Publications from Institute of Health and Society

• Molaug, Ina Charlotte; Engdahl, Bo Lars; Mehlum, Ingrid Sivesind; Stokholm, Zara Ann; Kolstad, Henrik & Aarhus, Lisa (2022). Quantitative levels of noise exposure and 20-year hearing decline: findings from a prospective cohort study (the HUNT Study). International Journal of Audiology. ISSN 1499-2027. doi: 10.1080/14992027.2022.2143432.
• Van Walsem, Marleen Regina; Frich, Jan C; Monica, Gomez; Howe, Emilie; Pihlstrøm, Lasse & Andelic, Nada [Show all 7 contributors for this article] (2022). Health Related Quality of Life, service utilization and costs for patients with Huntington’s disease in Norway . BMC Health Services Research. ISSN 1472-6963.
• Dahli, Mina Piiksi; Haavet, Ole Rikard; Ruud, Torleif & Brekke, Mette (2022). GPs’ identification of patients with mental distress: a coupled questionnaire and cohort study from norwegian urban general practice. BMC Primary Care. ISSN 2731-4553. 23(1). doi: 10.1186/s12875-022-01865-x.
• Clementsen, Ståle; Jakobsen, Rune Bruhn; Hammer, Ola-Lars & Randsborg, Per-Henrik (2022). The Effect of Ulnar Styloid Fractures on Patient-Reported Outcomes After Surgically Treated Distal Radial Fractures. JBJS Open Access. ISSN 2472-7245. 7(3). doi: 10.2106/JBJS.OA.22.00021.
• Wintrup, James (2022). Health by the people, again? The lost lessons of Alma-Ata in a community health worker programme in Zambia. Social Science and Medicine. ISSN 0277-9536. doi: 10.1016/j.socscimed.2022.115257.
• Kaußner, Yvonne; Röver, Christian; Heinz, Judith; Hummers, Eva; Debray, Thomas P.A. & Hay, Alastair D. [Show all 18 contributors for this article] (2022). Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis. Clinical Microbiology and Infection (CMI). ISSN 1198-743X. doi: 10.1016/j.cmi.2022.06.017.
• Muwonge, Adrian; Mpyangu, Christine Mbabazi; Nsangi, Allen; Mugerwa, Ibrahim; Bronsvoort, Barend M DeC & Porphyre, Thibaud [Show all 10 contributors for this article] (2022). Developing digital contact tracing tailored to haulage in East Africa to support COVID-19 surveillance: a protocol. BMJ Open. ISSN 2044-6055. 12(9). doi: 10.1136/bmjopen-2021-058457.
• Keller, Luise; Stelzle, Dominik; Schmidt, Veronika; Carabin, Hélène; Reinhold, Ann-Kristin & Keller, Claudius [Show all 12 contributors for this article] (2022). Community-level prevalence of epilepsy and of neurocysticercosis among people with epilepsy in the Balaka district of Malawi: A cross-sectional study. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 16(9). doi: 10.1371/journal.pntd.0010675.
• Yang, Yanping; Yin, Li; Liu, Qianwei; Sun, Jiangwei; Adami, Hans Olov & Ye, Weimin [Show all 8 contributors for this article] (2022). Hospital-Treated Infections and Increased Risk of Two EBV-Related Malignancies: A Nested Case-Control Study. Cancers. ISSN 2072-6694. 14(15). doi: 10.3390/cancers14153804.
• Pervjakova, Natalia; Moen, Gunn-Helen Øiseth; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P. & Allard, Catherine [Show all 73 contributors for this article] (2022). Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Human Molecular Genetics. ISSN 0964-6906. 31(19), p. 3377–3391. doi: 10.1093/hmg/ddac050. Full text in Research Archive
• Bjørnelv, Gudrun Maria Waaler; Hagen, Terje P.; Forma, Leena & Aas, Eline (2022). Care pathways at end-of-life for cancer decedents: registry based analyses of the living situation, healthcare utilization and costs for all cancer decedents in Norway in 2009-2013 during their last 6 months of life. BMC Health Services Research. ISSN 1472-6963. 22(1). doi: 10.1186/s12913-022-08526-w.
• Chesire, Faith; Ochieng, Marlyn; Mugisha, Michael; Ssenyonga, Ronald; Oxman, Matt & Nsangi, Allen [Show all 13 contributors for this article] (2022). Contextualizing critical thinking about health using digital technology in secondary schools in Kenya: a qualitative analysis. BMC Pilot and Feasibility Studies. ISSN 2055-5784. 8(1). doi: 10.1186/s40814-022-01183-0.
• Johannessen, Tonje Rambøll; Halvorsen, Sigrun; Atar, Dan; Munkhaugen, John; Nore, Anne Kathrine & Wisløff, Torbjørn [Show all 7 contributors for this article] (2022). Cost-effectiveness of a rule-out algorithm of acute myocardial infarction in low-risk patients: emergency primary care versus hospital setting. BMC Health Services Research. ISSN 1472-6963. 22. doi: 10.1186/s12913-022-08697-6. Full text in Research Archive Show summary

