Ingvar Jarle Vaage

• Torp, May-Kristin; Stensløkken, Kåre-Olav & Vaage, Ingvar Jarle (2024). When Our Best Friend Becomes Our Worst Enemy: The Mitochondrion in Trauma, Surgery, and Critical Illness. Journal of Intensive Care Medicine. ISSN 0885-0666. doi: 10.1177/08850666241237715.
• Chaban, Viktoriia; de Boer, Eline; Ekholt, Karin; Vaage, Ingvar Jarle; Mollnes, Tom Eirik & Nilsson, Per [Show all 8 contributors for this article] (2023). Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo. Molecular Immunology. ISSN 0161-5890. 157, p. 70–77. doi: 10.1016/j.molimm.2023.03.006. Full text in Research Archive
• Torp, May-Kristin; Vaage, Ingvar Jarle & Stensløkken, Kåre-Olav (2023). Mitochondria-derived damage-associated molecular patterns and inflammation in the ischemic-reperfused heart. Acta Physiologica. ISSN 1748-1708. 237(3). doi: 10.1111/apha.13920. Full text in Research Archive
• Baysa, Anton; Maghazachi, Azzam; Sand, Kristin Larsen; Campesan, Marika; Zaglia, Tania & Mongillo, Marco [Show all 13 contributors for this article] (2022). Toll-like receptor 9 signaling after myocardial infarction: Role of p66ShcA adaptor protein. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 644, p. 70–78. doi: 10.1016/j.bbrc.2022.12.085. Full text in Research Archive
• Semenova, Daria; Zabirnyk, Arsenii; Lobov, Arseniy; Boyarskaya, Nadezda; Kachanova, Olga & Uspensky, Vladimir [Show all 16 contributors for this article] (2022). Multi-omics of in vitro aortic valve calcification. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 9. doi: 10.3389/fcvm.2022.1043165. Full text in Research Archive
• de Boer, Eline; Sokolova, Marina; Quach, Huy Quang; Mc Adam, Karin Ekholt; Götz, Maximilian P. & Chaban, Viktoriia [Show all 13 contributors for this article] (2022). Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release. Journal of Immunology. ISSN 0022-1767. 209(9), p. 1760–1767. doi: 10.4049/jimmunol.2101191. Full text in Research Archive
• Kaljusto, Mari-Liis; Bautin, Andrey; Jakobsen, Øyvind; Wilimski, Radoslaw; Brunborg, Cathrine & Wennemo, Marte [Show all 15 contributors for this article] (2022). Effects of ischaemic postconditioning in aortic valve replacement: a multicenter randomized controlled trial. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 61(5), p. 1144–1152. doi: 10.1093/ejcts/ezab500.
• Bogdanova, Mariia; Zabirnyk, Arsenii; Malashicheva, Anna; Semenova, Daria; Kvitting, John-Peder & Kaljusto, Mari-Liis [Show all 12 contributors for this article] (2022). Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview. Frontiers in Pharmacology. ISSN 1663-9812. 13. doi: 10.3389/fphar.2022.835825. Full text in Research Archive
• Torp, May-Kristin; Ranheim, Trine; Schjalm, Camilla; Hjorth, Marit; Heiestad, Christina Mathisen & Dalen, Knut Tomas [Show all 13 contributors for this article] (2022). Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis. Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.870811. Full text in Research Archive Show summary

  The innate immune system is rapidly activated during myocardial infarction and blockade of extracellular complement system reduces infarct size. Intracellular complement, however, appears to be closely linked to metabolic pathways and its role in ischemia-reperfusion injury is unknown and may be different from complement activation in the circulation. The purpose of the present study was to investigate the role of intracellular complement in isolated, retrogradely buffer-perfused hearts and cardiac cells from adult male wild type mice (WT) and from adult male mice with knockout of complement component 3 (C3KO). Main findings: (i) Intracellular C3 protein was expressed in isolated cardiomyocytes and in whole hearts, (ii) after ischemia-reperfusion injury, C3KO hearts had larger infarct size (32 ± 9% in C3KO vs. 22 ± 7% in WT; p=0.008) and impaired post-ischemic relaxation compared to WT hearts, (iii) C3KO cardiomyocytes had lower basal oxidative respiration compared to WT cardiomyocytes, (iv) blocking mTOR decreased Akt phosphorylation in WT, but not in C3KO cardiomyocytes, (v) after ischemia, WT hearts had higher levels of ATP, but lower levels of both reduced and oxidized nicotinamide adenine dinucleotide (NADH and NAD+, respectively) compared to C3KO hearts. Conclusion: intracellular C3 protected the heart against ischemia-reperfusion injury, possibly due to its role in metabolic pathways important for energy production and cell survival.

