Randi Opheim

• Janson, Astri Letnes; Hellesø, Ragnhild; Norlyk, Annelise; Sulosaari, Virpi & Opheim, Randi (2026). Becoming an advanced practice nurse educator. Scandinavian Journal of Educational Research. ISSN 0031-3831. p. 1–11. doi: 10.1080/00313831.2026.2727859. Full text in Research Archive
• Borge, Christine Råheim; Eik, Hedda; Wahl, Astrid Klopstad; Bragstad, Line Kildal; Sylwander, Charlotte & Hjorthaug, Kristin [Show all 26 contributors for this article] (2026). Health literacy research in primary healthcare services – A scoping review. Patient Education and Counseling. ISSN 0738-3991. 149, p. 109675–109675. doi: 10.1016/j.pec.2026.109675. Full text in Research Archive Show summary

  Objective To systematically map existing evidence on health literacy among people with non-communicable diseases (NCDs) in primary healthcare. Methods An interdisciplinary research group conducted a scoping review following the Arksey and O’Malley framework, refined by Levac and Peters, and reported according to PRISMA-ScR. The review was registered in OSF and applied the Population–Concept–Context framework to define inclusion criteria. Searches were conducted in Medline, APA PsycInfo, Scopus, and Cochrane for studies published between 2000–2025. Peer-reviewed studies were screened in Rayyan, and data were charted and thematically analyzed through team-based consensus. Results The search identified 7952 studies, of which 106 studies met the inclusion criteria. Participants’ mean age was 59 years; 56% were female. Studies originated from 29 countries, mainly the USA, China, and Canada, with an increase after 2013. Three main themes were identified: (1) health literacy, social status, and ethnicity, (2) health literacy, disease, and health outcomes, and (3) health literacy, NCD knowledge, and self-management. Many studies reported associations between health literacy, and self-management, quality of life, and some clinical outcomes, but findings across designs and outcomes were heterogeneous and not consistently positive. Conclusions Improved communication, greater cultural competence, and tailored health literacy interventions are associated with better self-management and disease outcomes in non-communicable diseases, but most evidence is associative rather than causal, intervention effects are mixed, and research on health literacy experiences remains limited. Practice Implications More rigorously designed intervention studies and broader conceptualization and measurement of health literacy with multidimensional instruments are needed to strengthen the evidence and clarify how health literacy relates to social status, disease outcomes, and self-management in primary healthcare. Training healthcare professionals to assess and address health literacy is essential to promote equity and effective patient engagement.

• Maseng, Maria Gjerstad; Hansen, Simen Hyll; Grännö, Olle; Bang, Corinna; Lund, Charlotte & Huppertz-Hauss, Gert [Show all 22 contributors for this article] (2026). Disentangling the gut microbiome and inflammation in inflammatory bowel diseases: longitudinal observations from the IBSEN III study. Inflammatory Bowel Diseases. ISSN 1078-0998. doi: 10.1093/ibd/izag051. Full text in Research Archive Show summary

  Background and Aim Despite the well-established involvement of the gut microbiome in inflammatory bowel disease (IBD), less is known about how the gut microbiome changes over time and how it varies with clinical disease activity and fecal calprotectin (f-calprotectin). To address this gap, we utilized samples from the population-based inception cohort of the Inflammatory Bowel Disease in South-Eastern Norway III (IBSEN III) study. Methods Data and stool samples from study participants with IBD and symptomatic controls were collected at diagnosis and after 3, 6, and 12 months. Microbiome profiling of stool samples was performed targeting the V3-V4 region of the 16S rRNA gene, and a consensus-based approach of mixed models was employed for the longitudinal microbiome analysis. Results We included 1251 samples from 744 patients with ulcerative colitis, 618 samples from 356 patients with Crohn’ s disease and 266 samples from 164 symptomatic non-IBD controls. In the IBD population, we observed that levels of f-calprotectin decreased over time, as did the patient-reported disease activity (P < .001). Distinct changes in the gut microbiome of IBD patients were observed throughout the first year, such as increased alpha diversity (P < .001) and significant taxonomic changes. Notably, there was no covariation between the changes in alpha diversity and f-calprotectin or symptom score. Conclusion The gut microbiome during the first year after IBD diagnosis showed changes that paralleled inflammation and clinical disease activity, albeit without covariation, suggesting that there may be a disease-driving impact of gut microbiome independent of inflammation and inflammation-driven symptoms.

• Mathisen, Charlotte Bache-Wiig; Nyström, Niklas; Bazov, Igor; Øyås, Ove; Zucknick, Manuela & Andersen, Svend [Show all 23 contributors for this article] (2026). A novel diagnostic serum protein signature for pediatric inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition - JPGN. ISSN 0277-2116. doi: 10.1002/jpn3.70379. Full text in Research Archive Show summary

  Abstract Objectives Diagnostic delay is common in pediatric inflammatory bowel disease (PIBD), and fecal calprotectin (FCP) is often limited by challenges with sample collection. Therefore, we aimed to identify and validate a blood‐based diagnostic protein signature of PIBD. Methods Proteins were analyzed using proximity extension assay in plasma samples from treatment‐naïve pediatric patients in a Swedish inception cohort referred for suspected inflammatory bowel disease (IBD) and validated in an independent Norwegian population‐based pediatric inception cohort. Diagnostic performance was estimated by the area under the curve (AUC) with 95% confidence intervals (CIs). Results The discovery cohort included 58 patients with PIBD and 36 symptomatic controls without evidence of IBD, while the validation cohort consisted of 79 patients with PIBD and 37 symptomatic controls. In total, 154 proteins were examined. Univariable analyses identified 26 differentially regulated proteins for PIBD versus symptomatic controls in the discovery cohort ( q  < 0.05), whereas 29 proteins were differentially regulated in the validation cohort. Using regularized logistic regression, we identified a diagnostic model of 31 proteins that differentiated PIBD from symptomatic controls in the discovery cohort (AUC = 0.83; 95% CI: 0.74–0.90). The protein signature was further reduced to a clinically relevant biomarker consisting of high‐sensitivity C‐reactive protein (hsCRP) and seven other proteins with diagnostic capacity (AUC = 0.85, 95% CI: 0.78–0.92) outperforming hsCRP in the validation cohort ( p  = 0.006). Conclusions We identified and validated a blood‐based protein signature for PIBD with superior diagnostic performance compared to hsCRP. Given the challenges of fecal sample collection, further assay development may enable integration of these biomarkers into diagnostic pathways for PIBD. Trial Registration ClinicalTrials.gov identifier: NCT02727959.

• Johansen, Ingunn; Hagen, Milada; Løkkeberg, Stine Eileen Torp; Aabrekk, Tone Bergene; Asak, Øyvind & Bengtson, May-Bente [Show all 22 contributors for this article] (2026). Anxiety and depression in newly diagnosed patients with inflammatory bowel disease (the IBSEN III study) compared with the general population in Norway. Journal of Crohn's and Colitis. ISSN 1873-9946. 20(3). doi: 10.1093/ecco-jcc/jjag021. Full text in Research Archive Show summary

  Background and Aims: Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD); the aim of this study was to assess the proportion of anxiety and depression in patients newly diagnosed with IBD, compare the rates with the Norwegian general population (NGP), and examine associations with selected sociodemographic, psychological, and disease-related factors. Methods: This prospective cohort study included newly diagnosed patients with IBD, and data from the HUNT4 survey of the NGP. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Crude statistical comparisons were performed using t-tests, Mann–Whitney U test, chi-square tests, or Fisher’s exact tests. Adjusted associations were modeled using multiple robust linear regression and multiple logistic regression. Results: In total, 938/1562 (62.1%) patients with IBD completed the Hospital Anxiety and Depression Scale (Crohn’s disease [CD]: n = 297, ulcerative colitis [UC]: n = 641). The proportion of anxiety was 37.4% in CD and 32.1% in UC, while depression was reported by 21.9% and 16.8%, respectively. Both rates were significantly higher than those observed in the NGP (17.5% for anxiety and 9.4% for depression). Compared with the NGP, males with CD had significantly higher levels of anxiety and depression, males with UC had elevated anxiety only, while females with CD and UC showed increased anxiety and depression. Both substantial fatigue and general self-efficacy were significantly associated with anxiety and depression in IBD. Conclusions: Newly diagnosed patients with IBD experienced significant psychological challenges compared with the NGP. Early identification of anxiety and depression may enable targeted interventions.

