Thomas Sæther

Førsteamanuensis - Seksjon for Biokjemi
Bilde av Thomas Sæther
English version of this page
Telefon +47 22851510
Rom 2245
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 Oslo
Postadresse Postboks 1112 Blindern 0317 Oslo

Faglige interesser

Mitt forskningsfokus ligger i skjæringspunktet mellom transkripsjon, genregulering og ernæring. For tiden jobber jeg som førsteamanuensis i kromatingruppa ved avdeling for molekylærmedisin. Her fokuserer vi på regulering av kromatin i fettstamceller. Vi studerer også hvordan transkripsjonsfaktorer samarbeider i reguleringen av nysyntese av fett i lever.
 

Undervisning

  • MED1100 (forelesninger, smågruppeundervisning og labkurs)
  • MED2200 (smågruppeundervisning)
  • ERN2300 (tidl. emneansvarlig)
  • ERN3200 (veiledning i artikkelskriving)
  • ERN4210 (forelesninger)

Sosiale medier

Bakgrunn

  • Førsteamanuensis i Kjerneresptorgruppa ved Avdeling for ernæringsvitenskap, UiO, fra 2015-2018.
  • Postdoktor i Kjerneresptorgruppa ved Avdeling for ernæringsvitenskap, UiO og Institutt for medisinsk biologi, UiT fra 2012-2015, med fokus på marin bioprospektering etter nye PPAR agonister.
  • Postdoktor i MYB-gruppa ved IMBV, UiO, fra 2008 til 2012 hvor jeg studerte transkripsjonsfaktoren c-Myb, eukaryot genregulering, transkripsjon, kromatin, epigenetikk og posttranslasjonell modifisering, spesielt SUMOylering.
  • PhD i molekylær biovitenskap, UiO, 2008: Positive and negative modulation of the transactivation potential of the transcription factor c-Myb - novel regulatory mechanisms for a classical proto-oncoprotein. Les mer
  • Hovedfag i biokjemi, UiO, 2003: Metabolism of polyunsaturated fatty acids in rat testis. Les mer

Priser

  • Direktør Throne Holst Stiftelse for ernæringsforsknings pris for beste poster 2016: Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Nordic Association for Andrology’s Young Scientist Award, 2001: Effect of dietary fats, insulin and dexamethasone on delta-6-desaturase expression in rat testis.

Samarbeid

  • Prof. Trond Vidar Hansen, Farmasøytisk institutt, UiO: kjemisk syntese av PPAR-aktiverende forbindelser.
  • Prof. Ingebrigt Sylte, Institutt for medisinsk biologi, UiT Norges arktiske universitet: 3D in silico docking av PPAR-agonister.
  • Seniorforsker Steinar Paulsen, MabCent - SFI, UiT Norges arktiske universitet: HTS etter nye kjernereseptorligander fra marine invertebrater.
  • Prof. Hilde Nebb, tidl. Avd. for ernæringsvitenskap, UiO: metabolsk genregulering og livsstilssykdommer. 
  • Prof. Dan Voytas, University of Minnesota: Design av zinkfingernukleaser for målrettet modifisering av gener.
  • Prof. Tom Gonda, University of Queensland: Studier av de transformerende egenskapene til transkripsjonsfaktoren c-Myb.
Emneord: Ernæring, Molekylær ernæring, Livsstilssykdommer, Diabetes og hormoner, Kjernereseptorer, Transkripsjon

Publikasjoner

Hjorth M, Doncheva A, Norheim F, Ulven SM, Holven KB, Sæther T, Dalen KT (2022). Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6J mice. Eur J Nutr, In press.

Hjorth M, Galigniana NM, Ween O, Ulven SM, Holven KB, Dalen KT, Sæther T (2022). Postprandial Effects of Salmon Fishmeal and Whey on Metabolic Markers in Serum and Gene Expression in Liver Cells. Nutrients, 14(8): 1593.

Hustad KS, Ottestad I, Olsen T, Sæther T, Ulven SM, Holven KB (2022). Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomized controlled trial. Eur J Nutr, In press.

