Tom Stiris

• Roehr, Charles Christoph; Szczapa, Tomasz; Stiris, Tom; Hadjipanayis, Adamos; Koletzko, Berthold & Ross-Russell, Rob [Show all 9 contributors for this article] (2024). European Training Requirements in Neonatology 2021: The ESPR, EAP, and UEMS Accredited European Syllabus for Neonatal Training. Neonatology. ISSN 1661-7800. doi: 10.1159/000536247.
• Engel, Corinna; Rüdiger, Mario; Benders, Manon J. N. L.; van Bel, Frank; Allegaert, Karel & Naulaers, Gunnar [Show all 21 contributors for this article] (2024). Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III). Trials. ISSN 1745-6215. 25(1). doi: 10.1186/s13063-023-07828-6.
• Moltu, Sissel Jennifer; Nordvik, Tone; Rossholt, Madelaine; Wendel, Kristina; Chawla, Maninder Singh & Server, Andrés [Show all 18 contributors for this article] (2023). Arachidonic and docosahexaenoic acid supplementation and brain maturation in preterm infants; a double blind RCT. Clinical Nutrition. ISSN 0261-5614. 43(1), p. 176–186. doi: 10.1016/j.clnu.2023.11.037.
• Wendel, Kristina; Rossholt, Madelaine Eloranta; Gunnarsdottir, Gunnþórunn; Aas, Marlen Fossan; Westvik, Asbjørn & Pripp, Are Hugo [Show all 10 contributors for this article] (2023). Lung function in preterm infants at 3 months corrected age after neonatal LC-PUFA supplementation. Pediatric Pulmonology. ISSN 8755-6863. 59(2), p. 389–398. doi: 10.1002/ppul.26760. Full text in Research Archive
• Rossholt, Madelaine; Bratlie, Marianne; Wendel, Kristina; Aas, Marlen Fossan; Gunnarsdottir, Gunnþórunn & Fugelseth, Drude [Show all 11 contributors for this article] (2023). Effect of arachidonic and docosahexaenoic acid supplementation on quality of growth in preterm infants: A secondary analysis of a randomized controlled trial. Clinical Nutrition. ISSN 0261-5614. 42(12), p. 2311–2319. doi: 10.1016/j.clnu.2023.10.005. Full text in Research Archive
• Wendel, Kristina; Gunnarsdottir, Gunnþórunn; Aas, Marlen Fossan; Westvik, Asbjørn; Pripp, Are Hugo & Fugelseth, Drude [Show all 8 contributors for this article] (2023). Essential Fatty Acid Supplementation and Early Inflammation in Preterm Infants: Secondary Analysis of a Randomized Clinical Trial. Neonatology. ISSN 1661-7800. 120(4), p. 465–472. doi: 10.1159/000530129. Full text in Research Archive
• Nordvik, Tone; Server, Andrés; Nygaard, Cathrine Skorpen; Schumacher, Eva Margrethe; Larsson, Pål Gunnar & Pripp, Are Hugo [Show all 7 contributors for this article] (2023). Combining MRI and Spectral EEG for Assessment of Neurocognitive Outcomes in Preterm Infants. Neonatology. ISSN 1661-7800. 120(4), p. 482–490. doi: 10.1159/000530648. Full text in Research Archive
• Stevenson, Nathan J; Nordvik, Tone; Nygaard, Cathrine Skorpen; Giordano, Vito; Moltu, Sissel Jennifer & Larsson, Pål Gunnar [Show all 9 contributors for this article] (2023). Inter-site generalizability of EEG based age prediction algorithms in the preterm infant. Physiological Measurement. ISSN 0967-3334. 44(7). doi: 10.1088/1361-6579/ace755.