• Holten, Kristina Ingeborg Aass; Bernklev, Tomm; Opheim, Randi; Olsen, Bjørn Christian Elias Grova; Johansen, Ingunn & Strande, Vibeke [Show all 19 contributors for this article] (2026). Fatigue Trajectory During the First Year of an Inflammatory Bowel Disease Diagnosis, Results from the IBSEN III study. Digestive Diseases and Sciences. ISSN 0163-2116. 71, p. 2476–2487. doi: 10.1007/s10620-025-09661-0. Full text in Research Archive Show summary

  Background: Fatigue is common in Crohn's disease (CD) and ulcerative colitis (UC), but the pathogenesis remains poorly understood. Aims: This study aimed to assess changes in fatigue prevalence during the first year after diagnosis and examine the association between disease course and substantial fatigue (SF) at the 1-year follow-up. Methods: Adults with newly diagnosed CD or UC were recruited from the population-based IBSEN III cohort. Fatigue was assessed at diagnosis and the 1-year follow-up using the Fatigue Questionnaire. Associations between SF at the 1-year follow-up and disease-related factors were quantified using multivariate logistic regression adjusted for sex, age and comorbidities. Results: In total, 596 patients were included (CD: 196, UC: 400). SF was present at both baseline and after one year of disease for 46.9% (n = 92/196) and 40.5% (n = 162/400) of patients with CD and UC, respectively. In CD, development of endoscopically non-passable stricture and/or surgically treated stricture within first year of disease (OR = 4.52, 95%CI [1.61;12.68]), self-reported flares since diagnosis (OR = 2.55, 95%CI [1.26;5.16]), female sex (OR = 3.12, 95%CI [1.53;6.37]) and comorbidities (OR = 4.05, 95%CI [1.89;8.69]) were independently associated with SF at the 1-year follow-up. In UC, SF was associated with current biological treatment (OR = 5.14, 95%CI [1.56;16.96]), increasing Mayo endoscopic score at the 1-year follow-up (OR = 1.54, 95%CI [1.01;2.35]), self-reported flares since diagnosis (OR = 2.66, 95%CI [1.24;5.72]) and female sex (OR = 2.20, 95%CI [1.06;4.57]). Conclusions: Fatigue frequently persists through the first year after IBD diagnosis. Clinical factors reflecting a more severe disease course were associated with SF one year after diagnosis in both CD and UC.

• Mahdy, Aya K. H.; Schöpfel, Valentina; Huppertz-Hauss, Gert; Perminow, Gøri Margrete; Tran, Florian & Bang, Corinna [Show all 17 contributors for this article] (2025). Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease. Frontiers in Immunology. 16. doi: 10.3389/fimmu.2025.1638522. Full text in Research Archive Show summary

  Introduction Crohn’s disease (CD) is a clinical subset of inflammatory bowel disease that is characterized by patchy transmural inflammation across the gastrointestinal tract. Although the exact etiology remains unknown, recent findings suggest that it is a complex multifactorial disease with contributions from the host genetics and environmental factors such as the microbiome. We have previously shown that the T cell repertoire of individuals with CD harbors a group of highly expanded T cells which hints toward an antigen-mediated pathology. Methods We simultaneously profiled the αβ and γδ T cell repertoire in addition to the B cell repertoire of both the blood and the colonic mucosa of 27 treatment-naïve individuals with CD and 27 age-matched symptomatic controls. Results Regardless of disease status, we observed multiple physiological differences between the immune repertoire of blood and colonic mucosa. Additionally, by comparing the repertoire of individuals with CD relative to controls, we observed different alterations that were only detected in the blood or colonic mucosa. These include a depletion of mucosal-associated invariant T (MAIT) cells and an expansion of TRAV29/DV5-TRAJ5 + clonotypes in the blood repertoire of individuals with CD. Also, a significant depletion of multiple IGHV3-33-IGHJ4 + and IGHV3-33-IGHJ6 + clonotypes in the blood and gut IGH repertoire of individuals with CD. Discussion Our findings highlight the importance of studying the immune repertoire in a tissue-specific manner and the need to profile the T and B cell immune repertoire of gut tissues as not all disease-induced alterations will be detected in the blood.

• Andersen, Svend; Bernklev, Tomm; Størdal, Ketil; Hagen, Milada; Kristensen, Vendel Ailin & Opheim, Randi [Show all 13 contributors for this article] (2025). Specific phenotypes may drive an increased incidence of pediatric inflammatory bowel disease in South‐Eastern Norway. Journal of Pediatric Gastroenterology and Nutrition - JPGN. ISSN 0277-2116. 81(5), p. 1227–1236. doi: 10.1002/jpn3.70148. Full text in Research Archive Show summary

  Abstract Objectives Pediatric inflammatory bowel disease (PIBD) incidence has increased in recent decades but may be stabilizing, prompting exploration of incidence changes, disease distribution, and severity. Methods From 2017 to 2019, patients under 18 years with PIBD symptoms were recruited from nine hospitals in South‐Eastern Norway for Inflammatory Bowel Disease in South‐Eastern Norway III (IBSEN III), a population‐based inception cohort study. The primary outcome was a diagnosis of any PIBD subtype as defined by revised Porto criteria. Paris classification system defined disease phenotypes, and descriptions of covariates were gathered from patients in IBSEN III. Results We identified 324 PIBD patients, with 216 consenting to the IBSEN III study. The crude incidence rate was 17.8 per 100,000 person‐years (PY) (95% confidence interval [CI]: 15.9–19.8). Crohn's disease (CD) was found in 118 patients (54.6%); 48% had ileocolonic distribution, 40% had upper gastrointestinal disease, and 12.8% had perianal disease. Complications (stricturing and/or penetrating) were noted in 18%. Ulcerative colitis (UC) was diagnosed in 78 patients (36.1%), predominantly pancolitis (41%), with 30% having proctitis. One in five suffered severe disease. IBD unclassified was found in 20 patients (9.3%). PIBD incidence in those under 16 was 13.6/100,000 PY, up from 4.7 in the IBSEN study 27 years ago. Terminal ileitis (11%–23%) and proctitis (14%–25%) rose from IBSEN (1990–1993) to IBSEN III, while stricturing/penetrating disease changed insignificantly (17%–16%). Conclusions The incidence of PIBD has risen in South‐Eastern Norway, with increased cases of terminal ileitis in CD, unchanged stricturing/penetrating disease, and increased proctitis in UC compared to the original IBSEN study. Trial registration ClinicalTrials.gov identifier: NCT02727959.

• Olsen, Bjørn Christian Elias Grova; Opheim, Randi; Kristensen, Vendel Ailin; Høivik, Marte Lie; Lund, Charlotte & Aabrekk, Tone Bergene [Show all 22 contributors for this article] (2025). Prevalence of Irritable Bowel Syndrome Based on Rome IV Criteria in Patients in Biochemical and Endoscopic Remission From Newly Diagnosed Inflammatory Bowel Disease: One- and Three-Year Results (the IBSEN III Cohort). Inflammatory Bowel Diseases. ISSN 1078-0998. 31(10), p. 2704–2713. doi: 10.1093/ibd/izaf047. Full text in Research Archive Show summary

  Background: Distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) flare-ups is challenging. This study used objective remission markers to accurately determine IBS prevalence in a population-based cohort of patients with IBD. Methods: Adults with ulcerative colitis and Crohn’s disease were recruited from the IBD in South-Eastern Norway III cohort study. Irritable bowel-like symptoms were assessed using the Rome IV criteria for patients in remission from IBD at 1- and 3-year follow-ups. Remission was defined objectively using the biochemical marker fecal calprotectin (FC) ≤ 250 μg/g, and comparisons to remission based on endoscopic indices were made at 1-year follow-up. Results: Among patients with FC ≤ 250 μg/g, IBS prevalences were 21.9% (n = 62/283) and 16.1% (n = 49/304) at the 1- and 3-year follow-ups, respectively, which were higher than that in the Norwegian population (9.5%; P < .005). Of patients in endoscopic remission at 1-year follow-up, 19.2% (n = 43/224) reported IBS-like symptoms, which was not significantly different from IBS prevalence for patients with FC ≤ 250 μg/g. Irritable bowel syndrome was independently associated with substantial fatigue (odds ratio: 3.05 [95% CI, 1.48-6.27]) and female sex (odds ratio: 2.67 [95% CI, 1.34-5.32]) at the 1-year follow-up. Patients with IBS reported significantly reduced health-related quality of life (HRQoL) scores. Conclusions: The prevalence of IBS among patients in remission from IBD was approximately twice as common as that in the Norwegian population. Irritable bowel syndrome was independently associated with substantial fatigue, female sex, and reduced HRQoL.

• Zerouga, Insaf; Valeur, Jørgen; Sommer, Christine; Carlsen, Monica Hauger; Hagen, Milada & Høivik, Marte Lie [Show all 22 contributors for this article] (2025). Habitual Intake of Macronutrients and Fermentable Oligo-, Di-, Monosaccharides and Polyols is not associated with Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease. Clinical Nutrition ESPEN. ISSN 2405-4577. 67, p. 105–113. doi: 10.1016/j.clnesp.2025.03.005. Full text in Research Archive
• Maurud, Sigurd; Lunde, Lene; Moen, Anne & Opheim, Randi (2025). Mapping conditional health literacy and digital health literacy in patients with inflammatory bowel disease to optimise availability of digital health information: a cross-sectional study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. doi: 10.1080/00365521.2025.2497952. Full text in Research Archive
• Strande, Vibeke; Hagen, Milada; Lund, Charlotte; Asak, Øivind Wessel; Bengtson, May-Bente & Cetinkaya, Raziye Boyar [Show all 26 contributors for this article] (2025). Predicting severe inflammatory bowel disease: a risk matrix model based on the IBSEN III inception cohort. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 60(7), p. 716–727. doi: 10.1080/00365521.2025.2512591. Full text in Research Archive Show summary