• Chaban, Viktoriia; Nakstad, Espen R.; Stær-Jensen, Henrik; Schjalm, Camilla; Seljeflot, Ingebjørg & Vaage, Ingvar Jarle [Show all 12 contributors for this article] (2021). Complement activation is associated with poor outcome after out-of-hospital cardiac arrest. Resuscitation. ISSN 0300-9572. 166, p. 129–136. doi: 10.1016/j.resuscitation.2021.05.038. Full text in Research Archive
• Li, Yuchuan; Khanal, Prabhat; Norheim, Frode; Hjorth, Marit; Bjellaas, Thomas & Drevon, Christian A [Show all 9 contributors for this article] (2021). Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex. Journal of Lipid Research. ISSN 0022-2275. 62. doi: 10.1016/J.JLR.2021.100048. Full text in Research Archive
• Li, Yuchuan; Torp, May-Kristin; Norheim, Frode; Khanal, Prabhat; Kimmel, Alan R. & Stensløkken, Kåre-Olav [Show all 8 contributors for this article] (2020). Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1866(4). doi: 10.1016/j.bbalip.2020.158873. Full text in Research Archive Show summary

  Plin5 is abundantly expressed in the heart where it binds to lipid droplets (LDs) and facilitates physical interaction between LDs and mitochondria. We isolated cardiomyocytes from adult Plin5+/+ and Plin5-/- mice to study the role of Plin5 for fatty acid uptake, LD accumulation, fatty acid oxidation, and tolerance to hypoxia. Cardiomyocytes isolated from Plin5-/- mice cultured with oleic acid stored less LDs than Plin5+/+, but comparable levels to Plin5+/+ cardiomyocytes when adipose triglyceride lipase activity was inhibited. The ability to oxidize fatty acids into CO2 was similar between Plin5+/+ and Plin5-/- cardiomyocytes, but Plin5-/- cardiomyocytes had a transient increase in intracellular fatty acid oxidation intermediates. After pre-incubation with oleic acids, Plin5-/- cardiomyocytes retained a higher content of glycogen and showed improved tolerance to hypoxia compared to Plin5+/+. In isolated, perfused hearts, deletion of Plin5 had no important effect on ventricular pressures or infarct size after ischemia. Old Plin5-/- mice had reduced levels of cardiac triacylglycerides, increased heart weight, and apart from modest elevated expression of mRNAs for beta myosin heavy chain Myh7 and the fatty acid transporter Cd36, other genes involved in fatty acid oxidation, glycogen metabolism and glucose utilization were essentially unchanged by removal of Plin5. Plin5 seems to facilitate cardiac LD storage primarily by repressing adipose triglyceride lipase activity without altering cardiac fatty acid oxidation capacity. Expression of Plin5 and cardiac LD content of isolated cardiomyocytes has little importance for tolerance to acute hypoxia and ischemia, which contrasts the protective role for Plin5 in mouse models during myocardial ischemia.