• Rossholt, Madelaine; Wendel, Kristina; Bratlie, Marianne; Aas, Marlen Fossan; Gunnarsdottir, Gunnþórunn & Fugelseth, Drude [Show all 11 contributors for this article] (2023). Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure. Nutrients. ISSN 2072-6643. 15(2). doi: 10.3390/nu15020441. Full text in Research Archive
• Rossholt, Madelaine; Bratlie, Marianne; Wendel, Kristina; Aas, Marlen Fossan; Gunnarsdottir, Gunnþórunn & Fugelseth, Drude [Show all 10 contributors for this article] (2023). A standardized feeding protocol ensured recommended nutrient intakes and prevented growth faltering in preterm infants < 29 weeks gestation. Clinical Nutrition ESPEN. ISSN 2405-4577. 53, p. 251–259. doi: 10.1016/j.clnesp.2022.12.024. Full text in Research Archive
• Wendel, Kristina; Aas, Marlen Fossan; Gunnarsdottir, Gunnþórunn; Rossholt, Madelaine; Bratlie, Marianne & Nordvik, Tone [Show all 12 contributors for this article] (2023). Effect of arachidonic and docosahexaenoic acid supplementation on respiratory outcomes and neonatal morbidities in preterm infants. Clinical Nutrition. ISSN 0261-5614. 42(1), p. 22–28. doi: 10.1016/j.clnu.2022.11.012. Full text in Research Archive
• Giuffrida, Francesca; Fleith, Mathilde; Goyer, Amélie; Samuel, Tinu Mary; Elmelegy-Masserey, Isabelle & Fontannaz, Patric [Show all 25 contributors for this article] (2022). Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-021-02788-6.
• Nordvik, Tone; Schumacher, Eva Margrethe; Larsson, Pål Gunnar; Pripp, Are Hugo; Løhaugen, Gro & Stiris, Tom (2022). Early spectral EEG in preterm infants correlates with neurocognitive outcomes in late childhood. Pediatric Research. ISSN 0031-3998. 92, p. 1132–1139. doi: 10.1038/s41390-021-01915-7. Full text in Research Archive Show summary

  Background Evidence regarding the predictive value of early amplitude-integrated electroencephalography (aEEG)/EEG on neurodevelopmental outcomes at school age and beyond is lacking. We aimed to investigate whether there is an association between early postnatal EEG and neurocognitive outcomes in late childhood. Methods This study is an observational prospective cohort study of premature infants with a gestational age <28 weeks. The total absolute band powers (tABP) of the delta, theta, alpha, and beta bands were analyzed from EEG recordings during the first three days of life. At 10–12 years of age, neurocognitive outcomes were assessed using the Wechsler Intelligence Scale for Children 4th edition (WISC-IV), Vineland adaptive behavior scales 2nd edition, and Behavior Rating Inventory of Executive Function (BRIEF). The mean differences in tABP were assessed for individuals with normal versus unfavorable neurocognitive scores. Results Twenty-two infants were included. tABP values in all four frequency bands were significantly lower in infants with unfavorable results in the main composite scores (full intelligence quotient, adaptive behavior composite score, and global executive composite score) on all three tests (p < 0.05). Conclusions Early postnatal EEG has the potential to assist in predicting cognitive outcomes at 10–12 years of age in extremely premature infants <28 weeks’ gestation. Impact Evidence regarding the value of early postnatal EEG in long-term prognostication in preterm infants is limited. Our study suggests that early EEG spectral analysis correlates with neurocognitive outcomes in late childhood in extremely preterm infants. Early identification of infants at-risk of later impairment is important to initiate early and targeted follow-up and intervention.

• Binia, Aristea; Lavalle, Luca; Chen, Cheng; Austin, Sean; Agosti, Massimo & Al-Jashi, Isam [Show all 21 contributors for this article] (2021). Human milk oligosaccharides, infant growth, and adiposity over the first 4 months of lactation. Pediatric Research. ISSN 0031-3998. 90(3), p. 684–693. doi: 10.1038/s41390-020-01328-y.