  Background and aims: Identifying patients at risk of developing severe inflammatory bowel disease (IBD) can aid treatment decisions. However, predicting disease course remains challenging. We aimed to identify predictive factors associated with severe disease course in the first year after IBD diagnosis. Methods: Newly diagnosed adult (≥18 years) patients with IBD were recruited from a population-based inception cohort (IBSEN III study). Preselected baseline factors were tested for associations with severe disease course, defined as IBD-related hospitalisation, surgery, treatment with ≥2 steroid courses, >2 biologics and/or new event of complication (stricture, fistula, abscess only applicable Crohn's disease (CD)). From a best fitted multivariable logistic regression model stratified by diagnosis and age (18-40/>40 years), probability of severe disease for given combinations of predictive factors was summarised in prediction matrices. Results: At one-year follow-up, 90/559 (16%) patients with ulcerative colitis (UC) and 74/312 (24%) with CD had severe disease. Treatment with systemic steroids, vitamin D deficiency, Simple Clinical Colitis Activity Index >2, and hypoalbuminemia at diagnosis were all significantly associated with severe disease in UC patients. CD patients with stricturing or penetrating disease behaviour, systemic steroids and hypoalbuminemia at diagnosis were associated with severe disease course. The least favourable combination of these factors increased the probability of severe disease from 3% (95%CI[0-5%]) to 72% (95%CI[66-79%]) for UC and from 8% (95%CI[3-13%]) to 88% (95%CI[84-93%]) for CD. Conclusions: Our study identified predictive factors associated with severe disease the first year after diagnosis. The probability of severe disease summarised in matrices enables easy risk stratification.

• Pertsinidou, Eleftheria; Salomon, Benita; Bergemalm, Daniel; Salihovic, Samira; Hedin, Charlotte R.H. & Lundström, Maria [Show all 30 contributors for this article] (2025). Anti-integrin αvβ6 IgG antibody as a diagnostic and prognostic marker in ulcerative colitis: A cross-sectional and longitudinal study defining a specific disease phenotype. Journal of Crohn's and Colitis. ISSN 1873-9946. 19(5). doi: 10.1093/ecco-jcc/jjaf062. Full text in Research Archive
• Hansen, Simen Hyll; Maseng, Maria Gjerstad; Grännö, Olle; Vestergaard, Marie V; Bang, Corinna & Olsen, Bjørn Christian Elias Grova [Show all 33 contributors for this article] (2025). Fecal Microbiome Reflects Disease State and Prognosis in Inflammatory Bowel Disease in an Adult Population-Based Inception Cohort. Inflammatory Bowel Diseases. ISSN 1078-0998. 31(8), p. 2066–2080. doi: 10.1093/ibd/izaf060. Full text in Research Archive
• Salihovic, Samira; Nyström, Niklas; Mathisen, Charlotte Bache-Wiig; Kruse, Robert; Olbjørn, Christine & Andersen, Svend [Show all 30 contributors for this article] (2024). Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease. Nature Communications. 15(1). doi: 10.1038/s41467-024-48763-7. Full text in Research Archive Show summary

  Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

• Strande, Vibeke; Lund, Charlotte; Hagen, Milada; Bengtson, May-Bente; Cetinkaya, Raziye Boyar & Detlie, Trond Espen [Show all 23 contributors for this article] (2024). Clinical course of ulcerative colitis: Frequent use of biologics and low colectomy rate first year after diagnosis—results from the IBSEN III inception cohort. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 60(3), p. 357–368. doi: 10.1111/apt.18097. Full text in Research Archive Show summary

  Background: The introduction of biologic therapies and the 'treat-to-target' treatment strategy may have changed the disease course of ulcerative colitis (UC). Aims: To describe the early disease course and disease outcome at 1-year follow-up in a population-based inception cohort of adult patients with newly diagnosed UC. Methods: The Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III study is a population-based inception cohort study with prospective follow-up. Patients newly diagnosed with inflammatory bowel disease during 2017-2019 were included. Patients ≥18 years at diagnosis of UC who attended the 1-year follow-up were investigated. We registered clinical, endoscopic and demographic data at diagnosis and 1-year follow-up. Results: We included 877 patients with UC (median age 36 years (range: 18-84), 45.8% female). At diagnosis, 39.2% presented with proctitis, 24.7% left-sided colitis and 36.0% extensive colitis. At the 1-year follow-up, 13.9% experienced disease progression, and 14.5% ha

• Maurud, Sigurd; Lunde, Lene; Moen, Anne & Opheim, Randi (2024). Exploring the foundations of a digital health information service for patients with inflammatory bowel disease: a mixed method study in Gravitate-Health. BMC Gastroenterology. 24(1). doi: 10.1186/s12876-024-03272-1. Full text in Research Archive Show summary

  Background Providing relevant digital health information of high quality may promote treatment adherence and self-management for patients with inflammatory bowel disease. The development of digital health services is optimised by considering end users’ needs. Aim To identify key aspects required for digital promotion of inflammatory bowel disease patients’ self-management by exploring their health information needs and the preferences of both patients and healthcare professionals in relation to the digital provision of inflammatory bowel disease health services. Methods Data from an audit of 1,481 electronic health record summaries from an inflammatory bowel disease help line, 17 semi-structured interviews with inflammatory bowel disease patients and 2 focus group interviews with 11 healthcare professionals were analysed. Results Patients primarily contacted the hospital due to concerns about symptoms, examinations and tests, and medicines. Their concerns appeared to vary according to diagnosis, gender, age and disease duration. The interviews identified two overarching themes: (1) the available health information and patients’ health information needs, and (2) whishes, thoughts and preferences for a digital solution in IBD care with relevant and individualised information. Conclusions The findings delineate key aspects for developing a suitable digital health information service. Patients seek information from healthcare professionals about treatment; however, in a digital solution, they want access to relevant and practical information about the disease, treatment and self-management. Both patients and healthcare professionals saw opportunities for increasing health data availability to patients. However, healthcare professionals expressed concerns about adapting, maintaining and ensuring the relevance of patient health information without increasing their workload and, thus, reducing quality of care.

• Lund, Charlotte; Strande, Vibeke; Hagen, Milada; Bengtson, May-Bente; Cetinkaya, Raziye Boyar & Detlie, Trond Espen [Show all 26 contributors for this article] (2024). Low Surgery Rates in Early Crohn's Disease: Results from a Prospective Population-Based Inception Cohort—The Inflammatory Bowel Disease in South-Eastern Norway III Study. Inflammatory Bowel Diseases. ISSN 1078-0998. doi: 10.1093/ibd/izae297. Full text in Research Archive Show summary

  Background and aims: The emergence of biologic therapy has coincided with a decline in surgery rates for Crohn's disease (CD). This study aims to describe the disease course, including intra-abdominal surgery rates, biologic therapy use, and variables associated with biologic therapy initiation in a cohort of newly diagnosed CD patients. Methods: The Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III study is a population-based inception cohort study. From 2017 to 2019, newly diagnosed inflammatory bowel disease patients were included for prospective follow-up. The present study included CD patients ≥ 18 years. Clinical, endoscopic, and demographic data were collected at diagnosis and 1-year follow-up. Data were analyzed by using the Kaplan-Meier method and regression analyses. Results: In total, 424 CD patients (median age 37.0 years (range 18-80), female 55.0%) were included. At diagnosis, 50.5% presented with ileal disease and 80.7% with inflammatory behavior. Within a 1-year follow-up, 39.6%

• Ulleriks, Ingrid Christine; Opheim, Randi; Børøsund, Elin & Henni, Silje Havrevold (2024). Pasienters erfaringer med utveksling av informasjon ved regionalanestesi i forbindelse med kirurgi – en kvalitativ studie. Inspira – tidsskrift for anestesi-, operasjon- og intensivsykepleiere. ISSN 0809-9707. 19(2), p. 56–70. doi: 10.23865/inspira.v19.6399. Full text in Research Archive Show summary

  Bakgrunn: Tidligere forskning viser at selv om pasienter får mye informasjon vedrørende anestesi i forbindelse med et kirurgisk inngrep, har ikke pasientenes erfaringer og ønsker blitt tatt hensyn til ved utveksling av informasjon. Forskning indikerer også et behov for mer kunnskap om pasientenes erfaringer med utveksling av informasjon mellom helsepersonell og pasient. Hensikt: Å undersøke pasientenes erfaringer med informasjon om regionalanestesi i tilknytning til et kirurgisk inngrep. Metode: Ti pasienter ble intervjuet etter et kirurgisk inngrep. Det ble gjort lydopptak som ble transkribert verbatimt. Gjennom en kvalitativ innholdsanalyse ble data bearbeidet for å identifisere subkategorier, kategorier og felles tema på tvers av intervjuene. COREQ sjekkliste er fulgt for å sikre studiens kvalitet. Resultat: Informantenes erfaringer kan relateres til 1) varierende innhold i informasjon om anestesiform ved kirurgi, 2) betraktninger som påvirker holdning til kirurgi og anestesi, 3) usikkerhet rundt medvirkning ved valg av anestesiform og 4) varierende erfaring med regionalanestesi. Informantene hadde ulik grad av informasjonsbehov i forkant av det kirurgiske inngrepet. Informasjonen de fikk i forbindelse med prosedyrer ble omtalt som tilfredsstillende og beroligende. Informantene synes det var utfordrende å stille spørsmål om noe de ikke kjente til, og opplevde at det var helsepersonellet som var de beste til å ta avgjørelsene for dem. Tidligere erfaringer med kirurgi og anestesi hadde innvirkning på preferanser for det nåværende sykehusoppholdet. Det midlertidige funksjonstapet relatert til nerveblokaden skapte mye uro ettersom dette var ukjent for flere av informantene. Konklusjon: Informantene hadde opplevelse av å ikke være godt nok informerte. Mangelen på informasjon hemmet medvirkning, men informantene var allikevel fornøyde. Dette synliggjør at dialogen mellom helsepersonellet og pasientene kan struktureres bedre, slik at pasientene får dekket sitt behov for informasjon.