• Zabirnyk, Arsenii; Perez, Maria del Mar; Blasco, Marc; Stensløkken, Kåre-Olav; Ferrer, Miguel D. & Salcedo, Carolina [Show all 7 contributors for this article] (2020). A Novel Ex Vivo Model of Aortic Valve Calcification. A Preliminary Report. Frontiers in Pharmacology. ISSN 1663-9812. 11. doi: 10.3389/fphar.2020.568764. Full text in Research Archive
• Arain, Fizza Kanwal; Abraityte, Judita Aurelija; Bogdanova, Mariia; Solberg, Ole Geir; Michelsen, Annika & Lekva, Tove [Show all 19 contributors for this article] (2020). YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis. Circulation: Heart Failure. ISSN 1941-3289. 13(10). doi: 10.1161/CIRCHEARTFAILURE.119.006643. Full text in Research Archive
• Mariero, Lars Henrik; Torp, May-Kristin; Heiestad, Christina Mathisen; Baysa, Anton; Li, Yuchuan & Valen, Guro [Show all 8 contributors for this article] (2019). Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation. British Journal of Pharmacology. ISSN 0007-1188. 176(22), p. 4360–4372. doi: 10.1111/bph.14830. Full text in Research Archive
• Zabirnyk, Arsenii; Ferrer, Miguel David; Bogdanova, Mariia; Perez, MM; Salcedo, C & Kaljusto, Mari-Liis [Show all 10 contributors for this article] (2019). SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification. Vascular pharmacology. ISSN 1537-1891. p. 1–7. doi: 10.1016/j.vph.2019.106583. Full text in Research Archive
• Bogdanova, Mariia; Zabirnyk, Arsenii; Malashicheva, Anna; Zihlavnikova, Katarina; Karlsen, Tommy Aleksander & Kaljusto, Mari-Liis [Show all 13 contributors for this article] (2019). Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties. Scientific Reports. ISSN 2045-2322. 9:12934, p. 1–13. doi: 10.1038/s41598-019-49016-0. Full text in Research Archive Show summary

  Valve interstitial cells (VICs) are crucial in the development of calcific aortic valve disease. The purpose of the present investigation was to compare the phenotype, differentiation potential and stem cell-like properties of cells from calcified and healthy aortic valves. VICs were isolated from human healthy and calcified aortic valves. Calcification was induced with osteogenic medium. Unlike VICs from healthy valves, VICs from calcified valves cultured without osteogenic medium stained positively for calcium deposits with Alizarin Red confirming their calcific phenotype. Stimulation of VICs from calcified valves with osteogenic medium increased calcification (p = 0.02), but not significantly different from healthy VICs. When stimulated with myofibroblastic medium, VICs from calcified valves had lower expression of myofibroblastic markers, measured by flow cytometry and RT-qPCR, compared to healthy VICs. Contraction of collagen gel (a measure of myofibroblastic activity) was attenuated in cells from calcified valves (p = 0.04). Moreover, VICs from calcified valves, unlike cells from healthy valves had lower potential to differentiate into adipogenic pathway and lower expression of stem cell-associated markers CD106 (p = 0.04) and aldehyde dehydrogenase (p = 0.04). In conclusion, VICs from calcified aortic have reduced multipotency compared to cells from healthy valves, which should be considered when investigating possible medical treatments of aortic valve calcification.

• Rutkovskiy, Arkady; Olovyannikova, Maria; Siamansour, Tanja; Reine, Trine M.; Kolset, Svein Olav & Sand, Kristin Larsen [Show all 12 contributors for this article] (2019). Mechanical stress alters the expression of calcification-related genes in vascular interstitial and endothelial cells. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 28(5), p. 803–811. doi: 10.1093/icvts/ivy339.
• Baysa, Anton; Fedorov, Anton; Kondratov, Kirill; Ruusalepp, Arno; Minasian, Sarkis & Galagudza, Michael [Show all 13 contributors for this article] (2018). Release of mitochondrial and nuclear DNA during on-pump heart surgery: Kinetics and relation to extracellular vesicles. Journal of Cardiovascular Translational Research (JCTR). ISSN 1937-5387. p. 1–9. doi: 10.1007/s12265-018-9848-3.