• Wendel, Kristina; Pfeiffer, Helle Cecilie; Fugelseth, Drude; Nestaas, Eirik; Domellöf, Magnus & Skålhegg, Bjørn Steen [Show all 42 contributors for this article] (2021). Effects of nutrition therapy on growth, inflammation and metabolism in immature infants: a study protocol of a double-blind randomized controlled trial (ImNuT). BMC Pediatrics. ISSN 1471-2431. 21. doi: 10.1186/s12887-020-02425-x. Full text in Research Archive Show summary

  Background: Current nutritional management of infants born very preterm results in significant deficiency of the essential fatty acids (FAs) arachidonic acid (ARA) and docosahexaenoic acid (DHA). The impact of this deficit on brain maturation and inflammation mediated neonatal morbidities are unknown. The aim of this study is to determine whether early supply of ARA and DHA improves brain maturation and neonatal outcomes in infants born before 29 weeks of gestation. Methods: Infants born at Oslo University Hospital are eligible to participate in this double-blind randomized controlled trial. Study participants are randomized to receive an enteral FA supplement of either 0.4 ml/kg MCT-oil™ (medium chain triglycerides) or 0.4 ml/kg Formulaid™ (100 mg/kg of ARA and 50 mg/kg of DHA). The FA supplement is given from the second day of life to 36 weeks' postmenstrual age (PMA). The primary outcome is brain maturation assessed by Magnetic Resonance Imaging (MRI) at term equivalent age. Secondary outcomes include quality of growth, incidence of neonatal morbidities, cardiovascular health and neuro-development. Target sample size is 120 infants (60 per group), this will provide 80% power to detect a 0.04 difference in mean diffusivity (MD, mm2/sec) in major white matter tracts on MRI. Discussion: Supplementation of ARA and DHA has the potential to improve brain maturation and reduce inflammation related diseases. This study is expected to provide valuable information for future nutritional guidelines for preterm infants. Trial registration: Clinicaltrials.gov ID: NCT03555019 . Registered 4 October 2018- Retrospectively registered.

• Kongstorp, Mette; Bogen, Inger Lise; Stiris, Tom & Andersen, Jannike Mørch (2020). Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats. Drug and Alcohol Dependence. ISSN 0376-8716. 212(108008), p. 1–9. doi: 10.1016/j.drugalcdep.2020.108008. Full text in Research Archive
• Schrier, Lenneke; Hadjipanayis, Adamos; Stiris, Tom; Ross-Russell, Robert; Valiulis, Arunas & Turner, Mark A [Show all 11 contributors for this article] (2020). Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology. European Journal of Pediatrics. ISSN 0340-6199. 179(5), p. 839–847. doi: 10.1007/s00431-019-03556-9.
• Kongstorp, Mette; Bogen, Inger Lise; Steinsland, Synne; Nerem, Elisabeth; Salih, Triske Woshyar & Stiris, Tom [Show all 7 contributors for this article] (2020). Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain. International Journal of Developmental Neuroscience. ISSN 0736-5748. 80(5), p. 443–453. doi: 10.1002/jdn.10043. Full text in Research Archive
• Samuel, Tinu Mary; de Castro, Carlos Antonio; Dubascoux, Stephane; Affolter, Michael; Giuffrida, Francesca & Billeaud, Claude [Show all 23 contributors for this article] (2019). Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth. Nutrients. ISSN 2072-6643. 12(1). doi: 10.3390/nu12010105.
• Samuel, Tinu Mary; Binia, Aristea; de Castro, Carlos Antonio; Thakkar, Sagar K; Billeaud, Claude & Agosti, Massimo [Show all 17 contributors for this article] (2019). Impact of maternal characteristics on human milk oligosaccharide composition over the first 4 months of lactation in a cohort of healthy European mothers. Scientific Reports. ISSN 2045-2322. 9(1), p. 1–10. doi: 10.1038/s41598-019-48337-4.
• Kongstorp, Mette; Bogen, Inger Lise; Stiris, Tom & Andersen, Jannike Mørch (2019). High accumulation of methadone compared with buprenorphine in fetal rat brain after maternal exposure. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. 371(1), p. 130–137. doi: 10.1124/jpet.119.259531.