• Jacobsen, Vegard Andreas; Børøsund, Elin; Henni, Silje Havrevold; Bergsaker, Anne Schad & Opheim, Randi (2024). Kartlegging av søvnkvalitet blant sykepleiere i spesialisthelsetjenesten – en tverrsnittsundersøkelse. Sykepleien Forskning. ISSN 1890-2936. 19, p. 1–18. doi: 10.4220/Sykepleienf.2024.96926. Full text in Research Archive Show summary

  Bakgrunn: Søvn er viktig for at mennesket skal fungere. Kvaliteten på søvnen avgjør i hvor stor grad man får dekket søvnbehovet. Sykepleiere kan være en utsatt gruppe fordi skiftarbeid kan føre til søvnproblemer og dermed redusert helse, omsorgskvalitet og jobbtilfredshet. Hensikt: Hensikten med studien var å kartlegge søvnkvaliteten til sykepleiere på sengepost i spesialisthelsetjenesten. Vi ville også undersøke sammenhenger mellom søvnkvalitet og ulike demografiske og arbeidsrelaterte faktorer. Metode: Vi gjennomførte en tverrsnittsstudie med sykepleiere på sengepost i spesialisthelsetjenesten i Norge fra desember 2020 til februar 2021. Søvnkvalitet ble kartlagt med The Pittsburgh Sleep Quality Index (PSQI). Dårlig søvnkvalitet ble definert som PSQI > 5. Vi analyserte sammenhenger mellom søvnkvalitet og demografiske og arbeidsrelaterte faktorer med Pearsons khikvadrattest, Fishers eksakte test, Mann-Whitneys test og lineær regresjonsanalyse. Resultat: Det var 259 sykepleiere som samtykket til å delta. Av disse var 235 (90,7 prosent) sykepleiere på sengepost i spesialisthelsetjenesten, og de ble dermed inkludert i studien. Gjennomsnittlig totalskår på PSQI var 9,38 (standardavvik 3,42). Dårlig søvnkvalitet ble målt hos 86,4 prosent av deltakerne. Kort hviletid mellom kvelds- og dagskift og mer medvirkning i utarbeidelsen av egen turnus var assosiert med dårligere søvnkvalitet. Tilfredshet med turnus var assosiert med bedre søvnkvalitet. Konklusjon: Denne studien viser at sykepleiere på sengepost i spesialisthelsetjenesten har dårlig søvnkvalitet. Søvnkvaliteten er dårligere sammenliknet med liknende grupper i andre studier. For sykepleiere på sengepost i spesialisthelsetjenesten kan det se ut til at hviletid, turnusmedvirkning og turnustilfredshet er faktorer som er assosiert med søvnkvalitet, og som derfor bør inkluderes i kommende studier.

• Holten, Kristina Ingeborg; Bernklev, Tomm; Opheim, Randi; Olsen, Bjørn Christian Elias Grova; Detlie, Trond Espen & Strande, Vibeke [Show all 18 contributors for this article] (2024). Fatigue in Patients with Inflammatory Bowel Disease in Remission One Year after Diagnosis (the IBSEN III Study). Journal of Crohn's and Colitis. ISSN 1873-9946. 19(4). doi: 10.1093/ecco-jcc/jjae170. Full text in Research Archive Show summary

  Background and aims: Fatigue is commonly observed in Crohn's disease (CD) and ulcerative colitis (UC), but its association to achieving remission is not clearly established. In this study we describe the odds for fatigue in patients with CD/UC one year after diagnosis based on different definitions of remission and identified factors associated with chronic fatigue (CF) among patients in endoscopic/radiological remission. Methods: Patients ≥18 years with CD/UC were recruited from the IBSEN III cohort. Using the Fatigue Questionnaire, and dichotomizing the score, CF was defined as the presence of substantial fatigue (SF) for ≥6 months. Remission was divided into symptomatic (CD: HBI score<5/UC: SCCAI score<3), biochemical (faecal calprotectin ≤250µg/g), endoscopic/radiological (CD: normal intestinal MRI/CT combined with normal endoscopy/UC: Mayo endoscopic score 0) and histological (normal mucosal biopsies). Both the likelihood of SF/CF, depending on the definition of remission, and associations between CF an

• Zerouga, Insaf; Valeur, Jørgen; Sommer, Christine; Småstuen, Milada Cvancarova; Medhus, Asle Wilhelm & Lund, Charlotte [Show all 22 contributors for this article] (2024). Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 59(6), p. 1–9. doi: 10.1080/00365521.2024.2313056. Full text in Research Archive Show summary

  Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim of this study was to compare dietary intakes and nutritional status in men and women with newly diagnosed IBD with a general population sample, and to investigate whether intakes were in line with the Nordic Nutrition Recommendations. Methods: This was a cross-sectional study including adults≥ 40 years with IBD from the Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III cohort study. A validated food frequency questionnaire (FFQ) was used in dietary data collection, and a sample from the seventh survey of the Tromsø Study was included as a comparison group. Results: A total of 227 men and women with IBD were included. IBD patients had higher intake of grain products, sweetened beverages, energy, fat and polyunsaturated fat (PUFA), but lower intake of dairy products, alcohol and iodine compared to adults from the comparison sample (p < 0.01). Intakes of saturated fat and carbohydrates in both genders, and vitamin D in women were not within recommended levels. Anemia and hypoalbuminemia were more prevalent in IBD patients than in the comparison sample. Conclusions: Dietary intakes in newly diagnosed IBD patients were mostly in line with Nordic Nutrition Recommendations. Higher proportion of IBD patients exceeded recommended allowances of fat and added sugar than the comparison sample. Insufficient micronutrient intake, anemia and hypoalbuminemia are present challenges in IBD patients that require monitoring.

• Johansen, Ingunn; Småstuen, Milada Cvancarova; Løkkeberg, Stine Eileen Torp; Kristensen, Vendel Ailin; Høivik, Marte Lie & Lund, Charlotte [Show all 16 contributors for this article] (2023). Symptoms and symptom clusters in patients newly diagnosed with inflammatory bowel disease: results from the IBSEN III Study. BMC Gastroenterology. 23(1). doi: 10.1186/s12876-023-02889-y. Full text in Research Archive Show summary

  Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine the prevalence of symptoms and explore symptom clusters and possible associations between symptom clusters and socio-demographic and clinical variables in patients newly diagnosed with inflammatory bowel disease. Methods The IBSEN III study is a prospective population-based inception cohort of patients with inflammatory bowel disease. This study used patient data from the three largest hospitals in the study catchment area. The Memorial Symptom Assessment Scale was used to assess the prevalence of symptoms. Symptom clusters were identified using principal component analysis. Possible associations between socio-demographic and clinical variables and symptom cluster membership were estimated using regression analysis. Results Of the 573 patients (age, ≥18 years) diagnosed with inflammatory bowel disease, 350 (61.1%) completed the questionnaire (responders). Eleven symptoms were reported by >50% of the responders. The three most prevalent symptoms were bloating (84%), drowsiness (81%), and lack of energy (81%). Three symptom clusters were identified: psychological (56% of the patients), impaired energy (28%), and physical (16%) clusters. Multinomial regression analysis revealed that vitamin D deficiency was significantly associated with the impaired energy cluster (odds ratio=2.49, 95% confidence interval [1.00-6.2], p=0.05). Conclusions We found high symptom prevalence in patients newly diagnosed with inflammatory bowel disease. Three distinct symptom clusters were identified, and the psychological cluster includes >50% of the patients. Vitamin D deficiency is the only factor associated with cluster membership, namely the impaired energy cluster.

• Holten, Kristina Ingeborg; Bernklev, Tomm; Opheim, Randi; Johansen, Ingunn; Olsen, Bjørn Christian Elias Grova & Lund, Charlotte [Show all 22 contributors for this article] (2023). Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study. Journal of Crohn's and Colitis. ISSN 1873-9946. 17(11), p. 1781–1790. doi: 10.1093/ecco-jcc/jjad094. Full text in Research Archive Show summary

  Background and aims: Although fatigue is common in inflammatory bowel disease (IBD), its pathogenesis remains unclear. This study aimed to determine the prevalence of fatigue and its associated factors in a cohort of patients newly diagnosed with IBD. Methods: Patients ≥18 years were recruited from the Inflammatory Bowel Disease South-Eastern Norway (IBSEN III) study, a population-based, observational inception cohort. Fatigue was assessed using the Fatigue Questionnaire and compared with data from a Norwegian general population. Univariate and multivariate linear and logistic regression analyses were performed to evaluate the associations of total fatigue (TF) (continuous score) and substantial fatigue (SF) (dichotomized score ≥4) with sociodemographic, clinical, endoscopic, laboratory, and other relevant patient data. Results: In total, 983/1509 (65.1%) patients with complete fatigue data were included (ulcerative colitis (UC), 68.2%; Crohn's disease (CD), 31.8%). The prevalence of SF was higher in CD (69.6%) compared with UC (60.2%) (p<0.01), and in both diagnoses when compared to the general population (p<0.001).In the multivariate analyses, depressive symptoms, pain intensity, and sleep disturbances were associated with increased TF for both diagnoses. In addition, increased clinical disease activity and Mayo endoscopic score were significantly associated with TF in UC, whereas all disease-related variables were insignificant in CD. Similar findings were observed for SF, except regarding the Mayo endoscopic score. Conclusions: SF affects approximately two-thirds of patients newly diagnosed with IBD. Fatigue was associated with depressive symptoms, sleep disturbances, and increased pain intensity in both diagnoses, while clinical and endoscopic activity were associated factors only in UC.