• Bogdanova, Mariia; Kostina, Aleksandra; Zihlavnikova, Katarina; Zabirnyk, Arsenii; Malashicheva, Anna & Stensløkken, Kåre-Olav [Show all 12 contributors for this article] (2018). Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells. Frontiers in Physiology. ISSN 1664-042X. 9. doi: 10.3389/fphys.2018.01635. Full text in Research Archive
• Kimose, Hans-Henrik; Randsbæk, Flemming; Christensen, Thomas Decker; Valen, Guro; Bøtker, Hans Erik & Vaage, Ingvar Jarle (2018). A dose-response study of glutamate supplementation in isolated, perfused rat hearts undergoing ischaemia and cold cardioplegia. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 53(3), p. 664–671. doi: 10.1093/ejcts/ezx368.
• Kostina, Aleksandra; Shishkova, A; Ignatieva, Elena; Irtyuga, Olga; Bogdanova, Mariia & Levchuk, K [Show all 15 contributors for this article] (2017). Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 114, p. 211–219. doi: 10.1016/j.yjmcc.2017.11.009.
• Rutkovskiy, Arkady; Sagave, Julia Fritzi; Czibik, Gabor Tamas; Baysa, Anton; Zihlavnikova, Katarina & Hillestad, Vigdis [Show all 14 contributors for this article] (2017). Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 77(5), p. 321–331. doi: 10.1080/00365513.2017.1318447.
• Rutkovskiy, Arkady; Malashicheva, Anna; Sullivan, Gareth; Bogdanova, Mariia; Kostareva, Anna & Stensløkken, Kåre-Olav [Show all 8 contributors for this article] (2017). Valve interstitial cells: The key to understanding the pathophysiology of heart valve calcification. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 6(9), p. 1–24. doi: 10.1161/JAHA.117.006339.
• Bliksøen, Marte; Rutkovskiy, Arkady; Vaage, Ingvar Jarle & Stensløkken, Kåre-Olav (2017). Mode of perfusion influences infarct size, coronary flow and stress kinases in the isolated mouse heart. Acta Physiologica. ISSN 1748-1708. 220(1), p. 36–46. doi: 10.1111/apha.12773. Full text in Research Archive Show summary

  Aim: The isolated, retrogradely perfused heart (modified Langendorff model) is a widely used method in experimental heart research. The presence of an intraventricular balloon is necessary to get functional measurements. We have previously shown that the balloon induces phosphorylation of some suggested cardioprotective mitogen-activated protein kinases (MAPK): P38-MAPK, ERK 1/2 and JNK. We hypothesized that the balloon could influence cardioprotection, protect against ischaemia reperfusion injury and interfere with coronary flow. Methods and Results: Isolated mouse hearts were perfused for 5, 10, 20, 40 and 60 min with a balloon in the left ventricle. We found a wavelike phosphorylation of all MAPK while AKT displayed a gradual dephosphorylation when compared to non-perfused hearts. Hearts were subjected to 20 min of stabilization with or without the balloon, followed by 35 min of ischaemia and 120 min of reperfusion. Although the MAPK were phosphorylated, the infarcts were larger in the balloon group. When the balloon was present during the entire protocol, compared to removal at the end of ischaemia, the infarct size was also larger, especially in the endocardial layer. The balloon reduced post-ischaemic endocardial coronary flow, despite a higher average flow, indicating a hyperperfused epicard. Blocking the balloon-induced ERK 1/2 phosphorylation during stabilization did not affect infarct size. The effect of post-conditioning was influenced by the balloon, showing reduced infarct size when the balloon was present. Conclusion: The balloon used for pressure measurements may contributes to cell death possibly by reducing endocardial coronary flow. Keywords coronary flow, kinases, Langendorff, perfusion, post-conditioning, pre-conditioning.

• Sonin, Dmitry; Papayan, Garry; Pochkaeva, Evgeniia; Chefu, Svetlana; Minasian, Sarkis & Kurapeev, Dmitry [Show all 9 contributors for this article] (2017). In vivo visualization and ex vivo quantification of experimental myocardial infarction by indocyanine green fluorescence imaging. Biomedical Optics Express. ISSN 2156-7085. 8(1), p. 151–161. doi: 10.1364/BOE.8.000151.