Stabell M, Sæther T, Røhr AK, Gabrielsen OS, Myklebost O (2021). Methylation-dependent SUMOylation of the architectural transcription factor HMGA2. Biochem Biophys Res Commun, 552: 91-97.

Hustad KS, Ottestad I, Hjorth M, Dalen KT, Sæther T, Sheikh NA, Strømnes M, Ulven SM, Holven KB (2021). No effect of salmon fishmeal on 2h-glucose in adults with increased risk of 2 type 2 diabetes: a randomised controlled trial. Br J Nutr, 126:1304-13.

Fan Q, Nørgaard RC, Grytten I, Ness CM, Lucas C, Vekterud K, Soedling H, Matthews J, Lemma RB, Gabrielsen OS, Bindesbøll C, Ulven SM, Nebb HI, Grønning-Wang LM, Sæther T (2020). LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells, 9(5):1214.

Brunet A, Forsberg F, Fan Q, Sæther T, Collas P (2019). Nuclear Lamin B1 Interactions with Chromatin during the Circadian Cycle Are Uncoupled from Periodic Gene Expression. Front Genet 10:917.

Arnesen H, Haj-Yasein NN, Tungen JE, Soedling H, Matthews J, Paulsen SM, Nebb HI, Sylte I, Hansen TV, Sæther T (2019). Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorg Med Chem 27(18):4059-68.

Sæther T, Paulsen SM, Tungen JE, Vik A, Aursnes M, Holen T, Hansen TV, Nebb HI (2018). Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. Eur J Med Chem 155:736-753.

Fan Q, Moen A, Anonsen JH, Bindesbøll C, Sæther T, Carlson CR, Grønning-Wang LM (2018) O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase. Biochem Biophys Res Commun 499(2): 354-360.

Moldes-Anaya, A, Sæther T, Uhlig S, Nebb HI, Larsen T, Eilertsen HC, Paulsen SM (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Mar Drugs 15(6):148.

Lorenzo PI, Brendeford EM, Gilfillan S, Gavrilov AA, Leedsak M, Razin SV, Eskeland R, Sæther T, Gabrielsen OS (2011) Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes Cancer 2(8):805-17.

Haugen TB, Tefre T, Malm G, Jönsson BA, Rylander L, Hagmar L, Bjørsvik C, Henrichsen T, Sæther T, Figenschau Y, Giwercman A (2011) Differences in serum levels of CB-153 and p,p'-DDE, and reproductive parameters between men living south and north in Norway. Reprod Toxicol 32(3):261-7.

Alm-Kristiansen AH, Lorenzo PI, Molværsmyr AK, Matre V, Ledsaak M, Sæther T, Gabrielsen OS (2011) PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Mol Cancer 10:21.

Sæther T, Pattabiraman DR, Alm-Kristiansen AH, Vogt-Kielland LT, Gonda TJ, Gabrielsen OS (2011) A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene 30(2):212-22.

Molværsmyr AK, Sæther T, Gilfillan S, Lorenzo PI, Kvaløy H, Matre V, Gabrielsen OS (2010) A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Res 38(15):4970-84.

Rylander L, Wetterstrand B, Haugen TB, Malm G, Malm J, Bjørsvik C, Henrichsen T, Sæther T, Giwercman A (2009) Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian J Androl 11(6):723-30.

Alm-Kristiansen AH, Sæther T, Matre V, Gilfillan S, Dahle O, Gabrielsen OS (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene 27(34):4644-56.

Berge T, Matre V, Brendeford EM, Sæther T, Lüscher B, Gabrielsen OS (2007) Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown. Blood Cells Mol Dis 39(3):278-86.

Ruhayel Y, Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Rylander L, Levine RJ, Giwercman A (2007) Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clin Endocrinol (Oxf). 67(1):85-92.

Sæther T, Berge T, Ledsaak M, Matre V, Alm-Kristiansen AH, Dahle O, Aubry F, Gabrielsen OS (2007) The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. J Biol Chem 282(19):13994-4005.

Sæther T, Tran TN, Rootwelt H, Grav HJ, Christophersen BO, Haugen TB (2007) Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction 133(2):467-77.