• Mølsæter, Anne Britt; Henni, Silje Havrevold; Opheim, Randi; Høye, Sigurd & Børøsund, Elin (2023). Antibiotikasmarte sykepleierstudenter? Sykepleierstudenters kunnskap og egenvurdert kompetanse om antibiotikabruk og -resistens. Sykepleien Forskning. ISSN 1890-2936. 18(93743), p. 1–13. doi: 10.4220/Sykepleienf.2023.93743. Full text in Research Archive Show summary

  Bakgrunn: Moderne medisin er avhengig av virksom antibiotika. Imidlertid har antibiotikaresistens blitt et raskt voksende problem i verden, som utgjør en alvorlig trussel mot den globale helsen. Riktig antibiotikabruk er avgjørende for å redusere antibiotikaresistensen i fremtiden. Norske sykepleierstudenters kunnskapsnivå om antibiotikabruk og -resistens er lite utforsket. Hensikt: Å kartlegge sykepleierstudenters kunnskap om antibiotikaresistens og antibiotikabruk. Vi ønsket også å undersøke hvordan de vurderer sin egen kompetanse på dette området. Metode: Studien har et deskriptivt tverrsnittsdesign. Dataene ble samlet inn via et spørreskjema utdelt til sykepleierstudenter ved fire utvalgte utdanningsinstitusjoner fra september 2019 til februar 2020. Kartleggingen besto av et spørreskjema med 43 spørsmål, fordelt på ni spørsmål om egenvurdering av kunnskap og 34 kunnskapsspørsmål om antibiotikabruk inndelt i seks temaer. Vi anvendte ANOVA, t-tester og bivariate korrelasjonsanalyser for å vurdere sammenhengen mellom faktisk kunnskap om antibiotikabruk og egenvurdering av kunnskap, tidligere arbeidserfaring i helsevesenet, frivillig eller obligatorisk undervisning, undervisningssted og alder. Resultat: Av 480 forespurte studenter deltok 410 (84,5 prosent) i studien. Studentene hadde en gjennomsnittskår på 48,6 prosent korrekte svar for alle kunnskapsspørsmålene samlet. De hadde minst kunnskap om temaene om antibiotikaforbruk, urinveisinfeksjon og asymptomatisk bakteriuri samt allergi og bivirkninger. En høy andel av studentene vurderte sin egen kunnskap om antibiotikaresistens og riktig antibiotikabruk som lav. Jo høyere studentene skåret på kunnskapsnivå, jo høyere vurderte de sin egen kunnskap. Verken alder, tidligere jobberfaring, eller hvorvidt undervisningen var frivillig eller obligatorisk, hadde sammenheng med kunnskapsnivået. Konklusjon: Sykepleierstudenter har mangelfull kunnskap om antibiotikaresistens og riktig antibiotikabruk, og de vurderer også selv at de har lite kunnskap og lav kompetanse. Resultatene indikerer et behov for å styrke studentenes kompetanse, slik at de kan benytte sin profesjon bedre til å påvirke og forebygge antibiotikaresistens. Videre forskning bør undersøke om kunnskapsnivået er forbedret etter at flere av studiestedene har satt i gang undervisning etter at studien ble utført.

• Olsen, Bjørn Christian Elias Grova; Opheim, Randi; Høivik, Marte Lie; Lund, Charlotte; Aabrekk, Tone Bergene & Johansen, Ingunn [Show all 15 contributors for this article] (2023). Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III). Quality of Life Research. ISSN 0962-9343. 32(10), p. 2951–2964. doi: 10.1007/s11136-023-03435-9. Full text in Research Archive Show summary

  Purpose This unselected, population-based cohort study aimed to determine the level of health-related quality of life (HRQoL) in patients with Crohn’s disease (CD) and ulcerative colitis (UC) at the time of diagnosis compared with a reference population and identify the demographic factors, psychosocial measures, and disease activity markers associated with HRQoL. Methods Adult patients newly diagnosed with CD or UC were prospectively enrolled. HRQoL was measured using the Short Form 36 (SF-36) and Norwegian Inflammatory Bowel Disease Questionnaires. Clinical significance was assessed using Cohen’s d effect size and further compared with a Norwegian reference population. Associations between HRQoL and symptom scores, demographic factors, psychosocial measures, and disease activity markers were analyzed. Results Compared with the Norwegian reference population, patients with CD and UC reported significantly lower scores in all SF-36 dimensions, except for physical functioning. Cohen’s d effect sizes for men and women in all SF-36 dimensions were at least moderate, except for bodily pain and emotional role for men with UC and physical functioning for both sexes and diagnoses. In the multivariate regression analysis, depression subscale scores ≥ 8 on the Hospital Anxiety and Depression Scale, substantial fatigue, and high symptom scores were associated with reduced HRQoL. Conclusion Patients newly diagnosed with CD and UC reported statistically and clinically significantly lower scores in seven of the eight SF-36 dimensions than the reference population. Symptoms of depression, fatigue, and elevated symptom scores were associated with poorer HRQoL.

• Svendsen, Edel Jannecke; Opheim, Randi; Hermansen, Bjørg Elisabeth & Hardeland, Camilla (2023). Ad hoc digital communication and assessment during clinical placements in nursing education; a qualitative research study of students', clinical instructors', and teachers' experiences. PLOS ONE. 18(7), p. 1–14. doi: 10.1371/journal.pone.0287438. Full text in Research Archive
• Lindemann, Kristina Yvonne Kathe; Danbolt, Svana Heimisdottir; Ramberg, Lene Kristine Marsby; Eyjólfsdóttir, Brynhildur; Wang, Yun & Heli-Haugestøl, Anne Gjertine [Show all 15 contributors for this article] (2023). Patient-reported nausea after implementation of an enhanced recovery after surgery protocol for gynae-oncology patients. International Journal of Gynecological Cancer. ISSN 1048-891X. 33(8), p. 1287–1294. doi: 10.1136/ijgc-2023-004356. Full text in Research Archive Show summary

  Objectives This study aimed to analyze the adherence to strategies to prevent post-operative nausea and vomiting after implementation of an enhanced recovery after surgery (ERAS) protocol for gynae-oncology patients. Patient-reported nausea before and after ERAS was also studied. Methods This prospective observational study included all patients undergoing laparotomy for a suspicious pelvic mass or confirmed advanced ovarian cancer before (pre-ERAS) and after the implementation of ERAS (post-ERAS) at Oslo University Hospital, Norway. Patients were a priori stratified according to the planned extent of surgery into two cohorts (Cohort 1: Surgery of advanced disease; Cohort 2: Surgery for a suspicious pelvic tumor). Clinical data including baseline characteristics and outcome data were prospectively collected. Results A total of 439 patients were included, 243 pre-ERAS and 196 post-ERAS. At baseline, 27% of the patients reported any grade of nausea. In the post-ERAS cohort, statistically significantly more patients received double post-operative nausea and vomiting prophylaxis (64% pre-ERAS vs 84% post-ERAS, p&lt;0.0001). There was no difference in the need for rescue medication (82% pre-ERAS vs 79% post-ERAS; p=0.17) and no statistically significant difference between pre- and post-ERAS or between the surgical cohorts in patient-reported nausea of any grade on day 2. Patients who reported none/mild nausea on day 2 had significantly less peri-operative fluid administered during surgery than those who reported moderate or severe nausea (median 12.5 mL/kg/hour vs 16.5 mL/kg/hour, p=0.045) but, in multivariable analysis, fluid management did not remain significantly associated with nausea. Conclusion Implementation of an ERAS protocol increased the adherence to post-operative nausea and vomiting prevention guidelines. Nausea, both before and after laparotomy, remains an unmet clinical need of gynae-oncology patients also in an ERAS program. Patient-reported outcome measures warrant further investigation in the evaluation of ERAS.

