Cell Cycle and Apoptosis
The main goal of the research group is to elucidate mechanisms involved in vitamin A- and cAMP-mediated regulation of cell cycle, DNA damage and apoptosis in lymphoid cells, in order to identify new targets for improved therapy of cancer and certain immune disorders.
About the group
The focus of our research group is to elucidate mechanisms involved in regulation of proliferation and death of cells in the immune system, in order to identify new targets for treatment of cancer and immune disorders.
At present our two main research aims are:
- understand how vitamin A stimulates the immune system, with specific focus on Toll like receptor 9-mediated regulation of human B-lymphocytes, and
- reveal the role of the cAMP-signaling pathway in development and treatment of cancer, with specific focus on DNA damage responses in B cell precursor acute lymphoblastic leukemia (BCP-ALL).