Nikolina Sekulic Group (Structural Biology and Chromatin) started at the Biotechnology Centre of Oslo, now NCMM, January 2016.
CENP-A nucleosome (PDB 3AN2). Illustration: Nikolina Sekulic.
The research group is using modern biophysical methods in combination with structural - and cell biology to answer important questions in the field of chromatin biology. We are particularly interested in centromere - the part of the chromosome that is governing chromosome segregation during cell division.
Dr. Sekulic's previous work in the lab of Prof. Ben Black at the University of Pennsylvania has set the foundation for biochemical understanding of centromeres by providing the first high-resolution structure of specialized histone (CENP-A) that is defining these chromosome loci.
The Sekulic Group are interested in understanding what unique properties of this histone are generating specialized chromatin at centromeres. Further, the group would like to understand the role of other centromere-associated proteins and dynamics of their association with centromere during cell division.