• Janson, Astri Letnes; Opheim, Randi & Hellesø, Ragnhild (2023). Advanced practice nurse education in its infancy: an exploratory study of Norwegian higher education institutions’ program descriptions. Scandinavian Journal of Educational Research. ISSN 0031-3831. doi: 10.1080/00313831.2023.2185810. Full text in Research Archive
• Håvi, Gry; Feiring, Eli & Opheim, Randi (2022). «Mer enn bare en håndlanger»: oppfatninger om sykepleierens betydning for kvalitet ved koloskopi. Sykepleien Forskning. ISSN 1890-2936. 17. doi: 10.4220/Sykepleienf.2022.90030. Full text in Research Archive
• Opheim, Randi; Moum, Kristian Marling; Småstuen, Milada Cvancarova & Moum, Bjørn Allan (2022). The impact of restrictions on psychological outcomes in patients with inflammatory bowel disease on biological treatment during the coronavirus pandemic in Norway. Quality of Life Research. ISSN 0962-9343. 20. doi: 10.1007/s11136-022-03254-4. Full text in Research Archive Show summary

  Abstract Purpose The coronavirus (COVID-19) pandemic restrictions have led to changes in the follow-up routine of patients in outpatient clinics at hospitals in Norway. The purpose of this study was to assess possible associations between psychological health and concerns regarding COVID-19 societal and hospital restrictions in patients with inflammatory bowel disease on biological therapy. Methods Patients with IBD (≥ 18 years) undergoing biological treatment (TNF-alpha inhibitor, ustekinumab, vedolizumab) for IBD were recruited from an IBD outpatient clinic in Norway. Data were collected through self-report, including questions covering concerns regarding their disease, medical therapy, and follow-up during the pandemic, Patient Health Questionnaire–9 (PHQ-9) and Generalized Anxiety Disorder–7 questionnaire (GAD-7). Multiple logistic regression with backward conditional selection was fitted to examine associations between patients’ depression and anxiety levels and their concerns about COVID-19 restrictions, controlled for sociodemographic and disease-related factors. Results Five-hundred and six patients were included in this study. General condition, self-isolation, employment status, fear of visiting the hospital, and changes to patients’ appointments made by the hospital were independently associated with higher levels of depression. Female gender, experiencing symptoms of COVID-19, self-isolation, experiencing an increased risk of COVID-19 because of IBD, being afraid to visit the hospital because of COVID-19 restrictions, and having their appointment cancelled due to COVID-19 were independently associated with higher anxiety levels. Conclusion Concerns about physical health and societal and hospital restrictions were associated with anxiety and depression in patients with IBD undergoing biological treatment. The findings will help facilitate healthcare services for patients with IBD in outpatient clinics and develop guidelines for follow-up.

• Moum, Kristian Marling; Moum, Bjørn & Opheim, Randi (2021). Patients with inflammatory bowel disease on immunosuppressive drugs: perspectives’ on COVID-19 and health care service during the pandemic. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(5), p. 1–8. doi: 10.1080/00365521.2021.1901308. Full text in Research Archive Show summary

  Background and aims Patients with inflammatory bowel diseases (IBD) have experienced changes to the routine management because of the SARS-CoV-2 pandemic. The aim of this study was to examine patients with IBD’s adherence to the restrictions imposed by society and the hospital, worries and concerns regarding medical treatment and clinical follow-up under the pandemic. Methods IBD patients (≥18 years) at the outpatient clinic at Oslo University Hospital were included and answered a self-report questionnaire including concerns regarding their disease, medical therapy and follow-up during SARS-CoV-2 pandemic. Results In total, 522 IBD patients were included, 317 Crohn’s disease, 205 ulcerative colitis, 386 patients <50 years. Eighteen percent were in obligatory quarantine, and more often patients <50 years compared to patients ≥50 years. Five patients tested positive to SARS- CoV-2. A higher proportion <50 years reported worries for their medical treatment and risk of COVID −19 disease compared to those ≥50 years. Forty percent avoided family, two-thirds avoided friends, and 4% cancelled their scheduled consultation at the hospital. The hospital changed physical consultation to telephone consultation for 15% of the patients. The preferred follow-up was physical consultation. A higher proportion of the patients <50 years preferred telephone consultation compared to those ≥50 years. Four out of five IBD patients were satisfied with the information about their IBD and COVID-19. Conclusions SARS-CoV-2 pandemic affects the daily lives for patients with IBD. It is important to develop evidence-base guidelines in follow-up and treatment, as well as patient information about COVID-19and IBD.

• Kristensen, Vendel Ailin; Opheim, Randi; Perminow, Gøri Margrete; Huppertz-Hauss, Gert; Detlie, Trond Espen & Lund, Charlotte [Show all 39 contributors for this article] (2021). Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(8), p. 899–905. doi: 10.1080/00365521.2021.1922746. Full text in Research Archive Show summary

  Background and aim: Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural disease course. Inception cohort studies are the gold standard for investigating such changes. We have initiated a new population-based inception cohort study; Inflammatory bowel disease in South Eastern Norway III (IBSEN III). In this article, we describe the study protocol and baseline characteristics of the cohort. Methods: IBSEN III is an ongoing, population-based observational inception cohort study with prospective follow-up. Adult and pediatric patients with suspected IBD in the South-Eastern Health Region of Norway (catchment area of 2.95 million inhabitants in 2017), during the 3-year period from 2017 to 2019, were eligible for inclusion. Comprehensive clinical, biochemical, endoscopic, demographic, and patient-reported data were collected at the time of diagnosis and throughout standardized follow-up. For a portion of the patients, extensive biological material was biobanked. Results: The study included 2168 patients, of whom 1779 were diagnosed with IBD (Crohn's disease: 626, ulcerative colitis: 1082, IBD unclassified: 71). In 124 patients, there were subtle findings indicative of, but not diagnostic for, IBD. The remaining 265 patients were classified as symptomatic non-IBD controls. Conclusion: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.

• Opheim, Randi; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Berset, Ingrid Prytz & Hovde, Øistein [Show all 9 contributors for this article] (2020). Self-esteem in patients with inflammatory bowel disease. Quality of Life Research. ISSN 0962-9343. 29(7), p. 1839–1846. doi: 10.1007/s11136-020-02467-9. Full text in Research Archive Show summary

  Purpose The purpose of this study was to explore self-esteem and associations between self-esteem and sociodemographic, clinical, and psychological factors in patients with infammatory bowel disease (IBD), a disease of chronic relapsing infammation of the gastrointestinal tract. IBD symptoms, including pain, fatigue, and diarrhea, as well as potential life-long medical treatment and surgery, may be demanding, cause signifcant challenges, and infuence self-esteem. Methods In this cross-sectional multicenter study, participants were recruited from nine hospitals in the southeastern and western regions of Norway from March 2013 to April 2014. Data were collected using self-report questionnaires. Selfesteem was assessed by the Rosenberg Self-Esteem Scale, fatigue was assessed by the Fatigue Questionnaire, self-efcacy was assessed by the General Self-Efcacy Scale, and disease activity was assessed by the Simple Clinical Colitis Activity Index for ulcerative colitis (UC) and Harvey Bradshaw Index for Crohn’s disease (CD). Multiple linear regression analysis was applied to examine associations between self-esteem and sociodemographic, clinical, and psychological factors. Results In total, 411 of 452 (91%) patients had evaluable data and were included in this study. The mean scores on selfesteem, self-efcacy, total fatigue, anxiety, and depression were similar between UC patients and CD patients. Male gender, being employed, and higher self-efcacy were independently associated with higher self-esteem, whereas anxiety and depression were independently associated with lower self-esteem. Neither disease activity nor fatigue were associated with self-esteem in the fnal multiple regression analyses. Conclusion Patient-centered interventions that improve self-esteem and reduce anxiety and depression seem to be important to optimize IBD management. Keywords Self-esteem · Self-efcacy · Coping · Infammatory bowel disease · Ulcerative colitis · Crohn’s disease · Health psychology · Chronic disease · Health-related quality of life

• Sundar, Turid Kristin Bigum; Riiser, Kirsti; Småstuen, Milada Cvancarova; Opheim, Randi; Løndal, Knut & Glavin, Kari [Show all 7 contributors for this article] (2020). Health-related quality of life among 13–14 year old adolescents with overweight−a mixed methods approach. Health and Quality of Life Outcomes. 18, p. 1–10. doi: 10.1186/s12955-020-01413-0. Full text in Research Archive Show summary

  Background: Overweight and obesity are public concerns with risk of adverse health outcomes. Health-related quality of life (HRQoL) is lower in adolescents than children in general. An increase in body mass index (BMI) is associated with a decrease in HRQoL. The purpose of this study was to measure and explore the HRQoL among adolescents with overweight or obesity who had participated in an intervention study, Young & Active, with the aim of increasing physical activity (PA), reducing BMI and promoting HRQoL. Methods: Mixed methods, with a convergent design, were used to investigate how different methodological approaches could expand our understanding of the adolescents’ HRQoL. Quantitative post-intervention data on HRQoL were collected among the 84 intervention participants, aged 13–14 years, using the KIDSCREEN 52 questionnaire. The data were compared with a Norwegian reference population of 244 individuals, and analysed using a non-parametric Mann-Whitney test. Qualitative semi-structured interviews were conducted with 21 adolescents from the intervention. A directed approach to content analysis was adopted, using the ten sub-scales from KIDSCREEN 52. Results: HRQoL in the intervention sample was significantly reduced on the sub-scale of physical well-being compared to the reference population. The reference population scored significantly lower than the intervention sample on the sub-scale of parent relation and home life. No significant differences were found on the other sub- scales. The qualitative data supported the quantitative findings on the sub-scale of physical well-being, but showed that perceptions of fitness, energy level or health could vary. Regarding parent relations, the interviewees extended this to include relationships to other family members as equally important. Most of the interviewees expressed a negative view of their bodies, but not their clothing or accessories. This may explain why no statistically significant differences were found on these aspects in the results from the KIDSCREEN questionnaire. Conclusion: The use of the KIDSCREEN 52 instrument gave important indications about the adolescents’ HRQoL and need for additional follow up. The qualitative data provided an in-depth understanding that nuanced the findings and widened our knowledge of the adolescents HRQoL. Combining methods enabled a comprehensive approach to research on HRQoL.