Aschim EL, Sæther T, Wiger R, Grotmol T, Haugen TB (2004). Differential distribution of splice variants of estrogen receptor beta in human testicular cells suggests specific functions in spermatogenesis. J Steroid Biochem Mol Biol 92(1-2):97-106.

Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Hagmar L, Rylander L, Levine RJ, Giwercman A (2004) Reproductive function during summer and winter in Norwegian men living north and south of the Arctic circle. J Clin Endocrinol Metab 89(9):4397-402.

Sæther T, Tran TN, Rootwelt H, Christophersen BO, Haugen TB (2003) Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Biol Reprod 69(1):117-24.

  • Hjorth, Marit; Galigniana, Natalia M.; Ween, Ola; Ulven, Stine Marie; Holven, Kirsten Bjørklund & Dalen, Knut Tomas [Vis alle 7 forfattere av denne artikkelen] (2022). Postprandial Effects of Salmon Fishmeal and Whey on Metabolic Markers in Serum and Gene Expression in Liver Cells. Nutrients. ISSN 2072-6643. 14(8). doi: 10.3390/nu14081593. Fulltekst i vitenarkiv
  • Hustad, Kristin Solheim; Ottestad, Inger; Olsen, Thomas; Sæther, Thomas; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2022). Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-022-02857-4.
  • Hustad, Kristin Solheim; Ottestad, Inger Olaug; Hjorth, Marit; Dalen, Knut Tomas; Sæther, Thomas & Sheikh, Navida Akhter [Vis alle 9 forfattere av denne artikkelen] (2021). No effect of salmon fish protein on 2-h glucose in adults with increased risk of type 2 diabetes: a randomised controlled trial. British Journal of Nutrition. ISSN 0007-1145. 126(9), s. 1304–1313. doi: 10.1017/S0007114521000040. Fulltekst i vitenarkiv
  • Stabell, Marianne; Sæther, Thomas; Kjendseth, Åsmund Røhr; Gabrielsen, Odd Stokke & Myklebost, Ola (2021). Methylation-dependent SUMOylation of the architectural transcription factor HMGA2. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 552, s. 91–97. doi: 10.1016/j.bbrc.2021.02.099. Fulltekst i vitenarkiv
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie; Lucas, Christin & Vekterud, Kristin [Vis alle 15 forfattere av denne artikkelen] (2020). LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells. ISSN 2073-4409. 9(5), s. 1–26. doi: 10.3390/cells9051214. Fulltekst i vitenarkiv
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Vis alle 15 forfattere av denne artikkelen] (2019). Open the LID: LXRα regulates ChREBPα transactivity in a target gene-specific manner through an agonist-modulated LBD-LID interaction. BioRxiv. ISSN 0362-4331. doi: 10.1101/2019.12.20.869974.
  • Brunet, Annaëlle; Forsberg, Anna Frida; Fan, Qiong; Sæther, Thomas & Collas, Philippe (2019). Nuclear lamin B1 interactions with chromatin during the circadian cycle are uncoupled from periodic gene expression. Frontiers in Genetics. ISSN 1664-8021. 10. doi: 10.3389/fgene.2019.00917. Fulltekst i vitenarkiv
  • Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Södling, Helen; Matthews, Jason & Paulsen, Steinar M [Vis alle 10 forfattere av denne artikkelen] (2019). Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 27(18), s. 4059–4068. doi: 10.1016/j.bmc.2019.07.032. Fulltekst i vitenarkiv
  • Sæther, Thomas; Paulsen, Steinar M; Tungen, Jørn Eivind; Vik, Anders; Aursnes, Marius & Holen, Torgeir [Vis alle 8 forfattere av denne artikkelen] (2018). Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. European Journal of Medicinal Chemistry. ISSN 0223-5234. 155, s. 736–753. doi: 10.1016/j.ejmech.2018.06.034. Fulltekst i vitenarkiv
  • Fan, Qiong; Moen, Anders; Anonsen, Jan Haug; Bindesbøll, Christian; Sæther, Thomas & Carlson, Cathrine Rein [Vis alle 7 forfattere av denne artikkelen] (2018). O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 499(2), s. 354–360. doi: 10.1016/j.bbrc.2018.03.164.
  • Moldes-Anaya, Angel; Sæther, Thomas; Uhlig, Silvio; Nebb, Hilde Irene; Larsen, Terje & Eilertsen, Hans Christian [Vis alle 7 forfattere av denne artikkelen] (2017). Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Marine Drugs. ISSN 1660-3397. 15(148). doi: 10.3390/md15060148. Fulltekst i vitenarkiv