  Aims: Hospital admissions of patients with chest pain considered as low risk for acute coronary syndrome contribute to increased costs and crowding in the emergency departments. This study aims to estimate the cost-effectiveness of assessing these patients in a primary care emergency setting, using the European Society of Cardiology (ESC) 0/1-h algorithm for high-sensitivity cardiac troponin T, compared to routine hospital management. Methods: A cost-effectiveness analysis was conducted. For the primary care estimates, costs and health care expenditure from the observational OUT-ACS (One-hoUr Troponin in a low-prevalence population of Acute Coronary Syndrome) study were compared with anonymous extracted administrative data on low-risk patients at a large general hospital in Norway. Patients discharged home after the hs-cTnT assessment were defined as low risk in the primary care cohort. In the hospital setting, the low-risk group comprised patients discharged with a non-specific chest pain diagnosis (ICD-10 codes R07.4 and Z03.5). Loss of health related to a potential increase in acute myocardial infarctions the following 30-days was estimated. The primary outcome measure was the costs per quality-adjusted life year (QALY) of applying the ESC 0/1-h algorithm in primary care. The secondary outcomes were health care costs and length of stay in the two settings. Results: Differences in costs comprise personnel and laboratory costs of applying the algorithm at primary care level (€192) and expenses related to ambulance transports and complete hospital costs for low-risk patients admitted to hospital (€1986). Additional diagnostic procedures were performed in 31.9% (181/567) of the low-risk hospital cohort. The estimated reduction in health care cost when using the 0/1-h algorithm outside of hospital was €1794 per low-risk patient, with a mean decrease in length of stay of 18.9 h. These numbers result in an average per-person QALY gain of 0.0005. Increased QALY and decreased costs indicate that the primary care approach is clearly cost-effective. Conclusion: Using the ESC 0/1-h algorithm in low-risk patients in emergency primary care appears to be cost-effective compared to standard hospital management, with an extensive reduction in costs and length of stay per patient.

• Langa, Irene; Padama, Fernando; Nhancupe, Noémia; Pondja, Alberto; Hlashwayo, Delfina & Gouveia, Lidia [Show all 11 contributors for this article] (2022). The burden of T. solium cysticercosis and selected neuropsychiatric disorders in Mocuba district, Zambézia province, Mozambique. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 16(7). doi: 10.1371/journal.pntd.0010606.
• Batool, Narjis; Saleem, Zikria; Saeed, Hamid; Yasmeen, Sadia; Anwar, Rabia & Ahmad, Faheem [Show all 8 contributors for this article] (2022). Factors affecting health-related quality of life (HRQoL) in Pakistani children with thalassemia. Family Medicine and Primary Care Review. ISSN 1734-3402. 24(1), p. 37–42. doi: 10.5114/fmpcr.2022.113012.
• Lauppe, Rosa; Hansen, Johan Andre Liseth; Fornwall, Anna; Johansson, Katarina; Rozenbaum, Mark H. & Strand, Anne Mette [Show all 11 contributors for this article] (2022). Prevalence, characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy in the Nordic countries. ESC Heart Failure. ISSN 2055-5822. 9(4), p. 2528–2537. doi: 10.1002/ehf2.13961.
• Tsarpali, Vasiliki; Midtvedt, Karsten; Lønning, Kjersti; Bernklev, Tomm; Åsberg, Anders & Von der Lippe, Nanna [Show all 8 contributors for this article] (2022). Poor physical function trajectory predicts impaired patient survival in older recipients of deceased donor kidneys: A prospective cohort study. Transplantation direct. ISSN 2373-8731. 8(11). doi: 10.1097/TXD.0000000000001374. Full text in Research Archive Show summary

  Optimized health-related quality of life (HRQOL) at the time of kidney transplantation (KT) is associated with improved survival. In older KT recipients, we aimed to prospectively evaluate if HRQOL evolution during the first posttransplant year was associated with long-term patient survival. Methods: Recipients older than 65 y at KT who received an organ from a deceased brain-dead donor and survived >12 mo posttransplant were eligible. HRQOL was assessed pre-KT, at 10 wk, 6 mo, and 12 mo post-KT, using the Kidney Disease Quality of Life Short Form version 1.3 survey. A mixed-effect model was used to explore HRQOL evolution during the first posttransplant year in long-term survivors compared with nonsurvivors. Distinct HRQOL clusters were identified using a group-based trajectory modeling and their association with patient survival was investigated with Cox proportional hazard regression models. Results: We included 192 elderly recipients of deceased brain-dead donor kidneys who were transplanted from 2013 to 2020. Eleven died during the first year leaving 181 for evaluation (male, 125; mean age at KT, 72 y [65-84 y]). During a median observation time post-KT of 4.9 y (11.1-8.5 y), 57 recipients died. In survivors, all the generic and kidney-specific HRQOL domains substantially improved during the first year, whereas in nonsurvivors HRQOL deteriorated. Three longitudinal HRQOL trajectories indicating poor, fair, and good HRQOL evolution were identified. Poor physical function trajectory was significantly associated with higher mortality risk independent of covariates, as compared with good physical trajectory (hazard ratio, 2.38; 95% confidence interval, 1.15-5.01). Conclusions: In elderly KT recipients, detection of declining posttransplant physical function may imply impaired survival. Systematic HRQOL monitoring following KT provides added value when evaluating mortality and may guide therapeutic decisions.

• Liu, Q.; Yin, W.; Meijsen, J.J.; Reichenberg, A.; Gådin, J.R. & Schork, A.J. [Show all 10 contributors for this article] (2022). Cancer risk in individuals with autism spectrum disorder. Annals of Oncology. ISSN 0923-7534. 33(7), p. 713–719. doi: 10.1016/j.annonc.2022.04.006.

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• Bjørnelv, Gudrun Maria Waaler; Aas, Eline; Aaltonen, Mari; Hagen, Terje P. & Forma, Leena (2022). Place of living during end-of-life according to cause of death: a comparative analysis from Finland and Norway .
• Ahuja, Amisha & Mori, Yuichi (2022). High-quality Studies of Artificial Intelligence in Colonoscopy Illuminate a Next Important Step. Gastroenterology. ISSN 0016-5085. 163(3), p. 582–583. doi: 10.1053/j.gastro.2022.06.074.

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