• Normann, Cathrine Olaussen; Opheim, Randi; Kulle, Bettina; Bernklev, Tomm & Haug, Erik Skaaheim (2020). Health-related quality-of-life after radical cystectomy among Norwegian men and women compared to the general population. Scandinavian Journal of Urology. ISSN 2168-1805. 54(3), p. 181–187. doi: 10.1080/21681805.2020.1754906. Full text in Research Archive Show summary

  Objective: The aim of this study was to assess health-related quality-of-life (HRQoL) in men and women operated on with radical cystectomy, compared to the general Norwegian population. Materials and methods: All patients with bladder cancer who had undergone radical cystectomy (RC) between 2011–2017 and either received ileal conduit (IC) or orthotopic neobladder (ONB) as urinary diversion were included in a cross-sectional study. HRQoL and sociodemographic data was collected and measured with a questionnaire consisting of the generic EORTC QLQ-C30.v3 and the cancer specific EORTC QLQ-BLM30 and compared to a general population sample. Results: Of the 220 invited patients, 173 patients (78.6%) returned the questionnaires. The global quality-of-life (QoL) score was comparable with the general population. Women had significantly higher fatigue score, worse future perspective and symptoms like bloating, compared to male patients. Men had significantly lower social functioning, more constipation, diarrhoea and sleep disturbance compared to the general male population. There was no significant difference in HRQoL domains between female patients and the general female population. A follow-up (FU) period longer than 37 months since surgery was associated with significantly improved physical- and role-functioning, less fatigue and fewer problems with the urostoma, compared to a shorter FU time. Conclusion: This study found a high global QoL score after radical cystectomy, comparable with the general Norwegian population. Symptoms seem to improve over time. Difference in HRQoL outcomes between men and woman in the study population was comparable with the difference found in the general population.

• Torres, Joana; Ellul, Pierre; Langhorst, Jost; Mikocka-Walus, Antonina; Acosta, Manuel Barreiro-de & Basnayake, Chamara [Show all 15 contributors for this article] (2019). European Crohn's and colitis organisation topical review on complementary medicine and psychotherapy in inflammatory bowel disease. Journal of Crohn's and Colitis. ISSN 1873-9946. 13(6), p. 673–685e. doi: 10.1093/ecco-jcc/jjz051. Full text in Research Archive
• Jelsness-Jørgensen, Lars-Petter; Frigstad, Svein Oskar; Moum, Bjørn; Grimstad, Tore; Opheim, Randi & Jahnsen, Jørgen [Show all 7 contributors for this article] (2017). Pain may be an important factor to consider in inflammatory bowel disease patients troubled by fatigue. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 5(5), p. 687–693. doi: 10.1177/2050640616674654. Full text in Research Archive
• Lerdal, Anners; Opheim, Randi; Gay, Caryl; Moum, Bjørn; Fagermoen, May Solveig & Kottorp, Anders (2017). Psychometric limitations of the 13-item Sense of Coherence Scale assessed by Rasch analysis. BMC Psychology. 5(18). doi: 10.1186/s40359-017-0187-y. Full text in Research Archive Show summary

  Background A person’s sense of coherence (SOC) reflects their perception that the world is meaningful and predictable, and impacts their ability to deal with stressors in a health-promoting manner. A valid, reliable, and sensitive measure of SOC is needed to advance health promotion research based on this concept. The 13-item Sense of Coherence Scale (SOC-13) is widely used, but we reported in a previous evaluation its psychometric limitations when used with adults with morbid obesity. To determine whether the identified limitations were specific to that population or also generalize to other populations, we have replicated our prior study design and analysis in a new sample of adults with inflammatory bowel disease (IBD). Methods A sample of 428 adults with IBD completed the SOC-13 at a routine clinic visit in Norway between October 1, 2009 and May 31, 2011. Using a Rasch analysis approach, the SOC-13 and its three subscales were evaluated in terms of rating scale functioning, internal scale validity, person-response validity, person-separation reliability and differential item functioning. Results Collapsing categories at the low end of the 7-category rating scale improved its overall functioning. Two items demonstrated poor fit to the Rasch model, and once they were deleted from the scale, the remaining 11-item scale (SOC-11) demonstrated acceptable item fit. However, neither the SOC-13 nor the SOC-11 met the criteria for unidimensionality or person-response validity. While both the SOC-13 and SOC-11 were able to distinguish three groups of SOC, none of the subscales could distinguish any such groups. Minimal differential item functioning related to demographic characteristics was also observed. Conclusions An 11-item version of the sense of coherence scale has better psychometric properties than the original 13-item scale among adults with IBD. These findings are similar to those of our previous evaluation among adults with morbid obesity and suggest that the identified limitations may exist across populations. Further refinement of the SOC scale is therefore warranted.

• Huppertz-Hauss, Gert; Høivik, Marte; Jelsness-Jørgensen, Lars-Petter; Opheim, Randi; Henriksen, Magne & Høie, Ole Ingebreth [Show all 13 contributors for this article] (2017). Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 52(3), p. 351–358. doi: 10.1080/00365521.2016.1256425. Full text in Research Archive
• Jelsness-Jørgensen, Lars-Petter; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Opheim, Randi & Berset, Ingrid Prytz [Show all 11 contributors for this article] (2016). Validity, reliability, and responsiveness of the brief pain inventory in inflammatory bowel disease. Canadian Journal of Gastroenterology and Hepatology. ISSN 2291-2789. 2016:5624261. doi: 10.1155/2016/5624261. Full text in Research Archive
• Opheim, Randi; Høivik, Marte; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2016). The use of complementary and alternative medicine (CAM) among patients with inflammatory bowel disease (IBD) is associated with reduced health-related quality of life (HRQoL). Gastroenterology Research and Practice. ISSN 1687-6121. 2016. doi: 10.1155/2016/6453657. Full text in Research Archive
• Opheim, Randi (2014). Et biopsykososialt perspektiv på abdominale smerter ved inflammatorisk tarmsykdom. Gastroskopet, fagtidsskrift for sykepleiere innen gastroenterologi. Gastroskopet. ISSN 1890-4122. 27(2). Full text in Research Archive
• Opheim, Randi; Fagermoen, May Solveig; Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm & Moum, Bjørn (2014). Sense of coherence in patients with inflammatory bowel disease. Gastroenterology Research and Practice. ISSN 1687-6121. 2014:989038. doi: 10.1155/2014/989038. Full text in Research Archive
• Opheim, Randi; Fagermoen, May Solveig; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2014). Fatigue interference with daily living among patients with inflammatory bowel disease. Quality of Life Research. ISSN 0962-9343. 23(2), p. 709–719. doi: 10.1007/s11136-013-0508-4. Full text in Research Archive
• Opheim, Randi; Høivik, Marte; Solberg, Inger Camilla & Moum, Bjørn (2012). Complementary and alternative medicine in patients with inflammatory bowel disease: The results of a population-based inception cohort study (IBSEN). Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 6(3), p. 345–353. doi: 10.1016/j.crohns.2011.09.007. Full text in Research Archive
• Opheim, Randi; Bernklev, Tomm; Fagermoen, May Solveig; Småstuen, Milada C & Moum, Bjørn (2012). Use of complementary and alternative medicine in patients with inflammatory bowel disease: results of a cross-sectional study in Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 47(12), p. 1436–1447. doi: 10.3109/00365521.2012.725092. Full text in Research Archive

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• Hellesø, Ragnhild & Opheim, Randi (2023). Samhandling i helsetenesta - Sjukepleiarens faglege og organisatoriske rolle. Det Norske Samlaget. ISBN 9788234003110. 136 p. Full text in Research Archive