• Malashicheva, Anna; Kostina, Daria; Kostina, Aleksandra; Irtyuga, Olga; Voronkina, Irina & Smagina, Larisa [Show all 12 contributors for this article] (2016). Phenotypic and functional changes of endothelial and smooth muscle cells in thoracic aortic aneurysms. International Journal of Vascular Medicine. ISSN 2090-2824. 2016:3107879, p. 1–11. doi: 10.1155/2016/3107879.
• Bliksøen, Marte; Mariero, Lars Henrik; Torp, May-Kristin; Baysa, Anton; Ytrehus, Kirsti & Haugen, Fred [Show all 10 contributors for this article] (2016). Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes. Basic Research in Cardiology. ISSN 0300-8428. 111(42). doi: 10.1007/s00395-016-0553-6.
• Reine, Trine M.; Vuong, Tram Thu; Rutkovskiy, Arkady; Meen, Astri Jeanette; Vaage, Ingvar Jarle & Jenssen, Trond Geir [Show all 7 contributors for this article] (2015). Serglycin in Quiescent and Proliferating Primary Endothelial Cells. PLOS ONE. ISSN 1932-6203. 10(12). doi: 10.1371/journal.pone.0145584. Full text in Research Archive
• Risøe, Petter Kirkeby; Rutkovskiy, Arkady; Ågren, Joanna; Kolseth, Ingrid Moss; Kjeldsen, Signe Flood & Valen, Guro [Show all 8 contributors for this article] (2015). Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression. Human Immunology. ISSN 0198-8859. 76(6), p. 427–430. doi: 10.1016/j.humimm.2015.03.018.
• Baysa, Anton; Sagave, Julia Fritzi; Carpi, Andrea; Zaglia, Tania; Campesan, Marika & Dahl, Christen Peder [Show all 14 contributors for this article] (2015). The p66ShcA adaptor protein regulates healing after myocardial infarction. Basic Research in Cardiology. ISSN 0300-8428. 110(13). doi: 10.1007/s00395-015-0470-0.
• Nilsson, Göran Erik; Vaage, Ingvar Jarle & Stensløkken, Kåre-Olav (2015). Oxygen- and temperature-dependent expression of survival protein kinases in crucian carp (carassius carassius) heart and brain. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. ISSN 0363-6119. 308(1), p. R50–R61. doi: 10.1152/ajpregu.00094.2014.
• Bliksøen, Marte; Baysa, Anton; Eide, Lars; Bjørås, Magnar; Suganthan, Rajikala & Vaage, Ingvar Jarle [Show all 8 contributors for this article] (2015). Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 78, p. 9–22. doi: 10.1016/j.yjmcc.2014.11.010.
• Rutkovskiy, Arkady; Mariero, Lars Henrik & Vaage, Ingvar Jarle (2014). Deletion of the aquaporin-4 gene alters expression and phosphorylation of protective kinases in the mouse heart. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 74(6), p. 500–505. doi: 10.3109/00365513.2014.905698.
• Stensløkken, Kåre-Olav; Ellefsen, Stian; Vasieva, Olga; Fang, Youhan; Farrell, Anthony P. & Olohan, Lisa [Show all 9 contributors for this article] (2014). Life without Oxygen: Gene Regulatory Responses of the Crucian Carp (Carassius carassius) Heart Subjected to Chronic Anoxia. PLOS ONE. ISSN 1932-6203. 9(11). doi: 10.1371/journal.pone.0109978. Full text in Research Archive
• Wu, Xueping; Sagave, Julia Fritzi; Rutkovskiy, Arkady; Haugen, Fred; Baysa, Anton & Nygård, Ståle [Show all 11 contributors for this article] (2014). Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart. Life Sciences. ISSN 0024-3205. 97(2), p. 145–154. doi: 10.1016/j.lfs.2013.12.030.
• Rutkovskiy, Arkady; Bliksøen, Marte; Hillestad, Vigdis; Amin, Mubashar Mohammad; Czibik, Gabor Tamas & Valen, Guro [Show all 9 contributors for this article] (2013). Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia, and cardioplegia. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 56, p. 22–33. doi: 10.1016/j.yjmcc.2012.12.002.