• Hadjipanayis, Adamos; Efstathiou, Elisavet; Altorjai, Peter; Stiris, Tom; Valiulis, Arũnas & Koletzko, Berthold [Show all 7 contributors for this article] (2019). Social media and children: what is the paediatrician's role? European Journal of Pediatrics. ISSN 0340-6199. 178, p. 1605–1612. doi: 10.1007/s00431-019-03458-w.
• Schrier, Lenneke; Wyder, Corinne; del Torso, Stefano; Stiris, Tom; von Both, Ulrich & Brandenberger, Julia [Show all 7 contributors for this article] (2019). Medical care for migrant children in Europe: a practical recommendation for first and follow-up appointments. European Journal of Pediatrics. ISSN 0340-6199. 178(9), p. 1449–1467. doi: 10.1007/s00431-019-03405-9. Full text in Research Archive
• Ûner, Inger Louise; Johansen, Tove; Dahle, Julie; Persson, Mette; Stiris, Tom & Andresen, Jannicke Hanne (2019). Therapeutic hypothermia and N-PASS; results from implementation in a level 3 NICU. Early Human Development. ISSN 0378-3782. 137:104828, p. 1–4. doi: 10.1016/j.earlhumdev.2019.104828. Full text in Research Archive
• Zavrsnik, Jernej; Stiris, Tom; Schrier, Lenneke; Russell, Robert Ross; del Torso, Stefano & Valiulis, Arunas [Show all 9 contributors for this article] (2018). Basic training requirements for health care professionals who care for children. European Journal of Pediatrics. ISSN 0340-6199. 177(9), p. 1413–1417. doi: 10.1007/s00431-018-3150-x.
• Hadjipanayis, Adamos; Crawley, Francis P.; Stiris, Tom; Neubauer, David & Michaud, Pierre-Andre (2018). Child trafficking in Europe: what is the paediatrician's role?: A statement by the European Academy of Paediatrics. European Journal of Pediatrics. ISSN 0340-6199. 177(9), p. 1419–1423. doi: 10.1007/s00431-018-3190-2. Full text in Research Archive
• Schrier, Lenneke; Hadjipanayis, Adamos; del Torso, Stefano; Stiris, Tom; Emonts, Marieke & Dornbusch, Hans Jürgen (2018). European Antibiotic Awareness Day 2017: training the next generation of health care professionals in antibiotic stewardship. European Journal of Pediatrics. ISSN 0340-6199. 177(2), p. 279–283. doi: 10.1007/s00431-017-3055-0.
• Bührer, Christoph; Erdeve, Ömer; van Kaam, Anton; Berger, Angelika; Lechner, Evelyn & Bar-Oz, Benjamin [Show all 10 contributors for this article] (2017). N-terminal B-type natriuretic peptide urinary concentrations and retinopathy of prematurity. Pediatric Research. ISSN 0031-3998. 82(6), p. 958–963. doi: 10.1038/pr.2017.179.
• Schrier, Lenneke; Illy, K; Valiulis, Arũnas; Wyder, Corinne & Stiris, Tom (2017). EAP viewpoint on unpublished data from paediatric clinical trials. European Journal of Pediatrics. ISSN 0340-6199. 177(2), p. 275–277. doi: 10.1007/s00431-017-3005-x.
• Skranes, Janne Helen; Løhaugen, Gro; Schumacher, Eva Margrethe; Osredkar, Damjan; Server, Andrés & Cowan, Frances Mary [Show all 9 contributors for this article] (2017). Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age. Journal of Pediatrics. ISSN 0022-3476. 187, p. 34–42. doi: 10.1016/j.jpeds.2017.04.041.
• Dornbusch, Hans Jürgen; Hadjipanayis, Adamos; Del Torso, Stefano; Mercier, Jean-Christophe; Wyder, Corinne & Schrier, Lenneke [Show all 9 contributors for this article] (2017). We strongly support childhood immunisation-statement from the European Academy of Paediatrics (EAP). European Journal of Pediatrics. ISSN 0340-6199. 176(5), p. 679–680. doi: 10.1007/s00431-017-2885-0.