  • Haugen, Trine B.; Tefre, Toril; Malm, Gunilla; Jønsson, Bo AG; Rylander, Lars & Hagmar, Lars [Vis alle 11 forfattere av denne artikkelen] (2011). Differences in serum levels of CB-153 and p,p '-DDE, and reproductive parameters between men living south and north in Norway. Reproductive Toxicology. ISSN 0890-6238. 32(3), s. 261–267. doi: 10.1016/j.reprotox.2011.06.072.
  • Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Molværsmyr, Ann-Kristin; Matre, Vilborg; Ledsaak, Marit & Sæther, Thomas [Vis alle 7 forfattere av denne artikkelen] (2011). PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Molecular Cancer. ISSN 1476-4598. 10. doi: 10.1186/1476-4598-10-21.
  • Sæther, Thomas; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege; Vogt- Kielland, Linn Troye; Gonda, T.J. & Gabrielsen, Odd Stokke (2011). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene. ISSN 0950-9232. 30(2), s. 212–222. doi: 10.1038/onc.2010.397.
  • Lorenzo, Petra Isabel O.; Brendeford, Elen Margrethe; Gilfillan, Siv ; Gavrilov, Alexey A; Ledsaak, Marit & Razin, Sergey V [Vis alle 9 forfattere av denne artikkelen] (2011). Identification of c-Myb target genes in K562 cells reveals a role for c-Myb as a master regulator. Genes & cancer. ISSN 1947-6019. 2(8), s. 805–817. doi: 10.1177/1947601911428224.
  • Molværsmyr, Ann-Kristin; Sæther, Thomas; Gilfillan, Siv ; Lorenzo, Petra Isabel O.; Kvaløy, Heidi & Matre, Vilborg [Vis alle 7 forfattere av denne artikkelen] (2010). A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Research (NAR). ISSN 0305-1048. 38(15), s. 4970–4984. doi: 10.1093/nar/gkq245.
  • Rylander, Lars; Wetterstrand, Boel; Haugen, Trine B.; Malm, Gunilla; Malm, Johan & Bjørsvik, Cathrine [Vis alle 9 forfattere av denne artikkelen] (2009). Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian Journal of Andrology (AJA). ISSN 1008-682X. 11(6), s. 723–730. doi: 10.1038/aja.2009.64.
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Matre, Vilborg; Otnæss, Siv Kolstø; Dahle, Øyvind & Gabrielsen, Odd Stokke (2008). FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene. ISSN 0950-9232. 27, s. 4644–4656. doi: 10.1038/onc.2008.105.
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine & Grotmol, Tom [Vis alle 12 forfattere av denne artikkelen] (2007). Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clinical Endocrinology. ISSN 0300-0664. 67. doi: 10.1111/j.1365-2265.2007.02843.x.
  • Sæther, Thomas; Tran, TN; Rootwelt, H; Grav, HJ; Christophersen, BO & Haugen, Trine B. (2007). Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis. Reproduction. ISSN 1470-1626. 133(2), s. 467–477. doi: 10.1530/REP-06-00294.
  • Sæther, Thomas; Berge, T; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege & Dahle, O [Vis alle 8 forfattere av denne artikkelen] (2007). The chromatin remodeling factor Mi-2 alpha acts as a novel co-activator for human c-Myb. Journal of Biological Chemistry. ISSN 0021-9258. 282. doi: 10.1074/jbc.M700755200.
  • Berge, Tone; Matre, Vilborg; Brendeford, Elen Margrethe; Sæther, Thomas; Lüscher, Bernhard & Gabrielsen, Odd Stokke (2007). Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitaion and c-Myb knockdown. Blood Cells, Molecules & Diseases. ISSN 1079-9796. 39(3), s. 278–286. doi: 10.1016/j.bcmd.2007.05.007.
  • Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom & Sæther, Thomas [Vis alle 12 forfattere av denne artikkelen] (2004). Reproductive function during summer and winter in Norwegian men living north and south of the Arctic Circle. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 89(9), s. 4397–4402. doi: 10.1210/jc.2004-0427.
  • Aschim, Elin L.; Sæther, Thomas; Wiger, Richard; Grotmol, Tom & Haugen, Trine B. (2004). Differential distribution of splice variants of estrogen receptor β in human testicular cells suggests specific functions in spermatogenesis. Journal of Steroid Biochemistry and Molecular Biology. ISSN 0960-0760. 92(1-2), s. 97–106. doi: 10.1016/j.jsbmb.2004.05.008.
  • Sæther, Thomas; Tran, Thien Ngoc; Rootwelt, Helge; Christophersen, Bjørn & Haugen, Trine Berit (2003). Expression and Regulation of delta 5-Desaturase, delta 6-Desaturase, Stearoyl-Coenzyme A (CoA) Desaturase 1, and Stearoyl-CoA Desaturase 2 in Rat Testis. Biology of Reproduction. ISSN 0006-3363. 69, s. 117–124. doi: 10.1095/biolreprod.102.014035.

