Latest publications

  • Blomhoff R, Blomhoff HK. An overview of retinoid metabolism and function.   J. Neurobiology 66, 606-610, 2006
  • Låhne HU, Kloster MM, Lefdal S, Blomhoff HK, Naderi S. New pathway for degradation of cyclin D3 -  independent of Thr 283 phosphorylation. Oncogene, 25, 2468-2476, 2006 
  • Engedal N, Gjevik T, Blomhoff HK. All-trans retinoic acid stimulates IL-2-mediated proliferation of human T-lymphocytes: Early induction of cyclin D3. J Immunology, 177, 2851-2861, 2006 
  • Sivertsen EA, Hystad ME, Gutskow KB, Smeland EB, Blomhoff HK, and JH Myklebust JH PI3K/Akt dependent EPO-induced signalling and target genes in human early erythroid progenitor cells. British J Haematology. 135, 117-128, 2007
  • Ertesvåg Å, Åsheim HC, Naderi S, Blomhoff HK. CpG-mediated proliferation and differentiation of memory B-cells is stimulated by retinoic acid via rapid induction of p38MAPK. Blood 109, 3865-72, 2007
  • Kloster M, Hafte TT, Moltzau LR, Naderi EH, Dahle MK, Skålhegg BS, Gaudernack G, Levy FO, Naderi S, Blomhoff HK. EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase. Cell Signalling 20, 1169-78, 2008
  • Ugland H, Boquest AC, Naderi S, Collas P, Blomhoff HK. cAMP mediated induction of cyclin E sensetizes growth-arrested adipose stem cells to DNA damage-induced apoptosis. Mol.Biol.Cell, 19, 5082-92, 2008
  • Naderi S, Blomhoff HK. Activation of cAMP signaling enhances Fas-mediated apoptosis and AICD through potentiation of caspase 8 activation.  Hum. Immunology, 69, 833-6, 2008  
  • Ertesvåg Å, Naderi S,  Blomhoff HK. Review: Regulation of B cell proliferation and differentiation by retinoic acid. Seminars in Immunology, 21, 36-41, 2009 
  • Engedal N, Auberger P, Blomhoff HK. Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells. J. Leuc. Biol. 85, 469-80, 2009
  • Ertesvåg Å, Austenaa L, Carlsen H, Blomhoff R, Blomhoff HK. Retinoic acid inhibits IL-2 gene activity  and T cell activation in mice. Immunology, 126, 514-22, 2009 
  • Austenaa LMI, Carlsen H, Blomhoff HK, Blomhoff R. All-trans retinoic acid represses lipopolysaccharide-induced activation in reporter mice and human monoblasts through inhibition of nuclear factor-B. J. Nutr. Biochem, 20, 726-34, 2009
  • Naderi EH, Findley HW, Ruud E, Blomhoff HK, Naderi S. Activation of cAMP-signaling inhibits  DNA damage-induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation. Blood, 114, 608-18, 2009
  • Sand SL, Oppegård C, Ohara S, IijimaT, Naderi S, Blomhoff HK, Nissen-Meyer J, Sand O. Plantaricin A, a peptide pheromone produced by Lactobacillus plantarum, permeabilizes the cell membrane of both normal and cancerous lymphocytes and neuronal cells. Peptides, 31, 1237, 2010
  • Naderi EH, Jochemsen A, Blomhoff HK*, Naderi S*. cAMP signalling inhibits p53 stabilization through regulation of Hdm2 ubiquitin ligase activity. Neoplasia,  13, 653-663, 2011  * Shared senior author
  • Kloster MM, Naderi EH, Blomhoff HK, Naderi S. Hyperactivation of NF-κB is indispensable for the inhibitory effect of cAMP on DNA damage-induced apoptosis. Mol Cancer, 10, 45-57, 2011
  • Ugland H, Naderi S, Brech A, Collas P, Blomhoff HK. cAMP induces autophagy in mesenchymal stem cells: Identificaiton of a new pathway involving ERK and cyclin E. Autophagy, 7, 1199-1211, 2011
  • Follin-Arbelet V, Hofgaard PO, Hauglin H, Naderi S, Sundan A, Blomhoff  R, Bogen B, Blomhoff  HK. Elevated levels of cAMP induce apoptosis in multiple myeloma cells and inhibit tumor development in a mouse model. BMC Cancer, 11, 301-311, 2011
  • Eriksen AB, Indrevær RL, Holm KL, Landskron J, Blomhoff HK. TLR9-signaling is required for turning  retinoic acid into a potent stimulator of RP105 (CD180)-mediated proliferation and Ig synthesis in human memory B cells. Cell Immunology 279, 87-95, 2012 