• Rutkovskiy, Arkady; Valen, Guro & Vaage, Ingvar Jarle (2013). Cardiac aquaporins. Basic Research in Cardiology. ISSN 0300-8428. 108(6), p. 393–412. doi: 10.1007/s00395-013-0393-6.
• Troitskaya, Maria P.; Baysa, Anton; Vaage, Ingvar Jarle; Sand, Kristin Larsen; Maghazachi, Azzam & Valen, Guro (2012). IL-17 level is reduced during acute myocardial infarction. Role of chemokine receptor expression in monocytes and their in vitro chemotaxis towards chemokines. Toxins. ISSN 2072-6651. 4(12), p. 1427–1439. doi: 10.3390/toxins4121427.
• Rutkovskiy, Arkady; Mariero, Lars Henrik; Nygård, Ståle; Stensløkken, Kåre-Olav; Valen, Guro & Vaage, Ingvar Jarle (2012). Transient hyperosmolality modulates expression of cardiac aquaporins. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 425(1), p. 70–75. doi: 10.1016/j.bbrc.2012.07.052.
• Rutkovskiy, Arkady; Stensløkken, Kåre-Olav; Mariero, Lars Henrik; Skrbic, Biljana; Amiry-Moghaddam, Mahmood & Hillestad, Vigdis [Show all 12 contributors for this article] (2012). Aquaporin-4 in the heart: expression, regulation and functional role in ischemia. Basic Research in Cardiology. ISSN 0300-8428. 107. doi: 10.1007/s00395-012-0280-6.
• Ellefsen, Stian; Bliksøen, Marte; Rutkovskiy, Arkady; Johansen, Ida Beitnes; Kaljusto, Mari-Liis & Nilsson, Göran Erik [Show all 8 contributors for this article] (2012). Per-unit-living tissue normalization of real-time RT-PCR data in ischemic rat hearts. Physiological Genomics. ISSN 1094-8341. 44(12), p. 651–656. doi: 10.1152/physiolgenomics.00004.2012.
• Mariero, Lars Henrik; Rutkovskiy, Arkady; Stensløkken, Kåre-Olav & Vaage, Ingvar Jarle (2012). Hyperoxia during early reperfusion does not increase ischemia-reperfusion injury. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 41(1), p. 149–153. doi: 10.1016/j.ejcts.2011.04.022.
• Kaljusto, Mari-Liis; Rutkovskiy, Arkady; Stensløkken, Kåre-Olav & Vaage, Ingvar Jarle (2010). Postconditioning in mouse hearts is inhibited by blocking the reverse mode of the sodium - calcium exchanger. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 10, p. 743–748. doi: 10.1510/icvts.2009.217083.
• Stensløkken, Kåre-Olav; Ellefsen, Stian; Larsen, Helene Kile; Vaage, Ingvar Jarle & Nilsson, Göran Erik (2010). Expression of heat shock proteins in anoxic crucian carp (Carassius carassius): support for cold as a preparatory cue for anoxia. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. ISSN 0363-6119. 298(6), p. R1499–R1508. doi: 10.1152/ajpregu.00675.2009.
• Stensløkken, Kåre-Olav; Rutkovskiy, Arkady; Kaljusto, Mari-Liis; Hafstad, Anne Dragøy; Larsen, Terje Steinar & Vaage, Ingvar Jarle (2009). Inadvertent phosphorylation of survival kinases in isolated perfused hearts: a word of caution. Basic Research in Cardiology. ISSN 0300-8428. 104, p. 412–423.
• Bliksøen, Marte; Kaljusto, Mari-Liis; Vaage, Ingvar Jarle & Stensløkken, Kåre-Olav (2008). Effects of hydrogen sulphide on ischaemia-reperfusion injury and ischaemic preconditioning in the isolated, perfused rat heart. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 34, p. 344–349. doi: 10.1016/j.ejcts.2008.03.017.