Se alle arbeider i Cristin

  • Sæther, Thomas (2021). Muliggjørende bioteknologi - hva vi kan gjøre med den, og hva den kan gjøre med oss .
  • Sæther, Thomas (2020). Ressursperson genetikk. I Movafagh, Hilde Marie Øgreid (Red.), Hva er da et menneske ... . Norges Kristne Råd. ISSN 978-827941-035-5.
  • Heggøy, Oddvar; Shimmings, Paul; Nordsteien, Ola & Sæther, Thomas (2020). Magert med lappspurv i 2020. Vår Fuglefauna. ISSN 0332-5601. 43(4), s. 210–216.
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Vis alle 15 forfattere av denne artikkelen] (2019). LXRα interacts with the glucose-sensing transcription factor ChREBPα to regulate its transcriptional activity.
  • Sæther, Thomas; Ingvaldsen, Christoffer Aam & Lundby, Marit (2019). Denne fuglen er symbolet på det rike fuglelivet i Romerikes Amazonas. Nå er den i ferd med å forsvinne. [Avis]. Romerikes Blad.
  • Holven, Kirsten Bjørklund; Sæther, Thomas; Hjorth, Marit; Dalen, Knut Tomas; Ulven, Stine Marie & Ottestad, Inger [Vis alle 7 forfattere av denne artikkelen] (2019). Kan fisk utnyttes enda mer og samtidig fremme folkehelsen? Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. 17(2), s. 20–22.
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ulven, Stine Marie; Lucas, Christin & Bindesbøll, Christian [Vis alle 11 forfattere av denne artikkelen] (2018). LXRα interacts with the glucose-sensing transcription factor ChREBPα and increases its transcriptional activity.
  • Fan, Qiong; Nørgaard, Rikke Christine; Ulven, Stine Marie; Lucas, Christin; Bindesbøll, Christian & Grønning-Wang, Line Mariann [Vis alle 8 forfattere av denne artikkelen] (2018). Exploring the functional importance of a transcriptional cholesterol/sugar switch in liver.
  • Sæther, Thomas (2018). Digging into the ocean’s molecular treasure trove: Marine bioprospecting for anti-diabetic activities.
  • Nørgaard, Rikke Christine; Fan, Qiong; Lucas, Christin; Grønning-Wang, Line Mariann; Nebb, Hilde Irene & Sæther, Thomas (2017). LXRα interacts with the glucose-sensing transcription factor ChREBPα and increases its transcriptional activity.
  • Sæther, Thomas (2017). Havets hemmeligheter. [Internett]. UiOs Facebook-side.
  • Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar M & Sylte, Ingebrigt [Vis alle 8 forfattere av denne artikkelen] (2016). Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin & Sylte, Ingebrigt [Vis alle 8 forfattere av denne artikkelen] (2015). Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
  • Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M & Nebb, Hilde Irene (2014). Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs).
  • Sæther, Thomas (2014). Anti-diabetic activity from marine lipids (ADAM): New anti-diabetic drugs.
  • Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M & Nebb, Hilde Irene (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Sæther, Thomas; Moldes-Anaya, Angel; Larsen, Laila Norrheim; Larsen, Terje; Paulsen, Steinar & Nebb, Hilde Irene (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2013). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets.