  • Naderi EH,  Ugland HK,  Diep PP,  Josefsen D,  Ruud E,  Naderi S, Blomhoff HK. Selective inhibition of cell death in malignant versus normal B cell  precursors: Implications for cAMP in development and treatment of BCP-ALL.  Blood 121, 1805-13, 2013
  • Follin-Arbelet V, Thorgersen M, Naderi EH, Blomhoff HK. Death of multiple myeloma cells induced by cAMP-signaling involves downregulation of Mcl-1 via the JAK/STAT pathway. Cancer Letters  335, 323-31, 2013
  • Kloster MM, Naderi EH, Gjertsen BT, Blomhoff HK, Naderi S.  cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SRT deacetylases. Int Journal of Oncology 42, 1815-21, 2013
  • Indrevær R, Holm KL, Børre Fevang, Thorgersen M, Naderi EH, Pål Aukrust, Blomhoff  HK. Retinoic acid partly restores defective TLR9/RP105-mediated signaling in CVID-derived B cells. J Immunol 191, 3624-33, 2013
  • Eriksen AB, Berge T, Gustavsen MW, leikfoss IS, Bos, SD, Spurkland A, Harboe HF,  Blomhoff HK. Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis. J Neuroimmunol 278, 11-18, 2015 
  • Naderi EH, Ugland H, Myklebost O, Sandnes D, Torgersen M, Skah S. Josefsen D, Ruud E, Naderi S, Blomhoff HK. Bone marrow stroma protects BCP-ALL cells from DNA damage- induced p53 accumulation and cell death via PGE2. Mol Cancer 14, 14-26, 2015 
  • Eriksen A, Torgersen ML, Abrahamsen G, Spurkland A, Simonsen A, Blomhoff HK. Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy. Autophagy 11, 460-71,  2015
  • Follin-Arbelet V, Misund K, Naderi EH, Ugland HK, Sundan A, Blomhoff HK. The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Scientific Rep 5, 13001-11, 2015 
  • Indrevær R, Paur I, Bøhn SK, Jørgensen SF, Moskaug HØ, Blomhoff R; Aukrust B, Fevang B, Blomhoff HK. IRF4 is a critical gene in retinoic acid-mediated plasma cell formation and is deregulated in CVID-derived B cells. J Immunol 195, 2601-11, 2015  
  • Kolberg M, Pedersen S, Mitake M, Holm KL, Bøhn SK, Blomhoff HK, Carlsen H, Blomhoff  R, Paur I. Coffee inhibits nuclear factor-kappa B in prostate cancer cells and xenografts. J Nutr Biochem  27, 153-63, 2016
  • Klionsky DJ, Abdelmohsen K, Blomhoff HK, Zughaier SM (authors in  alphabetical  order). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd  edition). Autophagy 12,1-222 , 2016
  • Holm KL, Indrevær RL, Myklebust JH, Kolstad A, Naderi EH, Blomhoff HK. MCL-1 has a vital role in retinoic acid-mediated protection of  TLR9-stimulated B cells from spontaneous and DNA damage-induced apoptosis. Immunology 149, 62-73, 2016
  • López-Soop G, Rønningen T, Rogala A, Richartz N, Blomhoff HK, Thiede B, Collas P, Küntziger T. AKAP95 interacts with nucleoporin TRP in mitosis and is important for the spindle assembly checkpoint. Cell Cycle 16, 947-956,  2017
  • Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Lindrevær RL, Aukrust P, Fevang B, Blomhoff HK. TLR9 stimulation of B-cells induces treanscription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common Variable Immunodeficiency. PLoS One 12, e0185708, 2017
  • Skah S, Richartz N*, Duthil E*, Gilljam K, Bindesbøll C, Naderi EH, Simonsen A, Blomhoff HK.  Activation of the cAMP signaling pathway promotes DNA damage-induced autophagy and promotes survival of BCP-ALL via PARP. Submitted for publication, 2017
  • Duthil E, Richartz N, Ruud E, Ford T, Hallan Naderi E, Naderi S, Blomhoff HK, Skah S. The cox-inhibitor indomethacin slows down the progression of BCP-ALL xenografts in NSG-mice by preventing cAMP-signaling. Manuscript in preparation, 2017
  • Gilljam, Karin Margaretha; Holm, Kristine Lillebø; Zahoor, Muhammad; Centonze, Federica Grazia; Farhan, Hesso & Blomhoff, Heidi Kiil (2020). Differential Effects of Reactive Oxygen Species on IgG versus IgM Levels in TLR-Stimulated B Cells. Journal of Immunology. ISSN 0022-1767. 204(8), p. 2133–2142. doi: 10.4049/jimmunol.1901131.