• Fredly, Siv; Fugelseth, Drude; Nygaard, Cathrine Skorpen; Salerud, Gøran; Stiris, Tom & Kvernebo, Knut (2016). Noninvasive assessments of oxygen delivery from the microcirculation to skin in hypothermia-treated asphyxiated newborn infants. Pediatric Research. ISSN 0031-3998. 79, p. 902–906. doi: 10.1038/pr.2016.16.
• Fredly, Siv; Nygaard, Cathrine Skorpen; Skranes, Janne Helen; Stiris, Tom & Fugelseth, Drude (2016). Cooling effect on skin microcirculation in asphyxiated newborn infants with increased C-reactive protein. Neonatology. ISSN 1661-7800. 110(4), p. 270–276. doi: 10.1159/000446763.
• Sidaly, Rivan; Schmalfuss, Andreas Jørn; Skaare, Anne B; Sehic, Amer; Stiris, Tom & Espelid, Ivar (2016). Five-minute Apgar score ≤ 5 and molar incisor hypomineralisation (MIH) - a case control study. BMC Oral Health. ISSN 1472-6831. 17:25. doi: 10.1186/s12903-016-0253-5. Full text in Research Archive
• Schumacher, Eva Margrethe; Stiris, Tom & Larsson, Pål Gunnar (2015). Effective connectivity in long-term EEG monitoring in preterm infants. Clinical Neurophysiology. ISSN 1388-2457. 126(12), p. 2261–2268. doi: 10.1016/j.clinph.2015.01.017.
• Sidaly, Rivan; Risnes, Steinar; Khan, Qalbi; Stiris, Tom & Sehic, Amer (2015). The effect of hypoxia on the formation of mouse incisor enamel. Archives of Oral Biology. ISSN 0003-9969. 60(11), p. 1601–1612. doi: 10.1016/j.archoralbio.2015.08.009.
• Skranes, Janne Helen; Cowan, Frances; Stiris, Tom; Fugelseth, Drude; Thoresen, Marianne & SERVER, ANDRES (2015). Brain imaging in cooled encephalopathic neonates does not differ between four and 11 days after birth. Acta Paediatrica. ISSN 0803-5253. 104(8), p. 752–758. doi: 10.1111/apa.13016.
• Bousquet, Jean; Addis, Antoino; Adcock, Ian M.; Agache, Ioana; Agustí, Àlvar & Alonso, Albert [Show all 50 contributors for this article] (2014). Integrated care pathways for airway diseases (AIRWAYS-ICPs). European Respiratory Journal. ISSN 0903-1936. 44(2), p. 304–323. doi: 10.1183/09031936.00014614.
• Schumacher, Eva Margrethe; Larsson, Pål Gunnar; Pripp, Are Hugo & Stiris, Tom (2014). The Effect of Blood Glucose and pCO 2 on Spectral EEG of Premature Infants during the First Three Days of Life. Neonatology. ISSN 1661-7800. 105(4), p. 297–305. doi: 10.1159/000357291.
• Skranes, Janne Helen; Elstad, Maja; Thoresen, Marianne; Cowan, Frances; Stiris, Tom & Fugelseth, Drude (2014). Hypothermia Makes Cerebral Resistance Index a Poor Prognostic Tool in Encephalopathic Newborns. Neonatology. ISSN 1661-7800. 106(1), p. 17–23. doi: 10.1159/000358229.
• Haukland, Linda; Kutzsche, Stefan ; Hynås, Inger Anette & Stiris, Tom (2013). Neonatal seizures with reversible EEG changes after antenatal venlafaxine exposure. Acta Paediatrica. ISSN 0803-5253. 102(11), p. E524–E526. doi: 10.1111/apa.12375.
• Schumacher, Eva Margrethe; Larsson, Pål Gunnar; Sinding-Larsen, Charlotte; Aronsen, Roy Arne; Lindemann, Rolf & Skjeldal, Ola [Show all 7 contributors for this article] (2013). Automated Spectral EEG Analyses of Premature Infants during the First Three Days of Life Correlated with Developmental Outcomes at 24 Months. Neonatology. ISSN 1661-7800. 103(3), p. 205–212. doi: 10.1159/000345923.