  • Bindesbøll, Christian; Fan, Qiong; Sæther, Thomas; Dalen, Knut Tomas; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2013). Nuclear receptors as targets for treatment and prevention of metabolic diseases.
  • Moldes-Anaya, Angel; Sæther, Thomas; Norrheim-Larsen, Laila; Nebb, Hilde Irene; Larsen, Terje & Paulsen, Steinar (2013). Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae.
  • Moldes-Anaya, Angel; Sæther, Thomas; Larsen, Laila Norrheim; Larsen, Terje; Nebb, Hilde Irene & Paulsen, Steinar (2013). Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae.
  • Sæther, Thomas; Bengtsen, Mads; Molværsmyr, Ann-Kristin; Pattabiraman, D.R.; Alm-Kristiansen, Anne Hege & Ledsaak, Marit [Vis alle 8 forfattere av denne artikkelen] (2012). Regulating the regulator: SUMO functions as a master switch for the transcription factor c-Myb.
  • Molværsmyr, Ann-Kristin; Ledsaak, Marit; Alm-Kristiansen, Anne Hege; Lorenzo, Petra Isabel O.; Matre, Vilborg & Sæther, Thomas [Vis alle 7 forfattere av denne artikkelen] (2012). The SUMO E3 ligase PIAS1 interacts with c-Myb and enhances its transcriptional activity.
  • Matre, Vilborg; Aabel, Linn Ingeborg; Ledsaak, Marit; Vollsund, Pernille; Sæther, Thomas & Gabrielsen, Odd Stokke (2012). PTM-crosstalk: SUMO1 acts as a docking domain for the nuclear kinase HIPK1 mediating SUMO-linked phosphorylation of c-Myb and other targets.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Gilfillan, Siv ; Alm-Kristiansen, Anne Hege; Aabel, Linn Ingeborg & Matre, Vilborg [Vis alle 7 forfattere av denne artikkelen] (2011). The hematopoietic transcription factor c-Myb functions as an epigenetic organizer.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Gilfillan, Siv ; Kvaløy, Heidi & Matre, Vilborg [Vis alle 7 forfattere av denne artikkelen] (2010). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch.
  • Rangberg, Anbjørg ; Sæther, Thomas & Gabrielsen, Odd Stokke (2010). Design of a system for inducible SUMOylation of the transcription factor c-Myb.
  • Sæther, Thomas; Pattabiraman, D.R.; Aabel, Linn Ingeborg; Matre, Vilborg; Gonda, T.J. & Gabrielsen, Odd Stokke (2010). A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Lorenzo, Petra Isabel O.; Kvaløy, Heidi; Matre, Vilborg & Gabrielsen, Odd Stokke (2009). A SUMO-regulated activation function (SRAF) controls synergy of c-Myb through a repressor-activator switch.
  • Vollsund, Pernille; Bergholtz, Stine Louise; Sæther, Thomas; Aasland, Rein & Gabrielsen, Odd Stokke (2009). Understanding the phosphorylation-sumoylation cross talk in the transcription factor c-Myb.
  • Sæther, Thomas; Molværsmyr, Ann-Kristin; Matre, Vilborg; Lorenzo, Petra Isabel O. & Gabrielsen, Odd Stokke (2008). SUMO-conjugation of the transcription factor c-Myb controls cooperative behaviour and induces an activator-to-repressor switch in the negative regulatory domain.
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Matre, Vilborg; Alm-Kristiansen, Anne Hege & Dahle, Øyvind [Vis alle 8 forfattere av denne artikkelen] (2007). The chromatin remodelling factor Mi-2alpha acts as a novel co-activator for human c-Myb.