  • Richartz, Nina; Duthil, Eva; Ford, Anthony; Naderi, Elin Hallan; Bhagwat, Sampada & Gilljam, Karin Margaretha [Show all 10 contributors for this article] (2019). Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. Blood Advances. ISSN 2473-9529. 3(21), p. 3181–3190. doi: 10.1182/bloodadvances.2019000473.
  • Skah, Seham; Richartz, Nina; Duthil, Eva; Gilljam, Karin Margaretha; Bindesbøll, Christian & Naderi, Elin Hallan [Show all 11 contributors for this article] (2018). cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53. OncoTarget. ISSN 1949-2553. 9(54), p. 30434–30449. doi: 10.18632/oncotarget.25758. Full text in Research Archive
  • Holm, Kristine Lillebø; Syljuåsen, Randi G.; Hasvold, Grete; Alsøe, Lene; Nilsen, Hilde Loge & Ivanauskiene, Kristina [Show all 13 contributors for this article] (2017). TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLOS ONE. ISSN 1932-6203. 12(10). doi: 10.1371/journal.pone.0185708. Full text in Research Archive
  • Lopez Soop, Graciela; Rønningen, Torunn; Rogala, Agnieszka; Richartz, Nina; Blomhoff, Heidi Kiil & Thiede, Bernd [Show all 8 contributors for this article] (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle. ISSN 1538-4101. 16(10), p. 947–956. doi: 10.1080/15384101.2017.1310350. Full text in Research Archive
  • Holm, Kristine Lillebø; Indrevær, Randi Larsen; Myklebust, June; Kolstad, Arne; Moskaug, Jan Øivind & Naderi, Elin Hallan [Show all 7 contributors for this article] (2016). Myeloid cell leukaemia 1 has a vital role in retinoic acid-mediated protection of Toll-like receptor 9-stimulated B cells from spontaneous and DNA damage-induced apoptosis. Immunology. ISSN 0019-2805. 149(1), p. 62–73. doi: 10.1111/imm.12629.
  • Van Liefferinge, Joeri; Bentea, Eduard; Demuyser, Thomas; Albertini, Giulia; Follin-Arbelet, Virginie & Holmseth, Silvia [Show all 13 contributors for this article] (2016). Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed. Journal of Comparative Neurology. ISSN 0021-9967. 524(5), p. 1015–1032. doi: 10.1002/cne.23889.
  • Kolberg, Marit; Pedersen, Sigrid; Mitake, Maiko; Lillebø Holm, Kristine; Bøhn, Siv Kjølsrud & Blomhoff, Heidi Kiil [Show all 9 contributors for this article] (2016). Coffee inhibits nuclear factor-kappa B in prostate cancer cells and xenografts. Journal of Nutritional Biochemistry. ISSN 0955-2863. 27, p. 153–163. doi: 10.1016/j.jnutbio.2015.08.028.
  • Indrevær, Randi Larsen; Moskaug, Jan Øivind; Paur, Ingvild; Bøhn, Siv Kjølsrud; Jørgensen, Silje Fjellgård & Blomhoff, Rune [Show all 9 contributors for this article] (2015). IRF4 is a critical gene in retinoic acid-mediated plasma cell formation and is deregulated in common variable immunodeficiency-derived B cells. Journal of Immunology. ISSN 0022-1767. 195(6), p. 2601–2611. doi: 10.4049/jimmunol.1500250.
  • Follin-Arbelet, Virginie; Misund, Kristine; Naderi, Elin Hallan; Ugland, Hege Katrin; Sundan, Anders & Blomhoff, Heidi Kiil (2015). The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Scientific Reports. ISSN 2045-2322. 5:13001. doi: 10.1038/srep13001. Full text in Research Archive
  • Ertesvåg, Åse; Åsheim, Hans-Christian; Naderi, Soheil & Blomhoff, Heidi Kiil (2007). Vitamin A potentiates CpG-mediated memory B-cell proliferation and differentiation: involvement of early activation of p38MAPK. Blood. ISSN 0006-4971. doi: 10.1182/blood-2006-09-046748.
