does not induce desaturases in testis, like in epididymis and liver.
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Dahle, Øyvind; Matre, Vilborg; Lüscher, Bernhard & Gabrielsen, Odd Stokke (2004). Human c-Myb interacts with the Mi-2alpha subunit of the NuRD complex.
  • Sæther, Thomas (2003). Lipid Dynamics And Sperm Function.
  • Sæther, Thomas (2003). Metabolism of Polyunsaturated Fatty Acids in Rat Testis - Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-CoA desaturase 1, stearoyl-CoA desaturase 2 and the nuclear receptors peroxisome proliferator-activated receptor alpha, delta and gamma .
  • Malm, Gunilla; Haugen, Trine Berit; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom; Sæther, Thomas; Malm, Johan; Figenschau, Y.; Levine, Richard J. & Giwercman, Aleksander (2002). No Seasonal Variation in Sperm Parameters despite Extreme Differences in Daylight Conditions North of the Arctic Circle.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2001). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Tran, Thien Ngoc; Sæther, Thomas; Christophersen, Bjørn; Rootwelt, Helge; Retterstøl, Kjetil & Haugen, Trine Berit (2001). Expression of delta6- and delta5-desaturase in Rat Testis.

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Published Feb. 10, 2014 2:03 PM - Last modified Sep. 25, 2017 1:31 PM

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