• Schumacher, Eva Margrethe; Westvik, Asbjørn Schumacher; Larsson, Pål Gunnar; Lindemann, Rolf; Westvik, Jostein & Stiris, Tom (2011). Feasibility of Long-Term Continuous EEG Monitoring During the First Days of Life in Preterm Infants: An Automated Quantification of the EEG Activity. Pediatric Research. ISSN 0031-3998. 69(5), p. 413–417. doi: 10.1203/pdr.0b013e31821267d2.
• Lindemann, Rolf; Svenningsen, Leif; Kjeldsen-Kragh, Jens; Stiris, Tom; Killie, Mette K & Husebekk, Anne (2004). Tre spesielle graviditetsforløp til ettertanke. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 124(17), p. 2244–2245.

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• Volstad, K; Melheim, Maria; Saugstad, Ola Didrik; Stiris, Tom; Baumbusch, Lars Oliver & Andresen, Jannicke Hanne (2023). Effect of nicotine on brain-derived neurotrophic factor and brain-derived neurotrophic factor antisense in newborn asphyxiated piglets.
• Kongstorp, Mette; Andersen, Jannike Mørch; Bogen, Inger Lise & Stiris, Tom (2019). Prenatal exposure to opioid maintenance treatment (OMT) reduces cognitive performance in young adult rats.
• Maiwald, Christian A.; Annink, Kim V.; Rüdiger, Mario; Benders, Manon J.N.L.; van Bel, Frank & Allegaert, Karel [Show all 19 contributors for this article] (2019). Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III). BMC Pediatrics. ISSN 1471-2431. 19:210(210), p. 1–10. doi: 10.1186/s12887-019-1566-8.
• Grossman, Zachi; Hadjipanayis, Adamos; Stiris, Tom; del Torso, Stefano; Mercier, Jean-Christophe & Valiulis, Arunas [Show all 7 contributors for this article] (2017). Vitamin D in European children - statement from the European Academy of Paediatrics (EAP). European Journal of Pediatrics. ISSN 0340-6199. 176(6), p. 829–831. doi: 10.1007/s00431-017-2903-2.
• Ludvigsson, Jonas F.; Hadjipanayis, Adamos; Del Torso, Stefano; Mercier, Jean-Christophe; Valiulis, Arunas & Stiris, Tom (2017). Appropriate use of antibiotics is vital for public health. Acta Paediatrica. ISSN 0803-5253. 106(5). doi: 10.1111/apa.13772.
• Wood, Thomas Ragnar; Skranes, Janne Helen; Falck, Mari; Lohaugen, GC; Stiris, Tom & Loberg, EM [Show all 8 contributors for this article] (2016). Core Temperature After Neonatal Hypoxia-Ischaemia Predicts Long-term Cerebral Injury.
• Skranes, Janne Helen; Cowan, Frances; Stiris, Tom; Fugelseth, Drude ; Thoresen, Marianne & SERVER, ANDRES (2014). Cerebral MRI on Days 4 and 11 in Encephalopathic Neonates Treated With Hypothermia.
• Skranes, Janne Helen; Thoresen, Marianne; Stiris, Tom; Cowan, Frances; Server, Andres Alonso & Fugelseth, Drude [Show all 7 contributors for this article] (2013). Changes in Cerebral Resistance Index (RI) after rewarming from day three of cooling predicts good but not poor outcome in infants undergoing therapeutic hypothermia.
• Kalikstad, Betty; Wesenberg, Finn; Brunvand, Leif; Stiris, Tom & Hansen, Thor Willy (2007). Sikrere medisiner for barn. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. Show summary

  Det er på høy tid at Norge er med på å ta et ansvar for å utvikle sikrere og bedre legemiddelbehandling av barn. A-Magasinet 23. mars gir informasjon om åpningen av Nordens første forskningspost for medikamentell behandling av barn ved Haukeland Universitetssykehus.

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