  • Sivertsen, Einar Andreas; Hystad, Marit Elise; Gutzkow, Kristine B; Døsen, Guri; Smeland, Erlend B & Blomhoff, Heidi Kiil [Show all 7 contributors for this article] (2006). PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells. British Journal of Haematology. ISSN 0007-1048. 135(1), p. 117–128.
  • Josefsen, Dag; Myklebust, June; Lømo, Jon; Sioud, Mouldy; Blomhoff, Heidi Kiil & Smeland, Erlend B (2000). Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells . Stem Cells. ISSN 1066-5099. 18(4), p. 261–272.
  • Tasken, Kjetil; Andersson, Kristin Brevik; Erikstein, B. K.; Hansson, Vidar; Jahnsen, Tore & Blomhoff, Heidi Kiil (1994). Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase. Endocrinology. ISSN 0013-7227. 135(5), p. 2109–2119.
  • Åsheim, Hans-Christian; Aas-Eng, Anne; Deggerdal, Arne Helge; Funderud, Steinar; Blomhoff, Heidi Kiil & Smeland, Erlend B. (1993). Cell specific expression of human b -galactoside a 2,6-sialyltransferase transcripts differing in the 5' untranslated region. European Journal of Biochemistry (EJB). ISSN 0014-2956. doi: 10.1111/j.1432-1033.1993.tb17783.x..
  • Tasken, Kjetil; Skålhegg, Bjørn Steen; Solberg, Rigmor; Andersson, Kristin Brevik; Taylor, S. S. & Lea, Tor [Show all 9 contributors for this article] (1993). Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes. Journal of Biological Chemistry. ISSN 0021-9258. 268(28), p. 21276–21283.
  • Tasken, Kjetil; Andersson, Kristin Brevik; Skålhegg, Bjørn Steen; Tasken, Kristin Austlid; Hansson, Vidar & Jahnsen, Tore [Show all 7 contributors for this article] (1993). Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh). Journal of Biological Chemistry. ISSN 0021-9258. 268(31), p. 23483–23489.
  • Stamenkovic, Ivan; Åsheim, Hans-Christian; Deggerdal, Arne Helge; Blomhoff, Heidi Kiil; Smeland, Erlend B. & Funderud, Steinar (1990). The B cell antigen CD75 is a cell surface sialyltransferase. Journal of Experimental Medicine (JEM). ISSN 0022-1007. doi: 10.1084/jem.172.2.641..
  • Funderud, Steinar; Erikstein, Bjørn; Åsheim, Hans-Christian; Blomhoff, Heidi Kiil; Smeland, Erlend B. & Holte, Harald (1990). Functional properties of CD19+ B lymphocytes positively selected from buffy coats by immunomagnetic seperation. . European Journal of Immunology. ISSN 0014-2980. doi: 10.1002/eji.1830200129.
  • Smeland, Erlend B.; Holte, Harald; Funderud, Steinar; Blomhoff, Heidi Kiil; Torjesen, Peter A & aasheim, Hans-Christian [Show all 7 contributors for this article] (1990). Inhibition of polyphosphoinositide breakdown and c-myc induction accompanying inhibition of human B-cell activation by two monoclonal antibodies against the leucocyte common antigen . Scandinavian Journal of Immunology. ISSN 0300-9475. 31(5), p. 583–591. doi: 10.1111/j.1365-3083.1990.tb02809.x.

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  • López-Soop, Graciela; Rønningen, Torunn; Rogala, Agnieszka; Richartz, Nina; Blomhoff, Heidi Kiil & Thiede, Bernd [Show all 8 contributors for this article] (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle. ISSN 1538-4101. 16(10), p. 947–956. doi: 10.1080/15384101.2017.1310350..
  • Blomhoff, Heidi Kiil (2017). Mechanisms of immune regulation by vitamin A. In Calder, Philip C (Eds.), Nutrition, Immunity, and Infection. CRC Press. ISSN 9781482253979. p. 159–181.
  • Blomhoff, Heidi Kiil (2017). Vitamin A in plasma cell formation and IgG production.
  • Pietka, Wojciech (2018). Interleukin-33 in skin stress and inflammation. Universitetet i Oslo. ISSN 978-82-8377-299-9.

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