• Chen, F; Eriksson, P; Whatling, C; Vaage, Ingvar Jarle & Valen, Guro (2008). Surgical handling of saphenous vein grafts induces expression of matrix metalloproteinase 9. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 42, p. 327–336. doi: 10.1080/14017430801919540.
• Czibik, Gabor Tamas; Vaage, Ingvar Jarle; Valen, Guro; Wu, Zhongkai; Berne, Gabrielle Paulsson & Tarkka, Matti [Show all 8 contributors for this article] (2008). Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 34(5), p. 976–984. doi: 10.1016/j.ejcts.2008.07.066.
• Valen, Guro; Hinokiyama, K; Vedin, J & Vaage, Ingvar Jarle (2007). Preoperative unstable angina causes venous adaptation to surgical graft injury. Basic Research in Cardiology. ISSN 0300-8428. 102. doi: 10.1007/s00395-007-0642-7.
• Labruto, F; Song, XL; Valen, Guro & Vaage, Ingvar Jarle (2006). Lazaroid U-83836E improves tolerance to hemorrhagic shock and limb ischemia and reperfusion in rats and increases cardiac heat shock protein 72. Academic Emergency Medicine (AEM). ISSN 1069-6563. 13, p. 7–12.
• Valen, Guro & Vaage, Ingvar Jarle (2005). Pre- and postconditioning during cardiac surgery. Basic Research in Cardiology. ISSN 0300-8428. 100, p. 179–186.
• Valen, Guro & Vaage, Ingvar Jarle (2005). The role of tumor necrosis factor alpha and its receptor 1 in preconditioning by hyperoxia. Basic Research in Cardiology. ISSN 0300-8428. 100, p. 198–207.
• Valen, Guro & Vaage, Ingvar Jarle (2005). Intraperitoneal injections of fluid adapts the mouse heart to ischemia. Laboratory Animals. ISSN 0023-6772. 39, p. 298–307.
• Valen, Guro & Vaage, Ingvar Jarle (2004). Metabolic changes induced by ischemia and cardioplegia: A study employing microdialysis in pigs on cardiopulmonary bypass. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 25, p. 69–75.
• Valen, Guro & Vaage, Ingvar Jarle (2004). Brief global ischemia converts persistant reperfusion-induced ventricular fibrillation into regular rhythm in the rat heart. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 25, p. 1006–1010.
• Valen, Guro & Vaage, Ingvar Jarle (2004). Myocardial protection by remote preconditioning: The role of nuclear factor kappa B p105 and inducible nitric oxide synthase. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 26, p. 968–973.

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• Bliksoen, M; Rutkovskiy, Arkady; Mariero, Lars Henrik; Vaage, Ingvar Jarle & Stensløkken, Kåre-Olav (2010). Phosphorylation of survival kinases is not a guarantee for protection of ischemia-reperfusion injury in the isolated, perfused mouse heart. Cardiovascular Research (CVR). ISSN 0008-6363. 87, p. S85–S85.
• Rutkovskiy, Arkady; Mariero, Lars Henrik; Stensløkken, Kåre-Olav; Valen, Guro & Vaage, Ingvar Jarle (2010). Osmotic pressure regulates expression levels of cardiac aquaporins 1 and 4. Cardiovascular Research (CVR). ISSN 0008-6363. 87, p. S104–S104.
• Mariero, Lars Henrik; Rutkovskiy, Arkady; Stensløkken, Kåre-Olav & Vaage, Ingvar Jarle (2010). May hyperoxic ventilation during early reperfusion increase infarct size? Cardiovascular Research (CVR). ISSN 0008-6363. 87, p. S134–S134.
• Manne, Per Erik; Lode, Beate; Thorsen, Kirsten; Vaage, Ingvar Jarle; Johnsen, Kari Bjørgo & Helgesen, Carsten Gunnar [Show all 11 contributors for this article] (2015). Retningslinjer for karakterskalaen bestått/ikke beståttRapport fra en arbeidsgruppe oppnevnt av Utdanningsutvalget i UHRNovember 2015. Universitets- og Høgskolerådet/The Norwegian Association of Higher Education Institutions.

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