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• Maseng, Maria Gjerstad; Hansen, S Hyll; Bang, Corina; Valeur, Jørgen; Huppertz-Hauss, Gert & Opheim, Randi [Show all 18 contributors for this article] (2025). Longitudinal Changes in Gut Microbiota During the First Year following diagnosis of Inflammatory Bowel Disease – the IBSEN III study. Journal of Crohn's and Colitis. ISSN 1873-9946. 19, p. i2387–i2387. doi: 10.1093/ecco-jcc/jjae190.1498. Full text in Research Archive
• Maseng, Maria Gjerstad; Hansen, Simen Hyll; Bang, Corina; Valeur, Jørgen; Huppertz-Hauss, Gert & Opheim, Randi [Show all 18 contributors for this article] (2025). Longitudinal Changes in Gut Microbiota During the First Year following diagnosis of Inflammatory Bowel Disease – the IBSEN III study. Full text in Research Archive
• Maseng, Maria Gjerstad; Hansen, Simen Hyll; Bang, Corina; Detlie, Trond Espen; Huppertz-Hauss, Gert & Kristensen, Vendel Ailin [Show all 18 contributors for this article] (2024). Longitudinal Changes in Gut Microbiota During the First Year following diagnosis of Inflammatory Bowel Disease– the IBSEN III study. Full text in Research Archive
• Johansen, Ingunn; Hagen, Milada; Løkkeberg, Stine Eileen Torp; Kristensen, Vendel; Høivik, Marte Lie & Lund, Charlotte [Show all 24 contributors for this article] (2024). P247 Anxiety and depression in newly diagnosed patients with Inflammatory Bowel Disease – Results from the IBSEN III study. Full text in Research Archive
• Bazov, I.; Kruse, R.; Bergemalm, D.; Eriksson, C.; Hedin, C.R. & Nieuwenhoven, M. van [Show all 28 contributors for this article] (2023). A novel serum protein signature as biomarker for Inflammatory Bowel Disease: A diagnostic performance and prediction modelling study using data from two independent inception cohorts. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, p. i314–i315. doi: 10.1093/ecco-jcc/jjac190.0284. Full text in Research Archive
• Mathisen, Carl Magnus Bache Wiig; Nyström, N.; Bazov, I.; Andersen, S.; Olbjørn, Christine & Perminow, Gøri Margrete [Show all 22 contributors for this article] (2023). A novel diagnostic serum protein signature for paediatric Inflammatory Bowel Disease: A discovery and validation study in two independent inception cohorts. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, p. i71–i71. doi: 10.1093/ecco-jcc/jjac190.0051. Full text in Research Archive
• Hansen, Simen Hyll; Maseng, M Gjerstad; Bjørkqvist, O; Halfvarsson, J; Bang, C & Detlie, Trond Espen [Show all 23 contributors for this article] (2023). Gut microbiota at diagnosis is associated with clinical features and future disease course in Inflammatory Bowel Disease: Data from IBSEN III, a new large Norwegian population-based inception cohort. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, p. i1028–I2029. doi: 10.1093/ecco-jcc/jjac190.1050. Full text in Research Archive
• Janson, Astri Letnes; Opheim, Randi & Hellesø, Ragnhild (2023). Applying document analysis in nursing research – possibilities for understanding advanced practice nurse education. Full text in Research Archive
• Zerouga, Insaf; Sommer, Christine; Carlsen, Monica Hauger; Valeur, Jørgen; Kristensen, Vendel Ailin & Høivik, Marte Lie [Show all 8 contributors for this article] (2023). Kosthold og ernæringsstatus ved nydiagostisert IBD: resultater fra IBSEN III. Full text in Research Archive
• Johansen, Ingunn; Småstuen, Milada Cvancarova; Løkkeberg, Stine Eileen Torp; Kristensen, Vendel Ailin; Høivik, Marte Lie & Lund, Charlotte [Show all 16 contributors for this article] (2022). Symptoms and symptom clusters in patients newly diagnosed with inflammtory bowel disease – results from the IBSEN III study. Full text in Research Archive
• Strande, Vibeke; Småstuen, Milada C.; Lund, Charlotte; Bengtson, May-Bente; Høie, Ole & Cetinkaya, Raziye Boyar [Show all 26 contributors for this article] (2022). Klinisk karakteristika hos nydiagnostiserte pasienter med inflammatorisk tarmsykdom - resultater fra IBSEN III-studien. Full text in Research Archive
• Strande, Vibeke; Småstuen, Milada C; Huppertz-Hauss, Gert; Perminow, Gøri; Henriksen, Magne & Bengtson, May-Bente [Show all 17 contributors for this article] (2022). Fecal calprotectin at diagnosis is associated with oral steroid use first year of inflammatory bowel disease. Full text in Research Archive
• Janson, Astri Letnes; Opheim, Randi & Hellesø, Ragnhild (2021). Kliniske masterutdanninger for sykepleiere. Kompetanseheving for primærhelsetjenesten? Full text in Research Archive
• Strande, Vibeke; Småstuen, Milada C.; Hasund, Audun; Huppertz-Hauss, Gert; Pallenschat, Jens & Bengtson, May-Bente [Show all 18 contributors for this article] (2021). Clinical characteristics associated with biochemical remission three months after diagnosis of ulcerative colitis. Full text in Research Archive
• Strande, Vibeke; Småstuen, Milada C.; Hasund, Audun; Huppertz-Hauss, Gert; Pallenschat, Jens & Bengtson, May-Bente [Show all 18 contributors for this article] (2021). Clinical characteristics associated with biochemical remission three months after diagnosis of Crohn's disease. Full text in Research Archive
• Kristensen, Vendel Ailin; Lund, Charlotte; Opheim, Randi; Ricanek, Petr; Huppertz-Hauss, Gert & Perminow, Gøri Margrete [Show all 37 contributors for this article] (2020). Inflammatory Bowel Disease in South-Eastern Norway III – IBSEN III. Full text in Research Archive
• Reime, Marit Hegg & Opheim, Randi (2019). Sykepleie til pasienter med fordøyelsessykdom. In Knutstad, Unni (Eds.), Utøvelse av klinisk sykepleie. Sykepleieboken 3. Cappelen Damm Akademisk. ISSN 9788202543099. p. 278–383. Full text in Research Archive
• Opheim, Randi; Jahnsen, Jørgen; Bernklev, Tomm; Høie, Ole Ingebreth; Huppertz-Hauss, Gert & Moum, Bjørn (2019). Complementary and alternative medicine in patients with inflammatory bowel disease 20 years after diagnosis: Results from the IBSEN study. American Journal of Gastroenterology. ISSN 0002-9270. 114, p. S12–S13. doi: 10.14309/01.ajg.0000578256.56976.23. Full text in Research Archive
• Kristensen, Vendel Ailin; Opheim, Randi; Ricanek, Petr; Detlie, Trond Espen; Perminow, Gøri Margrete & Høivik, Marte Lie (2018). IBSEN III—a new population-based inception cohort from South-Eastern Norway. Full text in Research Archive
• Opheim, Randi; Bernklev, Tomm; Jahnsen, Jørgen; Grimstad, Tore; Hovde, Øistein & Berset, Ingrid Prytz [Show all 8 contributors for this article] (2018). Chronic fatigue in patients with inflammatory bowel disease is associated with lower health–related quality of life, low self-esteem, increased anxiety and depression. Full text in Research Archive
• Opheim, Randi (2018). Complementary and alterantive therapies in inflammatory bowel disease. Full text in Research Archive
• Opheim, Randi (2018). Complementary therapies in IBD. Full text in Research Archive
• Opheim, Randi (2018). Psykososial helse blant barn og ungdom med inflammatorisk tarmsykdom - en populasjonsbasert prospektiv observasjonsstudie - IBSEN III studien. Full text in Research Archive
• Opheim, Randi (2017). Psychosocial health and health-related quality of life in children and adolescents with IBD - an overview of the literature. Full text in Research Archive
• Opheim, Randi (2017). “Measurement of conditions”. Full text in Research Archive
• Bernklev, Tomm; Huppertz-Hauss, Gert; Opheim, Randi; Høivik, Marte; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter [Show all 7 contributors for this article] (2016). Co-existing Irritable Bowel Syndrome (IBS) in Inflammatory Bowel Disease (IBD) is associated with increased risk of chronic fatigue (CF), especially in females. Full text in Research Archive
• Opheim, Randi (2015). Hver tredje pasient med inflammatorisk tarmsykdom oppsøker alternativ behandler. Best Practice Gastroenterology. Full text in Research Archive
• Jelsness-Jørgensen, Lars-Petter; Høivik, Marte Lie; Moum, Bjørn; Opheim, Randi; Huppertz-Hauss, Gert & Grimstad, Tore [Show all 10 contributors for this article] (2015). Fatigue is associated with increased pain intensity and interference in IBD. Inflammatory Bowel Diseases. ISSN 1078-0998. doi: 10.1080/00365521. Full text in Research Archive
• Opheim, Randi; Lie, Marte Høivik; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2015). Relationship between use of complementary and alternative medicine (CAM) and health-related quality of life (HRQoL) among patients with inflammatory bowel disease. Journal of Crohn’s and Coltis Supplements. ISSN 1873-9954. 9. Full text in Research Archive
• Bernklev, Tomm; Huppertz-Hauss, Gert; Jelsness-Jørgensen, Lars-Petter; Høivik, Marte; Opheim, Randi & Jahnsen, Jørgen [Show all 7 contributors for this article] (2014). Chronic Fatigue Twenty Years After Diagnosis. Results from the IBSEN-Study. Inflammatory Bowel Diseases. ISSN 1078-0998. 20(12), p. 31–32. doi: 10.1097/01.MIB.0000456782.03905.38. Full text in Research Archive
• Opheim, Randi (2012). “Bruk av komplementær og alternativ medisin blant pasienter med inflammatoriske tarmsykdommer”. Full text in Research Archive
• Opheim, Randi (2010). Complementary and alternative medicine among patients with Inflammatory Bowel Disease. Classification criteria determine level of use. Full text in Research Archive
• Antonsen, Anniken; Opheim, Randi; Schnierer, Martin; Bernklev, Tomm; Hyrdel, Rudolf & Moum, Bjørn (2010). Use of complementary and alternative medicine in Inflammatory bowel disease. Results from a hospital based registry in Slovakia. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 45, p. 51–51. Full text in Research Archive

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