  • Molværsmyr, Ann-Kristin; Kvaløy, Heidi; Sæther, Thomas; Matre, Vilborg & Gabrielsen, Odd Stokke (2007). Controlling gene expression through SUMO-conjugation - the importance of synergy.
  • Alm-Kristiansen, Anne Hege; Sæther, Thomas; Ledsaak, Marit; Matre, Vilborg & Gabrielsen, Odd Stokke (2006). FLASH is a coregulator of the transcription factor c-Myb.
  • Sæther, Thomas; Tran, Thien N.; Rootwelt, Helge; Grav, Hans J.; Christophersen, Bjørn O. & Haugen, Trine B. (2006). Desaturase expression, lipid profile, and sperm morphology are differently affected by fat free diet in cauda and caput epididymis in the rat.
  • Sæther, Thomas; Berge, Tone; Ledsaak, Marit; Dahle, Øyvind; Matre, Vilborg & Lüscher, Bernhard [Vis alle 7 forfattere av denne artikkelen] (2004). Human c-Myb interacts with the Mi-2alpha subunit of the NuRD complex.
  • Ruhayel, Yasir; Malm, Gunilla; Haugen, Trine B.; Henrichsen, Trine; Bjørsvik, Cathrine & Grotmol, Tom [Vis alle 13 forfattere av denne artikkelen] (2004). Seasonal Variation in Melatonin, Reproductive Hormones and Semen Parameters in Men living North and South of the Arctic Circle.
  • Sæther, Thomas; Christophersen, Bjørn O. & Haugen, Trine B. (2004). Essential fatty acid deficiency does not induce desaturases in testis, like in epididymis and liver.
  • Sæther, Thomas (2003). Lipid Dynamics And Sperm Function.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Malm, Gunilla; Haugen, Trine Berit; Henrichsen, Trine; Bjørsvik, Cathrine; Grotmol, Tom & Sæther, Thomas [Vis alle 10 forfattere av denne artikkelen] (2002). No Seasonal Variation in Sperm Parameters despite Extreme Differences in Daylight Conditions North of the Arctic Circle.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2002). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Sæther, Thomas; Tran, Thien Ngoc; Christophersen, Bjørn & Haugen, Trine Berit (2001). Effect of Dietary Fats, Insulin and Dexamethasone on delta6-desaturase Expression in Rat Testis.
  • Tran, Thien Ngoc; Sæther, Thomas; Christophersen, Bjørn; Rootwelt, Helge; Retterstøl, Kjetil & Haugen, Trine Berit (2001). Expression of delta6- and delta5-desaturase in Rat Testis.
  • Sæther, Thomas; Aspelund, Trond; Eie, Knut; Hobøl, Erling; Ingvaldsen, Christoffer Aam & Starholm, Trude (2018). NØFs vannfugltellinger i Nordre Øyeren - kortrapport 2018 og regresjonsanalyser i forbindelse med flomtappingsprosjektet. Nordre Øyeren fuglestasjon.
  • Sæther, Thomas; Aspelund, Trond; Eie, Knut; Hobøl, Erling; Ingvaldsen, Christoffer Aam & Starholm, Trude (2018). Sluttrapport fra vaderregistreringer på Årnestangen 2015-2018. Nordre Øyeren fuglestasjon.
  • Sæther, Thomas & Erling, Hobøl (2010). Hekkefugltaksering på Fautøya og Rossholmens vesttange, Sesongrapport 2010. Nordre Øyeren fuglestasjon.
  • Kvebæk, Yngve; Sæther, Thomas; Aspelund, Trond & Hobøl, Erling (2009). NORDRE ØYEREN - Trend, trekkprofil og preferanseområde for viktige vannfuglarter - Komplett statusliste og øvrige artsvurderinger. Fylkesmannen i Oslo og Akershus.

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Publisert 14. aug. 2012 13:04 - Sist endret 6. juli 2022 15:52